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Recent advances on the inhibition of human solute carriers: Therapeutic implications and mechanistic insights.

Publication ,  Journal Article
Wright, NJ; Lee, S-Y
Published in: Curr Opin Struct Biol
June 2022

Solute carriers (SLCs) are membrane transport proteins tasked with mediating passage of hydrophilic molecules across lipid bilayers. Despite the extensive roles played in all aspects of human biology, SLCs remain vastly under-explored as therapeutic targets. In this brief review, we first discuss a few successful cases of drugs that exert their mechanisms of action through inhibition of human SLCs, and introduce select examples of human SLCs that have untapped therapeutic potential. We then highlight two recent structural studies which uncovered detailed structural mechanisms of inhibition exhibited against two different human major facilitator superfamily (MFS) transporters of clinical relevance.

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Published In

Curr Opin Struct Biol

DOI

EISSN

1879-033X

Publication Date

June 2022

Volume

74

Start / End Page

102378

Location

England

Related Subject Headings

  • Membrane Transport Proteins
  • Hydrophobic and Hydrophilic Interactions
  • Humans
  • Biophysics
  • Biological Transport
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
  • 0304 Medicinal and Biomolecular Chemistry
 

Citation

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Wright, N. J., & Lee, S.-Y. (2022). Recent advances on the inhibition of human solute carriers: Therapeutic implications and mechanistic insights. Curr Opin Struct Biol, 74, 102378. https://doi.org/10.1016/j.sbi.2022.102378
Wright, Nicholas J., and Seok-Yong Lee. “Recent advances on the inhibition of human solute carriers: Therapeutic implications and mechanistic insights.Curr Opin Struct Biol 74 (June 2022): 102378. https://doi.org/10.1016/j.sbi.2022.102378.
Wright, Nicholas J., and Seok-Yong Lee. “Recent advances on the inhibition of human solute carriers: Therapeutic implications and mechanistic insights.Curr Opin Struct Biol, vol. 74, June 2022, p. 102378. Pubmed, doi:10.1016/j.sbi.2022.102378.
Journal cover image

Published In

Curr Opin Struct Biol

DOI

EISSN

1879-033X

Publication Date

June 2022

Volume

74

Start / End Page

102378

Location

England

Related Subject Headings

  • Membrane Transport Proteins
  • Hydrophobic and Hydrophilic Interactions
  • Humans
  • Biophysics
  • Biological Transport
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
  • 0304 Medicinal and Biomolecular Chemistry