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Multiple Cranial Neuropathies as the Initial Presentation of Primary Ductal Adenocarcinoma of the Lacrimal Gland.

Publication ,  Journal Article
Kim, JS; Proia, AD; Liss, J; Morgenlander, J; Meekins, LC
Published in: Ophthalmic Plast Reconstr Surg
May 2022

Primary ductal adenocarcinoma of the lacrimal gland is a rare, aggressive malignancy that clinically and histologically resembles salivary duct carcinoma. Similar to other malignant epithelial lacrimal gland tumors, ductal adenocarcinoma typically presents with unilateral proptosis, pain, upper eyelid swelling, palpable mass, diplopia, ptosis, and blurred or decreased vision. Rarely, primary malignant epithelial lacrimal gland tumors may first present with multiple cranial neuropathies due to occult spread to the cavernous sinus, as in this case. With such a vast differential diagnosis, a practical yet systematic approach to multiple cranial neuropathies, as guided by clinical history, exam, and neuroimaging, allows for a more targeted diagnostic evaluation, especially when multiple diagnostic tests and interventions return unrevealing. A repeat biopsy or complete excision of the lacrimal gland may be necessary to yield the correct diagnosis.

Duke Scholars

Published In

Ophthalmic Plast Reconstr Surg

DOI

EISSN

1537-2677

Publication Date

May 2022

Volume

38

Issue

3

Start / End Page

e75 / e77

Location

United States

Related Subject Headings

  • Ophthalmology & Optometry
  • Lacrimal Apparatus Diseases
  • Lacrimal Apparatus
  • Humans
  • Eye Neoplasms
  • Cranial Nerve Diseases
  • Carcinoma, Ductal
  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry
 

Citation

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MLA
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Kim, J. S., Proia, A. D., Liss, J., Morgenlander, J., & Meekins, L. C. (2022). Multiple Cranial Neuropathies as the Initial Presentation of Primary Ductal Adenocarcinoma of the Lacrimal Gland. Ophthalmic Plast Reconstr Surg, 38(3), e75–e77. https://doi.org/10.1097/IOP.0000000000002111
Kim, Jane S., Alan D. Proia, Jason Liss, Joel Morgenlander, and Landon C. Meekins. “Multiple Cranial Neuropathies as the Initial Presentation of Primary Ductal Adenocarcinoma of the Lacrimal Gland.Ophthalmic Plast Reconstr Surg 38, no. 3 (May 2022): e75–77. https://doi.org/10.1097/IOP.0000000000002111.
Kim JS, Proia AD, Liss J, Morgenlander J, Meekins LC. Multiple Cranial Neuropathies as the Initial Presentation of Primary Ductal Adenocarcinoma of the Lacrimal Gland. Ophthalmic Plast Reconstr Surg. 2022 May;38(3):e75–7.
Kim, Jane S., et al. “Multiple Cranial Neuropathies as the Initial Presentation of Primary Ductal Adenocarcinoma of the Lacrimal Gland.Ophthalmic Plast Reconstr Surg, vol. 38, no. 3, May 2022, pp. e75–77. Pubmed, doi:10.1097/IOP.0000000000002111.
Kim JS, Proia AD, Liss J, Morgenlander J, Meekins LC. Multiple Cranial Neuropathies as the Initial Presentation of Primary Ductal Adenocarcinoma of the Lacrimal Gland. Ophthalmic Plast Reconstr Surg. 2022 May;38(3):e75–e77.

Published In

Ophthalmic Plast Reconstr Surg

DOI

EISSN

1537-2677

Publication Date

May 2022

Volume

38

Issue

3

Start / End Page

e75 / e77

Location

United States

Related Subject Headings

  • Ophthalmology & Optometry
  • Lacrimal Apparatus Diseases
  • Lacrimal Apparatus
  • Humans
  • Eye Neoplasms
  • Cranial Nerve Diseases
  • Carcinoma, Ductal
  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry