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15N-Azides as practical and effective tags for developing long-lived hyperpolarized agents.

Publication ,  Journal Article
Bae, J; Zhang, G; Park, H; Warren, WS; Wang, Q
Published in: Chemical science
November 2021

Azide moieties, unique linear species containing three nitrogen atoms, represent an attractive class of molecular tag for hyperpolarized magnetic resonance imaging (HP-MRI). Here we demonstrate (15N)3-azide-containing molecules exhibit long-lasting hyperpolarization lifetimes up to 9.8 min at 1 T with remarkably high polarization levels up to 11.6% in water, thus establishing (15N)3-azide as a powerful spin storage for hyperpolarization. A single (15N)-labeled azide has also been examined as an effective alternative tag with long-lived hyperpolarization. A variety of biologically important molecules are studied in this work, including choline, glucose, amino acid, and drug derivatives, demonstrating great potential of 15N-labeled azides as universal hyperpolarized tags for nuclear magnetic resonance imaging applications.

Duke Scholars

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Published In

Chemical science

DOI

EISSN

2041-6539

ISSN

2041-6520

Publication Date

November 2021

Volume

12

Issue

42

Start / End Page

14309 / 14315

Related Subject Headings

  • 34 Chemical sciences
  • 03 Chemical Sciences
 

Citation

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Bae, J., Zhang, G., Park, H., Warren, W. S., & Wang, Q. (2021). 15N-Azides as practical and effective tags for developing long-lived hyperpolarized agents. Chemical Science, 12(42), 14309–14315. https://doi.org/10.1039/d1sc04647k
Bae, Junu, Guannan Zhang, Hyejin Park, Warren S. Warren, and Qiu Wang. “15N-Azides as practical and effective tags for developing long-lived hyperpolarized agents.Chemical Science 12, no. 42 (November 2021): 14309–15. https://doi.org/10.1039/d1sc04647k.
Bae J, Zhang G, Park H, Warren WS, Wang Q. 15N-Azides as practical and effective tags for developing long-lived hyperpolarized agents. Chemical science. 2021 Nov;12(42):14309–15.
Bae, Junu, et al. “15N-Azides as practical and effective tags for developing long-lived hyperpolarized agents.Chemical Science, vol. 12, no. 42, Nov. 2021, pp. 14309–15. Epmc, doi:10.1039/d1sc04647k.
Bae J, Zhang G, Park H, Warren WS, Wang Q. 15N-Azides as practical and effective tags for developing long-lived hyperpolarized agents. Chemical science. 2021 Nov;12(42):14309–14315.
Journal cover image

Published In

Chemical science

DOI

EISSN

2041-6539

ISSN

2041-6520

Publication Date

November 2021

Volume

12

Issue

42

Start / End Page

14309 / 14315

Related Subject Headings

  • 34 Chemical sciences
  • 03 Chemical Sciences