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De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity.

Publication ,  Journal Article
Shao, M; Vishvanath, L; Busbuso, NC; Hepler, C; Shan, B; Sharma, AX; Chen, S; Yu, X; An, YA; Zhu, Y; Holland, WL; Gupta, RK
Published in: Nat Commun
March 1, 2018

Pathologic expansion of white adipose tissue (WAT) in obesity is characterized by adipocyte hypertrophy, inflammation, and fibrosis; however, factors triggering this maladaptive remodeling are largely unknown. Here, we test the hypothesis that the potential to recruit new adipocytes from Pdgfrβ+ preadipocytes determines visceral WAT health in obesity. We manipulate levels of Pparg, the master regulator of adipogenesis, in Pdgfrβ+ precursors of adult mice. Increasing the adipogenic capacity of Pdgfrβ+ precursors through Pparg overexpression results in healthy visceral WAT expansion in obesity and adiponectin-dependent improvements in glucose homeostasis. Loss of mural cell Pparg triggers pathologic visceral WAT expansion upon high-fat diet feeding. Moreover, the ability of the TZD class of anti-diabetic drugs to promote healthy visceral WAT remodeling is dependent on mural cell Pparg. These data highlight the protective effects of de novo visceral adipocyte differentiation in these settings, and suggest Pdgfrβ+ adipocyte precursors as targets for therapeutic intervention in diabetes.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

March 1, 2018

Volume

9

Issue

1

Start / End Page

890

Location

England

Related Subject Headings

  • Receptor, Platelet-Derived Growth Factor beta
  • PPAR gamma
  • Obesity
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Intra-Abdominal Fat
  • Humans
  • Female
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
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Shao, M., Vishvanath, L., Busbuso, N. C., Hepler, C., Shan, B., Sharma, A. X., … Gupta, R. K. (2018). De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity. Nat Commun, 9(1), 890. https://doi.org/10.1038/s41467-018-03196-x
Shao, Mengle, Lavanya Vishvanath, Napoleon C. Busbuso, Chelsea Hepler, Bo Shan, Ankit X. Sharma, Shiuhwei Chen, et al. “De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity.Nat Commun 9, no. 1 (March 1, 2018): 890. https://doi.org/10.1038/s41467-018-03196-x.
Shao M, Vishvanath L, Busbuso NC, Hepler C, Shan B, Sharma AX, et al. De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity. Nat Commun. 2018 Mar 1;9(1):890.
Shao, Mengle, et al. “De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity.Nat Commun, vol. 9, no. 1, Mar. 2018, p. 890. Pubmed, doi:10.1038/s41467-018-03196-x.
Shao M, Vishvanath L, Busbuso NC, Hepler C, Shan B, Sharma AX, Chen S, Yu X, An YA, Zhu Y, Holland WL, Gupta RK. De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity. Nat Commun. 2018 Mar 1;9(1):890.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

March 1, 2018

Volume

9

Issue

1

Start / End Page

890

Location

England

Related Subject Headings

  • Receptor, Platelet-Derived Growth Factor beta
  • PPAR gamma
  • Obesity
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Intra-Abdominal Fat
  • Humans
  • Female
  • Animals