Colin S Duckett | Scholars@Duke

Colin S Duckett
Professor of Pathology

Current Appointments & Affiliations

Professor of Pathology, Pathology, Clinical Science Departments 2023
Vice Dean for Basic Science, Pharmacology & Cancer Biology, Basic Science Departments 2018
Core Faculty in Innovation & Entrepreneurship, Duke Innovation & Entrepreneurship, Initiatives 2021
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2022
Member of the Duke Human Vaccine Institute, Duke Human Vaccine Institute, Institutes and Centers 2022

Contact Information

Dean's Suite, Rm 128, Davison Building, Durham,, NC 27710
Dean's Suite, Room 128, Davison Building, Durham, NC 27710
colin.duckett@duke.edu (919) 668-4729

Background
Education, Training, & Certifications
- Ph.D., University of London (United Kingdom) 1993
Previous Appointments & Affiliations
- Interim Chair of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2020 - 2023
- Professor of Pathology, Pathology, Clinical Science Departments 2021 - 2022
- Research Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2019 - 2021
- Instructor in the Department of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2018 - 2019
Recognition
In the News
- OCT 25, 2022 School of Medicine
  
  A New Generation of Tools To Fight Cancer
- FEB 5, 2021 School of Medicine
  
  School of Medicine Faculty, Students Shine During Duke University Research Week
- MAY 7, 2020
  
  Duke Researchers To Begin Slowly Returning to Their Labs, With Masks
- MAR 18, 2020
  
  A Quick Mobilization on COVID-19 Research at Duke
Research
Selected Grants
- Medical Scientist Training Program awarded by National Institutes of Health 2022 - 2027
- Developmental and Injury Regulation of Polyploidy in the Drosophila Heart awarded by American Heart Association 2023 - 2024
- Studying the impact of aberrant beta(2)-adrenergic receptor trafficking on endosomal signaling and cellular responses awarded by American Heart Association 2022 - 2023
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Galluzzi, Lorenzo, Ilio Vitale, Stuart A. Aaronson, John M. Abrams, Dieter Adam, Patrizia Agostinis, Emad S. Alnemri, et al. “Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.” Cell Death Differ 25, no. 3 (March 2018): 486–541. https://doi.org/10.1038/s41418-017-0012-4.
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  - Srinivasan, Sharan R., Laura C. Cesa, Xiaokai Li, Olivier Julien, Min Zhuang, Hao Shao, Jooho Chung, et al. “Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades.” Mol Cancer Res 16, no. 1 (January 2018): 58–68. https://doi.org/10.1158/1541-7786.MCR-17-0408.
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  - Toubai, Tomomi, Corinne Rossi, Katherine Oravecz-Wilson, Chen Liu, Cynthia Zajac, Shin-Rong Julia Wu, Yaping Sun, et al. “IAPs protect host target tissues from graft-versus-host disease in mice.” Blood Adv 1, no. 19 (August 22, 2017): 1517–32. https://doi.org/10.1182/bloodadvances.2017004242.
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  - Ashley, Shanna L., Thomas H. Sisson, Amanda K. Wheaton, Kevin K. Kim, Carol A. Wilke, Iyabode O. Ajayi, Natalya Subbotina, et al. “Targeting Inhibitor of Apoptosis Proteins Protects from Bleomycin-Induced Lung Fibrosis.” Am J Respir Cell Mol Biol 54, no. 4 (April 2016): 482–92. https://doi.org/10.1165/rcmb.2015-0148OC.
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  - Kocab, Andrew J., and Colin S. Duckett. “Inhibitor of apoptosis proteins as intracellular signaling intermediates.” Febs J 283, no. 2 (January 2016): 221–31. https://doi.org/10.1111/febs.13554.
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  - Kocab, A. J., A. Veloso, M. T. Paulsen, M. Ljungman, and C. S. Duckett. “Effects of physiological and synthetic IAP antagonism on c-IAP-dependent signaling.” Oncogene 34, no. 43 (October 2015): 5472–81. https://doi.org/10.1038/onc.2015.3.
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  - Kenneth, Niall S., George E. Hucks, Andrew J. Kocab, Annie L. McCollom, and Colin S. Duckett. “Copper is a potent inhibitor of both the canonical and non-canonical NFκB pathways.” Cell Cycle 13, no. 6 (2014): 1006–14. https://doi.org/10.4161/cc.27922.
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  - Yang, Wensheng, Mariana Cooke, Colin S. Duckett, Xiaolu Yang, and Jay F. Dorsey. “Distinctive effects of the cellular inhibitor of apoptosis protein c-IAP2 through stabilization by XIAP in glioblastoma multiforme cells.” Cell Cycle 13, no. 6 (2014): 992–1005. https://doi.org/10.4161/cc.27880.
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  - Kenneth, Niall S., and Colin S. Duckett. “IAP proteins: regulators of cell migration and development.” Curr Opin Cell Biol 24, no. 6 (December 2012): 871–75. https://doi.org/10.1016/j.ceb.2012.11.004.
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  - Kenneth, Niall S., J Michael Younger, Elizabeth D. Hughes, Danielle Marcotte, Philip A. Barker, Thomas L. Saunders, and Colin S. Duckett. “An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1.” Biochem J 443, no. 2 (April 15, 2012): 355–59. https://doi.org/10.1042/BJ20120249.
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  - Oetjen, Karolyn A., and Colin S. Duckett. “Identifying the trigger of c-IAPs: structural and functional characterization of CARD-mediated modulation of ubiquitin ligase activity.” Mol Cell 42, no. 5 (June 10, 2011): 553–54. https://doi.org/10.1016/j.molcel.2011.05.018.
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  - Brady, Graham F., Stefanie Galbán, Xuwen Liu, Venkatesha Basrur, Jonathan D. Gitlin, Kojo S. J. Elenitoba-Johnson, Thomas E. Wilson, and Colin S. Duckett. “Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination.” Mol Cell Biol 30, no. 8 (April 2010): 1923–36. https://doi.org/10.1128/MCB.00900-09.
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  - Galbán, S., and C. S. Duckett. “XIAP as a ubiquitin ligase in cellular signaling.” Cell Death Differ 17, no. 1 (January 2010): 54–60. https://doi.org/10.1038/cdd.2009.81.
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  - Csomos, Rebecca A., Graham F. Brady, and Colin S. Duckett. “Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2.” J Biol Chem 284, no. 31 (July 31, 2009): 20531–39. https://doi.org/10.1074/jbc.M109.029983.
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  - Choi, Young Eun, Michael Butterworth, Srinivas Malladi, Colin S. Duckett, Gerald M. Cohen, and Shawn B. Bratton. “The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing.” J Biol Chem 284, no. 19 (May 8, 2009): 12772–82. https://doi.org/10.1074/jbc.M807550200.
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  - Csomos, Rebecca A., Casey W. Wright, Stefanie Galbán, Karolyn A. Oetjen, and Colin S. Duckett. “Two distinct signalling cascades target the NF-kappaB regulatory factor c-IAP1 for degradation.” Biochem J 420, no. 1 (April 28, 2009): 83–91. https://doi.org/10.1042/BJ20082140.
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  - Brady, Graham F., and Colin S. Duckett. “A caspase homolog keeps CED-3 in check.” Trends Biochem Sci 34, no. 3 (March 2009): 104–7. https://doi.org/10.1016/j.tibs.2008.11.003.
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  - Galbán, Stefanie, Clara Hwang, Julie M. Rumble, Karolyn A. Oetjen, Casey W. Wright, Alain Boudreault, Jon Durkin, et al. “Cytoprotective effects of IAPs revealed by a small molecule antagonist.” Biochem J 417, no. 3 (February 1, 2009): 765–71. https://doi.org/10.1042/BJ20081677.
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  - Wright, Casey W., and Colin S. Duckett. “The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription.” Science 323, no. 5911 (January 9, 2009): 251–55. https://doi.org/10.1126/science.1162818.
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  - Rumble, Julie M., Karolyn A. Oetjen, Paul L. Stein, Pamela L. Schwartzberg, Bethany B. Moore, and Colin S. Duckett. “Phenotypic differences between mice deficient in XIAP and SAP, two factors targeted in X-linked lymphoproliferative syndrome (XLP).” Cell Immunol 259, no. 1 (2009): 82–89. https://doi.org/10.1016/j.cellimm.2009.05.017.
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  - Galbán, Stefanie, Graham F. Brady, and Colin S. Duckett. “Caspases and IAPs: a dance of death ensures cell survival.” Mol Cell 32, no. 4 (November 21, 2008): 462–63. https://doi.org/10.1016/j.molcel.2008.11.005.
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  - Rumble, Julie M., and Colin S. Duckett. “Diverse functions within the IAP family.” J Cell Sci 121, no. Pt 21 (November 1, 2008): 3505–7. https://doi.org/10.1242/jcs.040303.
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  - O’Riordan, Mary X. D., Laura D. Bauler, Fiona L. Scott, and Colin S. Duckett. “Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation.” Dev Cell 15, no. 4 (October 2008): 497–508. https://doi.org/10.1016/j.devcel.2008.09.012.
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  - Rumble, Julie M., Mathieu J. M. Bertrand, Rebecca A. Csomos, Casey W. Wright, Lori Albert, Tak W. Mak, Philip A. Barker, and Colin S. Duckett. “Apoptotic sensitivity of murine IAP-deficient cells.” Biochem J 415, no. 1 (October 1, 2008): 21–25. https://doi.org/10.1042/BJ20081188.
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  - Bauler, Laura D., Colin S. Duckett, and Mary X. D. O’Riordan. “XIAP regulates cytosol-specific innate immunity to Listeria infection.” Plos Pathog 4, no. 8 (August 29, 2008): e1000142. https://doi.org/10.1371/journal.ppat.1000142.
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  - Hwang, C., K. A. Oetjen, D. Kosoff, K. J. Wojno, M. A. Albertelli, R. L. Dunn, D. M. Robins, K. A. Cooney, and C. S. Duckett. “X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model.” Cell Death Differ 15, no. 5 (May 2008): 831–40. https://doi.org/10.1038/cdd.2008.15.
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  - Hwang, Clara, Veda N. Giri, John C. Wilkinson, Casey W. Wright, Amanda S. Wilkinson, Kathleen A. Cooney, and Colin S. Duckett. “EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor.” Breast Cancer Res Treat 107, no. 2 (January 2008): 235–42. https://doi.org/10.1007/s10549-007-9542-7.
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  - Wilkinson, John C., Amanda S. Wilkinson, Stefanie Galbán, Rebecca A. Csomos, and Colin S. Duckett. “Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP.” Mol Cell Biol 28, no. 1 (January 2008): 237–47. https://doi.org/10.1128/MCB.01065-07.
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  - Wright, Casey W., and Colin S. Duckett. “New insights into the function of IAP proteins: modulation of the MYC/MAX/MAD network.” Dev Cell 14, no. 1 (January 2008): 3–4. https://doi.org/10.1016/j.devcel.2007.12.015.
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  - Mufti, Arjmand R., Ezra Burstein, and Colin S. Duckett. “XIAP: cell death regulation meets copper homeostasis.” Arch Biochem Biophys 463, no. 2 (July 15, 2007): 168–74. https://doi.org/10.1016/j.abb.2007.01.033.
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  - Wright, Casey W., Julie M. Rumble, and Colin S. Duckett. “CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells.” J Biol Chem 282, no. 14 (April 6, 2007): 10252–62. https://doi.org/10.1074/jbc.M608817200.
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  - Bie, Prim de, Bart van de Sluis, Ezra Burstein, Karen J. Duran, Ruud Berger, Colin S. Duckett, Cisca Wijmenga, and Leo W. J. Klomp. “Characterization of COMMD protein-protein interactions in NF-kappaB signalling.” Biochem J 398, no. 1 (August 15, 2006): 63–71. https://doi.org/10.1042/BJ20051664.
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  - Xia, Yan, Rachel Novak, Jennifer Lewis, Colin S. Duckett, and Andrew C. Phillips. “Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP.” Mol Cell Biochem 286, no. 1–2 (June 2006): 67–76. https://doi.org/10.1007/s11010-005-9094-2.
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  - Mufti, Arjmand R., Ezra Burstein, Rebecca A. Csomos, Paul C. F. Graf, John C. Wilkinson, Robert D. Dick, Madhavi Challa, et al. “XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders.” Mol Cell 21, no. 6 (March 17, 2006): 775–85. https://doi.org/10.1016/j.molcel.2006.01.033.
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  - Wright, Casey W., and Colin S. Duckett. “Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function.” J Clin Invest 115, no. 10 (October 2005): 2673–78. https://doi.org/10.1172/JCI26251.
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  - Kucharczak, J. F., M. J. Simmons, C. S. Duckett, and C. Gélinas. “Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor.” Cell Death Differ 12, no. 9 (September 2005): 1225–39. https://doi.org/10.1038/sj.cdd.4401684.
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  - Burstein, Ezra, Jamie E. Hoberg, Amanda S. Wilkinson, Julie M. Rumble, Rebecca A. Csomos, Christine M. Komarck, Gabriel N. Maine, John C. Wilkinson, Marty W. Mayo, and Colin S. Duckett. “COMMD proteins, a novel family of structural and functional homologs of MURR1.” J Biol Chem 280, no. 23 (June 10, 2005): 22222–32. https://doi.org/10.1074/jbc.M501928200.
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  - Kamradt, Merideth C., Meiling Lu, Michael E. Werner, Toni Kwan, Feng Chen, Anne Strohecker, Shayna Oshita, et al. “The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3.” J Biol Chem 280, no. 12 (March 25, 2005): 11059–66. https://doi.org/10.1074/jbc.M413382200.
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  - Rudd, Brian D., Ezra Burstein, Colin S. Duckett, Xiaoxia Li, and Nicholas W. Lukacs. “Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression.” J Virol 79, no. 6 (March 2005): 3350–57. https://doi.org/10.1128/JVI.79.6.3350-3357.2005.
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  - Duckett, Colin S. “IAP proteins: sticking it to Smac.” Biochem J 385, no. Pt 1 (January 1, 2005): e1–2. https://doi.org/10.1042/BJ20041800.
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  - Wilkinson, John C., Bettina W. M. Richter, Amanda S. Wilkinson, Ezra Burstein, Julie M. Rumble, Blerina Balliu, and Colin S. Duckett. “VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation.” J Biol Chem 279, no. 49 (December 3, 2004): 51091–99. https://doi.org/10.1074/jbc.M409623200.
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  - Wilkinson, John C., Enrique Cepero, Lawrence H. Boise, and Colin S. Duckett. “Upstream regulatory role for XIAP in receptor-mediated apoptosis.” Mol Cell Biol 24, no. 16 (August 2004): 7003–14. https://doi.org/10.1128/MCB.24.16.7003-7014.2004.
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  - Creagh, Emma M., Brona M. Murphy, Patrick J. Duriez, Colin S. Duckett, and Seamus J. Martin. “Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins.” J Biol Chem 279, no. 26 (June 25, 2004): 26906–14. https://doi.org/10.1074/jbc.M313859200.
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  - Lewis, Jennifer, Ezra Burstein, Stephanie Birkey Reffey, Shawn B. Bratton, Anita B. Roberts, and Colin S. Duckett. “Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis.” J Biol Chem 279, no. 10 (March 5, 2004): 9023–29. https://doi.org/10.1074/jbc.M312891200.
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  - Steinman, Heather A., Ezra Burstein, Christopher Lengner, Joseph Gosselin, German Pihan, Colin S. Duckett, and Stephen N. Jones. “An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis.” J Biol Chem 279, no. 6 (February 6, 2004): 4877–86. https://doi.org/10.1074/jbc.M305966200.
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  - Jacob, Jaison, John M. Louis, B. W. M. Richter, Colin S. Duckett, and Dennis A. Torchia. “The C-terminal domain of viral IAP associated factor (cVIAF) is a structural homologue of phosducin: resonance assignments and secondary structure of the C-terminal domain of VIAF.” J Biomol Nmr 28, no. 2 (February 2004): 197–98. https://doi.org/10.1023/B:JNMR.0000013820.43366.99.
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  - Beltrami, Elena, Janet Plescia, John C. Wilkinson, Colin S. Duckett, and Dario C. Altieri. “Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis.” J Biol Chem 279, no. 3 (January 16, 2004): 2077–84. https://doi.org/10.1074/jbc.M309479200.
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  - Burstein, Ezra, Lakshmanan Ganesh, Robert D. Dick, Bart van De Sluis, John C. Wilkinson, Leo W. J. Klomp, Cisca Wijmenga, George J. Brewer, Gary J. Nabel, and Colin S. Duckett. “A novel role for XIAP in copper homeostasis through regulation of MURR1.” Embo J 23, no. 1 (January 14, 2004): 244–54. https://doi.org/10.1038/sj.emboj.7600031.
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  - Ganesh, Lakshmanan, Ezra Burstein, Anuradha Guha-Niyogi, Mark K. Louder, John R. Mascola, Leo W. J. Klomp, Cisca Wijmenga, Colin S. Duckett, and Gary J. Nabel. “The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes.” Nature 426, no. 6968 (December 18, 2003): 853–57. https://doi.org/10.1038/nature02171.
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  - Burstein, Ezra, and Colin S. Duckett. “Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery.” Curr Opin Cell Biol 15, no. 6 (December 2003): 732–37. https://doi.org/10.1016/j.ceb.2003.10.005.
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  - Shin, Hwain, Kazuya Okada, John C. Wilkinson, Katherine M. Solomon, Colin S. Duckett, John C. Reed, and Guy S. Salvesen. “Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein.” Biochem J 373, no. Pt 3 (August 1, 2003): 965–71. https://doi.org/10.1042/BJ20030583.
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  - Hunter, Allison M., Dan Kottachchi, Jennifer Lewis, Colin S. Duckett, Robert G. Korneluk, and Peter Liston. “A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO.” J Biol Chem 278, no. 9 (February 28, 2003): 7494–99. https://doi.org/10.1074/jbc.C200695200.
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  - Bratton, S. B., J. Lewis, M. Butterworth, C. S. Duckett, and G. M. Cohen. “XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis.” Cell Death Differ 9, no. 9 (September 2002): 881–92. https://doi.org/10.1038/sj.cdd.4401069.
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  - Salvesen, Guy S., and Colin S. Duckett. “IAP proteins: blocking the road to death's door.” Nat Rev Mol Cell Biol 3, no. 6 (June 2002): 401–10. https://doi.org/10.1038/nrm830.
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  - Duckett, Colin S. “Apoptosis and NF-kappa B: the FADD connection.” J Clin Invest 109, no. 5 (March 2002): 579–80. https://doi.org/10.1172/JCI15197.
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  - Salvesen, G. S., and C. S. Duckett. “Improvement of polynomial methods for reproducing functional dependences.” Measurement Techniques 45, no. 12 (January 1, 2002): 1229–36. https://doi.org/10.1023/A:1022976905528.
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  - Kim, R. H., K. C. Flanders, S. Birkey Reffey, L. A. Anderson, C. S. Duckett, N. D. Perkins, and A. B. Roberts. “SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators.” J Biol Chem 276, no. 49 (December 7, 2001): 46297–304. https://doi.org/10.1074/jbc.M103819200.
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  - Levi, E., W. M. Pfeifer, and M. E. Kadin. “CD30-activation-mediated growth inhibition of anaplastic large-cell lymphoma cell lines: apoptosis or cell-cycle arrest?” Blood 98, no. 5 (September 1, 2001): 1630–32. https://doi.org/10.1182/blood.v98.5.1630.
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  - Birkey Reffey, S., J. U. Wurthner, W. T. Parks, A. B. Roberts, and C. S. Duckett. “X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling.” J Biol Chem 276, no. 28 (July 13, 2001): 26542–49. https://doi.org/10.1074/jbc.M100331200.
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  - Lewis, J., L. J. Eiben, D. L. Nelson, J. I. Cohen, K. E. Nichols, H. D. Ochs, L. D. Notarangelo, and C. S. Duckett. “Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.” Clin Immunol 100, no. 1 (July 2001): 15–23. https://doi.org/10.1006/clim.2001.5035.
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  - Richter, B. W., S. S. Mir, L. J. Eiben, J. Lewis, S. B. Reffey, A. Frattini, L. Tian, et al. “Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family.” Mol Cell Biol 21, no. 13 (July 2001): 4292–4301. https://doi.org/10.1128/MCB.21.13.4292-4301.2001.
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  - Czar, M. J., E. N. Kersh, L. A. Mijares, G. Lanier, J. Lewis, G. Yap, A. Chen, et al. “Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP.” Proc Natl Acad Sci U S A 98, no. 13 (June 19, 2001): 7449–54. https://doi.org/10.1073/pnas.131193098.
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  - Harlin, H., S. B. Reffey, C. S. Duckett, T. Lindsten, and C. B. Thompson. “Characterization of XIAP-deficient mice.” Mol Cell Biol 21, no. 10 (May 2001): 3604–8. https://doi.org/10.1128/MCB.21.10.3604-3608.2001.
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  - Clem, R. J., T. T. Sheu, B. W. Richter, W. W. He, N. A. Thornberry, C. S. Duckett, and J. M. Hardwick. “c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment.” J Biol Chem 276, no. 10 (March 9, 2001): 7602–8. https://doi.org/10.1074/jbc.M010259200.
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  - Mir, S. S., B. W. Richter, and C. S. Duckett. “Differential effects of CD30 activation in anaplastic large cell lymphoma and Hodgkin disease cells.” Blood 96, no. 13 (December 15, 2000): 4307–12.
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  - Larisch, S., Y. Yi, R. Lotan, H. Kerner, S. Eimerl, W. Tony Parks, Y. Gottfried, et al. “A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.” Nat Cell Biol 2, no. 12 (December 2000): 915–21. https://doi.org/10.1038/35046566.
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  - Nakajima, H., M. Cella, A. Bouchon, H. L. Grierson, J. Lewis, C. S. Duckett, J. I. Cohen, and M. Colonna. “Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity.” Eur J Immunol 30, no. 11 (November 2000): 3309–18. https://doi.org/10.1002/1521-4141(200011)30:11<3309::AID-IMMU3309>3.0.CO;2-3.
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  - Richter, B. W., and C. S. Duckett. “The IAP proteins: caspase inhibitors and beyond.” Sci Stke 2000, no. 44 (August 8, 2000): pe1. https://doi.org/10.1126/stke.2000.44.pe1.
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  - Lappalainen, I., S. Giliani, R. Franceschini, J. Y. Bonnefoy, C. Duckett, L. D. Notarangelo, and M. Vihinen. “Structural basis for SH2D1A mutations in X-linked lymphoproliferative disease.” Biochem Biophys Res Commun 269, no. 1 (March 5, 2000): 124–30. https://doi.org/10.1006/bbrc.2000.2146.
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  - Sanna, M. G., C. S. Duckett, B. W. Richter, C. B. Thompson, and R. J. Ulevitch. “Selective activation of JNK1 is necessary for the anti-apoptotic activity of hILP.” Proc Natl Acad Sci U S A 95, no. 11 (May 26, 1998): 6015–20. https://doi.org/10.1073/pnas.95.11.6015.
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  - Duckett, C. S., F. Li, Y. Wang, K. J. Tomaselli, C. B. Thompson, and R. C. Armstrong. “Human IAP-like protein regulates programmed cell death downstream of Bcl-xL and cytochrome c.” Mol Cell Biol 18, no. 1 (January 1998): 608–15. https://doi.org/10.1128/MCB.18.1.608.
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  - Eiben, L. J., and C. S. Duckett. “The IAP family of apoptotic regulators.” Results Probl Cell Differ 24 (1998): 91–104. https://doi.org/10.1007/978-3-540-69185-3_5.
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  - Duckett, C. S., and C. B. Thompson. “CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival.” Genes Dev 11, no. 21 (November 1, 1997): 2810–21. https://doi.org/10.1101/gad.11.21.2810.
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  - Clem, R. J., and C. S. Duckett. “The iap genes: unique arbitrators of cell death.” Trends Cell Biol 7, no. 9 (September 1997): 337–39. https://doi.org/10.1016/S0962-8924(97)01088-X.
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  - Chuang, E., M. L. Alegre, C. S. Duckett, P. J. Noel, M. G. Vander Heiden, and C. B. Thompson. “Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression.” J Immunol 159, no. 1 (July 1, 1997): 144–51.
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  - Duckett, C. S., R. W. Gedrich, M. C. Gilfillan, and C. B. Thompson. “Induction of nuclear factor kappaB by the CD30 receptor is mediated by TRAF1 and TRAF2.” Mol Cell Biol 17, no. 3 (March 1997): 1535–42. https://doi.org/10.1128/MCB.17.3.1535.
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  - Chuany, E., M. Vanderhejden, M. L. Alegre, P. Noel, E. Herbert, C. Duckett, and C. B. Thompson. “Identification of proteins which interact with the cytoplasmic domain of CTLA-4.” Faseb Journal 10, no. 6 (December 1, 1996).
  - Shiels, H., C. Duckett, and C. Thompson. “A new family of apoptotic cell death inhibitors.” Faseb Journal 10, no. 6 (December 1, 1996).
  - Duckett, C. S., V. E. Nava, R. W. Gedrich, R. J. Clem, J. L. Van Dongen, M. C. Gilfillan, H. Shiels, J. M. Hardwick, and C. B. Thompson. “A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.” Embo J 15, no. 11 (June 3, 1996): 2685–94.
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  - Gedrich, R. W., M. C. Gilfillan, C. S. Duckett, J. L. Van Dongen, and C. B. Thompson. “CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins.” J Biol Chem 271, no. 22 (May 31, 1996): 12852–58. https://doi.org/10.1074/jbc.271.22.12852.
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  - Yang, H., C. S. Duckett, and T. Lindsten. “iPABP, an inducible poly(A)-binding protein detected in activated human T cells.” Mol Cell Biol 15, no. 12 (December 1995): 6770–76. https://doi.org/10.1128/MCB.15.12.6770.
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  - Duckett, C. S., N. D. Perkins, K. Leung, A. B. Agranoff, and G. J. Nabel. “Cytokine induction of nuclear factor kappa B in cycling and growth-arrested cells. Evidence for cell cycle-independent activation.” J Biol Chem 270, no. 32 (August 11, 1995): 18836–40. https://doi.org/10.1074/jbc.270.32.18836.
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  - Wu, B. Y., C. Woffendin, C. S. Duckett, T. Ohno, and G. J. Nabel. “Regulation of human retroviral latency by the NF-kappa B/I kappa B family: inhibition of human immunodeficiency virus replication by I kappa B through a Rev-dependent mechanism.” Proc Natl Acad Sci U S A 92, no. 5 (February 28, 1995): 1480–84. https://doi.org/10.1073/pnas.92.5.1480.
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  - Perkins, N. D., A. B. Agranoff, C. S. Duckett, and G. J. Nabel. “Transcription factor AP-2 regulates human immunodeficiency virus type 1 gene expression.” J Virol 68, no. 10 (October 1994): 6820–23. https://doi.org/10.1128/JVI.68.10.6820-6823.1994.
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  - Shu, H. B., A. B. Agranoff, E. G. Nabel, K. Leung, C. S. Duckett, A. S. Neish, T. Collins, and G. J. Nabel. “Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-kappa B subunits in endothelial and epithelial cells.” Mol Cell Biol 13, no. 10 (October 1993): 6283–89. https://doi.org/10.1128/mcb.13.10.6283-6289.1993.
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  - Perkins, N. D., N. L. Edwards, C. S. Duckett, A. B. Agranoff, R. M. Schmid, and G. J. Nabel. “A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation.” Embo J 12, no. 9 (September 1993): 3551–58. https://doi.org/10.1002/j.1460-2075.1993.tb06029.x.
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  - Duckett, C. S., N. D. Perkins, T. F. Kowalik, R. M. Schmid, E. S. Huang, A. S. Baldwin, and G. J. Nabel. “Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3).” Mol Cell Biol 13, no. 3 (March 1993): 1315–22. https://doi.org/10.1128/mcb.13.3.1315-1322.1993.
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  - Kerr, L. D., C. S. Duckett, P. Wamsley, Q. Zhang, P. Chiao, G. Nabel, T. W. McKeithan, P. A. Baeuerle, and I. M. Verma. “The proto-oncogene bcl-3 encodes an I kappa B protein.” Genes Dev 6, no. 12A (December 1992): 2352–63. https://doi.org/10.1101/gad.6.12a.2352.
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  - Perkins, N. D., R. M. Schmid, C. S. Duckett, K. Leung, N. R. Rice, and G. J. Nabel. “Distinct combinations of NF-kappa B subunits determine the specificity of transcriptional activation.” Proc Natl Acad Sci U S A 89, no. 5 (March 1, 1992): 1529–33. https://doi.org/10.1073/pnas.89.5.1529.
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  - Bednarik, D. P., C. Duckett, S. U. Kim, V. L. Perez, K. Griffis, P. C. Guenthner, and T. M. Folks. “DNA CpG methylation inhibits binding of NF-kappa B proteins to the HIV-1 long terminal repeat cognate DNA motifs.” New Biol 3, no. 10 (October 1991): 969–76.
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  - Schmid, R. M., N. D. Perkins, C. S. Duckett, P. C. Andrews, and G. J. Nabel. “Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65.” Nature 352, no. 6337 (August 22, 1991): 733–36. https://doi.org/10.1038/352733a0.
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- Conference Papers
  - Duckett, C. S., and C. B. Thompson. “The control and execution of programmed cell death: an update.” In Biochim Biophys Acta, 1332:R45–47, 1997. https://doi.org/10.1016/s0304-419x(97)00002-4.
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