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Lineage-specific laminar organization of cortical GABAergic interneurons.

Publication ,  Journal Article
Ciceri, G; Dehorter, N; Sols, I; Huang, ZJ; Maravall, M; Marín, O
Published in: Nat Neurosci
September 2013

In the cerebral cortex, pyramidal cells and interneurons are generated in distant germinal zones, and so the mechanisms that control their precise assembly into specific microcircuits remain an enigma. Here we report that cortical interneurons labeled at the clonal level do not distribute randomly but rather have a strong tendency to cluster in the mouse neocortex. This behavior is common to different classes of interneurons, independently of their origin. Interneuron clusters are typically contained within one or two adjacent cortical layers, are largely formed by isochronically generated neurons and populate specific layers, as revealed by unbiased hierarchical clustering methods. Our results suggest that different progenitor cells give rise to interneurons populating infra- and supragranular cortical layers, which challenges current views of cortical neurogenesis. Thus, specific lineages of cortical interneurons seem to be produced to primarily mirror the laminar structure of the cerebral cortex, rather than its columnar organization.

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Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

September 2013

Volume

16

Issue

9

Start / End Page

1199 / 1210

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Transcription Factors
  • Tamoxifen
  • Selective Estrogen Receptor Modulators
  • Pregnancy
  • Neurology & Neurosurgery
  • Neural Stem Cells
  • Nerve Tissue Proteins
  • Mice, Transgenic
  • Mice
 

Citation

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Ciceri, G., Dehorter, N., Sols, I., Huang, Z. J., Maravall, M., & Marín, O. (2013). Lineage-specific laminar organization of cortical GABAergic interneurons. Nat Neurosci, 16(9), 1199–1210. https://doi.org/10.1038/nn.3485
Ciceri, Gabriele, Nathalie Dehorter, Ignasi Sols, Z Josh Huang, Miguel Maravall, and Oscar Marín. “Lineage-specific laminar organization of cortical GABAergic interneurons.Nat Neurosci 16, no. 9 (September 2013): 1199–1210. https://doi.org/10.1038/nn.3485.
Ciceri G, Dehorter N, Sols I, Huang ZJ, Maravall M, Marín O. Lineage-specific laminar organization of cortical GABAergic interneurons. Nat Neurosci. 2013 Sep;16(9):1199–210.
Ciceri, Gabriele, et al. “Lineage-specific laminar organization of cortical GABAergic interneurons.Nat Neurosci, vol. 16, no. 9, Sept. 2013, pp. 1199–210. Pubmed, doi:10.1038/nn.3485.
Ciceri G, Dehorter N, Sols I, Huang ZJ, Maravall M, Marín O. Lineage-specific laminar organization of cortical GABAergic interneurons. Nat Neurosci. 2013 Sep;16(9):1199–1210.

Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

September 2013

Volume

16

Issue

9

Start / End Page

1199 / 1210

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Transcription Factors
  • Tamoxifen
  • Selective Estrogen Receptor Modulators
  • Pregnancy
  • Neurology & Neurosurgery
  • Neural Stem Cells
  • Nerve Tissue Proteins
  • Mice, Transgenic
  • Mice