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Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine.

Publication ,  Journal Article
Patel, SM; Shaik-Dasthagirisaheb, YB; Congdon, M; Young, RR; Patel, MZ; Mazhani, T; Boiditswe, S; Leburu, T; Lechiile, K; Arscott-Mills, T ...
Published in: PLoS One
2022

Pneumococcal conjugate vaccines reduce the burden of invasive pneumococcal disease, but the sustained effect of these vaccines can be diminished by an increase in disease caused by non-vaccine serotypes. To describe pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine (PCV-13) in July 2012, we performed molecular serotyping of 268 pneumococcal strains isolated from 221 children between 2012 and 2017. The median (interquartile range) age of the children included in this analysis was 6 (3,12) months. Fifty-nine percent of the children had received at least one dose of PCV-13 and 35% were fully vaccinated with PCV-13. While colonization by vaccine serotypes steadily declined following PCV-13 introduction, 25% of strains isolated more than 3 years after vaccine introduction were PCV-13 serotypes. We also observed an increase in colonization by non-vaccine serotypes 21 and 23B, which have been associated with invasive pneumococcal disease and antibiotic resistance in other settings.

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2022

Volume

17

Issue

1

Start / End Page

e0262225

Location

United States

Related Subject Headings

  • Streptococcus pneumoniae
  • Serotyping
  • Population Surveillance
  • Pneumococcal Vaccines
  • Pneumococcal Infections
  • Phylogeny
  • Nasopharynx
  • Male
  • Infant
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Patel, S. M., Shaik-Dasthagirisaheb, Y. B., Congdon, M., Young, R. R., Patel, M. Z., Mazhani, T., … Kelly, M. S. (2022). Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine. PLoS One, 17(1), e0262225. https://doi.org/10.1371/journal.pone.0262225
Patel, Sweta M., Yazdani B. Shaik-Dasthagirisaheb, Morgan Congdon, Rebecca R. Young, Mohamed Z. Patel, Tiny Mazhani, Sefelani Boiditswe, et al. “Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine.PLoS One 17, no. 1 (2022): e0262225. https://doi.org/10.1371/journal.pone.0262225.
Patel SM, Shaik-Dasthagirisaheb YB, Congdon M, Young RR, Patel MZ, Mazhani T, et al. Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine. PLoS One. 2022;17(1):e0262225.
Patel, Sweta M., et al. “Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine.PLoS One, vol. 17, no. 1, 2022, p. e0262225. Pubmed, doi:10.1371/journal.pone.0262225.
Patel SM, Shaik-Dasthagirisaheb YB, Congdon M, Young RR, Patel MZ, Mazhani T, Boiditswe S, Leburu T, Lechiile K, Arscott-Mills T, Steenhoff AP, Feemster KA, Shah SS, Cunningham CK, Pelton SI, Kelly MS. Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine. PLoS One. 2022;17(1):e0262225.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2022

Volume

17

Issue

1

Start / End Page

e0262225

Location

United States

Related Subject Headings

  • Streptococcus pneumoniae
  • Serotyping
  • Population Surveillance
  • Pneumococcal Vaccines
  • Pneumococcal Infections
  • Phylogeny
  • Nasopharynx
  • Male
  • Infant
  • Humans