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Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery.

Publication ,  Journal Article
Burstein, E; Duckett, CS
Published in: Curr Opin Cell Biol
December 2003

The transcription factor nuclear factor kappaB (NF-kappaB) is a pleiotropic protein complex that is activated from a sequestered, cytoplasmic form by pro-inflammatory extracellular signals and cellular stress. Several hundred cellular genes have been shown to be regulated by NF-kappaB, including cytokines, chemokines and adhesion molecules. Nearly eight years ago, a flurry of publications showed that loss or suppression of NF-kappaB results in an enhanced sensitivity to apoptosis. In the ensuing years, activation of NF-kappaB has become almost synonymous with enhanced cell survival, although more recent data suggests that this transcription factor plays a more complex role in the regulation of cell death.

Duke Scholars

Published In

Curr Opin Cell Biol

DOI

ISSN

0955-0674

Publication Date

December 2003

Volume

15

Issue

6

Start / End Page

732 / 737

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Signal Transduction
  • NF-kappa B
  • Models, Biological
  • Humans
  • Hepatocytes
  • Enzyme Activation
  • Developmental Biology
  • Cell Survival
  • Apoptosis
 

Citation

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ICMJE
MLA
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Burstein, E., & Duckett, C. S. (2003). Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery. Curr Opin Cell Biol, 15(6), 732–737. https://doi.org/10.1016/j.ceb.2003.10.005
Burstein, Ezra, and Colin S. Duckett. “Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery.Curr Opin Cell Biol 15, no. 6 (December 2003): 732–37. https://doi.org/10.1016/j.ceb.2003.10.005.
Burstein E, Duckett CS. Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery. Curr Opin Cell Biol. 2003 Dec;15(6):732–7.
Burstein, Ezra, and Colin S. Duckett. “Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery.Curr Opin Cell Biol, vol. 15, no. 6, Dec. 2003, pp. 732–37. Pubmed, doi:10.1016/j.ceb.2003.10.005.
Burstein E, Duckett CS. Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery. Curr Opin Cell Biol. 2003 Dec;15(6):732–737.
Journal cover image

Published In

Curr Opin Cell Biol

DOI

ISSN

0955-0674

Publication Date

December 2003

Volume

15

Issue

6

Start / End Page

732 / 737

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Signal Transduction
  • NF-kappa B
  • Models, Biological
  • Humans
  • Hepatocytes
  • Enzyme Activation
  • Developmental Biology
  • Cell Survival
  • Apoptosis