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HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses.

Publication ,  Journal Article
Schust, DJ; Tortorella, D; Ploegh, HL
Published in: Semin Cancer Biol
February 1999

Immunoevasive viruses which effect antigen presentation by class I major histocompatibility complex (MHC) molecules have helped to broaden our understanding of the intracellular transport and processing of HLA-G and HLA-C in the placenta. Cellular infection with herpes simplex virus (HSV) and human cytomegalovirus (HCMV) are each associated with the downregulation of surface expression of HLA-A and -B, albeit by remarkably distinct mechanisms. Investigations on the effects of HSV and HCMV infection on HLA-G and HLA-C in the trophoblast have revealed both hypothesized similarities and surprising differences between trophoblast and classical class I products.

Duke Scholars

Published In

Semin Cancer Biol

DOI

ISSN

1044-579X

Publication Date

February 1999

Volume

9

Issue

1

Start / End Page

37 / 46

Location

England

Related Subject Headings

  • Simplexvirus
  • Pregnancy
  • Oncology & Carcinogenesis
  • Maternal-Fetal Exchange
  • Humans
  • Histocompatibility Antigens Class I
  • HLA-G Antigens
  • HLA-C Antigens
  • HLA Antigens
  • Female
 

Citation

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ICMJE
MLA
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Schust, D. J., Tortorella, D., & Ploegh, H. L. (1999). HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses. Semin Cancer Biol, 9(1), 37–46. https://doi.org/10.1006/scbi.1998.0106
Schust, D. J., D. Tortorella, and H. L. Ploegh. “HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses.Semin Cancer Biol 9, no. 1 (February 1999): 37–46. https://doi.org/10.1006/scbi.1998.0106.
Schust DJ, Tortorella D, Ploegh HL. HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses. Semin Cancer Biol. 1999 Feb;9(1):37–46.
Schust, D. J., et al. “HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses.Semin Cancer Biol, vol. 9, no. 1, Feb. 1999, pp. 37–46. Pubmed, doi:10.1006/scbi.1998.0106.
Schust DJ, Tortorella D, Ploegh HL. HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses. Semin Cancer Biol. 1999 Feb;9(1):37–46.
Journal cover image

Published In

Semin Cancer Biol

DOI

ISSN

1044-579X

Publication Date

February 1999

Volume

9

Issue

1

Start / End Page

37 / 46

Location

England

Related Subject Headings

  • Simplexvirus
  • Pregnancy
  • Oncology & Carcinogenesis
  • Maternal-Fetal Exchange
  • Humans
  • Histocompatibility Antigens Class I
  • HLA-G Antigens
  • HLA-C Antigens
  • HLA Antigens
  • Female