Skip to main content
Journal cover image

Photoacoustic imaging of 3D-printed vascular networks.

Publication ,  Journal Article
Ma, C; Li, W; Li, D; Chen, M; Wang, M; Jiang, L; Mille, LS; Garciamendez, CE; Zhao, Z; Zhou, Q; Zhang, YS; Yao, J
Published in: Biofabrication
January 2022

Thrombosis in the circulation system can lead to major myocardial infarction and cardiovascular deaths. Understanding thrombosis formation is necessary for developing safe and effective treatments. In this work, using digital light processing (DLP)-based 3D printing, we fabricated sophisticatedin vitromodels of blood vessels with internal microchannels that can be used for thrombosis studies. In this regard, photoacoustic microscopy (PAM) offers a unique advantage for label-free visualization of the 3D-printed vessel models, with large penetration depth and functional sensitivity. We compared the imaging performances of two PAM implementations: optical-resolution PAM and acoustic-resolution PAM, and investigated 3D-printed vessel structures with different patterns of microchannels. Our results show that PAM can provide clear microchannel structures at depths up to 3.6 mm. We further quantified the blood oxygenation in the 3D-printed vascular models, showing that thrombi had lower oxygenation than the normal blood. We expect that PAM can find broad applications in 3D printing and bioprinting forin vitrostudies of various vascular and other diseases.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Biofabrication

DOI

EISSN

1758-5090

ISSN

1758-5082

Publication Date

January 2022

Volume

14

Issue

2

Related Subject Headings

  • Spectrum Analysis
  • Printing, Three-Dimensional
  • Photoacoustic Techniques
  • Microscopy
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 1099 Other Technology
  • 1004 Medical Biotechnology
  • 0903 Biomedical Engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ma, C., Li, W., Li, D., Chen, M., Wang, M., Jiang, L., … Yao, J. (2022). Photoacoustic imaging of 3D-printed vascular networks. Biofabrication, 14(2). https://doi.org/10.1088/1758-5090/ac49d5
Ma, Chenshuo, Wanlu Li, Daiwei Li, Maomao Chen, Mian Wang, Laiming Jiang, Luis Santiago Mille, et al. “Photoacoustic imaging of 3D-printed vascular networks.Biofabrication 14, no. 2 (January 2022). https://doi.org/10.1088/1758-5090/ac49d5.
Ma C, Li W, Li D, Chen M, Wang M, Jiang L, et al. Photoacoustic imaging of 3D-printed vascular networks. Biofabrication. 2022 Jan;14(2).
Ma, Chenshuo, et al. “Photoacoustic imaging of 3D-printed vascular networks.Biofabrication, vol. 14, no. 2, Jan. 2022. Epmc, doi:10.1088/1758-5090/ac49d5.
Ma C, Li W, Li D, Chen M, Wang M, Jiang L, Mille LS, Garciamendez CE, Zhao Z, Zhou Q, Zhang YS, Yao J. Photoacoustic imaging of 3D-printed vascular networks. Biofabrication. 2022 Jan;14(2).
Journal cover image

Published In

Biofabrication

DOI

EISSN

1758-5090

ISSN

1758-5082

Publication Date

January 2022

Volume

14

Issue

2

Related Subject Headings

  • Spectrum Analysis
  • Printing, Three-Dimensional
  • Photoacoustic Techniques
  • Microscopy
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 1099 Other Technology
  • 1004 Medical Biotechnology
  • 0903 Biomedical Engineering