Matthew Kelly | Scholars@Duke

Matthew Kelly
Assistant Professor of Pediatrics

Current Research Interests

As a pediatrician with specialty training in infectious diseases and global health, my career goal is to develop strategies that use targeted manipulation of the microbiome for the prevention and treatment of infections in children. My current research focuses on elucidating the complex relationships that exist between sociodemographic factors, the upper respiratory microbiome, and colonization by pneumonia pathogens among infants in Botswana. Ultimately, we aim to develop microbiome therapeutics that effectively prevent pneumonia and other respiratory infections in children.

Current Appointments & Affiliations

Assistant Professor of Pediatrics, Pediatrics, Infectious Diseases, Pediatrics 2016
Assistant Professor of Global Health, Duke Global Health Institute, University Institutes and Centers 2019

Contact Information

2301 Erwin Rd, Durham, NC 27710
2301 Erwin Road, T915 Chc, Durham, NC 27710
msk37@dm.duke.edu (919) 684-6335

Background
Education, Training, & Certifications
- Pediatric Infectious Diseases Fellowship, Pediatrics, Duke University School of Medicine 2013 - 2016
- David N. Pincus Pediatric Global Health Fellowship, Pediatrics, Children's Hospital of Philadelphia 2011 - 2013
- Internship/Residency, Pediatrics, Children's Hospital, Boston 2007 - 2010
- M.D., Harvard Medical School 2007
- M.P.H., Harvard University 2007
Leadership & Clinical Positions at Duke
- Program Director, Pediatric Infectious Diseases Fellowship Program, Duke University (2018 -
  Assistant Director, Duke Pediatric Research Scholars Program (2018 -
  Associate Director of Physician-Scientist Development, Office of Pediatric Education, Duke University (2018 -
Recognition
In the News
- FEB 26, 2018 Children's Hospital of Philadelphia
  
  Advancing Pneumonia Research and Care Delivery in Botswana
Research
Selected Grants
- Nasopharyngeal Microbiome and Risk of Bacterial Pathogen Colonization in Infants awarded by National Institutes of Health 2018 - 2023
- Merck MK6072 2018 - 2022
- Single dose PK Study of MK-7655A in Pediatric Subjects 2017 - 2020
- The effect of household air pollution on the health outcomes of infants in Botswana 2018 - 2020
- VTEU Task C Option 2 Protocol 14-0079.B1C1.0028 awarded by National Institutes of Health 2017 - 2020
- The impact of HIV infection or exposure on the upper respiratory microbiome of children in Botswana 2019 - 2020
- Fungal biomarkers for diagnosis and response to therapy for pediatric candidemia awarded by Duke University 2016 - 2020
- LOC-IMPAACT Leadership Group awarded by Johns Hopkins University 2017 - 2019
- LOC-IMPAACT Leadership Group awarded by Johns Hopkins University 2017 - 2018
- RFTP 2016 CISA 03 - Option 1 - Fever after Simultaneous Vaccination (Lead) 2017 - 2018
- American Society of Tropical Medicine and Hygiene awarded by Burroughs Wellcome Fund 2016 - 2018
- Multi-center studies to improve diagnosis and treatment of pediatric candidiasis awarded by Duke University 2016 - 2018
- VTEU Task C Option 1 Protocol 14-0079.B1C1.0028 awarded by National Institutes of Health 2016 - 2018
- RFTP 2016 CISA 03 - Base - Fever after simultaneous vaccination (Lead) 2016 - 2017
- VTEU Task B Base Protocol 14-0079.B1C1.0028 awarded by National Institutes of Health 2015 - 2016
- The Effect of In Utero Exposure to HIV and Antiretroviral Therapy on the Microbiology and Outcomes of Severe Pneumonia 2013 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Abu-Raya, Bahaa, David M. Goldfarb, Marek Smieja, Kathy Luinstra, Melissa Richard-Greenblatt, Andrew P. Steenhoff, Kristen A. Feemster, et al. “The prevalence and clinical characteristics of pertussis-associated pneumonia among infants in Botswana..” Bmc Pediatr 19, no. 1 (November 16, 2019). https://doi.org/10.1186/s12887-019-1820-0.
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  - Patel, Sweta M., Sabelle Jallow, Sefelani Boiditswe, Shabir A. Madhi, Kristen A. Feemster, Andrew P. Steenhoff, Tonya Arscott-Mills, et al. “Placental Transfer of Respiratory Syncytial Virus Antibody Among HIV-Exposed, Uninfected Infants..” J Pediatric Infect Dis Soc, September 24, 2019. https://doi.org/10.1093/jpids/piz056.
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  - Patel, Sweta M., Lisa Spees, Marek Smieja, Kathy Luinstra, Andrew P. Steenhoff, Kristen A. Feemster, Tonya Arscott-Mills, et al. “Predictors of Poor Outcomes Among Infants With Respiratory Syncytial Virus-associated Acute Lower Respiratory Infection in Botswana..” Pediatr Infect Dis J 38, no. 5 (May 2019): 525–27. https://doi.org/10.1097/INF.0000000000002168.
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  - Spees, Lisa P., Paul L. Martin, Joanne Kurtzberg, Andre Stokhuyzen, Lauren McGill, Vinod K. Prasad, Timothy A. Driscoll, et al. “Reduction in Mortality after Umbilical Cord Blood Transplantation in Children Over a 20-Year Period (1995-2014)..” Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 25, no. 4 (April 2019): 756–63. https://doi.org/10.1016/j.bbmt.2018.11.018.
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  - Kelly, Matthew S., Jiayin Zheng, Sefelani Boiditswe, Andrew P. Steenhoff, Kristen A. Feemster, Tonya Arscott-Mills, Boitshepe Seme, et al. “Investigating Mediators of the Poor Pneumonia Outcomes of Human Immunodeficiency Virus-Exposed but Uninfected Children..” J Pediatric Infect Dis Soc 8, no. 1 (March 28, 2019): 13–20. https://doi.org/10.1093/jpids/pix092.
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  - Kelly, Matthew S., Michael G. Surette, Marek Smieja, Laura Rossi, Kathy Luinstra, Andrew P. Steenhoff, David M. Goldfarb, et al. “Pneumococcal Colonization and the Nasopharyngeal Microbiota of Children in Botswana..” Pediatr Infect Dis J 37, no. 11 (November 2018): 1176–83. https://doi.org/10.1097/INF.0000000000002174.
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  - Kelly, Matthew S., Lisa Spees, Richard Vinesett, Andre Stokhuyzen, Lauren McGill, Alan D. Proia, Kirsten Jenkins, Mehreen Arshad, Patrick C. Seed, and Paul L. Martin. “Utility of Autopsy among Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients: One Last Chance to Learn?.” Biol Blood Marrow Transplant 24, no. 9 (September 2018): 1861–65. https://doi.org/10.1016/j.bbmt.2018.05.030.
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  - Kelly, Matthew S., Michael G. Surette, Marek Smieja, Jeffrey M. Pernica, Laura Rossi, Kathy Luinstra, Andrew P. Steenhoff, et al. “The Nasopharyngeal Microbiota of Children With Respiratory Infections in Botswana..” Pediatr Infect Dis J 36, no. 9 (September 2017): e211–18. https://doi.org/10.1097/INF.0000000000001607.
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  - Salerno, Sara, Christoph P. Hornik, Michael Cohen-Wolkowiez, P Brian Smith, Lawrence C. Ku, Matthew S. Kelly, Reese Clark, Daniel Gonzalez, and Daniel Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee. “Use of Population Pharmacokinetics and Electronic Health Records to Assess Piperacillin-Tazobactam Safety in Infants..” Pediatr Infect Dis J 36, no. 9 (September 2017): 855–59. https://doi.org/10.1097/INF.0000000000001610.
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  - Wynn, James L., Matthew S. Kelly, Daniel K. Benjamin, Reese H. Clark, Rachel Greenberg, and P Brian Smith. “Timing of Multiorgan Dysfunction among Hospitalized Infants with Fatal Fulminant Sepsis..” Am J Perinatol 34, no. 7 (June 2017): 633–39. https://doi.org/10.1055/s-0036-1597130.
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  - Pernica, Jeffrey M., Andrew P. Steenhoff, Margaret Mokomane, Banno Moorad, Kwana Lechiile, Marek Smieja, Loeto Mazhani, et al. “Rapid enteric testing to permit targeted antimicrobial therapy, with and without Lactobacillus reuteri probiotics, for paediatric acute diarrhoeal disease in Botswana: A pilot, randomized, factorial, controlled trial..” Plos One 12, no. 10 (2017). https://doi.org/10.1371/journal.pone.0185177.
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  - Kelly, Matthew S., Eric J. Crotty, Mantosh S. Rattan, Kathleen E. Wirth, Andrew P. Steenhoff, Coleen K. Cunningham, Tonya Arscott-Mills, et al. “Chest Radiographic Findings and Outcomes of Pneumonia Among Children in Botswana..” Pediatr Infect Dis J 35, no. 3 (March 2016): 257–62. https://doi.org/10.1097/INF.0000000000000990.
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  - Kelly, Matthew S., Daniel K. Benjamin, Karen M. Puopolo, Matthew M. Laughon, Reese H. Clark, Sagori Mukhopadhyay, P Brian Smith, and Sallie R. Permar. “Postnatal Cytomegalovirus Infection and the Risk for Bronchopulmonary Dysplasia..” Jama Pediatr 169, no. 12 (December 2015). https://doi.org/10.1001/jamapediatrics.2015.3785.
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  - Kelly, Matthew S., Kathleen E. Wirth, Andrew P. Steenhoff, Coleen K. Cunningham, Tonya Arscott-Mills, Sefelani C. Boiditswe, Mohamed Z. Patel, et al. “Treatment Failures and Excess Mortality Among HIV-Exposed, Uninfected Children With Pneumonia..” J Pediatric Infect Dis Soc 4, no. 4 (December 2015): e117–26. https://doi.org/10.1093/jpids/piu092.
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  - Kelly, M. S., K. E. Wirth, J. Madrigano, K. A. Feemster, C. K. Cunningham, T. Arscott-Mills, S. Boiditswe, S. S. Shah, R. Finalle, and A. P. Steenhoff. “The effect of exposure to wood smoke on outcomes of childhood pneumonia in Botswana..” Int J Tuberc Lung Dis 19, no. 3 (March 2015): 349–55. https://doi.org/10.5588/ijtld.14.0557.
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  - Kelly, Matthew S., Daniel K. Benjamin, and P Brian Smith. “The epidemiology and diagnosis of invasive candidiasis among premature infants..” Clin Perinatol 42, no. 1 (March 2015): 105–ix. https://doi.org/10.1016/j.clp.2014.10.008.
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  - Kelly, Matthew S., Marek Smieja, Kathy Luinstra, Kathleen E. Wirth, David M. Goldfarb, Andrew P. Steenhoff, Tonya Arscott-Mills, et al. “Association of respiratory viruses with outcomes of severe childhood pneumonia in Botswana..” Plos One 10, no. 5 (2015). https://doi.org/10.1371/journal.pone.0126593.
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  - Kelly, Matthew S., Margaret Conway, Kathleen E. Wirth, Gail Potter-Bynoe, Amy L. Billett, and Thomas J. Sandora. “Microbiology and Risk Factors for Central Line–Associated Bloodstream Infections Among Pediatric Oncology Outpatients.” Journal of Pediatric Hematology/Oncology 35, no. 2 (March 2013): e71–76. https://doi.org/10.1097/mph.0b013e3182820edd.
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  - Kelly, Matthew, Margaret Conway, Kathleen Wirth, Gail Potter-Bynoe, Amy L. Billett, and Thomas J. Sandora. “Moving CLABSI Prevention beyond the Intensive Care Unit: Risk Factors in Pediatric Oncology Patients.” Infection Control & Hospital Epidemiology 32, no. 11 (November 2011): 1079–85. https://doi.org/10.1086/662376.
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  - Xiang, Zhou, Ronglih Liao, Matthew S. Kelly, and Myron Spector. “Collagen?GAG Scaffolds Grafted onto Myocardial Infarcts in a Rat Model: A Delivery Vehicle for Mesenchymal Stem Cells.” Tissue Engineering 0, no. 0 (n.d.): 060913044658014–060913044658014. https://doi.org/10.1089/ten.2006.12.ft-197.
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- Conference Papers
  - Patel, S., L. Spees, M. Smieja, K. Luinstra, D. M. Goldfarb, A. P. Steenhoff, C. K. Cunningham, et al. “Predictors of Treatment Failure Among Infants with Acute Lower Respiratory Infection Due to Respiratory Syncytial Virus in Botswana.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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Education, Training, & Certifications

Leadership & Clinical Positions at Duke

In the News

Selected Grants

Selected Publications

Academic Articles

Conference Papers