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Seok-Yong Lee

George Barth Geller Distinguished Professor of Molecular Biology
Biochemistry
Duke Box 3711, Sands 269, Durham, NC 27710
269 Sands, 303 Research Dr, Durham, NC 27710

Selected Grants


Structure, function, and pharmacology of sensory receptors

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2032

TRPM8 in eye health and disease

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2029

Catalysis and inhibition of chitin synthesis from pathogenic fungi

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2022 - 2027

Developing equilibrative nucleoside transporter inhibitors as non-opioid pain therapeutics

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2026

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

MRI: Acquisition of a Microscale Thermophoresis System

EquipmentMajor User · Awarded by National Science Foundation · 2022 - 2025

Pharmacological Sciences Training Grant

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2025

Molecular principles of anti-COVID-19 drug uptake by human nucleoside transporters

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2024

Structure, function, and pharmacology of neuronal membrane transport proteins

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2024

Structural and chemical biology of human equilibrative nucleoside transporters

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2024

Structural studies of insect TRP channels

ResearchPrincipal Investigator · Awarded by BASF Corporation · 2020 - 2023

Structural and physiological studies on the human equilibrative nucleoside transporter 3

FellowshipPrincipal Investigator · Awarded by Helen Hay Whitney Foundation · 2022 - 2023

Structure guided design of novel adenosine reuptake inhibitors

FellowshipPrincipal Investigator · Awarded by American Heart Association · 2020 - 2021

Structural and Mechanistic Characterization of MraY Catalysis and Inhibition

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2020

Organization and Function of Cellular Structure

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020

Conformational ensembles associated with TRPV3 gating

ResearchPrincipal Investigator · Awarded by Scripps Research Institute · 2018 - 2020

Development of novel therapeutics for pain and itch relief

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2018

Structure and Function of Concentrative Nucleoside Transporters

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2017

Pharmacology and biophysics of the voltage-gated sodium channel Nav1.7: a therapeutic target for pain

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2016

Structural Biology and Biophysics Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2015

High sensitivity multi-purpose electron paramagnetic resonance spectroscopy for biotechnological and biomedical research

EquipmentCollaborating Investigator · Awarded by North Carolina Biotechnology Center · 2014 - 2015

Automated detection of protein crystals in high-throughput crystallography experiments

ResearchMajor User · Awarded by North Carolina Biotechnology Center · 2014 - 2015

New Console and Cold Probe for the Duke 600 MHz NMR Spectrometer System

EquipmentMajor User · Awarded by National Institutes of Health · 2013 - 2014

External Relationships


  • Peng Zhan, Professor, School of Pharmaceutical Sciences, Shandong University, P.R. China

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.