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Novel Methodology for Measuring Regional Myocardial Efficiency.

Publication ,  Journal Article
Gullberg, GT; Shrestha, UM; Veress, AI; Segars, WP; Liu, J; Ordovas, K; Seo, Y
Published in: IEEE Trans Med Imaging
June 2021

Our approach differs from the usual global measure of cardiac efficiency by using PET/MRI to measure efficiency of small pieces of cardiac tissue whose limiting size is equal to the spatial resolution of the PET scanner. We initiated a dynamic cardiac PET study immediately prior to the injection of 15.1 mCi of 11C-acetate acquiring data for 25 minutes while simultaneously acquiring MRI cine data. 1) A 3D finite element (FE) biomechanical model of the imaged heart was constructed by utilizing nonrigid deformable image registration to alter the Dassault Systèmes FE Living Heart Model (LHM) to fit the geometry in the cardiac MRI cine data. The patient specific FE cardiac model with estimates of stress, strain, and work was transformed into PET/MRI format. 2) A 1-tissue compartment model was used to calculate wash-in (K1) and the linear portion of the decay in the PET 11C-acetate time activity curve (TAC) was used to calculate the wash-out k2(mono) rate constant. K1 was used to calculate blood flow and k2(mono) was used to calculate myocardial volume oxygen consumption ( MVO2 ). 3) Estimates of stress and strain were used to calculate Myocardial Equivalent Minute Work ( MEMW ) and Cardiac Efficiency = MEMW/MVO2 was then calculated for 17 tissue segments of the left ventricle. The global MBF was 0.96 ± 0.15 ml/min/gm and MVO2 ranged from 8 to 17 ml/100gm/min. Six central slices of the MRI cine data provided a range of MEMW of 0.1 to 0.4 joules/gm/min and a range of Cardiac Efficiency of 6 to 18%.

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Published In

IEEE Trans Med Imaging

DOI

EISSN

1558-254X

Publication Date

June 2021

Volume

40

Issue

6

Start / End Page

1711 / 1725

Location

United States

Related Subject Headings

  • Oxygen Consumption
  • Nuclear Medicine & Medical Imaging
  • Myocardium
  • Magnetic Resonance Imaging, Cine
  • Humans
  • Heart Ventricles
  • Heart
  • Coronary Circulation
  • 46 Information and computing sciences
  • 40 Engineering
 

Citation

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Gullberg, G. T., Shrestha, U. M., Veress, A. I., Segars, W. P., Liu, J., Ordovas, K., & Seo, Y. (2021). Novel Methodology for Measuring Regional Myocardial Efficiency. IEEE Trans Med Imaging, 40(6), 1711–1725. https://doi.org/10.1109/TMI.2021.3065219
Gullberg, Grant T., Uttam M. Shrestha, Alexander I. Veress, W Paul Segars, Jing Liu, Karen Ordovas, and Youngho Seo. “Novel Methodology for Measuring Regional Myocardial Efficiency.IEEE Trans Med Imaging 40, no. 6 (June 2021): 1711–25. https://doi.org/10.1109/TMI.2021.3065219.
Gullberg GT, Shrestha UM, Veress AI, Segars WP, Liu J, Ordovas K, et al. Novel Methodology for Measuring Regional Myocardial Efficiency. IEEE Trans Med Imaging. 2021 Jun;40(6):1711–25.
Gullberg, Grant T., et al. “Novel Methodology for Measuring Regional Myocardial Efficiency.IEEE Trans Med Imaging, vol. 40, no. 6, June 2021, pp. 1711–25. Pubmed, doi:10.1109/TMI.2021.3065219.
Gullberg GT, Shrestha UM, Veress AI, Segars WP, Liu J, Ordovas K, Seo Y. Novel Methodology for Measuring Regional Myocardial Efficiency. IEEE Trans Med Imaging. 2021 Jun;40(6):1711–1725.

Published In

IEEE Trans Med Imaging

DOI

EISSN

1558-254X

Publication Date

June 2021

Volume

40

Issue

6

Start / End Page

1711 / 1725

Location

United States

Related Subject Headings

  • Oxygen Consumption
  • Nuclear Medicine & Medical Imaging
  • Myocardium
  • Magnetic Resonance Imaging, Cine
  • Humans
  • Heart Ventricles
  • Heart
  • Coronary Circulation
  • 46 Information and computing sciences
  • 40 Engineering