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Development of a multimodal mobile colposcope for real-time cervical cancer detection.

Publication ,  Journal Article
Coole, JB; Brenes, D; Possati-Resende, JC; Antoniazzi, M; Fonseca, BDO; Maker, Y; Kortum, A; Vohra, IS; Schwarz, RA; Carns, J; Borba Souza, KC ...
Published in: Biomedical optics express
October 2022

Cervical cancer remains a leading cause of cancer death among women in low-and middle-income countries. Globally, cervical cancer prevention programs are hampered by a lack of resources, infrastructure, and personnel. We describe a multimodal mobile colposcope (MMC) designed to diagnose precancerous cervical lesions at the point-of-care without the need for biopsy. The MMC integrates two complementary imaging systems: 1) a commercially available colposcope and 2) a high speed, high-resolution, fiber-optic microendoscope (HRME). Combining these two image modalities allows, for the first time, the ability to locate suspicious cervical lesions using widefield imaging and then to obtain co-registered high-resolution images across an entire lesion. The MMC overcomes limitations of high-resolution imaging alone; widefield imaging can be used to guide the placement of the high-resolution imaging probe at clinically suspicious regions and co-registered, mosaicked high-resolution images effectively increase the field of view of high-resolution imaging. Representative data collected from patients referred for colposcopy at Barretos Cancer Hospital in Brazil, including 22,800 high resolution images and 9,900 colposcope images, illustrate the ability of the MMC to identify abnormal cervical regions, image suspicious areas with subcellular resolution, and distinguish between high-grade and low-grade dysplasia.

Duke Scholars

Published In

Biomedical optics express

DOI

EISSN

2156-7085

ISSN

2156-7085

Publication Date

October 2022

Volume

13

Issue

10

Start / End Page

5116 / 5130

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics
 

Citation

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Coole, J. B., Brenes, D., Possati-Resende, J. C., Antoniazzi, M., Fonseca, B. D. O., Maker, Y., … Richards-Kortum, R. (2022). Development of a multimodal mobile colposcope for real-time cervical cancer detection. Biomedical Optics Express, 13(10), 5116–5130. https://doi.org/10.1364/boe.463253
Coole, Jackson B., David Brenes, Júlio César Possati-Resende, Márcio Antoniazzi, Bruno de Oliveira Fonseca, Yajur Maker, Alex Kortum, et al. “Development of a multimodal mobile colposcope for real-time cervical cancer detection.Biomedical Optics Express 13, no. 10 (October 2022): 5116–30. https://doi.org/10.1364/boe.463253.
Coole JB, Brenes D, Possati-Resende JC, Antoniazzi M, Fonseca BDO, Maker Y, et al. Development of a multimodal mobile colposcope for real-time cervical cancer detection. Biomedical optics express. 2022 Oct;13(10):5116–30.
Coole, Jackson B., et al. “Development of a multimodal mobile colposcope for real-time cervical cancer detection.Biomedical Optics Express, vol. 13, no. 10, Oct. 2022, pp. 5116–30. Epmc, doi:10.1364/boe.463253.
Coole JB, Brenes D, Possati-Resende JC, Antoniazzi M, Fonseca BDO, Maker Y, Kortum A, Vohra IS, Schwarz RA, Carns J, Borba Souza KC, Vidigal Santana IV, Kreitchmann R, Salcedo MP, Ramanujam N, Schmeler KM, Richards-Kortum R. Development of a multimodal mobile colposcope for real-time cervical cancer detection. Biomedical optics express. 2022 Oct;13(10):5116–5130.
Journal cover image

Published In

Biomedical optics express

DOI

EISSN

2156-7085

ISSN

2156-7085

Publication Date

October 2022

Volume

13

Issue

10

Start / End Page

5116 / 5130

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics