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Fixation alters the physical properties of tumor tissue that regulate nanomedicine transport.

Publication ,  Journal Article
Martin, JD; Mpekris, F; Chauhan, VP; Martin, MR; Walsh, ME; Stuber, MD; McDonald, DM; Yuan, F; Stylianopoulos, T; Jain, RK
Published in: Drug delivery
December 2024

To have the desired therapeutic effect, nanomedicines and macromolecular medications must move from the site of injection to the site of action, without having adverse effects. Transvascular transport is a critical step of this navigation, as exemplified by the Enhanced Permeability and Retention (EPR) effect in solid tumors, not found in normal organs. Numerous studies have concluded that passive, diffusion- and convection-based transport predominates over active, cellular mechanisms in this effect. However, recent work using a new approach reevaluated this principle by comparing tumors with or without fixation and concluded the opposite. Here, we address the controversy generated by this new approach by reporting evidence from experimental investigations and computer simulations that separate the contributions of active and passive transport. Our findings indicate that tissue fixation reduces passive transport as well as active transport, indicating the need for new methods to distinguish the relative contributions of passive and active transport.

Duke Scholars

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Published In

Drug delivery

DOI

EISSN

1521-0464

ISSN

1071-7544

Publication Date

December 2024

Volume

31

Issue

1

Start / End Page

2430528

Related Subject Headings

  • Pharmacology & Pharmacy
  • Permeability
  • Neoplasms
  • Nanomedicine
  • Mice
  • Humans
  • Drug Delivery Systems
  • Diffusion
  • Computer Simulation
  • Biological Transport, Active
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Martin, J. D., Mpekris, F., Chauhan, V. P., Martin, M. R., Walsh, M. E., Stuber, M. D., … Jain, R. K. (2024). Fixation alters the physical properties of tumor tissue that regulate nanomedicine transport. Drug Delivery, 31(1), 2430528. https://doi.org/10.1080/10717544.2024.2430528
Martin, John D., Fotios Mpekris, Vikash P. Chauhan, Margaret R. Martin, Megan E. Walsh, Matthew D. Stuber, Donald M. McDonald, Fan Yuan, Triantafyllos Stylianopoulos, and Rakesh K. Jain. “Fixation alters the physical properties of tumor tissue that regulate nanomedicine transport.Drug Delivery 31, no. 1 (December 2024): 2430528. https://doi.org/10.1080/10717544.2024.2430528.
Martin JD, Mpekris F, Chauhan VP, Martin MR, Walsh ME, Stuber MD, et al. Fixation alters the physical properties of tumor tissue that regulate nanomedicine transport. Drug delivery. 2024 Dec;31(1):2430528.
Martin, John D., et al. “Fixation alters the physical properties of tumor tissue that regulate nanomedicine transport.Drug Delivery, vol. 31, no. 1, Dec. 2024, p. 2430528. Epmc, doi:10.1080/10717544.2024.2430528.
Martin JD, Mpekris F, Chauhan VP, Martin MR, Walsh ME, Stuber MD, McDonald DM, Yuan F, Stylianopoulos T, Jain RK. Fixation alters the physical properties of tumor tissue that regulate nanomedicine transport. Drug delivery. 2024 Dec;31(1):2430528.

Published In

Drug delivery

DOI

EISSN

1521-0464

ISSN

1071-7544

Publication Date

December 2024

Volume

31

Issue

1

Start / End Page

2430528

Related Subject Headings

  • Pharmacology & Pharmacy
  • Permeability
  • Neoplasms
  • Nanomedicine
  • Mice
  • Humans
  • Drug Delivery Systems
  • Diffusion
  • Computer Simulation
  • Biological Transport, Active