Kathryn Haas | Scholars@Duke

Kathryn Haas
Associate Professor of the Practice of Chemistry

Office Hours

Office Hours by appointment (click here).

Current Appointments & Affiliations

Associate Professor of the Practice of Chemistry, Chemistry, Trinity College of Arts & Sciences 2021

Contact Information

1224 French Science Center, 124 Science Drive Box 90346, Durham, NC 27708
Box 90346, Durham, NC 27708-0346
kathryn.haas@duke.edu (919) 660-1525
Haas Group Website

Background
Education, Training, & Certifications
- Postdoctoral Intramural Research Training Fellow, Laboratory Of Toxicology And Pharmacology, National Institutes of Health 2010 - 2011
- Ph.D., Duke University 2010
Academic Positions Outside Duke
- Associate Professor, Department of Chemistry and Physics, Saint Mary's College, IN. 2019 - 2021
- Assistant Professor, Department of Chemistry and Physics, Saint Mary's College, IN. 2012 - 2019
- Visiting Assistant Professor, Department of Chemistry and Biochemistry, Indiana University, South Bend, IN. 2012
Expertise
Subject Headings
- Muser Mentor
Research
Selected Grants
- MRI: Acquisition of a Microscale Thermophoresis System awarded by National Science Foundation 2022 - 2025
- Communicating Science: 12 Profound Scientific Breakthroughs awarded by Research Corporation for Science Advancement 2022 - 2023
- Transporting Cu(I) as Cargo and Using Cu(III) as a Killer Cofactor: Histidine-rich Motifs in Ctr1 and Histatin 5 Control Cu Oxidation State and Reactivity awarded by Research Corporation for Science Advancement 2021 - 2023
- A plant cell-based platform to target human proteostasis diseases awarded by Gordon & Betty Moore Foundation 2021 - 2022
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Schulte, Natalie B., M Jake Pushie, Ana Martinez, Madison Sendzik, Maria Escobedo, Kristin Kuter, and Kathryn L. Haas. “Exploration of the Potential Role of Serum Albumin in the Delivery of Cu(I) to Ctr1.” Inorganic Chemistry 62, no. 10 (March 2023): 4021–34. https://doi.org/10.1021/acs.inorgchem.2c03753.
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  - Stefaniak, Ewelina, M Jake Pushie, Catherine Vaerewyck, David Corcelli, Chloe Griggs, Whitney Lewis, Emma Kelley, et al. “Exploration of the Potential Role for Aβ in Delivery of Extracellular Copper to Ctr1.” Inorganic Chemistry 59, no. 23 (December 2020): 16952–66. https://doi.org/10.1021/acs.inorgchem.0c02100.
    Full Text
  - Pushie, M Jake, Ewelina Stefaniak, Madison R. Sendzik, Dimosthenis Sokaras, Thomas Kroll, and Kathryn L. Haas. “Using N-Terminal Coordination of Cu(II) and Ni(II) to Isolate the Coordination Environment of Cu(I) and Cu(II) Bound to His13 and His14 in Amyloid-β(4-16).” Inorganic Chemistry 58, no. 22 (November 2019): 15138–54. https://doi.org/10.1021/acs.inorgchem.9b01940.
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  - Stefaniak, Ewelina, Dawid Płonka, Simon C. Drew, Karolina Bossak-Ahmad, Kathryn L. Haas, M Jake Pushie, Peter Faller, Nina E. Wezynfeld, and Wojciech Bal. “The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1.” Metallomics : Integrated Biometal Science 10, no. 12 (December 2018): 1723–27. https://doi.org/10.1039/c8mt00274f.
    Full Text
  - Haas, Kathryn L., Jennifer M. Heemstra, Marnix H. Medema, and Louise K. Charkoudian. “Collaborating with Undergraduates To Contribute to Biochemistry Community Resources.” Biochemistry 57, no. 4 (January 2018): 383–89. https://doi.org/10.1021/acs.biochem.7b00872.
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  - Sendzik, Madison, M Jake Pushie, Ewelina Stefaniak, and Kathryn L. Haas. “Structure and Affinity of Cu(I) Bound to Human Serum Albumin.” Inorganic Chemistry 56, no. 24 (December 2017): 15057–65. https://doi.org/10.1021/acs.inorgchem.7b02397.
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  - Conklin, S. E., E. C. Bridgman, Q. Su, P. Riggs-Gelasco, and K. J. Franz. “Specific Histidine Residues Confer Histatin Peptides with Copper-Dependent Activity against Candida albicans.” Biochemistry, August 1, 2017. https://doi.org/10.1021/acs.biochem.7b00348.
    Full Text Open Access Copy Link to Item
  - Schwab, Stefanie, Jason Shearer, Steven E. Conklin, Bruno Alies, and Kathryn L. Haas. “Sequence proximity between Cu(II) and Cu(I) binding sites of human copper transporter 1 model peptides defines reactivity with ascorbate and O2.” Journal of Inorganic Biochemistry 158 (May 2016): 70–76. https://doi.org/10.1016/j.jinorgbio.2015.12.021.
    Full Text Open Access Copy
  - Pushie, M Jake, Katharine Shaw, Katherine J. Franz, Jason Shearer, and Kathryn L. Haas. “Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1.” Inorganic Chemistry 54, no. 17 (September 2015): 8544–51. https://doi.org/10.1021/acs.inorgchem.5b01162.
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  - Haas, Kathryn L., Allison B. Putterman, Daniel R. White, Dennis J. Thiele, and Katherine J. Franz. “Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1.” Journal of the American Chemical Society 133, no. 12 (March 2011): 4427–37. https://doi.org/10.1021/ja108890c.
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  - Ciesienski, Katie L., Kathryn L. Haas, and Katherine J. Franz. “Development of next-generation photolabile copper cages with improved copper binding properties.” Dalton Transactions (Cambridge, England : 2003) 39, no. 40 (October 2010): 9538–46. https://doi.org/10.1039/c0dt00770f.
    Full Text Open Access Copy
  - Ciesienski, K. L., L. M. Hyman, D. T. Yang, K. L. Haas, M. G. Dickens, R. J. Holbrook, and K. J. Franz. “A photo-caged platinum(II) complex that increases cytotoxicity upon light activation.” European Journal of Inorganic Chemistry, no. 15 (January 1, 2010): 2224–28. https://doi.org/10.1002/ejic.201000098.
    Full Text
  - Haas, Kathryn L., and Katherine J. Franz. “Application of metal coordination chemistry to explore and manipulate cell biology.” Chemical Reviews 109, no. 10 (October 2009): 4921–60. https://doi.org/10.1021/cr900134a.
    Full Text
  - Ciesienski, Katie L., Kathryn L. Haas, Marina G. Dickens, Yohannes T. Tesema, and Katherine J. Franz. “A photolabile ligand for light-activated release of caged copper.” Journal of the American Chemical Society 130, no. 37 (September 2008): 12246–47. https://doi.org/10.1021/ja8047442.
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  - Charkoudian, L. K., J. J. Heymann, M. J. Adler, K. L. Haas, K. A. Mies, and J. F. Bonk. “Forensics as a gateway: Promoting undergraduate interest in science and graduate student professional development through a first-year seminar course.” Journal of Chemical Education 85, no. 6 (January 1, 2008): 807–12. https://doi.org/10.1021/ed085p807.
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- Conference Papers
  - Franz, Katherine J., and Kathryn L. Haas. “Insights into the role of histidine in Ctr1-dependent copper uptake.” In Abstracts of Papers of the American Chemical Society, Vol. 240. AMER CHEMICAL SOC, 2010.
    Link to Item
  - Haas, Kathryn L., Daniel R. White, and Katherine J. Franz. “Spectroscopic studies of N-terminal Cu(II)- and Cu(I)-binding hCtrl model peptides.” In Abstracts of Papers of the American Chemical Society, Vol. 238. AMER CHEMICAL SOC, 2009.
    Link to Item
  - Ciesienski, Katie L., Kathryn L. Haas, Marina G. Dickens, and Katherine J. Franz. “Photolabile ligand for light-activated release of caged copper.” In Abstracts of Papers of the American Chemical Society, Vol. 237. AMER CHEMICAL SOC, 2009.
    Link to Item
  - Heymann, Jared J., Louise K. Charkoudian, Marc J. Adler, Kathryn L. Haas, Kassy A. Mies, and James F. Bonk. “CSI in the classroom: Teaching science in a non-majors first-year seminar using forensics and chemistry.” In Abstracts of Papers of the American Chemical Society, Vol. 234, 2007.
    Link to Item
  - Franz, Katherine J., Kathryn Haas, Jeffrey Rubino, and David Pham. “INOR 1011-Copper(I) binding by methionine-rich domains of copper transport proteins.” In Abstracts of Papers of the American Chemical Society, Vol. 232. AMER CHEMICAL SOC, 2006.
    Link to Item
Teaching & Mentoring
Recent Courses
- CHEM 301L: Physical Chemistry Laboratory 2023
- CHEM 310L: Physical Chemistry I Laboratory 2023
- CHEM 311L: Physical Chemistry II Laboratory 2023
- CHEM 393: Research Independent Study 2023
- CHEM 394: Research Independent Study 2023
- CHEM 401L: Analytical Chemistry Laboratory 2023
- CHEM 493: Research Independent Study 2023
- CHEM 494: Research Independent Study 2023
- CHEM 301L: Physical Chemistry Laboratory 2022
- CHEM 310L: Physical Chemistry I Laboratory 2022
- CHEM 311L: Physical Chemistry II Laboratory 2022
- CHEM 393: Research Independent Study 2022
- CHEM 394: Research Independent Study 2022
- CHEM 401L: Analytical Chemistry Laboratory 2022
- CHEM 493: Research Independent Study 2022
- CHEM 494: Research Independent Study 2022
- CHEM 310L: Physical Chemistry I Laboratory 2021
- CHEM 393: Research Independent Study 2021
- CHEM 394: Research Independent Study 2021
- CHEM 401L: Analytical Chemistry Laboratory 2021
- CHEM 493: Research Independent Study 2021
- CHEM 494: Research Independent Study 2021

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Education, Training, & Certifications

Academic Positions Outside Duke

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Recent Courses