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Coupling Hematoma Evacuation with Immune Profiling for Analysis of Neuroinflammation After Primary Intracerebral Hemorrhage: A Pilot Study.

Publication ,  Journal Article
Lusk, JB; Quinones, QJ; Staats, JS; Weinhold, KJ; Grossi, PM; Nimjee, SM; Laskowitz, DT; James, ML
Published in: World Neurosurg
May 2022

OBJECTIVE: We sought to explore the use and feasibility of an integrated hematoma evacuation/tissue preservation system coupled with immune profiling to assess human ex vivo immune cell populations from brain hematoma samples after intracerebral hemorrhage (ICH). METHODS: In this nonrandomized, noncontrolled pilot/feasibility study of 7 patients with primary supratentorial ICH, a hematoma evacuation device and integrated tissue preservation system were used to obtain hematoma samples during surgical evacuation. Samples were processed, cryopreserved, and analyzed using flow cytometry to determine the relative distribution of immune cell populations compared with peripheral blood mononuclear cells from healthy control subjects. RESULTS: This study demonstrates proof of concept for an integrated hematoma evacuation and sample preservation system to collect human brain hematoma samples for flow cytometry analysis after acute human ICH. In our preliminary analysis, hematoma samples demonstrated a different makeup of white blood cells than peripheral blood from healthy controls. CONCLUSIONS: Flow cytometry analysis of hematoma samples in ICH demonstrates the potential to provide important insights into neuroinflammation associated with ICH.

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Published In

World Neurosurg

DOI

EISSN

1878-8769

Publication Date

May 2022

Volume

161

Start / End Page

162 / 168

Location

United States

Related Subject Headings

  • Pilot Projects
  • Neuroinflammatory Diseases
  • Leukocytes, Mononuclear
  • Humans
  • Hematoma
  • Cerebral Hemorrhage
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

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ICMJE
MLA
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Lusk, J. B., Quinones, Q. J., Staats, J. S., Weinhold, K. J., Grossi, P. M., Nimjee, S. M., … James, M. L. (2022). Coupling Hematoma Evacuation with Immune Profiling for Analysis of Neuroinflammation After Primary Intracerebral Hemorrhage: A Pilot Study. World Neurosurg, 161, 162–168. https://doi.org/10.1016/j.wneu.2022.02.062
Lusk, Jay B., Quintin J. Quinones, Janet S. Staats, Kent J. Weinhold, Peter M. Grossi, Shahid M. Nimjee, Daniel T. Laskowitz, and Michael L. James. “Coupling Hematoma Evacuation with Immune Profiling for Analysis of Neuroinflammation After Primary Intracerebral Hemorrhage: A Pilot Study.World Neurosurg 161 (May 2022): 162–68. https://doi.org/10.1016/j.wneu.2022.02.062.
Lusk JB, Quinones QJ, Staats JS, Weinhold KJ, Grossi PM, Nimjee SM, et al. Coupling Hematoma Evacuation with Immune Profiling for Analysis of Neuroinflammation After Primary Intracerebral Hemorrhage: A Pilot Study. World Neurosurg. 2022 May;161:162–8.
Lusk, Jay B., et al. “Coupling Hematoma Evacuation with Immune Profiling for Analysis of Neuroinflammation After Primary Intracerebral Hemorrhage: A Pilot Study.World Neurosurg, vol. 161, May 2022, pp. 162–68. Pubmed, doi:10.1016/j.wneu.2022.02.062.
Lusk JB, Quinones QJ, Staats JS, Weinhold KJ, Grossi PM, Nimjee SM, Laskowitz DT, James ML. Coupling Hematoma Evacuation with Immune Profiling for Analysis of Neuroinflammation After Primary Intracerebral Hemorrhage: A Pilot Study. World Neurosurg. 2022 May;161:162–168.
Journal cover image

Published In

World Neurosurg

DOI

EISSN

1878-8769

Publication Date

May 2022

Volume

161

Start / End Page

162 / 168

Location

United States

Related Subject Headings

  • Pilot Projects
  • Neuroinflammatory Diseases
  • Leukocytes, Mononuclear
  • Humans
  • Hematoma
  • Cerebral Hemorrhage
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences