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A neural circuit for spatial summation in visual cortex.

Publication ,  Journal Article
Adesnik, H; Bruns, W; Taniguchi, H; Huang, ZJ; Scanziani, M
Published in: Nature
October 11, 2012

The response of cortical neurons to a sensory stimulus is modulated by the context. In the visual cortex, for example, stimulation of a pyramidal cell's receptive-field surround can attenuate the cell's response to a stimulus in the centre of its receptive field, a phenomenon called surround suppression. Whether cortical circuits contribute to surround suppression or whether the phenomenon is entirely relayed from earlier stages of visual processing is debated. Here we show that, in contrast to pyramidal cells, the response of somatostatin-expressing inhibitory neurons (SOMs) in the superficial layers of the mouse visual cortex increases with stimulation of the receptive-field surround. This difference results from the preferential excitation of SOMs by horizontal cortical axons. By perturbing the activity of SOMs, we show that these neurons contribute to pyramidal cells' surround suppression. These results establish a cortical circuit for surround suppression and attribute a particular function to a genetically defined type of inhibitory neuron.

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Published In

Nature

DOI

EISSN

1476-4687

Publication Date

October 11, 2012

Volume

490

Issue

7419

Start / End Page

226 / 231

Location

England

Related Subject Headings

  • Visual Cortex
  • Retinal Neurons
  • Pyramidal Cells
  • Postsynaptic Potential Summation
  • Mice
  • General Science & Technology
  • Axons
  • Animals
 

Citation

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Adesnik, H., Bruns, W., Taniguchi, H., Huang, Z. J., & Scanziani, M. (2012). A neural circuit for spatial summation in visual cortex. Nature, 490(7419), 226–231. https://doi.org/10.1038/nature11526
Adesnik, Hillel, William Bruns, Hiroki Taniguchi, Z Josh Huang, and Massimo Scanziani. “A neural circuit for spatial summation in visual cortex.Nature 490, no. 7419 (October 11, 2012): 226–31. https://doi.org/10.1038/nature11526.
Adesnik H, Bruns W, Taniguchi H, Huang ZJ, Scanziani M. A neural circuit for spatial summation in visual cortex. Nature. 2012 Oct 11;490(7419):226–31.
Adesnik, Hillel, et al. “A neural circuit for spatial summation in visual cortex.Nature, vol. 490, no. 7419, Oct. 2012, pp. 226–31. Pubmed, doi:10.1038/nature11526.
Adesnik H, Bruns W, Taniguchi H, Huang ZJ, Scanziani M. A neural circuit for spatial summation in visual cortex. Nature. 2012 Oct 11;490(7419):226–231.
Journal cover image

Published In

Nature

DOI

EISSN

1476-4687

Publication Date

October 11, 2012

Volume

490

Issue

7419

Start / End Page

226 / 231

Location

England

Related Subject Headings

  • Visual Cortex
  • Retinal Neurons
  • Pyramidal Cells
  • Postsynaptic Potential Summation
  • Mice
  • General Science & Technology
  • Axons
  • Animals