Skip to main content
Journal cover image

Age-dependent white matter disruptions after military traumatic brain injury: Multivariate analysis results from ENIGMA brain injury.

Publication ,  Journal Article
Bouchard, HC; Sun, D; Dennis, EL; Newsome, MR; Disner, SG; Elman, J; Silva, A; Velez, C; Irimia, A; Davenport, ND; Sponheim, SR; Franz, CE ...
Published in: Hum Brain Mapp
June 1, 2022

Mild Traumatic brain injury (mTBI) is a signature wound in military personnel, and repetitive mTBI has been linked to age-related neurogenerative disorders that affect white matter (WM) in the brain. However, findings of injury to specific WM tracts have been variable and inconsistent. This may be due to the heterogeneity of mechanisms, etiology, and comorbid disorders related to mTBI. Non-negative matrix factorization (NMF) is a data-driven approach that detects covarying patterns (components) within high-dimensional data. We applied NMF to diffusion imaging data from military Veterans with and without a self-reported TBI history. NMF identified 12 independent components derived from fractional anisotropy (FA) in a large dataset (n = 1,475) gathered through the ENIGMA (Enhancing Neuroimaging Genetics through Meta-Analysis) Military Brain Injury working group. Regressions were used to examine TBI- and mTBI-related associations in NMF-derived components while adjusting for age, sex, post-traumatic stress disorder, depression, and data acquisition site/scanner. We found significantly stronger age-dependent effects of lower FA in Veterans with TBI than Veterans without in four components (q < 0.05), which are spatially unconstrained by traditionally defined WM tracts. One component, occupying the most peripheral location, exhibited significantly stronger age-dependent differences in Veterans with mTBI. We found NMF to be powerful and effective in detecting covarying patterns of FA associated with mTBI by applying standard parametric regression modeling. Our results highlight patterns of WM alteration that are differentially affected by TBI and mTBI in younger compared to older military Veterans.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Hum Brain Mapp

DOI

EISSN

1097-0193

Publication Date

June 1, 2022

Volume

43

Issue

8

Start / End Page

2653 / 2667

Location

United States

Related Subject Headings

  • White Matter
  • Veterans
  • Stress Disorders, Post-Traumatic
  • Multivariate Analysis
  • Military Personnel
  • Humans
  • Experimental Psychology
  • Brain Injuries, Traumatic
  • Brain Injuries
  • Brain Concussion
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bouchard, H. C., Sun, D., Dennis, E. L., Newsome, M. R., Disner, S. G., Elman, J., … Morey, R. A. (2022). Age-dependent white matter disruptions after military traumatic brain injury: Multivariate analysis results from ENIGMA brain injury. Hum Brain Mapp, 43(8), 2653–2667. https://doi.org/10.1002/hbm.25811
Bouchard, Heather C., Delin Sun, Emily L. Dennis, Mary R. Newsome, Seth G. Disner, Jeremy Elman, Annelise Silva, et al. “Age-dependent white matter disruptions after military traumatic brain injury: Multivariate analysis results from ENIGMA brain injury.Hum Brain Mapp 43, no. 8 (June 1, 2022): 2653–67. https://doi.org/10.1002/hbm.25811.
Bouchard HC, Sun D, Dennis EL, Newsome MR, Disner SG, Elman J, et al. Age-dependent white matter disruptions after military traumatic brain injury: Multivariate analysis results from ENIGMA brain injury. Hum Brain Mapp. 2022 Jun 1;43(8):2653–67.
Bouchard, Heather C., et al. “Age-dependent white matter disruptions after military traumatic brain injury: Multivariate analysis results from ENIGMA brain injury.Hum Brain Mapp, vol. 43, no. 8, June 2022, pp. 2653–67. Pubmed, doi:10.1002/hbm.25811.
Bouchard HC, Sun D, Dennis EL, Newsome MR, Disner SG, Elman J, Silva A, Velez C, Irimia A, Davenport ND, Sponheim SR, Franz CE, Kremen WS, Coleman MJ, Williams MW, Geuze E, Koerte IK, Shenton ME, Adamson MM, Coimbra R, Grant G, Shutter L, George MS, Zafonte RD, McAllister TW, Stein MB, Thompson PM, Wilde EA, Tate DF, Sotiras A, Morey RA. Age-dependent white matter disruptions after military traumatic brain injury: Multivariate analysis results from ENIGMA brain injury. Hum Brain Mapp. 2022 Jun 1;43(8):2653–2667.
Journal cover image

Published In

Hum Brain Mapp

DOI

EISSN

1097-0193

Publication Date

June 1, 2022

Volume

43

Issue

8

Start / End Page

2653 / 2667

Location

United States

Related Subject Headings

  • White Matter
  • Veterans
  • Stress Disorders, Post-Traumatic
  • Multivariate Analysis
  • Military Personnel
  • Humans
  • Experimental Psychology
  • Brain Injuries, Traumatic
  • Brain Injuries
  • Brain Concussion