Matthew Kelly | Scholars@Duke

Matthew Kelly
Assistant Professor of Pediatrics

Current Research Interests

As a pediatrician with specialty training in infectious diseases and global health, my career goal is to develop strategies that use targeted manipulation of the microbiome for the prevention and treatment of infections in children. My current research focuses on elucidating the complex relationships that exist between sociodemographic factors, the upper respiratory microbiome, and colonization by potential pneumonia pathogens among infants in Botswana. Ultimately, we aim to develop microbiome therapeutics that effectively prevent pneumonia and other respiratory infections among children.

Current Appointments & Affiliations

Assistant Professor of Pediatrics, Pediatrics, Infectious Diseases, Pediatrics 2016

Contact Information

2301 Erwin Rd, Durham, NC 27710
2301 Erwin Road, T915 CHC, Durham, NC 27710
msk37@dm.duke.edu (919) 684-6335

Background
Education, Training, & Certifications
- Pediatric Infectious Diseases Fellowship, Pediatrics, Duke University School of Medicine 2013 - 2016
- David N. Pincus Pediatric Global Health Fellowship, Pediatrics, Children's Hospital of Philadelphia 2011 - 2013
- Internship/Residency, Pediatrics, Children's Hospital Boston 2007 - 2010
- M.D., Harvard Medical School 2007
- M.P.H., Harvard University 2007
Leadership & Clinical Positions at Duke
- Program Director, Pediatric Infectious Diseases Fellowship Program, Duke University (2018 -
  Assistant Director, Duke Pediatric Research Scholars Program (2018 -
  Associate Director of Physician-Scientist Development, Office of Pediatric Education, Duke University (2018 -
Recognition
In the News
- FEB 26, 2018 Children's Hospital of Philadelphia
  
  Advancing Pneumonia Research and Care Delivery in Botswana
Research
Selected Grants
- Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections awarded by National Institutes of Health 2018 - 2023
- Nasopharyngeal Microbiome and Risk of Bacterial Pathogen Colonization in Infants awarded by National Institutes of Health 2018 - 2023
- Merck MK6072 awarded by Merck Sharp & Dohme 2018 - 2022
- Single dose PK Study of MK-7655A in Pediatric Subjects awarded by Merck Sharp & Dohme 2017 - 2020
- The effect of household air pollution on the health outcomes of infants in Botswana awarded by Thrasher Research Fund 2018 - 2020
- VTEU Task C Option 2 Protocol 14-0079.B1C1.0028 awarded by National Institutes of Health 2017 - 2019
- Fungal biomarkers for diagnosis and response to therapy for pediatric candidemia awarded by Duke University 2016 - 2019
- LOC-IMPAACT Leadership Group awarded by Johns Hopkins University 2017 - 2018
- RFTP 2016 CISA 03 - Option 1 - Fever after Simultaneous Vaccination (Lead) awarded by Centers for Disease Control and Prevention 2017 - 2018
- American Society of Tropical Medicine and Hygiene awarded by Burroughs Wellcome Fund 2016 - 2018
- Multi-center studies to improve diagnosis and treatment of pediatric candidiasis awarded by Duke University 2016 - 2018
- VTEU Task C Option 1 Protocol 14-0079.B1C1.0028 awarded by National Institutes of Health 2016 - 2018
- LOC-IMPAACT Leadership Group awarded by Johns Hopkins University 2017 - 2018
- RFTP 2016 CISA 03 - Base - Fever after simultaneous vaccination (Lead) awarded by Centers for Disease Control and Prevention 2016 - 2017
- VTEU Task B Base Protocol 14-0079.B1C1.0028 awarded by National Institutes of Health 2015 - 2016
- The Effect of In Utero Exposure to HIV and Antiretroviral Therapy on the Microbiology and Outcomes of Severe Pneumonia awarded by International AIDS Society 2013 - 2016
Publications & Artistic Works
Selected Publications
- Journal Articles
  - Kelly, MS, Spees, L, Vinesett, R, Stokhuyzen, A, McGill, L, Proia, AD, Jenkins, K, Arshad, M, Seed, PC, and Martin, PL. "Utility of Autopsy among Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients: One Last Chance to Learn?." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 24, no. 9 (September 2018): 1861-1865. Full Text Open Access Copy
  - Kelly, MS, Zheng, J, Boiditswe, S, Steenhoff, AP, Feemster, KA, Arscott-Mills, T, Seme, B, Ratshaa, B, Rulaganyang, I, Patel, MZ, Mantzor, S, Shah, SS, and Cunningham, CK. "Investigating Mediators of the Poor Pneumonia Outcomes of Human Immunodeficiency Virus-Exposed but Uninfected Children." Journal of the Pediatric Infectious Diseases Society (November 20, 2017). Full Text
  - Kelly, MS, Surette, MG, Smieja, M, Pernica, JM, Rossi, L, Luinstra, K, Steenhoff, AP, Feemster, KA, Goldfarb, DM, Arscott-Mills, T, Boiditswe, S, Rulaganyang, I, Muthoga, C, Gaofiwe, L, Mazhani, T, Rawls, JF, Cunningham, CK, Shah, SS, and Seed, PC. "The Nasopharyngeal Microbiota of Children With Respiratory Infections in Botswana." The Pediatric Infectious Disease Journal 36, no. 9 (September 2017): e211-e218. Full Text
  - Salerno, S, Hornik, CP, Cohen-Wolkowiez, M, Smith, PB, Ku, LC, Kelly, MS, Clark, R, Gonzalez, D, and Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee, . "Use of Population Pharmacokinetics and Electronic Health Records to Assess Piperacillin-Tazobactam Safety in Infants." The Pediatric Infectious Disease Journal 36, no. 9 (September 2017): 855-859. Full Text
  - Wynn, JL, Kelly, MS, Benjamin, DK, Clark, RH, Greenberg, R, Benjamin, DK, and Smith, PB. "Timing of Multiorgan Dysfunction among Hospitalized Infants with Fatal Fulminant Sepsis." American journal of perinatology 34, no. 7 (June 2017): 633-639. Full Text
  - Pernica, JM, Steenhoff, AP, Mokomane, M, Moorad, B, Lechiile, K, Smieja, M, Mazhani, L, Cheng, J, Kelly, MS, Loeb, M, Stordal, K, and Goldfarb, DM. "Rapid enteric testing to permit targeted antimicrobial therapy, with and without Lactobacillus reuteri probiotics, for paediatric acute diarrhoeal disease in Botswana: A pilot, randomized, factorial, controlled trial." Plos One 12, no. 10 (January 2017): e0185177-null. Full Text
  - Kelly, MS, Crotty, EJ, Rattan, MS, Wirth, KE, Steenhoff, AP, Cunningham, CK, Arscott-Mills, T, Boiditswe, S, Chimfwembe, D, David, T, Finalle, R, Feemster, KA, and Shah, SS. "Chest Radiographic Findings and Outcomes of Pneumonia Among Children in Botswana." The Pediatric infectious disease journal 35, no. 3 (March 2016): 257-262. Full Text
  - Kelly, MS, Benjamin, DK, Puopolo, KM, Laughon, MM, Clark, RH, Mukhopadhyay, S, Benjamin, DK, Smith, PB, and Permar, SR. "Postnatal Cytomegalovirus Infection and the Risk for Bronchopulmonary Dysplasia." JAMA pediatrics 169, no. 12 (December 7, 2015): e153785-. Full Text
  - Kelly, MS, Wirth, KE, Steenhoff, AP, Cunningham, CK, Arscott-Mills, T, Boiditswe, SC, Patel, MZ, Shah, SS, Finalle, R, Makone, I, and Feemster, KA. "Treatment Failures and Excess Mortality Among HIV-Exposed, Uninfected Children With Pneumonia." Journal of the Pediatric Infectious Diseases Society 4, no. 4 (December 2015): e117-e126. Full Text
  - Kelly, MS, Benjamin, DK, and Smith, PB. "The epidemiology and diagnosis of invasive candidiasis among premature infants." Clinics in Perinatology 42, no. 1 (March 2015): 105-ix. (Review) Full Text
  - Kelly, MS, Wirth, KE, Madrigano, J, Feemster, KA, Cunningham, CK, Arscott-Mills, T, Boiditswe, S, Shah, SS, Finalle, R, and Steenhoff, AP. "The effect of exposure to wood smoke on outcomes of childhood pneumonia in Botswana." The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease 19, no. 3 (March 2015): 349-355. Full Text
  - Kelly, MS, Smieja, M, Luinstra, K, Wirth, KE, Goldfarb, DM, Steenhoff, AP, Arscott-Mills, T, Cunningham, CK, Boiditswe, S, Sethomo, W, Shah, SS, Finalle, R, and Feemster, KA. "Association of respiratory viruses with outcomes of severe childhood pneumonia in Botswana." Plos One 10, no. 5 (January 2015): e0126593-null. Full Text
  - Kelly, MS, Conway, M, Wirth, KE, Potter-Bynoe, G, Billett, AL, and Sandora, TJ. "Microbiology and Risk Factors for Central Line–Associated Bloodstream Infections Among Pediatric Oncology Outpatients." Journal of Pediatric Hematology/Oncology 35, no. 2 (March 2013): e71-e76. Full Text
  - Kelly, M, Conway, M, Wirth, K, Potter-Bynoe, G, Billett, AL, and Sandora, TJ. "Moving CLABSI Prevention beyond the Intensive Care Unit: Risk Factors in Pediatric Oncology Patients." Infection Control & Hospital Epidemiology 32, no. 11 (November 2011): 1079-1085. Full Text
  - Xiang, Z, Liao, R, Kelly, MS, and Spector, M. "Collagen?GAG Scaffolds Grafted onto Myocardial Infarcts in a Rat Model: A Delivery Vehicle for Mesenchymal Stem Cells." Tissue Engineering 0, no. 0 (August 30, 2006): 060913044658014-060913044658014. Full Text

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Education, Training, & Certifications

Leadership & Clinical Positions at Duke

In the News

Selected Grants

Selected Publications

Journal Articles