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Can radiomic analysis of a single-phase dual-energy CT improve the diagnostic accuracy of differentiating enhancing from non-enhancing small renal lesions?

Publication ,  Journal Article
Ding, Y; Meyer, M; Lyu, P; Rigiroli, F; Ramirez-Giraldo, JC; Lafata, K; Yang, S; Marin, D
Published in: Acta Radiol
June 2022

BACKGROUND: The value of dual-energy computed tomography (DECT)-based radiomics in renal lesions is unknown. PURPOSE: To develop DECT-based radiomic models and assess their incremental values in comparison to conventional measurements for differentiating enhancing from non-enhancing small renal lesions. MATERIAL AND METHODS: A total of 349 patients with 519 small renal lesions (390 non-enhancing, 129 enhancing) who underwent contrast-enhanced nephrographic phase DECT examinations between June 2013 and January 2020 on multiple DECT platforms were retrospectively recruited. Cohort A included all lesions, while cohort B included Bosniak II-IV and solid enhancing renal lesions. Radiomic models were built with features selected by the least absolute shrinkage and selection operator regression (LASSO). ROC analyses were performed to compare the diagnostic accuracy among conventional and radiomic models for predicting enhancing renal lesions. RESULTS: The individual iodine concentration (IC), normalized IC, mean attenuation on 75-keV images, radiomic model of iodine images, 75-keV images and a combined model integrating all the above-mentioned features all demonstrated high AUCs for predicting renal lesion enhancement in cohort A (AUCs = 0.934-0.979) as well as in the test dataset (AUCs = 0.892-0.962) of cohort B (P values with Bonferroni correction >0.003). The AUC (0.864) of mean attenuation on 75-keV images was significantly lower than those of other models (all P values ≤0.001) except the radiomic model of 75-keV images (P = 0.038) in the training dataset of cohort B. CONCLUSION: No incremental value was found by adding radiomic and machine learning analyses to iodine images for differentiating enhancing from non-enhancing renal lesions.

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Published In

Acta Radiol

DOI

EISSN

1600-0455

Publication Date

June 2022

Volume

63

Issue

6

Start / End Page

828 / 838

Location

England

Related Subject Headings

  • Tomography, X-Ray Computed
  • Retrospective Studies
  • ROC Curve
  • Nuclear Medicine & Medical Imaging
  • Kidney
  • Iodine
  • Humans
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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ICMJE
MLA
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Ding, Y., Meyer, M., Lyu, P., Rigiroli, F., Ramirez-Giraldo, J. C., Lafata, K., … Marin, D. (2022). Can radiomic analysis of a single-phase dual-energy CT improve the diagnostic accuracy of differentiating enhancing from non-enhancing small renal lesions? Acta Radiol, 63(6), 828–838. https://doi.org/10.1177/02841851211010396
Ding, Yuqin, Mathias Meyer, Peijie Lyu, Francesca Rigiroli, Juan Carlos Ramirez-Giraldo, Kyle Lafata, Siyun Yang, and Daniele Marin. “Can radiomic analysis of a single-phase dual-energy CT improve the diagnostic accuracy of differentiating enhancing from non-enhancing small renal lesions?Acta Radiol 63, no. 6 (June 2022): 828–38. https://doi.org/10.1177/02841851211010396.
Ding Y, Meyer M, Lyu P, Rigiroli F, Ramirez-Giraldo JC, Lafata K, et al. Can radiomic analysis of a single-phase dual-energy CT improve the diagnostic accuracy of differentiating enhancing from non-enhancing small renal lesions? Acta Radiol. 2022 Jun;63(6):828–38.
Ding, Yuqin, et al. “Can radiomic analysis of a single-phase dual-energy CT improve the diagnostic accuracy of differentiating enhancing from non-enhancing small renal lesions?Acta Radiol, vol. 63, no. 6, June 2022, pp. 828–38. Pubmed, doi:10.1177/02841851211010396.
Ding Y, Meyer M, Lyu P, Rigiroli F, Ramirez-Giraldo JC, Lafata K, Yang S, Marin D. Can radiomic analysis of a single-phase dual-energy CT improve the diagnostic accuracy of differentiating enhancing from non-enhancing small renal lesions? Acta Radiol. 2022 Jun;63(6):828–838.
Journal cover image

Published In

Acta Radiol

DOI

EISSN

1600-0455

Publication Date

June 2022

Volume

63

Issue

6

Start / End Page

828 / 838

Location

England

Related Subject Headings

  • Tomography, X-Ray Computed
  • Retrospective Studies
  • ROC Curve
  • Nuclear Medicine & Medical Imaging
  • Kidney
  • Iodine
  • Humans
  • 3202 Clinical sciences
  • 1103 Clinical Sciences