Current Appointments & Affiliations
Professor of Pathology
·
2023 - Present
Pathology,
Clinical Science Departments
Vice Dean for Basic Science
·
2018 - Present
School of Medicine
Professor in Pharmacology and Cancer Biology
·
2023 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Core Faculty in Innovation & Entrepreneurship
·
2021 - Present
Duke Innovation & Entrepreneurship,
University Initiatives & Academic Support Units
Member of the Duke Cancer Institute
·
2022 - Present
Duke Cancer Institute,
Institutes and Centers
Member of the Duke Human Vaccine Institute
·
2022 - Present
Duke Human Vaccine Institute,
Institutes and Centers
Recent Publications
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Journal Article Cell Death Differ · March 2018 Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel ... Full text Open Access Link to item CiteHeat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades.
Journal Article Mol Cancer Res · January 2018 Hsp70 is a molecular chaperone that binds to "client" proteins and protects them from protein degradation. Hsp70 is essential for the survival of many cancer cells, but it is not yet clear which of its clients are involved. Using structurally distinct chem ... Full text Link to item CiteIAPs protect host target tissues from graft-versus-host disease in mice.
Journal Article Blood Adv · August 22, 2017 Inhibitors of apoptosis proteins (IAPs) regulate apoptosis, but little is known about the role of IAPs in the regulation of immunity. Development of IAP inhibition by second mitochondria-derived activator of caspase (SMAC) mimetics is emerging as a novel t ... Full text Link to item CiteRecent Grants
Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027Developmental and Injury Regulation of Polyploidy in the Drosophila Heart
FellowshipDepartment Head · Awarded by American Heart Association · 2023 - 2024Studying the impact of aberrant beta(2)-adrenergic receptor trafficking on endosomal signaling and cellular responses
FellowshipDepartment Head · Awarded by American Heart Association · 2022 - 2023View All Grants
Education, Training & Certifications
University of London (United Kingdom) ·
1993
Ph.D.