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The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1.

Publication ,  Journal Article
Stefaniak, E; Płonka, D; Drew, SC; Bossak-Ahmad, K; Haas, KL; Pushie, MJ; Faller, P; Wezynfeld, NE; Bal, W
Published in: Metallomics : integrated biometal science
December 2018

Human cells acquire copper primarily via the copper transporter 1 protein, hCtr1. We demonstrate that at extracellular pH 7.4 CuII is bound to the model peptide hCtr11-14via an ATCUN motif and such complexes are strong enough to collect CuII from albumin, supporting the potential physiological role of CuII binding to hCtr1.

Duke Scholars

Published In

Metallomics : integrated biometal science

DOI

EISSN

1756-591X

ISSN

1756-5901

Publication Date

December 2018

Volume

10

Issue

12

Start / End Page

1723 / 1727

Related Subject Headings

  • Serum Albumin, Human
  • Protein Binding
  • Peptide Fragments
  • Models, Molecular
  • Humans
  • Copper Transporter 1
  • Copper
  • Cation Transport Proteins
  • Biological Transport
  • Binding Sites
 

Citation

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Stefaniak, E., Płonka, D., Drew, S. C., Bossak-Ahmad, K., Haas, K. L., Pushie, M. J., … Bal, W. (2018). The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1. Metallomics : Integrated Biometal Science, 10(12), 1723–1727. https://doi.org/10.1039/c8mt00274f
Stefaniak, Ewelina, Dawid Płonka, Simon C. Drew, Karolina Bossak-Ahmad, Kathryn L. Haas, M Jake Pushie, Peter Faller, Nina E. Wezynfeld, and Wojciech Bal. “The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1.Metallomics : Integrated Biometal Science 10, no. 12 (December 2018): 1723–27. https://doi.org/10.1039/c8mt00274f.
Stefaniak E, Płonka D, Drew SC, Bossak-Ahmad K, Haas KL, Pushie MJ, et al. The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1. Metallomics : integrated biometal science. 2018 Dec;10(12):1723–7.
Stefaniak, Ewelina, et al. “The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1.Metallomics : Integrated Biometal Science, vol. 10, no. 12, Dec. 2018, pp. 1723–27. Epmc, doi:10.1039/c8mt00274f.
Stefaniak E, Płonka D, Drew SC, Bossak-Ahmad K, Haas KL, Pushie MJ, Faller P, Wezynfeld NE, Bal W. The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1. Metallomics : integrated biometal science. 2018 Dec;10(12):1723–1727.
Journal cover image

Published In

Metallomics : integrated biometal science

DOI

EISSN

1756-591X

ISSN

1756-5901

Publication Date

December 2018

Volume

10

Issue

12

Start / End Page

1723 / 1727

Related Subject Headings

  • Serum Albumin, Human
  • Protein Binding
  • Peptide Fragments
  • Models, Molecular
  • Humans
  • Copper Transporter 1
  • Copper
  • Cation Transport Proteins
  • Biological Transport
  • Binding Sites