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Seeing stars: Development and function of retinal astrocytes.

Publication ,  Journal Article
Paisley, CE; Kay, JN
Published in: Dev Biol
October 2021

Throughout the central nervous system, astrocytes adopt precisely ordered spatial arrangements of their somata and arbors, which facilitate their many important functions. Astrocyte pattern formation is particularly important in the retina, where astrocytes serve as a template that dictates the pattern of developing retinal vasculature. Thus, if astrocyte patterning is disturbed, there are severe consequences for retinal angiogenesis and ultimately for vision - as seen in diseases such as retinopathy of prematurity. Here we discuss key steps in development of the retinal astrocyte population. We describe how fundamental developmental forces - their birth, migration, proliferation, and death - sculpt astrocytes into a template that guides angiogenesis. We further address the radical changes in the cellular and molecular composition of the astrocyte network that occur upon completion of angiogenesis, paving the way for their adult functions in support of retinal ganglion cell axons. Understanding development of retinal astrocytes may elucidate pattern formation mechanisms that are deployed broadly by other axon-associated astrocyte populations.

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Published In

Dev Biol

DOI

EISSN

1095-564X

Publication Date

October 2021

Volume

478

Start / End Page

144 / 154

Location

United States

Related Subject Headings

  • Retinopathy of Prematurity
  • Retinal Vessels
  • Retinal Ganglion Cells
  • Retina
  • Nerve Fibers
  • Neovascularization, Physiologic
  • Humans
  • Developmental Biology
  • Cell Proliferation
  • Cell Movement
 

Citation

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Paisley, C. E., & Kay, J. N. (2021). Seeing stars: Development and function of retinal astrocytes. Dev Biol, 478, 144–154. https://doi.org/10.1016/j.ydbio.2021.07.007
Paisley, Caitlin E., and Jeremy N. Kay. “Seeing stars: Development and function of retinal astrocytes.Dev Biol 478 (October 2021): 144–54. https://doi.org/10.1016/j.ydbio.2021.07.007.
Paisley CE, Kay JN. Seeing stars: Development and function of retinal astrocytes. Dev Biol. 2021 Oct;478:144–54.
Paisley, Caitlin E., and Jeremy N. Kay. “Seeing stars: Development and function of retinal astrocytes.Dev Biol, vol. 478, Oct. 2021, pp. 144–54. Pubmed, doi:10.1016/j.ydbio.2021.07.007.
Paisley CE, Kay JN. Seeing stars: Development and function of retinal astrocytes. Dev Biol. 2021 Oct;478:144–154.
Journal cover image

Published In

Dev Biol

DOI

EISSN

1095-564X

Publication Date

October 2021

Volume

478

Start / End Page

144 / 154

Location

United States

Related Subject Headings

  • Retinopathy of Prematurity
  • Retinal Vessels
  • Retinal Ganglion Cells
  • Retina
  • Nerve Fibers
  • Neovascularization, Physiologic
  • Humans
  • Developmental Biology
  • Cell Proliferation
  • Cell Movement