Overview
Biological molecules can unlock and harness the special chemical power of metal ions, while also maintaining control of metal homeostasis. The Haas Lab investigates the interactions between metal ions and polypeptides, with a focus on the proteins that harness copper redox chemistry in human extracellular fluids and at membrane interfaces.
Current Appointments & Affiliations
Associate Professor of the Practice of Chemistry
·
2021 - Present
Chemistry,
Trinity College of Arts & Sciences
Recent Publications
Investigating Cu(I) binding to model peptides of N-terminal Aβ isoforms.
Journal Article Journal of inorganic biochemistry · April 2024 Amyloid beta (Aβ) peptides and copper (Cu) ions are each involved in critical biological processes including antimicrobial activity, regulation of synaptic function, angiogenesis, and others. Aβ binds to Cu and may play a role in Cu trafficking. Aβ peptide ... Full text CiteHow did STEM students respond to a cross-campus discussion forum about macroethics? An exploratory content analysis of students’ written reflections
Journal Article SN Social Sciences · September 1, 2023 Ethics education is increasingly recognized as an essential element of undergraduate programs focused on science, technology, engineering, and mathematics (STEM). One method is training future STEM professionals in responsible conduct of research at the in ... Full text CiteExploration of the Potential Role of Serum Albumin in the Delivery of Cu(I) to Ctr1.
Journal Article Inorganic chemistry · March 2023 Human serum albumin (HSA) is the major copper (Cu) carrier in blood. The majority of previous studies that have investigated Cu interactions with HSA have focused primarily on the Cu(II) oxidation state. Yet, cellular Cu uptake by the human copper transpor ... Full text CiteRecent Grants
Communicating Science: 12 Profound Scientific Breakthroughs
ResearchPrincipal Investigator · Awarded by Research Corporation for Science Advancement · 2022 - 2025MRI: Acquisition of a Microscale Thermophoresis System
EquipmentMajor User · Awarded by National Science Foundation · 2022 - 2025Transporting Cu(I) as Cargo and Using Cu(III) as a Killer Cofactor: Histidine-rich Motifs in Ctr1 and Histatin 5 Control Cu Oxidation State and Reactivity
ResearchPrincipal Investigator · Awarded by Research Corporation for Science Advancement · 2021 - 2024View All Grants
Education, Training & Certifications
Duke University ·
2010
Ph.D.