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Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch.

Publication ,  Journal Article
Ji, R-R
Published in: Annu Rev Pharmacol Toxicol
January 20, 2023

Specialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins, are endogenous lipid mediators that are synthesized from omega-3 polyunsaturated fatty acids during the acute phase or resolution phase of inflammation. Synthetic SPMs possess broad safety profiles and exhibit potent actions in resolving inflammation in preclinical models. Accumulating evidence in the past decade has demonstrated powerful analgesia of exogenous SPMs in rodent models of inflammatory, neuropathic, and cancer pain. Furthermore, endogenous SPMs are produced by sham surgery and neuromodulation (e.g., vagus nerve stimulation). SPMs produce their beneficial actions through multiple G protein-coupled receptors, expressed by immune cells, glial cells, and neurons. Notably, loss of SPM receptors impairs the resolution of pain. I also highlight the emerging role of SPMs in the control of itch. Pharmacological targeting of SPMs or SPM receptors has the potential to lead to novel therapeutics for pain and itch as emerging approaches in resolution pharmacology.

Duke Scholars

Published In

Annu Rev Pharmacol Toxicol

DOI

EISSN

1545-4304

Publication Date

January 20, 2023

Volume

63

Start / End Page

273 / 293

Location

United States

Related Subject Headings

  • Pharmacology & Pharmacy
  • Pain
  • Inflammation
  • Humans
  • 3214 Pharmacology and pharmaceutical sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ji, R.-R. (2023). Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch. Annu Rev Pharmacol Toxicol, 63, 273–293. https://doi.org/10.1146/annurev-pharmtox-051921-084047
Ji, Ru-Rong. “Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch.Annu Rev Pharmacol Toxicol 63 (January 20, 2023): 273–93. https://doi.org/10.1146/annurev-pharmtox-051921-084047.
Ji, Ru-Rong. “Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch.Annu Rev Pharmacol Toxicol, vol. 63, Jan. 2023, pp. 273–93. Pubmed, doi:10.1146/annurev-pharmtox-051921-084047.

Published In

Annu Rev Pharmacol Toxicol

DOI

EISSN

1545-4304

Publication Date

January 20, 2023

Volume

63

Start / End Page

273 / 293

Location

United States

Related Subject Headings

  • Pharmacology & Pharmacy
  • Pain
  • Inflammation
  • Humans
  • 3214 Pharmacology and pharmaceutical sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences