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Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue.

Publication ,  Journal Article
Joffin, N; Paschoal, VA; Gliniak, CM; Crewe, C; Elnwasany, A; Szweda, LI; Zhang, Q; Hepler, C; Kusminski, CM; Gordillo, R; Oh, DY; Gupta, RK ...
Published in: Cell Stem Cell
April 1, 2021

The adipose tissue stroma is a rich source of molecularly distinct stem and progenitor cell populations with diverse functions in metabolic regulation, adipogenesis, and inflammation. The ontology of these populations and the mechanisms that govern their behaviors in response to stimuli, such as overfeeding, however, are unclear. Here, we show that the developmental fates and functional properties of adipose platelet-derived growth factor receptor beta (PDGFRβ)+ progenitor subpopulations are tightly regulated by mitochondrial metabolism. Reducing the mitochondrial β-oxidative capacity of PDGFRβ+ cells via inducible expression of MitoNEET drives a pro-inflammatory phenotype in adipose progenitors and alters lineage commitment. Furthermore, disrupting mitochondrial function in PDGFRβ+ cells rapidly induces alterations in immune cell composition in lean mice and impacts expansion of adipose tissue in diet-induced obesity. The adverse effects on adipose tissue remodeling can be reversed by restoring mitochondrial activity in progenitors, suggesting therapeutic potential for targeting energy metabolism in these cells.

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Published In

Cell Stem Cell

DOI

EISSN

1875-9777

Publication Date

April 1, 2021

Volume

28

Issue

4

Start / End Page

702 / 717.e8

Location

United States

Related Subject Headings

  • Stem Cells
  • Mitochondria
  • Mice
  • Membrane Proteins
  • Iron-Binding Proteins
  • Developmental Biology
  • Animals
  • Adipose Tissue, White
  • Adipose Tissue
  • Adipogenesis
 

Citation

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Joffin, N., Paschoal, V. A., Gliniak, C. M., Crewe, C., Elnwasany, A., Szweda, L. I., … Scherer, P. E. (2021). Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue. Cell Stem Cell, 28(4), 702-717.e8. https://doi.org/10.1016/j.stem.2021.01.002
Joffin, Nolwenn, Vivian A. Paschoal, Christy M. Gliniak, Clair Crewe, Abdallah Elnwasany, Luke I. Szweda, Qianbin Zhang, et al. “Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue.Cell Stem Cell 28, no. 4 (April 1, 2021): 702-717.e8. https://doi.org/10.1016/j.stem.2021.01.002.
Joffin N, Paschoal VA, Gliniak CM, Crewe C, Elnwasany A, Szweda LI, et al. Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue. Cell Stem Cell. 2021 Apr 1;28(4):702-717.e8.
Joffin, Nolwenn, et al. “Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue.Cell Stem Cell, vol. 28, no. 4, Apr. 2021, pp. 702-717.e8. Pubmed, doi:10.1016/j.stem.2021.01.002.
Joffin N, Paschoal VA, Gliniak CM, Crewe C, Elnwasany A, Szweda LI, Zhang Q, Hepler C, Kusminski CM, Gordillo R, Oh DY, Gupta RK, Scherer PE. Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue. Cell Stem Cell. 2021 Apr 1;28(4):702-717.e8.
Journal cover image

Published In

Cell Stem Cell

DOI

EISSN

1875-9777

Publication Date

April 1, 2021

Volume

28

Issue

4

Start / End Page

702 / 717.e8

Location

United States

Related Subject Headings

  • Stem Cells
  • Mitochondria
  • Mice
  • Membrane Proteins
  • Iron-Binding Proteins
  • Developmental Biology
  • Animals
  • Adipose Tissue, White
  • Adipose Tissue
  • Adipogenesis