Current Appointments & Affiliations
George Barth Geller Distinguished Professor of Molecular Biology
·
2023 - Present
Biochemistry,
Basic Science Departments
Professor of Biochemistry
·
2020 - Present
Biochemistry,
Basic Science Departments
Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Professor in Neurobiology
·
2024 - Present
Neurobiology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2012 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Molecular basis of the urate transporter URAT1 inhibition by gout drugs.
Journal Article Nat Commun · June 4, 2025 Hyperuricemia is a condition when uric acid, a waste product of purine metabolism, accumulates in the blood. Untreated hyperuricemia can lead to crystal formation of monosodium urate in the joints, causing a painful inflammatory disease known as gout. Thes ... Full text Link to item CiteMolecular basis of neurosteroid and anticonvulsant regulation of TRPM3.
Journal Article Nat Struct Mol Biol · May 2025 Transient receptor potential channel subfamily M member 3 (TRPM3) is a Ca2+-permeable cation channel activated by the neurosteroid pregnenolone sulfate (PregS) or heat, serving as a nociceptor in the peripheral sensory system. Recent discoveries of autosom ... Full text Link to item CiteCombined clinical, structural and cellular studies discriminate pathogenic and benign TRPV4 variants.
Journal Article Brain · February 3, 2025 Dominant mutations in the calcium-permeable ion channel TRPV4 (transient receptor potential vanilloid 4) cause diverse and largely distinct channelopathies, including inherited forms of neuromuscular disease, skeletal dysplasias and arthropathy. Pathogenic ... Full text Link to item CiteRecent Grants
Structure, function, and pharmacology of sensory receptors
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2032Neurobiology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Neurological Disorders and Stroke · 2024 - 2029TRPM8 in eye health and disease
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2029View All Grants
Education, Training & Certifications
University of California, Berkeley ·
2003
Ph.D.
Yonsei University (South Korea) ·
1998
B.S.