Skip to main content
Journal cover image

A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow.

Publication ,  Journal Article
Basu, J; Srinivas, KV; Cheung, SK; Taniguchi, H; Huang, ZJ; Siegelbaum, SA
Published in: Neuron
September 18, 2013

How does coordinated activity between distinct brain regions implement a set of learning rules to sculpt information processing in a given neural circuit? Using interneuron cell-type-specific optical activation and pharmacogenetic silencing in vitro, we show that temporally precise pairing of direct entorhinal perforant path (PP) and hippocampal Schaffer collateral (SC) inputs to CA1 pyramidal cells selectively suppresses SC-associated perisomatic inhibition from cholecystokinin (CCK)-expressing interneurons. The CCK interneurons provide a surprisingly strong feedforward inhibitory drive to effectively control the coincident excitation of CA1 pyramidal neurons by convergent inputs. Thus, in-phase cortico-hippocampal activity provides a powerful heterosynaptic learning rule for long-term gating of information flow through the hippocampal excitatory macrocircuit by the silencing of the CCK inhibitory microcircuit.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

September 18, 2013

Volume

79

Issue

6

Start / End Page

1208 / 1221

Location

United States

Related Subject Headings

  • Synapses
  • Patch-Clamp Techniques
  • Parvalbumins
  • Optogenetics
  • Neurons
  • Neurology & Neurosurgery
  • Neural Pathways
  • Nerve Net
  • Models, Neurological
  • Mice, Transgenic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Basu, J., Srinivas, K. V., Cheung, S. K., Taniguchi, H., Huang, Z. J., & Siegelbaum, S. A. (2013). A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow. Neuron, 79(6), 1208–1221. https://doi.org/10.1016/j.neuron.2013.07.001
Basu, Jayeeta, Kalyan V. Srinivas, Stephanie K. Cheung, Hiroki Taniguchi, Z Josh Huang, and Steven A. Siegelbaum. “A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow.Neuron 79, no. 6 (September 18, 2013): 1208–21. https://doi.org/10.1016/j.neuron.2013.07.001.
Basu J, Srinivas KV, Cheung SK, Taniguchi H, Huang ZJ, Siegelbaum SA. A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow. Neuron. 2013 Sep 18;79(6):1208–21.
Basu, Jayeeta, et al. “A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow.Neuron, vol. 79, no. 6, Sept. 2013, pp. 1208–21. Pubmed, doi:10.1016/j.neuron.2013.07.001.
Basu J, Srinivas KV, Cheung SK, Taniguchi H, Huang ZJ, Siegelbaum SA. A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow. Neuron. 2013 Sep 18;79(6):1208–1221.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

September 18, 2013

Volume

79

Issue

6

Start / End Page

1208 / 1221

Location

United States

Related Subject Headings

  • Synapses
  • Patch-Clamp Techniques
  • Parvalbumins
  • Optogenetics
  • Neurons
  • Neurology & Neurosurgery
  • Neural Pathways
  • Nerve Net
  • Models, Neurological
  • Mice, Transgenic