Matthew Kelly
Associate Professor of Pediatrics
My research is broadly focused on elucidating the complex interactions that exist between the host microbiome and exogenous pathogens that cause infections in children. We have several ongoing projects evaluating: 1) the impact of the upper respiratory microbiome on the risk of colonization and invasion by bacterial respiratory pathogens among infants in Botswana; 2) associations between the gut microbiome of pediatric stem cell transplant recipients and the risk of infections (bloodstream infection, C. difficile infection) and graft-versus-host disease; and 3) the role of the gut and respiratory microbiomes in mediating COVID-19 infection susceptibility and disease severity in children. Ultimately, I aim to develop strategies that use targeted modification of the microbiome for the prevention of infections in children.
Current Research Interests
As a pediatrician with specialty training in infectious diseases and global health, my career goal is to develop strategies that use targeted manipulation of the microbiome for the prevention and treatment of infections in children. My current research focuses on elucidating the complex relationships that exist between sociodemographic factors, the upper respiratory microbiome, and colonization by pneumonia pathogens among infants in Botswana. Ultimately, we aim to develop microbiome therapeutics that effectively prevent pneumonia and other respiratory infections in children.
Current Appointments & Affiliations
- Associate Professor of Pediatrics, Pediatrics, Infectious Diseases, Pediatrics 2021
- Associate Research Professor of Global Health, Duke Global Health Institute, University Institutes and Centers 2021
- Associate Research Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2023
Contact Information
- 3 Genome Court, Msrb3, Room 4128, DUMC 102346, Durham, NC 27710
- 3 Genome Court, Msrb3, Room 4128, DUMC 102346, Durham, NC 27710
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msk37@dm.duke.edu
(919) 668-4855
- Background
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Education, Training, & Certifications
- Pediatric Infectious Diseases Fellowship, Pediatrics, Duke University School of Medicine 2013 - 2016
- David N. Pincus Pediatric Global Health Fellowship, Pediatrics, Children's Hospital of Philadelphia 2011 - 2013
- Internship/Residency, Pediatrics, Children's Hospital Boston 2007 - 2010
- M.D., Harvard Medical School 2007
- M.P.H., Harvard University 2007
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Medical Licensure
- 194411. North Carolina. 2023
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Previous Appointments & Affiliations
- Assistant Research Professor of Global Health, Duke Global Health Institute, University Institutes and Centers 2019 - 2021
- Assistant Professor of Pediatrics, Pediatrics, Infectious Diseases, Pediatrics 2021
- Assistant Professor of Pediatrics, Pediatrics, Infectious Diseases, Pediatrics 2016 - 2020
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Leadership & Clinical Positions at Duke
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Associate Professor of Pediatrics (Infectious Diseases), Global Health, and Molecular Genetics & Microbiology
Associate Director, Duke Microbiome Center
Associate Program Director, Pediatric Infectious Diseases Fellowship
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Associate Professor of Pediatrics (Infectious Diseases), Global Health, and Molecular Genetics & Microbiology
- Recognition
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In the News
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FEB 16, 2023 Duke Global Health Institute -
JUL 16, 2021 Duke Health News -
FEB 26, 2018 Children's Hospital of Philadelphia
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Awards & Honors
- Young Investigator Award. Pediatric Infectious Diseases Society. October 20, 2023
- Expertise
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Subject Headings
- Research
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Selected Grants
- Early life B cell responses and inflammation following SARS-CoV-2 infection awarded by National Institutes of Health 2021 - 2026
- Unified Program for Therapeutics in Children awarded by National Institutes of Health 2019 - 2024
- PTN 2.0 Task Order 7 HIV Lactation awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development 2020 - 2023
- Early life B cell responses and inflammation following SARS-CoV-2 infection awarded by Weill Cornell Medicine 2022 - 2023
- Clinical and gut microbial risk factors for Gram-negative bacterial late-onset sepsis among premature infants in Singapore awarded by KK Women's and Children's Hospital 2020 - 2023
- The serotype epidemiology and antibiotic resistance of Streptococcus pneumoniae in Botswana following introduction of 13-valent pneumococcal conjugate vaccine awarded by Merck 2019 - 2023
- Postdoctoral Training in Genomic Medicine Research awarded by National Institutes of Health 2017 - 2023
- Nasopharyngeal Microbiome and Risk of Bacterial Pathogen Colonization in Infants awarded by National Institutes of Health 2018 - 2023
- The effect of household air pollution on the health outcomes of infants in Botswana awarded by Thrasher Research Fund 2018 - 2022
- A Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of a Single Infusion of Bezlotoxumab (MK-6072, Human Monoclonal Antibody to C. difficile Toxin B) in Children Aged 1 to awarded by Merck Sharp & Dohme 2018 - 2022
- Gene expression profiling of children with SARS-CoV-2 infection or exposure awarded by Merck & Co., Inc. 2021 - 2022
- An Observational Cohort Study to Determine Late Outcomes and Immunological Responses after Infection with SARS-CoV-2 in Children with and without Multisystem InflammatorySyndrome (MIS-C) awarded by Cornell University 2021 - 2022
- LOC-IMPAACT Leadership Group-IMPAACT 2018 Protocol Co-Vice Chair awarded by Johns Hopkins University 2017 - 2021
- The impact of HIV infection or exposure on the upper respiratory microbiome of children in Botswana awarded by Vanderbilt University Medical Center 2019 - 2021
- VTEU Task C Option 2 Protocol 14-0079.B1C1.0028 awarded by National Institutes of Health 2017 - 2021
- A Phase 1b, Open-label Single dose study to Evaluate the Pharmacokinetics, Safety and Tolerability of MK-7655A in Pediatric Subjects from Birth to less than 18 years of Age with Confirmed or Suspected Gramnegative Infections awarded by Merck Sharp & Dohme 2017 - 2020
- Fungal biomarkers for diagnosis and response to therapy for pediatric candidemia awarded by Duke University 2016 - 2020
- LOC-IMPAACT Leadership Group-IMPAACT 2018 Protocol Vice Chair support awarded by Johns Hopkins University 2017 - 2018
- RFTP 2016 CISA 03 - Option 1 - Fever after Simultaneous Vaccination (Lead) awarded by Centers for Disease Control and Prevention 2017 - 2018
- American Society of Tropical Medicine and Hygiene awarded by Burroughs Wellcome Fund 2016 - 2018
- Multi-center studies to improve diagnosis and treatment of pediatric candidiasis awarded by Duke University 2016 - 2018
- VTEU Task C Option 1 Protocol 14-0079.B1C1.0028 awarded by National Institutes of Health 2016 - 2018
- RFTP 2016 CISA 03 - Base - Fever after simultaneous vaccination (Lead) awarded by Centers for Disease Control and Prevention 2016 - 2017
- VTEU Task B Base Protocol 14-0079.B1C1.0028 awarded by National Institutes of Health 2015 - 2016
- The Effect of In Utero Exposure to HIV and Antiretroviral Therapy on the Microbiology and Outcomes of Severe Pneumonia awarded by International AIDS Society 2013 - 2016
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External Relationships
- Invivyd
- Merck Sharpe & Dohme (Merck & Co, USA)
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Moorthy, Ganga S., Rebecca R. Young, Michael J. Smith, Michelle J. White, Hwanhee Hong, and Matthew S. Kelly. “Racial Inequities in Sepsis Mortality Among Children in the United States.” Pediatr Infect Dis J 42, no. 5 (May 1, 2023): 361–67. https://doi.org/10.1097/INF.0000000000003842.Full Text Link to Item
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Hicks, Elizabeth Daly, Noah O. Agada, Tyler R. Yates, Matthew S. Kelly, Jonathan S. Tam, Ronald M. Ferdman, Louis R. Dibernardo, John F. Madden, M Anthony Moody, and Mary Louise Markert. “Case Report: Nontuberculous mycobacterial infections in children with complete DiGeorge anomaly.” Front Immunol 14 (2023): 1078976. https://doi.org/10.3389/fimmu.2023.1078976.Full Text Link to Item
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Cunningham, Coleen K., Ruth A. Karron, Petronella Muresan, Matthew S. Kelly, Elizabeth J. McFarland, Charlotte Perlowski, Jennifer Libous, et al. “Evaluation of Recombinant Live-Attenuated Respiratory Syncytial Virus (RSV) Vaccines RSV/ΔNS2/Δ1313/I1314L and RSV/276 in RSV-Seronegative Children.” J Infect Dis 226, no. 12 (December 13, 2022): 2069–78. https://doi.org/10.1093/infdis/jiac253.Full Text Link to Item
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Hurst, Jillian H., Alexander W. McCumber, Jhoanna N. Aquino, Javier Rodriguez, Sarah M. Heston, Debra J. Lugo, Alexandre T. Rotta, et al. “Age-Related Changes in the Nasopharyngeal Microbiome Are Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Symptoms Among Children, Adolescents, and Young Adults.” Clin Infect Dis 75, no. 1 (August 24, 2022): e928–37. https://doi.org/10.1093/cid/ciac184.Full Text Open Access Copy Link to Item
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Uffman, Emilie A., Shuk Hang Li, Jui-Lin Chen, Noel Allen, Sefelani Boiditswe, Genevieve G. Fouda, Jillian H. Hurst, et al. “Kinetics of pneumococcal antibodies among HIV-exposed, uninfected infants in Botswana.” Vaccine 40, no. 33 (August 5, 2022): 4764–71. https://doi.org/10.1016/j.vaccine.2022.06.059.Full Text Link to Item
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Biddell, Caitlin B., Kimberly A. Kasow, Mary K. Killela, Kristin M. Page, Stephanie B. Wheeler, Sarah W. Drier, Matthew S. Kelly, Joanna M. Robles, and Lisa P. Spees. “Understanding the financial and psychological impact of employment disruption among caregivers of pediatric HSCT recipients: a mixed methods analysis.” Support Care Cancer 30, no. 6 (June 2022): 4747–57. https://doi.org/10.1007/s00520-022-06883-0.Full Text Link to Item
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Rao, Saahithi, Jillian H. Hurst, Congwen Zhao, Benjamin A. Goldstein, Laine Thomas, Jason E. Lang, and Matthew S. Kelly. “Asthma and the Risk of SARS-CoV-2 Infection Among Children and Adolescents.” Pediatrics 149, no. 6 (June 1, 2022). https://doi.org/10.1542/peds.2021-056164.Full Text Link to Item
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Kelly, Matthew S., Catherine Plunkett, Yahe Yu, Jhoanna N. Aquino, Sweta M. Patel, Jillian H. Hurst, Rebecca R. Young, et al. “Non-diphtheriae Corynebacterium species are associated with decreased risk of pneumococcal colonization during infancy.” Isme J 16, no. 3 (March 2022): 655–65. https://doi.org/10.1038/s41396-021-01108-4.Full Text Link to Item
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Heston, Sarah M., Rebecca R. Young, John S. Tanaka, Kirsten Jenkins, Richard Vinesett, Frances M. Saccoccio, Paul L. Martin, Nelson J. Chao, and Matthew S. Kelly. “Risk Factors for CMV Viremia and Treatment-Associated Adverse Events Among Pediatric Hematopoietic Stem Cell Transplant Recipients.” Open Forum Infect Dis 9, no. 2 (February 2022): ofab639. https://doi.org/10.1093/ofid/ofab639.Full Text Link to Item
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Chang, Yeh-Chung, Rebecca R. Young, Alisha M. Mavis, Eileen T. Chambers, Sonya Kirmani, Matthew S. Kelly, Ibukunoluwa C. Kalu, Michael J. Smith, and Debra J. Lugo. “Epstein-Barr Virus DNAemia and post-transplant lymphoproliferative disorder in pediatric solid organ transplant recipients.” Plos One 17, no. 10 (2022): e0269766. https://doi.org/10.1371/journal.pone.0269766.Full Text Link to Item
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Patel, Sweta M., Yazdani B. Shaik-Dasthagirisaheb, Morgan Congdon, Rebecca R. Young, Mohamed Z. Patel, Tiny Mazhani, Sefelani Boiditswe, et al. “Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine.” Plos One 17, no. 1 (2022): e0262225. https://doi.org/10.1371/journal.pone.0262225.Full Text Link to Item
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Congdon, Morgan, Tonya Arscott-Mills, and Matthew S. Kelly. “Reply to Anderson and Caniza.” Clin Infect Dis 73, no. 9 (November 2, 2021): e2835–36. https://doi.org/10.1093/cid/ciaa1628.Full Text Link to Item
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Hurst, Jillian H., Sarah M. Heston, Hailey N. Chambers, Hannah M. Cunningham, Meghan J. Price, Lilianna Suarez, Carter G. Crew, et al. “Severe Acute Respiratory Syndrome Coronavirus 2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study.” Clin Infect Dis 73, no. 9 (November 2, 2021): e2875–82. https://doi.org/10.1093/cid/ciaa1693.Full Text Open Access Copy Link to Item
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Garrido, Carolina, Jillian H. Hurst, Cynthia G. Lorang, Jhoanna N. Aquino, Javier Rodriguez, Trevor S. Pfeiffer, Tulika Singh, et al. “Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents.” Jci Insight 6, no. 17 (September 8, 2021). https://doi.org/10.1172/jci.insight.150909.Full Text Link to Item
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Mazur, Natalie I., Yvette N. Löwensteyn, Joukje E. Willemsen, Christopher J. Gill, Leah Forman, Lawrence M. Mwananyanda, Dianna M. Blau, et al. “Global Respiratory Syncytial Virus-Related Infant Community Deaths.” Clin Infect Dis 73, no. Suppl_3 (September 2, 2021): S229–37. https://doi.org/10.1093/cid/ciab528.Full Text Link to Item
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Bohannon, Lauren, Helen Tang, Kristin Page, Yi Ren, Sin-Ho Jung, Alexandra Artica, Anne Britt, et al. “Decreased Mortality in 1-Year Survivors of Umbilical Cord Blood Transplant vs. Matched Related or Matched Unrelated Donor Transplant in Patients with Hematologic Malignancies.” Transplantation and Cellular Therapy 27, no. 8 (August 2021): 669.e1-669.e8. https://doi.org/10.1016/j.jtct.2021.05.002.Full Text Open Access Copy
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Congdon, Morgan, Hwanhee Hong, Rebecca R. Young, Coleen K. Cunningham, Leslie A. Enane, Tonya Arscott-Mills, Francis M. Banda, et al. “Effect of Haemophilus influenzae Type b and 13-Valent Pneumococcal Conjugate Vaccines on Childhood Pneumonia Hospitalizations and Deaths in Botswana.” Clin Infect Dis 73, no. 2 (July 15, 2021): e410–16. https://doi.org/10.1093/cid/ciaa919.Full Text Link to Item
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Garrido, Carolina, Jillian H. Hurst, Cynthia G. Lorang, Jhoanna N. Aquino, Javier Rodriguez, Trevor S. Pfeiffer, Tulika Singh, et al. “Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents.” Medrxiv, April 20, 2021. https://doi.org/10.1101/2021.04.17.21255663.Full Text Link to Item
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Hurst, Jillian H., Alexander W. McCumber, Jhoanna N. Aquino, Javier Rodriguez, Sarah M. Heston, Debra J. Lugo, Alexandre T. Rotta, et al. “Age-related changes in the upper respiratory microbiome are associated with SARS-CoV-2 susceptibility and illness severity.” Medrxiv, March 23, 2021. https://doi.org/10.1101/2021.03.20.21252680.Full Text Open Access Copy Link to Item
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McClain, Micah T., Florica J. Constantine, Ricardo Henao, Yiling Liu, Ephraim L. Tsalik, Thomas W. Burke, Julie M. Steinbrink, et al. “Dysregulated transcriptional responses to SARS-CoV-2 in the periphery.” Nat Commun 12, no. 1 (February 17, 2021): 1079. https://doi.org/10.1038/s41467-021-21289-y.Full Text Open Access Copy Link to Item
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Elgarten, Caitlin W., Yimei Li, Kelly D. Getz, Michael Hemmer, Yuan-Shung V. Huang, Matthew Hall, Tao Wang, et al. “Broad-Spectrum Antibiotics and Risk of Graft-versus-Host Disease in Pediatric Patients Undergoing Transplantation for Acute Leukemia: Association of Carbapenem Use with the Risk of Acute Graft-versus-Host Disease.” Transplant Cell Ther 27, no. 2 (February 2021): 177.e1-177.e8. https://doi.org/10.1016/j.jtct.2020.10.012.Full Text Link to Item
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Broderick, David T. J., David W. Waite, Robyn L. Marsh, Carlos A. Camargo, Paul Cardenas, Anne B. Chang, William O. C. Cookson, et al. “Bacterial Signatures of Paediatric Respiratory Disease: An Individual Participant Data Meta-Analysis.” Front Microbiol 12 (2021): 711134. https://doi.org/10.3389/fmicb.2021.711134.Full Text Link to Item
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Singh, Tulika, Sarah M. Heston, Stephanie N. Langel, Maria Blasi, Jillian H. Hurst, Genevieve G. Fouda, Matthew S. Kelly, and Sallie R. Permar. “Lessons From COVID-19 in Children: Key Hypotheses to Guide Preventative and Therapeutic Strategies.” Clin Infect Dis 71, no. 8 (November 5, 2020): 2006–13. https://doi.org/10.1093/cid/ciaa547.Full Text Link to Item
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Heston, Sarah M., Rebecca R. Young, Hwanhee Hong, Ibukunoluwa C. Akinboyo, John S. Tanaka, Paul L. Martin, Richard Vinesett, et al. “Microbiology of Bloodstream Infections in Children After Hematopoietic Stem Cell Transplantation: A Single-Center Experience Over Two Decades (1997-2017).” Open Forum Infect Dis 7, no. 11 (November 2020): ofaa465. https://doi.org/10.1093/ofid/ofaa465.Full Text Link to Item
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Tanaka, John S., Rebecca R. Young, Sarah M. Heston, Kirsten Jenkins, Lisa P. Spees, Anthony D. Sung, Kelly Corbet, et al. “Anaerobic Antibiotics and the Risk of Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation.” Biol Blood Marrow Transplant 26, no. 11 (November 2020): 2053–60. https://doi.org/10.1016/j.bbmt.2020.07.011.Full Text Link to Item
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Hurst, Jillian H., Sarah M. Heston, Hailey N. Chambers, Hannah M. Cunningham, Meghan J. Price, Liliana Suarez, Carter G. Crew, et al. “SARS-CoV-2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study.” Medrxiv, September 1, 2020. https://doi.org/10.1101/2020.08.18.20166835.Full Text Open Access Copy Link to Item
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McClain, Micah T., Florica J. Constantine, Ricardo Henao, Yiling Liu, Ephraim L. Tsalik, Thomas W. Burke, Julie M. Steinbrink, et al. “Dysregulated transcriptional responses to SARS-CoV-2 in the periphery support novel diagnostic approaches.” Medrxiv, July 26, 2020. https://doi.org/10.1101/2020.07.20.20155507.Full Text Open Access Copy Link to Item
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Patel, Sweta M., Sabelle Jallow, Sefelani Boiditswe, Shabir A. Madhi, Kristen A. Feemster, Andrew P. Steenhoff, Tonya Arscott-Mills, et al. “Placental Transfer of Respiratory Syncytial Virus Antibody Among HIV-Exposed, Uninfected Infants.” J Pediatric Infect Dis Soc 9, no. 3 (July 13, 2020): 349–56. https://doi.org/10.1093/jpids/piz056.Full Text Link to Item
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Young, Rebecca R., Kirsten Jenkins, Felix Araujo-Perez, Patrick C. Seed, and Matthew S. Kelly. “Long-term stability of microbiome diversity and composition in fecal samples stored in eNAT medium.” Microbiologyopen 9, no. 7 (July 2020): e1046. https://doi.org/10.1002/mbo3.1046.Full Text Link to Item
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Fawole, Oluwatunmise A., Matthew S. Kelly, Andrew P. Steenhoff, Kristen A. Feemster, Eric J. Crotty, Mantosh S. Rattan, Thuso David, et al. “Interpretation of pediatric chest radiographs by non-radiologist clinicians in Botswana using World Health Organization criteria for endpoint pneumonia.” Pediatr Radiol 50, no. 7 (June 2020): 913–22. https://doi.org/10.1007/s00247-020-04625-0.Full Text Link to Item
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Liang, Guanxiang, Chunyu Zhao, Huanjia Zhang, Lisa Mattei, Scott Sherrill-Mix, Kyle Bittinger, Lyanna R. Kessler, et al. “The stepwise assembly of the neonatal virome is modulated by breastfeeding.” Nature 581, no. 7809 (May 2020): 470–74. https://doi.org/10.1038/s41586-020-2192-1.Full Text Link to Item
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Akinboyo, Ibukunoluwa C., Rebecca R. Young, Lisa P. Spees, Sarah M. Heston, Michael J. Smith, Yeh-Chung Chang, Lauren E. McGill, et al. “Microbiology and Risk Factors for Hospital-Associated Bloodstream Infections Among Pediatric Hematopoietic Stem Cell Transplant Recipients.” Open Forum Infect Dis 7, no. 4 (April 2020): ofaa093. https://doi.org/10.1093/ofid/ofaa093.Full Text Open Access Copy Link to Item
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Weimer, Kristin E. D., Matthew S. Kelly, Sallie R. Permar, Reese H. Clark, and Rachel G. Greenberg. “Association of Adverse Hearing, Growth, and Discharge Age Outcomes With Postnatal Cytomegalovirus Infection in Infants With Very Low Birth Weight.” Jama Pediatr 174, no. 2 (February 1, 2020): 133–40. https://doi.org/10.1001/jamapediatrics.2019.4532.Full Text Link to Item
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Abu-Raya, Bahaa, David M. Goldfarb, Marek Smieja, Kathy Luinstra, Melissa Richard-Greenblatt, Andrew P. Steenhoff, Kristen A. Feemster, et al. “The prevalence and clinical characteristics of pertussis-associated pneumonia among infants in Botswana.” Bmc Pediatr 19, no. 1 (November 16, 2019): 444. https://doi.org/10.1186/s12887-019-1820-0.Full Text Link to Item
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Kelly, Matthew S., Doyle V. Ward, Christopher J. Severyn, Mehreen Arshad, Sarah M. Heston, Kirsten Jenkins, Paul L. Martin, et al. “Gut Colonization Preceding Mucosal Barrier Injury Bloodstream Infection in Pediatric Hematopoietic Stem Cell Transplantation Recipients.” Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 25, no. 11 (November 2019): 2274–80. https://doi.org/10.1016/j.bbmt.2019.07.019.Full Text
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Patel, Sweta M., Lisa Spees, Marek Smieja, Kathy Luinstra, Andrew P. Steenhoff, Kristen A. Feemster, Tonya Arscott-Mills, et al. “Predictors of Poor Outcomes Among Infants With Respiratory Syncytial Virus-associated Acute Lower Respiratory Infection in Botswana.” Pediatr Infect Dis J 38, no. 5 (May 2019): 525–27. https://doi.org/10.1097/INF.0000000000002168.Full Text Link to Item
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Spees, Lisa P., Paul L. Martin, Joanne Kurtzberg, Andre Stokhuyzen, Lauren McGill, Vinod K. Prasad, Timothy A. Driscoll, et al. “Reduction in Mortality after Umbilical Cord Blood Transplantation in Children Over a 20-Year Period (1995-2014).” Biol Blood Marrow Transplant 25, no. 4 (April 2019): 756–63. https://doi.org/10.1016/j.bbmt.2018.11.018.Full Text Open Access Copy Link to Item
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Kelly, Matthew S., Jiayin Zheng, Sefelani Boiditswe, Andrew P. Steenhoff, Kristen A. Feemster, Tonya Arscott-Mills, Boitshepe Seme, et al. “Investigating Mediators of the Poor Pneumonia Outcomes of Human Immunodeficiency Virus-Exposed but Uninfected Children.” J Pediatric Infect Dis Soc 8, no. 1 (March 28, 2019): 13–20. https://doi.org/10.1093/jpids/pix092.Full Text Link to Item
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Kelly, Matthew S., Michael G. Surette, Marek Smieja, Laura Rossi, Kathy Luinstra, Andrew P. Steenhoff, David M. Goldfarb, et al. “Pneumococcal Colonization and the Nasopharyngeal Microbiota of Children in Botswana.” Pediatr Infect Dis J 37, no. 11 (November 2018): 1176–83. https://doi.org/10.1097/INF.0000000000002174.Full Text Link to Item
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Kelly, Matthew S., Lisa Spees, Richard Vinesett, Andre Stokhuyzen, Lauren McGill, Alan D. Proia, Kirsten Jenkins, Mehreen Arshad, Patrick C. Seed, and Paul L. Martin. “Utility of Autopsy among Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients: One Last Chance to Learn?” Biol Blood Marrow Transplant 24, no. 9 (September 2018): 1861–65. https://doi.org/10.1016/j.bbmt.2018.05.030.Full Text Open Access Copy Link to Item
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Salerno, Sara, Christoph P. Hornik, Michael Cohen-Wolkowiez, P Brian Smith, Lawrence C. Ku, Matthew S. Kelly, Reese Clark, Daniel Gonzalez, and Daniel Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee. “Use of Population Pharmacokinetics and Electronic Health Records to Assess Piperacillin-Tazobactam Safety in Infants.” Pediatr Infect Dis J 36, no. 9 (September 2017): 855–59. https://doi.org/10.1097/INF.0000000000001610.Full Text Link to Item
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Kelly, Matthew S., Michael G. Surette, Marek Smieja, Jeffrey M. Pernica, Laura Rossi, Kathy Luinstra, Andrew P. Steenhoff, et al. “The Nasopharyngeal Microbiota of Children With Respiratory Infections in Botswana.” Pediatr Infect Dis J 36, no. 9 (September 2017): e211–18. https://doi.org/10.1097/INF.0000000000001607.Full Text Link to Item
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Wynn, James L., Matthew S. Kelly, Daniel K. Benjamin, Reese H. Clark, Rachel Greenberg, and P Brian Smith. “Timing of Multiorgan Dysfunction among Hospitalized Infants with Fatal Fulminant Sepsis.” Am J Perinatol 34, no. 7 (June 2017): 633–39. https://doi.org/10.1055/s-0036-1597130.Full Text Link to Item
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Pernica, Jeffrey M., Andrew P. Steenhoff, Margaret Mokomane, Banno Moorad, Kwana Lechiile, Marek Smieja, Loeto Mazhani, et al. “Rapid enteric testing to permit targeted antimicrobial therapy, with and without Lactobacillus reuteri probiotics, for paediatric acute diarrhoeal disease in Botswana: A pilot, randomized, factorial, controlled trial.” Plos One 12, no. 10 (2017): e0185177. https://doi.org/10.1371/journal.pone.0185177.Full Text Link to Item
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Kelly, Matthew S., Eric J. Crotty, Mantosh S. Rattan, Kathleen E. Wirth, Andrew P. Steenhoff, Coleen K. Cunningham, Tonya Arscott-Mills, et al. “Chest Radiographic Findings and Outcomes of Pneumonia Among Children in Botswana.” Pediatr Infect Dis J 35, no. 3 (March 2016): 257–62. https://doi.org/10.1097/INF.0000000000000990.Full Text Link to Item
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Kelly, Matthew S., Kathleen E. Wirth, Andrew P. Steenhoff, Coleen K. Cunningham, Tonya Arscott-Mills, Sefelani C. Boiditswe, Mohamed Z. Patel, et al. “Treatment Failures and Excess Mortality Among HIV-Exposed, Uninfected Children With Pneumonia.” J Pediatric Infect Dis Soc 4, no. 4 (December 2015): e117–26. https://doi.org/10.1093/jpids/piu092.Full Text Link to Item
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Kelly, Matthew S., Daniel K. Benjamin, Karen M. Puopolo, Matthew M. Laughon, Reese H. Clark, Sagori Mukhopadhyay, P Brian Smith, and Sallie R. Permar. “Postnatal Cytomegalovirus Infection and the Risk for Bronchopulmonary Dysplasia.” Jama Pediatr 169, no. 12 (December 2015): e153785. https://doi.org/10.1001/jamapediatrics.2015.3785.Full Text Link to Item
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Kelly, M. S., K. E. Wirth, J. Madrigano, K. A. Feemster, C. K. Cunningham, T. Arscott-Mills, S. Boiditswe, S. S. Shah, R. Finalle, and A. P. Steenhoff. “The effect of exposure to wood smoke on outcomes of childhood pneumonia in Botswana.” Int J Tuberc Lung Dis 19, no. 3 (March 2015): 349–55. https://doi.org/10.5588/ijtld.14.0557.Full Text Link to Item
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Kelly, Matthew S., Daniel K. Benjamin, and P Brian Smith. “The epidemiology and diagnosis of invasive candidiasis among premature infants.” Clin Perinatol 42, no. 1 (March 2015): 105–ix. https://doi.org/10.1016/j.clp.2014.10.008.Full Text Link to Item
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Kelly, Matthew S., Marek Smieja, Kathy Luinstra, Kathleen E. Wirth, David M. Goldfarb, Andrew P. Steenhoff, Tonya Arscott-Mills, et al. “Association of respiratory viruses with outcomes of severe childhood pneumonia in Botswana.” Plos One 10, no. 5 (2015): e0126593. https://doi.org/10.1371/journal.pone.0126593.Full Text Link to Item
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Kelly, Matthew S., Margaret Conway, Kathleen E. Wirth, Gail Potter-Bynoe, Amy L. Billett, and Thomas J. Sandora. “Microbiology and Risk Factors for Central Line–Associated Bloodstream Infections Among Pediatric Oncology Outpatients.” Journal of Pediatric Hematology/Oncology 35, no. 2 (March 2013): e71–76. https://doi.org/10.1097/mph.0b013e3182820edd.Full Text
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Kelly, Matthew, Margaret Conway, Kathleen Wirth, Gail Potter-Bynoe, Amy L. Billett, and Thomas J. Sandora. “Moving CLABSI Prevention beyond the Intensive Care Unit: Risk Factors in Pediatric Oncology Patients.” Infection Control &Amp; Hospital Epidemiology 32, no. 11 (November 2011): 1079–85. https://doi.org/10.1086/662376.Full Text
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Xiang, Zhou, Ronglih Liao, Matthew S. Kelly, and Myron Spector. “Collagen?GAG Scaffolds Grafted onto Myocardial Infarcts in a Rat Model: A Delivery Vehicle for Mesenchymal Stem Cells.” Tissue Engineering 0, no. 0 (August 2, 2006): 060913044658014–060913044658014. https://doi.org/10.1089/ten.2006.12.ft-197.Full Text
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Book Sections
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Kelly, M. S., and M. A. Silverman. “Microbiome implications in transplantation and oncology.” In Pediatric Transplant and Oncology Infectious Diseases, 71-77.e3, 2020. https://doi.org/10.1016/B978-0-323-64198-2.00019-1.Full Text
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Conference Papers
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Patel, S., L. Spees, M. Smieja, K. Luinstra, D. M. Goldfarb, A. P. Steenhoff, C. K. Cunningham, et al. “Predictors of Treatment Failure Among Infants with Acute Lower Respiratory Infection Due to Respiratory Syncytial Virus in Botswana.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.Link to Item
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Preprints
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Rao, Saahithi, Jillian H. Hurst, Congwen Zhao, Benjamin A. Goldstein, Laine Thomas, Jason E. Lang, and Matthew S. Kelly. “Asthma and the Risk of SARS-CoV-2 Infection Among Children and Adolescents.” Cold Spring Harbor Laboratory, July 22, 2021. https://doi.org/10.1101/2021.07.20.21260871.Full Text
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