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Matthew Kelly

Associate Professor of Pediatrics
Pediatrics, Infectious Diseases
3 Genome Court, MSRB3, Room 4128, DUMC 102346, Durham, NC 27710
3 Genome Court, MSRB3, Room 4128, DUMC 102346, Durham, NC 27710


My research is broadly focused on elucidating the complex interactions that exist between the host microbiome and exogenous pathogens that cause infections in children. We have several ongoing projects evaluating: 1) the impact of the upper respiratory microbiome on the risk of colonization and invasion by bacterial respiratory pathogens among infants in Botswana; 2) associations between the gut microbiome of pediatric stem cell transplant recipients and the risk of infections (bloodstream infection, C. difficile infection) and graft-versus-host disease; and 3) the role of the gut and respiratory microbiomes in mediating COVID-19 infection susceptibility and disease severity in children. Ultimately, I aim to develop strategies that use targeted modification of the microbiome for the prevention of infections in children.

Current Appointments & Affiliations

Associate Professor of Pediatrics · 2021 - Present Pediatrics, Infectious Diseases, Pediatrics
Associate Research Professor in Molecular Genetics and Microbiology · 2023 - Present Molecular Genetics and Microbiology, Basic Science Departments
Member of the Human Vaccine Institute · 2024 - Present Duke Human Vaccine Institute, Institutes and Centers

Education, Training & Certifications

Harvard Medical School · 2007 M.D.
Harvard University · 2007 M.P.H.