Following the genes: a framework for animal modeling of psychiatric disorders.
Publication
, Journal Article
Mitchell, KJ; Huang, ZJ; Moghaddam, B; Sawa, A
Published in: BMC Biol
November 11, 2011
The number of individual cases of psychiatric disorders that can be ascribed to identified, rare, single mutations is increasing with great rapidity. Such mutations can be recapitulated in mice to generate animal models with direct etiological validity. Defining the underlying pathogenic mechanisms will require an experimental and theoretical framework to make the links from mutation to altered behavior in an animal or psychopathology in a human. Here, we discuss key elements of such a framework, including cell type-based phenotyping, developmental trajectories, linking circuit properties at micro and macro scales and definition of neurobiological phenotypes that are directly translatable to humans.
Duke Scholars
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Published In
BMC Biol
DOI
EISSN
1741-7007
Publication Date
November 11, 2011
Volume
9
Start / End Page
76
Location
England
Related Subject Headings
- Translational Research, Biomedical
- Signal Transduction
- Models, Biological
- Mental Disorders
- Humans
- Disease Models, Animal
- Developmental Biology
- Animals
- 31 Biological sciences
- 06 Biological Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Mitchell, K. J., Huang, Z. J., Moghaddam, B., & Sawa, A. (2011). Following the genes: a framework for animal modeling of psychiatric disorders. BMC Biol, 9, 76. https://doi.org/10.1186/1741-7007-9-76
Mitchell, Kevin J., Z Josh Huang, Bita Moghaddam, and Akira Sawa. “Following the genes: a framework for animal modeling of psychiatric disorders.” BMC Biol 9 (November 11, 2011): 76. https://doi.org/10.1186/1741-7007-9-76.
Mitchell KJ, Huang ZJ, Moghaddam B, Sawa A. Following the genes: a framework for animal modeling of psychiatric disorders. BMC Biol. 2011 Nov 11;9:76.
Mitchell, Kevin J., et al. “Following the genes: a framework for animal modeling of psychiatric disorders.” BMC Biol, vol. 9, Nov. 2011, p. 76. Pubmed, doi:10.1186/1741-7007-9-76.
Mitchell KJ, Huang ZJ, Moghaddam B, Sawa A. Following the genes: a framework for animal modeling of psychiatric disorders. BMC Biol. 2011 Nov 11;9:76.
Published In
BMC Biol
DOI
EISSN
1741-7007
Publication Date
November 11, 2011
Volume
9
Start / End Page
76
Location
England
Related Subject Headings
- Translational Research, Biomedical
- Signal Transduction
- Models, Biological
- Mental Disorders
- Humans
- Disease Models, Animal
- Developmental Biology
- Animals
- 31 Biological sciences
- 06 Biological Sciences