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Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity.

Publication ,  Journal Article
Roh, HC; Tsai, LTY; Shao, M; Tenen, D; Shen, Y; Kumari, M; Lyubetskaya, A; Jacobs, C; Dawes, B; Gupta, RK; Rosen, ED
Published in: Cell Metab
May 1, 2018

Beige and brown adipocytes generate heat in response to reductions in ambient temperature. When warmed, both beige and brown adipocytes exhibit morphological "whitening," but it is unknown whether or to what extent this represents a true shift in cellular identity. Using cell-type-specific profiling in vivo, we uncover a unique paradigm of temperature-dependent epigenomic plasticity of beige, but not brown, adipocytes, with conversion from a brown to a white chromatin state. Despite this profound shift in cellular identity, warm whitened beige adipocytes retain an epigenomic memory of prior cold exposure defined by an array of poised enhancers that prime thermogenic genes for rapid response during a second bout of cold exposure. We further show that a transcriptional cascade involving glucocorticoid receptor and Zfp423 can drive warm-induced whitening of beige adipocytes. These studies identify the epigenomic and transcriptional bases of an extraordinary example of cellular plasticity in response to environmental signals.

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Published In

Cell Metab

DOI

EISSN

1932-7420

Publication Date

May 1, 2018

Volume

27

Issue

5

Start / End Page

1121 / 1137.e5

Location

United States

Related Subject Headings

  • Transcription Factors
  • Thermogenesis
  • Receptors, Glucocorticoid
  • Mice, Knockout
  • Mice
  • Male
  • Gene-Environment Interaction
  • Epigenesis, Genetic
  • Endocrinology & Metabolism
  • DNA-Binding Proteins
 

Citation

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Roh, H. C., Tsai, L. T. Y., Shao, M., Tenen, D., Shen, Y., Kumari, M., … Rosen, E. D. (2018). Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity. Cell Metab, 27(5), 1121-1137.e5. https://doi.org/10.1016/j.cmet.2018.03.005
Roh, Hyun Cheol, Linus T. Y. Tsai, Mengle Shao, Danielle Tenen, Yachen Shen, Manju Kumari, Anna Lyubetskaya, et al. “Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity.Cell Metab 27, no. 5 (May 1, 2018): 1121-1137.e5. https://doi.org/10.1016/j.cmet.2018.03.005.
Roh HC, Tsai LTY, Shao M, Tenen D, Shen Y, Kumari M, et al. Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity. Cell Metab. 2018 May 1;27(5):1121-1137.e5.
Roh, Hyun Cheol, et al. “Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity.Cell Metab, vol. 27, no. 5, May 2018, pp. 1121-1137.e5. Pubmed, doi:10.1016/j.cmet.2018.03.005.
Roh HC, Tsai LTY, Shao M, Tenen D, Shen Y, Kumari M, Lyubetskaya A, Jacobs C, Dawes B, Gupta RK, Rosen ED. Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity. Cell Metab. 2018 May 1;27(5):1121-1137.e5.
Journal cover image

Published In

Cell Metab

DOI

EISSN

1932-7420

Publication Date

May 1, 2018

Volume

27

Issue

5

Start / End Page

1121 / 1137.e5

Location

United States

Related Subject Headings

  • Transcription Factors
  • Thermogenesis
  • Receptors, Glucocorticoid
  • Mice, Knockout
  • Mice
  • Male
  • Gene-Environment Interaction
  • Epigenesis, Genetic
  • Endocrinology & Metabolism
  • DNA-Binding Proteins