Current Appointments & Affiliations
George Barth Geller Distinguished Professor of Molecular Biology
·
2023 - Present
Biochemistry,
Basic Science Departments
Professor of Biochemistry
·
2020 - Present
Biochemistry,
Basic Science Departments
Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Professor in Neurobiology
·
2024 - Present
Neurobiology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2012 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Combined clinical, structural and cellular studies discriminate pathogenic and benign TRPV4 variants.
Journal Article Brain · February 3, 2025 Dominant mutations in the calcium-permeable ion channel TRPV4 (transient receptor potential vanilloid 4) cause diverse and largely distinct channelopathies, including inherited forms of neuromuscular disease, skeletal dysplasias and arthropathy. Pathogenic ... Full text Link to item CiteMolecular basis of neurosteroid and anticonvulsant regulation of TRPM3.
Journal Article Nat Struct Mol Biol · January 14, 2025 Transient receptor potential channel subfamily M member 3 (TRPM3) is a Ca2+-permeable cation channel activated by the neurosteroid pregnenolone sulfate (PregS) or heat, serving as a nociceptor in the peripheral sensory system. Recent discoveries of autosom ... Full text Link to item CiteDesign of an equilibrative nucleoside transporter subtype 1 inhibitor for pain relief.
Journal Article Nat Commun · December 30, 2024 The current opioid crisis urgently calls for developing non-addictive pain medications. Progress has been slow, highlighting the need to uncover targets with unique mechanisms of action. Extracellular adenosine alleviates pain by activating the adenosine A ... Full text Link to item CiteRecent Grants
Structure, function, and pharmacology of sensory receptors
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2032TRPM8 in eye health and disease
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2029Catalysis and inhibition of chitin synthesis from pathogenic fungi
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2022 - 2027View All Grants
Education, Training & Certifications
University of California, Berkeley ·
2003
Ph.D.
Yonsei University (South Korea) ·
1998
B.S.