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Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation.

Publication ,  Journal Article
Wang, QA; Song, A; Chen, W; Schwalie, PC; Zhang, F; Vishvanath, L; Jiang, L; Ye, R; Shao, M; Tao, C; Gupta, RK; Deplancke, B; Scherer, PE
Published in: Cell Metab
August 7, 2018

Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning. The fate of the original adipocytes during lactation and the developmental origin of the re-appearing adipocyte post involution are unclear. Here, we reveal that adipocytes in the mammary gland de-differentiate into Pdgfrα+ preadipocyte- and fibroblast-like cells during pregnancy and remain de-differentiated during lactation. Upon weaning, de-differentiated fibroblasts proliferate and re-differentiate into adipocytes. This cycle occurs over multiple pregnancies. These observations reveal the potential of terminally differentiated adipocytes to undergo repeated cycles of de-differentiation and re-differentiation in a physiological setting.

Duke Scholars

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Published In

Cell Metab

DOI

EISSN

1932-7420

Publication Date

August 7, 2018

Volume

28

Issue

2

Start / End Page

282 / 288.e3

Location

United States

Related Subject Headings

  • Weaning
  • Pregnancy
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Mammary Glands, Animal
  • Lactation
  • Female
  • Endocrinology & Metabolism
  • Animals
 

Citation

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Wang, Q. A., Song, A., Chen, W., Schwalie, P. C., Zhang, F., Vishvanath, L., … Scherer, P. E. (2018). Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation. Cell Metab, 28(2), 282-288.e3. https://doi.org/10.1016/j.cmet.2018.05.022
Wang, Qiong A., Anying Song, Wanze Chen, Petra C. Schwalie, Fang Zhang, Lavanya Vishvanath, Lei Jiang, et al. “Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation.Cell Metab 28, no. 2 (August 7, 2018): 282-288.e3. https://doi.org/10.1016/j.cmet.2018.05.022.
Wang QA, Song A, Chen W, Schwalie PC, Zhang F, Vishvanath L, et al. Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation. Cell Metab. 2018 Aug 7;28(2):282-288.e3.
Wang, Qiong A., et al. “Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation.Cell Metab, vol. 28, no. 2, Aug. 2018, pp. 282-288.e3. Pubmed, doi:10.1016/j.cmet.2018.05.022.
Wang QA, Song A, Chen W, Schwalie PC, Zhang F, Vishvanath L, Jiang L, Ye R, Shao M, Tao C, Gupta RK, Deplancke B, Scherer PE. Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation. Cell Metab. 2018 Aug 7;28(2):282-288.e3.
Journal cover image

Published In

Cell Metab

DOI

EISSN

1932-7420

Publication Date

August 7, 2018

Volume

28

Issue

2

Start / End Page

282 / 288.e3

Location

United States

Related Subject Headings

  • Weaning
  • Pregnancy
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Mammary Glands, Animal
  • Lactation
  • Female
  • Endocrinology & Metabolism
  • Animals