Nimmi Ramanujam
Robert W. Carr, Jr., Distinguished Professor of Biomedical Engineering
Dr. Ramanujam is the Robert W. Carr Professor of Engineering and Professor of Cancer Pharmacology and Global Health at Duke University and co-program leader of the Radiation Oncology and Imaging Program (ROIP) at the Duke Cancer Institute. She founded the Center for Global Women’s Health Technologies (GWHT) in 2013 where she empowers trainees to create impactful solutions to improve the lives of women and girls globally. This center, since inception, has catalyzed new research activities and the development and commercialization of several technologies that advance prevention and treatment of cervical and breast cancer.
Dr. Ramanujam’s work has led to low-cost and efficient health care and home-based technology innovations that provide surveillance of cancer and its recurrence. To complement her translational efforts, Dr. Ramanujam’s work exploits the dynamic changes in tumor metabolism that allow cancers to go under the radar and recur in a stealth mode when conditions are favorable. She is also creating a liquid-based ablative therapy with dual roles - (1) to address the pressing issue of cancer control in environments where access to surgery is scarce, and (2) enhance tumor kill through a combination of necrosis and T cell infiltration occurring as a result of tumor antigen presentation following ablation.
Dr. Ramanujam has built several global initiatives. The most notable is a consortium to impact cervical cancer prevention in low resource settings. Her MacArthur Foundation 100&Change proposal, Women-Inspired Strategies for Health: A Revolution against Cervical Cancer (WISH) was recognized as one of the Top 100 of the 755 proposals submitted to this $100M grant competition (Macarthur 100&Change). In addition to her cervical cancer prevention initiative, she has also created a global women’s education program that intersects design-thinking, STEM concepts, and the U.N. Sustainable Development Goals to promote social justice awareness (IGNITE). She has launched an arts and storytelling initiative to raise awareness of sexual and reproductive health inequities (The (In) Visible Organ).
She has created two companies Zenalux and Calla Health to commercialize her technologies.
Calla Health, a GWHT venture, is centered on sustainably improving women's access to cancer prevention and creating innovations that increase wide scale surveillance of cervical pre-cancers and cancers. Zenalux Biomedical, in collaboration with Duke University, is developing a suite of optical microscopy and spectroscopy tools for preclinical and clinical applications in cancer research. Zenalux’ newest product offering is the Zenascope™ ZF1, a combined portable platform for optical imaging and spectroscopy to characterize the major axes of metabolism along with key vascular features.
Dr. Ramanujam has more than 20 patents to-date and more than 150 publications for screening, diagnostic, and surgical applications. She has received funding from a agencies including NIH R01s and R21s, NIH Bioengineering Partnerships, NCI Academic Industry Partnerships, NIH Small Business grants, DOD, Burroughs Wellcome Fund, DIHI: Innovation Jam, Prevent Cancer and USAID funding. As the director of the Center for Global Women’s Health Technologies, she has developed a network of 50+ partners including international academic institutions and hospitals, non-governmental organizations, ministries of health, and commercial partners; this consortium works to ensure the technologies developed at the center are adopted by cancer control programs in geographically and economically diverse healthcare settings.
Dr. Ramanujam has received a number of awards including the MIT TR100 Young Innovator award (MIT), the Global Indus Technovator award (MIT), the Stansell Family award (Duke), multiple Era of Hope Scholar awards (DoD), the Emerging Leader in Global Health Award (CUGH), the Social Impact Abie Award (AnitaB.org), the Biophotonics Technology Innovator Award (SPIE), the Women in Molecular Imaging Leadership Award (WMIC), the Michael S. Feld Biophotonics Award (OSA) and the Wom C Global Impact Award (Duke). She is a fellow of several optical and biomedical engineering societies including OSA, SPIE, and AIMBE. She is a Fulbright scholar and the 2020 IEEE Distinguished Lecturer. She is an elected member of the National Academy of Inventors. She has demonstrated her work’s global impact through presentations at the United Nations and TEDx events, and a number of national and international plenary talks. Her work has been featured in a number of venues including Medical Daily, Wired Magazine, NPR and several podcasts.
Current Research Interests
Current Appointments & Affiliations
- Robert W. Carr, Jr., Distinguished Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2014
- Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2011
- Director of Center for Global Women's Health Technologies, Pratt School of Engineering, Duke University 2022
- Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2013
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2005
- Affiliate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2014
- Core Faculty Member, Duke-Margolis Center for Health Policy, Duke - Margolis Center For Health Policy, Initiatives 2019
Contact Information
- 367 Gross Hall, 140 Science Drive, Durham, NC 27708
- Box 90281, 1427 Fciemas, Durham, NC 27708-0281
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(919) 660-5307
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Center for Global Women's Health Technologies
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Google Scholar
- Background
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Education, Training, & Certifications
- Ph.D., University of Texas, Austin 1995
- M.S., University of Texas, Austin 1992
- B.S., University of Texas, Austin 1989
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Previous Appointments & Affiliations
- Research Professor of Global Health, Duke Global Health Institute, University Institutes and Centers 2012 - 2022
- Core Faculty in Innovation & Entrepreneurship, Duke Innovation & Entrepreneurship, Initiatives 2018 - 2021
- Director for the Center for Global Women's Health Technologies, Pratt School of Engineering, Duke University 2013 - 2016
- Associate Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2005 - 2010
- Recognition
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In the News
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MAY 5, 2020 -
MAY 1, 2020 Duke Mobile App Gateway -
APR 30, 2020 Diversity In Action Magazine -
APR 10, 2020 Thrive Global -
FEB 25, 2020 -
FEB 24, 2020 -
FEB 21, 2020 Pratt School of Engineering -
JAN 28, 2020 School of Medicine -
DEC 1, 2019 -
DEC 1, 2019 -
SEP 23, 2019 -
SEP 16, 2019 Medium -
AUG 27, 2019 Anita B.org -
MAY 20, 2019 Cisco -
APR 22, 2019 Pratt School of Engineering -
FEB 27, 2019 Duke Arts -
FEB 5, 2019 Duke Global -
OCT 9, 2018 Duke Arts -
DEC 13, 2017 -
FEB 15, 2017 Duke Global Health Institute -
DEC 19, 2016 -
NOV 22, 2016 Pratt School of Engineering -
MAR 16, 2016 -
MAY 1, 2015 -
OCT 2, 2014 -
SEP 19, 2014 -
JAN 13, 2014 -
OCT 23, 2013 -
JUN 7, 2013
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Awards & Honors
- Women In Molecular Imaging Network (WIMIN) Leadership Committee. WIMIN. 2020
- Associate Editor. Inaugural Editorial Board of IEEE OJEMB. 2020
- Michael S. Feld Biophotonics . OSA. 2020
- The WomC Global Impact Award. Duke University Women’s Center. 2020
- Associate Editor. Scientific Reports. 2019
- Biophotonics Technology Innovator Award. International Society for Optics and Photonics. 2019
- Program co-leader for Radiation Oncology and Imaging Program. Duke Cancer Institute. 2019
- Social Impact Abie Award. AnitaB.org . 2019
- Women in Molecular Imaging Network Outstanding Leadership in Molecular Imaging Award. World Molecular Imaging Society. 2019
- CUGH Emerging Leader in Global Health Innovation Faculty Award. Consortium of Universities for Global Health. 2018
- Fellow (NAI). National Academy of Inventors. 2017
- Fellow. National Academy of Inventors . 2017
- Fellow. International Society for Optics and Photonics. 2013
- Fellow. American Institute for Medical and Biological Engineering. 2012
- Fellow. Optical Society of America. 2010
- Expertise
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Global Scholarship
- Research
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Selected Grants
- Technology-enabled Single-Visit Model for Cervical Cancer Prevention at the Community Level awarded by National Institutes of Health 2022 - 2027
- Building Interdisciplinary Research Careers in Women's Health awarded by National Institutes of Health 2002 - 2027
- Duke Center for Advancement of Child Health (CAtCH). awarded by National Institutes of Health 2021 - 2026
- Duke Women's Reproductive Health Research Scholars awarded by National Institutes of Health 2020 - 2025
- Ignite: Empowering Local Students through STEM Curricula awarded by Burroughs Wellcome Fund 2020 - 2024
- Partnership to establish a practice based network to assess for head and neck cancers using a low-cost portable flexible nasopharyngoscope awarded by National Institutes of Health 2019 - 2024
- Novel see and treat strategies for cervical cancer prevention in low-resource settings awarded by National Institutes of Health 2019 - 2024
- Increasing Accessibility of Laparoscopic Surgery in Low- and Middle-Income Countries awarded by National Institutes of Health 2021 - 2023
- Closing the gap between identification and treatment of cervical abnormalities in Lima, Peru through integration of pocket colposcopy, telemedicine and visual counseling awarded by US Agency for International Development 2019 - 2023
- A Portable low-cost, Point of Investigation CapCell Scope to Image and Quantify the Major Axes of Metabolism and the Associated Vasculature in In vitro and In vivo Biological Models awarded by National Institutes of Health 2019 - 2022
- Translational Research in Surgical Oncology awarded by National Institutes of Health 2002 - 2022
- Culturally appropriate screening and diagnosis of cervical cancer in East Africa awarded by National Institutes of Health 2015 - 2021
- HOPE: Women helping women fight cervical cancer through self-HPV and VIA testing awarded by Prevent Cancer Foundation 2020 - 2021
- A novel platform to image metabolic reprogramming of residual disease and recurrence in HER2+ breast cancer awarded by National Institutes of Health 2019 - 2020
- Enhanced ethanol ablation as a surgical-alternative for head and neck cancer treatment in resource-limited settings awarded by National Institutes of Health 2019 - 2020
- Training in Medical Imaging awarded by National Institutes of Health 2003 - 2020
- A novel strategy to see and treat breast cancer: translation to intra-operative breast margin assessment awarded by National Institutes of Health 2017 - 2019
- Development of a low-cost tool for self, speculum-free, automated cervical cancer screening awarded by VentureWell 2018 - 2019
- Towards a viable solution for a see and treat paradigm for cervical pre-cancer in East Africa awarded by National Institutes of Health 2015 - 2018
- Speculum-free gynecology with applications to primary and secondary prevention of cervical cancer awarded by North Carolina Biotechnology Center 2017 - 2018
- A Novel Optical Spectral Imaging System for Rapid Imaging of Breast Tumor Margins awarded by National Institutes of Health 2011 - 2017
- Enhanced Design Experiences for Duke BME Students awarded by National Institutes of Health 2011 - 2017
- Targeted Chemoprevention of Breast Cancer: From the Bench to Clinical Testing awarded by National Institutes of Health 2012 - 2015
- Harnessing the power of light to see and treat breast cancer awarded by United States Army Medical Research and Materiel Command 2009 - 2015
- Smart Optical Sensor for Detection of Cervical Cancer In the Developing World awarded by National Institutes of Health 2011 - 2015
- Automated Micromanufacturing for Optical Sensing and Computational Imaging, Metamaterials, and Quantum Computing awarded by Air Force Office of Scientific Research 2012 - 2014
- A Fluorescence Histology System for In Vivo Breast Tumor Margin Assessment awarded by National Institutes of Health 2011 - 2013
- Can Optical Spectroscopy Predict Early Treatment Response in Solid Tumors awarded by National Institutes of Health 2010 - 2012
- A Smart Fiber Optic Sensor for in Vivo Tissue Optical Spectroscopy awarded by National Institutes of Health 2010 - 2012
- Investigation of Anti-Angiogenic Mechanisms Using Novel Imaging Techniques awarded by US Army Medical Research and Materiel Command 2009 - 2012
- Diagnosis of Breast Cancer using Optical Spectroscopy awarded by National Institutes of Health 2005 - 2010
- Near Infrared Spectroscopy for Improving Breast Core Needle Biopsy awarded by United States Army Medical Research and Materiel Command 2006 - 2009
- Multi-Label Molecular FLIM of Breast Cancer awarded by National Institutes of Health 2006 - 2009
- Fiber Probe Design for Epithelial Precancer Detection awarded by National Institutes of Health 2006 - 2009
- Optical Spectroscopy and Multiphoton Imaging for the Diagnosis and Characterization of Hyperplasias in the Mouse Mammary Gland awarded by United States Army Medical Research and Materiel Command 2005 - 2007
- Diffuse Optical Spectroscopy Guided Breast Needle Biopsy awarded by National Institutes of Health 2005 - 2007
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External Relationships
- Calla health Foundation
- Zenalux Biomedical
- Publications & Artistic Works
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Selected Publications
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Books
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Boas, D. A., C. Pitris, and N. Ramanujam. Handbook of biomedical optics, 2016.
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Academic Articles
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Natarajan, J., M. Krieger, N. Ramanujam, S. Vashist, and N. Bhatla. “Feasibility and Outcome of Training Field Workers to Use the Transvaginal Colposcope for Point of Care Diagnosis and Management of Precancerous Cervical Lesions.” Indian Journal of Gynecologic Oncology 21, no. 1 (March 1, 2023). https://doi.org/10.1007/s40944-022-00681-6.Full Text
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Natarajan, Jayashree, Sandeep Mathur, Sreenivas Vishnubhatla, Sunesh Kumar, Shachi Vashist, Nimmi Ramanujam, Seema Singhal, Jyoti Meena, Pranay Tanwar, and Neerja Bhatla. “Can portable Colposcopes Replace Standard-of-care Colposcopes? A Crossover Trial of Two Portable Colposcopes with a Standard-of-Care Video Colposcope.” Asian Pacific Journal of Cancer Prevention : Apjcp 23, no. 12 (December 2022): 4013–21. https://doi.org/10.31557/apjcp.2022.23.12.4013.Full Text
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Coole, Jackson B., David Brenes, Júlio César Possati-Resende, Márcio Antoniazzi, Bruno de Oliveira Fonseca, Yajur Maker, Alex Kortum, et al. “Development of a multimodal mobile colposcope for real-time cervical cancer detection.” Biomedical Optics Express 13, no. 10 (October 2022): 5116–30. https://doi.org/10.1364/boe.463253.Full Text
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Ramanujam, N., and M. Madonna. “Editorial overview: Biomedical engineering and women's health: Breaking new ground in gender- and sex-specific research.” Current Opinion in Biomedical Engineering 22 (June 1, 2022). https://doi.org/10.1016/j.cobme.2022.100392.Full Text
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Deutsch, Riley J., Victoria W. D’Agostino, Enakshi D. Sunassee, Michelle Kwan, Megan C. Madonna, Gregory Palmer, Brian T. Crouch, and Nimmi Ramanujam. “A Spectroscopic Technique to Simultaneously Characterize Fatty Acid Uptake, Mitochondrial Activity, Vascularity, and Oxygen Saturation for Longitudinal Studies In Vivo.” Metabolites 12, no. 5 (April 19, 2022). https://doi.org/10.3390/metabo12050369.Full Text Link to Item
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Gupta, Aryaman, Erin Brown, Joseph T. Davis, John Sekabira, Nimmi Ramanujam, Jenna Mueller, and Tamara N. Fitzgerald. “KeyLoop: Mechanical Retraction of the Abdominal Wall for Gasless Laparoscopy.” Surg Innov 29, no. 1 (February 2022): 88–97. https://doi.org/10.1177/15533506211031084.Full Text Link to Item
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Solingapuram Sai, Kiran Kumar, Xiaofei Chen, Zhe Li, Caigang Zhu, Kirtikar Shukla, Tom E. Forshaw, Hanzhi Wu, et al. “[18F]Fluoro-DCP, a first generation PET radiotracer for monitoring protein sulfenylation in vivo.” Redox Biology 49 (February 2022): 102218. https://doi.org/10.1016/j.redox.2021.102218.Full Text
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Perez, Luiza, Kimberley Tran, Vanessa Alvarenga-Bezerra, Diya Chadha, Libby Dotson, Fernanda Assir, Eduardo Cordioli, et al. “Cervical Cancer-Related Knowledge, Attitudes, Practices and Self-Screening Acceptance Among Patients, Employees, and Social Media Followers of Major Brazilian Hospital.” Cancer Control : Journal of the Moffitt Cancer Center 29 (January 2022): 10732748221135440. https://doi.org/10.1177/10732748221135441.Full Text
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Shin, Michelle B., Patricia J. Garcia, Mary Elizabeth Dotson, María Valderrama, Marina Chiappe, Nimmi Ramanujam, Marlee Krieger, et al. “Evaluation of Women's Empowerment in a Community-Based Human Papillomavirus Self-Sampling Social Entrepreneurship Program (Hope Project) in Peru: A Mixed-Method Study.” Frontiers in Public Health 10 (January 2022): 858552. https://doi.org/10.3389/fpubh.2022.858552.Full Text
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Mueller, Jenna L., Robert Morhard, Michael DeSoto, Erika Chelales, Jeffrey Yang, Corrine Nief, Brian Crouch, et al. “Optimizing ethyl cellulose-ethanol delivery towards enabling ablation of cervical dysplasia.” Sci Rep 11, no. 1 (August 19, 2021): 16869. https://doi.org/10.1038/s41598-021-96223-9.Full Text Link to Item
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Mueller, Jenna L., Natalie Rozman, Enakshi D. Sunassee, Aryaman Gupta, Cayla Schuval, Arushi Biswas, Bailey Knight, et al. “An Accessible Laparoscope for Surgery in Low- and Middle- Income Countries.” Ann Biomed Eng 49, no. 7 (July 2021): 1657–69. https://doi.org/10.1007/s10439-020-02707-6.Full Text Link to Item
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Rossman, Andrea H., Hadley W. Reid, Michelle M. Pieters, Cecelia Mizelle, Megan von Isenburg, Nimmi Ramanujam, Megan J. Huchko, and Lavanya Vasudevan. “Digital Health Strategies for Cervical Cancer Control in Low- and Middle-Income Countries: Systematic Review of Current Implementations and Gaps in Research.” J Med Internet Res 23, no. 5 (May 27, 2021): e23350. https://doi.org/10.2196/23350.Full Text Link to Item
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Thoumi, Andrea, Sarah J. Bond, Mary Elizabeth Dotson, Marlee Krieger, Patricia J. Garcia, and Nirmala Ramanujam. “Policy Considerations to Promote Equitable Cervical Cancer Screening and Treatment in Peru.” Annals of Global Health 87, no. 1 (January 2021): 116. https://doi.org/10.5334/aogh.3442.Full Text
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Rossman, Andrea H., Hadley W. Reid, Michelle M. Pieters, Cecelia Mizelle, Megan von Isenburg, Nimmi Ramanujam, Megan J. Huchko, and Lavanya Vasudevan. “Digital Health Strategies for Cervical Cancer Control in Low- and Middle-Income Countries: Systematic Review of Current Implementations and Gaps in Research (Preprint),” August 17, 2020. https://doi.org/10.2196/preprints.23350.Full Text
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Morhard, Robert, Jenna L. Mueller, Qishun Tang, Corrine Nief, Erika Chelales, Christopher T. Lam, Daniel Adrianzen Alvarez, Michael Rubinstein, David F. Katz, and Nimmi Ramanujam. “Understanding Factors Governing Distribution Volume of Ethyl Cellulose-Ethanol to Optimize Ablative Therapy in the Liver.” Ieee Transactions on Bio Medical Engineering 67, no. 8 (August 2020): 2337–48. https://doi.org/10.1109/tbme.2019.2960049.Full Text
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Bowden, Audrey K., Nicholas J. Durr, David Erickson, Aydogan Ozcan, Nirmala Ramanujam, and Paulino Vacas Jacques. “Optical Technologies for Improving Healthcare in Low-Resource Settings: introduction to the feature issue.” Biomedical Optics Express 11, no. 6 (June 2020): 3091–94. https://doi.org/10.1364/boe.397698.Full Text
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Asiedu, Mercy Nyamewaa, Anish Simhal, Usamah Chaudhary, Jenna L. Mueller, Christopher T. Lam, John W. Schmitt, Gino Venegas, Guillermo Sapiro, and Nimmi Ramanujam. “Development of Algorithms for Automated Detection of Cervical Pre-Cancers With a Low-Cost, Point-of-Care, Pocket Colposcope.” Ieee Trans Biomed Eng 66, no. 8 (August 2019): 2306–18. https://doi.org/10.1109/TBME.2018.2887208.Full Text Link to Item
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Madonna, Megan C., Douglas B. Fox, Brian T. Crouch, Jihong Lee, Caigang Zhu, Amy F. Martinez, James V. Alvarez, and Nirmala Ramanujam. “Optical Imaging of Glucose Uptake and Mitochondrial Membrane Potential to Characterize Her2 Breast Tumor Metabolic Phenotypes.” Mol Cancer Res 17, no. 7 (July 2019): 1545–55. https://doi.org/10.1158/1541-7786.MCR-18-0618.Full Text Link to Item
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Zhu, Caigang, Martin Li, Thomas Vincent, Hannah L. Martin, Brian T. Crouch, Amy F. Martinez, Megan C. Madonna, Gregory M. Palmer, Mark W. Dewhirst, and Nimmi Ramanujam. “Simultaneous in vivo optical quantification of key metabolic and vascular endpoints reveals tumor metabolic diversity in murine breast tumor models.” J Biophotonics 12, no. 4 (April 2019): e201800372. https://doi.org/10.1002/jbio.201800372.Full Text Link to Item
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Crouch, Brian T., Jennifer Gallagher, Roujia Wang, Joy Duer, Allison Hall, Mary Scott Soo, Philip Hughes, Timothy Haystead, and Nirmala Ramanujam. “Exploiting heat shock protein expression to develop a non-invasive diagnostic tool for breast cancer.” Sci Rep 9, no. 1 (March 5, 2019): 3461. https://doi.org/10.1038/s41598-019-40252-y.Full Text Link to Item
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Mueller, J. L., C. T. Lam, D. Dahl, M. N. Asiedu, M. S. Krieger, Y. Bellido-Fuentes, M. Kellish, et al. “Portable Pocket colposcopy performs comparably to standard-of-care clinical colposcopy using acetic acid and Lugol's iodine as contrast mediators: an investigational study in Peru.” Bjog 125, no. 10 (September 2018): 1321–29. https://doi.org/10.1111/1471-0528.15326.Full Text Open Access Copy Link to Item
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Zhu, Caigang, Hannah L. Martin, Brian T. Crouch, Amy F. Martinez, Martin Li, Gregory M. Palmer, Mark W. Dewhirst, and Nimmi Ramanujam. “Near-simultaneous quantification of glucose uptake, mitochondrial membrane potential, and vascular parameters in murine flank tumors using quantitative diffuse reflectance and fluorescence spectroscopy.” Biomed Opt Express 9, no. 7 (July 1, 2018): 3399–3412. https://doi.org/10.1364/BOE.9.003399.Full Text Link to Item
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Palmer, Gregory M., Hengtao Zhang, Chen-Ting Lee, Husam Mikati, Joseph A. Herbert, Marlee Krieger, Jesko von Windheim, et al. “Assessing effects of pressure on tumor and normal tissue physiology using an automated self-calibrated, pressure-sensing probe for diffuse reflectance spectroscopy.” J Biomed Opt 23, no. 5 (May 2018): 1–8. https://doi.org/10.1117/1.JBO.23.5.057004.Full Text Link to Item
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Martinez, Amy F., Samuel S. McCachren, Marianne Lee, Helen A. Murphy, Caigang Zhu, Brian T. Crouch, Hannah L. Martin, et al. “Metaboloptics: Visualization of the tumor functional landscape via metabolic and vascular imaging.” Sci Rep 8, no. 1 (March 8, 2018): 4171. https://doi.org/10.1038/s41598-018-22480-w.Full Text Link to Item
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Lam, Christopher T., Jenna Mueller, Betsy Asma, Mercy Asiedu, Marlee S. Krieger, Rhea Chitalia, Denali Dahl, Peyton Taylor, John W. Schmitt, and Nimmi Ramanujam. “An integrated strategy for improving contrast, durability, and portability of a Pocket Colposcope for cervical cancer screening and diagnosis.” Plos One 13, no. 2 (2018): e0192530. https://doi.org/10.1371/journal.pone.0192530.Full Text Link to Item
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Hu, Fangyao, Hannah Martin, Amy Martinez, Jeffrey Everitt, Alaattin Erkanli, Walter T. Lee, Mark Dewhirst, and Nimmi Ramanujam. “Distinct Angiogenic Changes during Carcinogenesis Defined by Novel Label-Free Dark-Field Imaging in a Hamster Cheek Pouch Model.” Cancer Res 77, no. 24 (December 15, 2017): 7109–19. https://doi.org/10.1158/0008-5472.CAN-17-1058.Full Text Link to Item
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Crouch, Brian, Helen Murphy, Stella Belonwu, Amy Martinez, Jennifer Gallagher, Allison Hall, Mary Scott Soo, et al. “Leveraging ectopic Hsp90 expression to assay the presence of tumor cells and aggressive tumor phenotypes in breast specimens.” Sci Rep 7, no. 1 (December 13, 2017): 17487. https://doi.org/10.1038/s41598-017-17832-x.Full Text Link to Item
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Zhu, Caigang, Amy F. Martinez, Hannah L. Martin, Martin Li, Brian T. Crouch, David A. Carlson, Timothy A. J. Haystead, and Nimmi Ramanujam. “Near-simultaneous intravital microscopy of glucose uptake and mitochondrial membrane potential, key endpoints that reflect major metabolic axes in cancer.” Sci Rep 7, no. 1 (October 23, 2017): 13772. https://doi.org/10.1038/s41598-017-14226-x.Full Text Link to Item
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Morhard, Robert, Corrine Nief, Carlos Barrero Castedo, Fangyao Hu, Megan Madonna, Jenna L. Mueller, Mark W. Dewhirst, David F. Katz, and Nirmala Ramanujam. “Development of enhanced ethanol ablation as an alternative to surgery in treatment of superficial solid tumors.” Sci Rep 7, no. 1 (August 18, 2017): 8750. https://doi.org/10.1038/s41598-017-09371-2.Full Text Link to Item
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Mueller, Jenna L., Elizabeth Asma, Christopher T. Lam, Marlee S. Krieger, Jennifer E. Gallagher, Alaattin Erkanli, Roopa Hariprasad, et al. “International Image Concordance Study to Compare a Point-of-Care Tampon Colposcope With a Standard-of-Care Colposcope.” J Low Genit Tract Dis 21, no. 2 (April 2017): 112–19. https://doi.org/10.1097/LGT.0000000000000306.Full Text Open Access Copy Link to Item
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Nichols, Brandon S., Antonio Llopis, Gregory M. Palmer, Samuel S. McCachren, Ozlem Senlik, David Miller, Martin A. Brooke, et al. “Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins.” J Biomed Opt 22, no. 2 (February 1, 2017): 26007. https://doi.org/10.1117/1.JBO.22.2.026007.Full Text Link to Item
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Asiedu, Mercy Nyamewaa, Júlia Agudogo, Marlee S. Krieger, Robert Miros, Rae Jean Proeschold-Bell, John W. Schmitt, and Nimmi Ramanujam. “Design and preliminary analysis of a vaginal inserter for speculum-free cervical cancer screening.” Plos One 12, no. 5 (2017): e0177782. https://doi.org/10.1371/journal.pone.0177782.Full Text Link to Item
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Hu, Fangyao, Karthik Vishwanath, Joseph K. Salama, Alaattin Erkanli, Bercedis Peterson, James R. Oleson, Walter T. Lee, David M. Brizel, Nimmi Ramanujam, and Mark W. Dewhirst. “Oxygen and Perfusion Kinetics in Response to Fractionated Radiation Therapy in FaDu Head and Neck Cancer Xenografts Are Related to Treatment Outcome.” Int J Radiat Oncol Biol Phys 96, no. 2 (October 1, 2016): 462–69. https://doi.org/10.1016/j.ijrobp.2016.06.007.Full Text Link to Item
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Hu, Fangyao, Robert Morhard, Helen A. Murphy, Caigang Zhu, and Nimmi Ramanujam. “Dark field optical imaging reveals vascular changes in an inducible hamster cheek pouch model during carcinogenesis.” Biomedical Optics Express 7, no. 9 (September 2016): 3247–61. https://doi.org/10.1364/boe.7.003247.Full Text
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Chitalia, Rhea, Jenna Mueller, Henry L. Fu, Melodi Javid Whitley, David G. Kirsch, J Quincy Brown, Rebecca Willett, and Nimmi Ramanujam. “Algorithms for differentiating between images of heterogeneous tissue across fluorescence microscopes.” Biomed Opt Express 7, no. 9 (September 1, 2016): 3412–24. https://doi.org/10.1364/BOE.7.003412.Full Text Link to Item
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Mueller, Jenna L., Jennifer E. Gallagher, Rhea Chitalia, Marlee Krieger, Alaattin Erkanli, Rebecca M. Willett, Joseph Geradts, and Nimmi Ramanujam. “Rapid staining and imaging of subnuclear features to differentiate between malignant and benign breast tissues at a point-of-care setting.” J Cancer Res Clin Oncol 142, no. 7 (July 2016): 1475–86. https://doi.org/10.1007/s00432-016-2165-9.Full Text Link to Item
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Kennedy, Stephanie, Matthew Caldwell, Torre Bydlon, Christine Mulvey, Jenna Mueller, Lee Wilke, William Barry, Nimmi Ramanujam, and Joseph Geradts. “Correlation of breast tissue histology and optical signatures to improve margin assessment techniques.” J Biomed Opt 21, no. 6 (June 1, 2016): 66014. https://doi.org/10.1117/1.JBO.21.6.066014.Full Text Link to Item
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Ramanujam, N. “WE-FG-201-01: Patient Centric Technologies for Diagnosis of Breast and Cervical Cancer.” Medical Physics 43, no. 6 (June 2016): 3822. https://doi.org/10.1118/1.4957893.Full Text
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Lazarides, Alexander L., Melodi J. Whitley, David B. Strasfeld, Diana M. Cardona, Jorge M. Ferrer, Jenna L. Mueller, Henry L. Fu, et al. “A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma.” Theranostics 6, no. 2 (2016): 155–66. https://doi.org/10.7150/thno.13536.Full Text Open Access Copy Link to Item
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Mueller, Jenna L., Henry L. Fu, Jeffrey K. Mito, Melodi J. Whitley, Rhea Chitalia, Alaattin Erkanli, Leslie Dodd, et al. “A quantitative microscopic approach to predict local recurrence based on in vivo intraoperative imaging of sarcoma tumor margins.” Int J Cancer 137, no. 10 (November 15, 2015): 2403–12. https://doi.org/10.1002/ijc.29611.Full Text Link to Item
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Dobbs, Jessica L., Jenna L. Mueller, Savitri Krishnamurthy, Dongsuk Shin, Henry Kuerer, Wei Yang, Nirmala Ramanujam, and Rebecca Richards-Kortum. “Micro-anatomical quantitative optical imaging: toward automated assessment of breast tissues.” Breast Cancer Research : Bcr 17 (August 2015): 105. https://doi.org/10.1186/s13058-015-0617-9.Full Text
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Leitgeb, Rainer A., Peter E. Andersen, Jürgen Popp, Nimmi Ramanujam, and Katarina Svanberg. “Light for Life: International Year of Light 2015.” Journal of Biomedical Optics 20, no. 6 (June 2015): 061101. https://doi.org/10.1117/1.jbo.20.6.061101.Full Text
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Bydlon, Torre M., Rami Nachabé, Nimmi Ramanujam, Henricus J. C. M. Sterenborg, and Benno H. W. Hendriks. “Chromophore based analyses of steady-state diffuse reflectance spectroscopy: current status and perspectives for clinical adoption.” Journal of Biophotonics 8, no. 1–2 (January 2015): 9–24. https://doi.org/10.1002/jbio.201300198.Full Text
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Nichols, Brandon S., Christine E. Schindler, Jonathon Q. Brown, Lee G. Wilke, Christine S. Mulvey, Marlee S. Krieger, Jennifer Gallagher, et al. “A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins.” Plos One 10, no. 6 (2015): e0127525. https://doi.org/10.1371/journal.pone.0127525.Full Text Link to Item
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Lam, Christopher T., Marlee S. Krieger, Jennifer E. Gallagher, Betsy Asma, Lisa C. Muasher, John W. Schmitt, and Nimmi Ramanujam. “Design of a Novel Low Cost Point of Care Tampon (POCkeT) Colposcope for Use in Resource Limited Settings.” Plos One 10, no. 9 (2015): e0135869. https://doi.org/10.1371/journal.pone.0135869.Full Text Open Access Copy Link to Item
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Rajaram, Narasimhan, Andrew F. Reesor, Christine S. Mulvey, Amy E. Frees, and Nirmala Ramanujam. “Non-invasive, simultaneous quantification of vascular oxygenation and glucose uptake in tissue.” Plos One 10, no. 1 (January 2015): e0117132. https://doi.org/10.1371/journal.pone.0117132.Full Text
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Hu, Fangyao, Karthik Vishwanath, H Wolfgang Beumer, Liana Puscas, Hamid R. Afshari, Ramon M. Esclamado, Richard Scher, et al. “Assessment of the sensitivity and specificity of tissue-specific-based and anatomical-based optical biomarkers for rapid detection of human head and neck squamous cell carcinoma.” Oral Oncol 50, no. 9 (September 2014): 848–56. https://doi.org/10.1016/j.oraloncology.2014.06.015.Full Text Link to Item
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Yu, Bing, Amy Shah, Bingqing Wang, Narasimhan Rajaram, Quanli Wang, Nirmala Ramanujam, Gregory M. Palmer, and Mark W. Dewhirst. “Measuring tumor cycling hypoxia and angiogenesis using a side-firing fiber optic probe.” J Biophotonics 7, no. 7 (July 2014): 552–64. https://doi.org/10.1002/jbio.201200187.Full Text Link to Item
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Frees, Amy E., Narasimhan Rajaram, Samuel S. McCachren, Andrew N. Fontanella, Mark W. Dewhirst, and Nimmi Ramanujam. “Delivery-corrected imaging of fluorescently-labeled glucose reveals distinct metabolic phenotypes in murine breast cancer.” Plos One 9, no. 12 (2014): e115529. https://doi.org/10.1371/journal.pone.0115529.Full Text Link to Item
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Fu, H. L., J. L. Mueller, M. Javid, D. G. Kirsch, N. Ramanujam, and J. Q. Brown. “Optimization of illumination frequency and preclinical validation of a wide-field structured illumination microscope designed for imaging in situ tumor margins.” Cleo: Applications and Technology, Cleo at 2013, November 19, 2013.
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Barrott, Jared J., Philip F. Hughes, Takuya Osada, Xiao-Yi Yang, Zachary C. Hartman, David R. Loiselle, Neil L. Spector, et al. “Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.” Chem Biol 20, no. 9 (September 19, 2013): 1187–97. https://doi.org/10.1016/j.chembiol.2013.08.004.Full Text Link to Item
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Mueller, J. L., Z. T. Harmany, J. K. Mito, S. A. Kennedy, Y. Kim, L. Dodd, J. Geradts, et al. “Quantitative segmentation of fluorescence microscopy images of heterogeneous tissue: Approach for tuning algorithm parameters.” Progress in Biomedical Optics and Imaging Proceedings of Spie 8587 (May 27, 2013). https://doi.org/10.1117/12.2006429.Full Text
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Yu, B., A. Shah, B. Wang, N. Rajaram, Q. Wang, N. Ramanujam, G. M. Palmer, and M. W. Dewhirst. “Monitoring of cycling hypoxia and angiogenesis in FaDu head and neck tumors using a side-firing sensor.” Progress in Biomedical Optics and Imaging Proceedings of Spie 8578 (May 27, 2013). https://doi.org/10.1117/12.2002837.Full Text
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Zhong, Jim, Narasimhan Rajaram, David M. Brizel, Amy E. Frees, Nirmala Ramanujam, Ines Batinic-Haberle, and Mark W. Dewhirst. “Radiation induces aerobic glycolysis through reactive oxygen species.” Radiother Oncol 106, no. 3 (March 2013): 390–96. https://doi.org/10.1016/j.radonc.2013.02.013.Full Text Link to Item
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Brown, J Quincy, Torre M. Bydlon, Stephanie A. Kennedy, Matthew L. Caldwell, Jennifer E. Gallagher, Marlee Junker, Lee G. Wilke, William T. Barry, Joseph Geradts, and Nimmi Ramanujam. “Optical spectral surveillance of breast tissue landscapes for detection of residual disease in breast tumor margins.” Plos One 8, no. 7 (2013): e69906. https://doi.org/10.1371/journal.pone.0069906.Full Text Link to Item
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Fu, H. L., J. L. Mueller, M. Javid, D. G. Kirsch, N. Ramanujam, and J. Q. Brown. “Optimization of illumination frequency and preclinical validation of a wide-field structured illumination microscope designed for imaging in situ tumor margins.” 2013 Conference on Lasers and Electro Optics, Cleo 2013, January 1, 2013. https://doi.org/10.1364/cleo_at.2013.ath1n.3.Full Text
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Fu, Henry L., Jenna L. Mueller, Melodi P. Javid, Jeffrey K. Mito, David G. Kirsch, Nimmi Ramanujam, and J Quincy Brown. “Optimization of a widefield structured illumination microscope for non-destructive assessment and quantification of nuclear features in tumor margins of a primary mouse model of sarcoma.” Plos One 8, no. 7 (2013): e68868. https://doi.org/10.1371/journal.pone.0068868.Full Text Open Access Copy Link to Item
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Hu, Fangyao, Karthik Vishwanath, Justin Lo, Alaattin Erkanli, Christine Mulvey, Walter T. Lee, and Nimmi Ramanujam. “Rapid determination of oxygen saturation and vascularity for cancer detection.” Plos One 8, no. 12 (2013): e82977. https://doi.org/10.1371/journal.pone.0082977.Full Text Link to Item
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Lo, Justin Y., J Quincy Brown, Sulochana Dhar, Bing Yu, Gregory M. Palmer, Nan M. Jokerst, and Nirmala Ramanujam. “Wavelength optimization for quantitative spectral imaging of breast tumor margins.” Plos One 8, no. 4 (2013): e61767. https://doi.org/10.1371/journal.pone.0061767.Full Text Open Access Copy Link to Item
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Mueller, Jenna L., Zachary T. Harmany, Jeffrey K. Mito, Stephanie A. Kennedy, Yongbaek Kim, Leslie Dodd, Joseph Geradts, et al. “Quantitative Segmentation of Fluorescence Microscopy Images of Heterogeneous Tissue: Application to the Detection of Residual Disease in Tumor Margins.” Plos One 8, no. 6 (2013): e66198. https://doi.org/10.1371/journal.pone.0066198.Full Text Link to Item
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Rajaram, Narasimhan, Amy E. Frees, Andrew N. Fontanella, Jim Zhong, Katherine Hansen, Mark W. Dewhirst, and Nirmala Ramanujam. “Delivery rate affects uptake of a fluorescent glucose analog in murine metastatic breast cancer.” Plos One 8, no. 10 (2013): e76524. https://doi.org/10.1371/journal.pone.0076524.Full Text Link to Item
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Ramanujam, N., and J. Popp. “Introduction.” Progress in Biomedical Optics and Imaging Proceedings of Spie 8087 (July 25, 2011).
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Gill, E. M., C. A. Ivarie, K. W. Eliceiri, N. Ramanujam, J. G. White, and B. L. Allen-Hoffmann. “Imaging human stratified squamous epithelia using nonlinear optical microscopy.” Journal of Investigative Dermatology 126 (April 1, 2006): 64–64.Link to Item
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Ramanujam, N., and J. Q. Brown. “Physiologic, metabolic, and structural alterations in breast cancer: Assessment via optical technologies.” Optics Infobase Conference Papers, January 1, 2006.
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Ramanujam, N., and J. Quincy Brown. “Physiologic, metabolic, and structural alterations in breast cancer: Assessment via optical technologies.” Optics Infobase Conference Papers, January 1, 2006.
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Ramanujam, N., and J. Quincy Brown. “Physiologic, metabolic, and structural alterations in breast cancer: Assessment via optical technologies.” Optics Infobase Conference Papers, January 1, 2006.
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Ramanujam, N., H. Long, M. Rode, I. Forouzan, M. Morgan, and B. Chance. “Antepartum, transabdominal near infrared spectroscopy: Feasibility of measuring photon migration through the fetal head in utero.” Journal of Maternal Fetal and Neonatal Medicine 8, no. 6 (January 1, 1999): 275–88. https://doi.org/10.3109/14767059909020498.Full Text
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Falletta, J. M., N. Ramanujam, K. A. Starling, and D. J. Fernbach. “Ig-positive lymphocytes in Hodgkin's disease.” N Engl J Med 288, no. 11 (March 15, 1973): 581–82.Link to Item
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Book Sections
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Yu, B., and N. Ramanujam. “Quantitative diffuse reflectance imaging of tumor margins.” In Biomedical Photonics Handbook, 565–86, 2014.
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Vo-Dinh, T. “Preface,” ix–xi, 2014. https://doi.org/10.1201/b17289.Full Text
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Rajaram, N., and N. Ramanujam. “One-Photon Autofluorescence Microscopy.” In Natural Biomarkers for Cellular Metabolism: Biology, Techniques, and Applications, 67–76, 2014. https://doi.org/10.1201/b17427-10.Full Text
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Other Articles
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Brown, J. Q., L. Dodd, J. Geradts, Z. Harmany, S. Kennedy, Y. Kim, David Guy Kirsch, et al. “Data set for "Quantitative segmentation of fluorescence microscopy images of heterogeneous tissue: Application to the detection of residual disease in tumor margins",” March 12, 2013.Open Access Copy
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Conference Papers
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Asiedu, Mercy N., Erica Skerrett, Guillermo Sapiro, and Nirmala Ramanujam. “Combining multiple contrasts for improving machine learning-based classification of cervical cancers with a low-cost point-of-care Pocket colposcope.” In Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual International Conference, 2020:1148–51, 2020. https://doi.org/10.1109/embc44109.2020.9175858.Full Text
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Wang, R., R. Deutsch, D. A. Alvarez, C. Lam, B. T. Crouch, T. Haystead, and N. Ramanujam. “Leveraging surface Hsp90 expression for rapid-on-site breast cancer diagnostics.” In Optics Infobase Conference Papers, Vol. Part F178-Translational-2020, 2020.
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Madonna, M. C., J. Duer, D. Fox, J. Alvarez, and N. Ramanujam. “In vivo metabolic imaging reveals mitochondrial membrane potential reprogramming following Her2-targeted therapy and dormant disease.” In Optics Infobase Conference Papers, Vol. Part F178-Translational-2020, 2020.
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Asiedu, M. N., A. Simhal, C. T. Lam, J. Mueller, U. Chaudhary, J. W. Schmitt, G. Sapiro, and N. Ramanujam. “Image processing and machine learning techniques to automate diagnosis of Lugol's iodine cervigrams for a low-cost point-of-care digital colposcope.” In Progress in Biomedical Optics and Imaging Proceedings of Spie, Vol. 10485, 2018. https://doi.org/10.1117/12.2282792.Full Text
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Crouch, B. T., J. Duer, R. Wang, J. Gallagher, A. Hall, M. S. Soo, P. Hughes, T. A. J. Haystead, and N. Ramanujam. “Optimizing fluorescently-tethered Hsp90 inhibitor dose for maximal specific uptake by breast tumors.” In Progress in Biomedical Optics and Imaging Proceedings of Spie, Vol. 10478, 2018. https://doi.org/10.1117/12.2285210.Full Text
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Ramanujam, N. “Preventing over treatment through smart health technologies.” In Optics Infobase Conference Papers, Vol. Part F91-TRANSLATIONAL 2018, 2018. https://doi.org/10.1364/TRANSLATIONAL.2018.CTu4B.1.Full Text
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Zhu, C., H. L. Martin, M. Li, B. Crouch, A. F. Martinez, G. M. Palmer, M. W. Dewhirst, and N. Ramanujam. “Non-invasive, simultaneous quantification of vascular oxygenation, glucose uptake and mitochondria membrane potential in a flank tumor model.” In Optics Infobase Conference Papers, Vol. Part F91-TRANSLATIONAL 2018, 2018. https://doi.org/10.1364/TRANSLATIONAL.2018.CF2B.2.Full Text
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Mueller, J. L., C. T. Lam, M. Kellish, J. Peters, M. Asiedu, M. S. Krieger, J. E. Gallagher, et al. “Clinical evaluation of a portable pocket colposcope for cervical cancer screening in the United States, Perú, and Tanzania.” In 2017 Ieee Healthcare Innovations and Point of Care Technologies, Hi Poct 2017, 2017-December:117–20, 2017. https://doi.org/10.1109/HIC.2017.8227598.Full Text
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Zhu, C., A. F. Martinez, M. Li, H. L. Martin, B. Crouch, F. Hu, H. A. Murphy, M. Lee, and N. Ramanujam. “Imaging of 2-NBDG and TMRE reveals glucose uptake and mitochondrial membrane potential in dorsal window chamber models.” In Optics Infobase Conference Papers, Vol. Part F63-OMP 2017, 2017. https://doi.org/10.1364/OMP.2017.OmS2D.1.Full Text
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Hu, Fangyao, Robert Morhard, Heather Liu, Helen Murphy, Sina Farsiu, and Nimmi Ramanujam. “Label-free vascular imaging in a spontaneous hamster cheek pouch carcinogen model for pre-cancer detection (Conference Presentation).” In Optical Biopsy Xiv: Toward Real Time Spectroscopic Imaging and Diagnosis, edited by Robert R. Alfano and Stavros G. Demos. SPIE, 2016. https://doi.org/10.1117/12.2213782.Full Text
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Nichols, B. S., S. S. McCachren, G. M. Palmer, and N. Ramanujam. “Portable system for wide-field, sub-millimeter functional imaging of the morphological landscape of breast tumor margins.” In Optics Infobase Conference Papers, 2016. https://doi.org/10.1364/TRANSLATIONAL.2016.TM4B.6.Full Text
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Martinez, A. F., S. S. McCachren, M. Lee, H. A. Murphy, N. Rajaram, M. W. Dewhirst, and N. Ramanujam. “Hyperspectral imaging of glucose uptake, mitochondrial membrane potential, and vascular oxygenation differentiates breast cancers with distinct metastatic potential in vivo.” In Optics Infobase Conference Papers, 2014. https://doi.org/10.1364/CANCER.2016.CTh4A.6.Full Text
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Zhu, C., A. F. Martinez, F. Hu, M. Li, M. C. Madonna, M. Lee, H. A. Murphy, and N. Ramanujam. “Integrated dual-modal microscope for imaging of key metabolic and vascular endpoints in preclinical cancer models.” In Optics Infobase Conference Papers, 2014. https://doi.org/10.1364/FIO.2016.FF5A.1.Full Text
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Frees, A., N. Rajaram, S. McCachren, A. Vaz, M. Dewhirst, and N. Ramanujam. “Optical monitoring of glucose demand and vascular delivery in a preclinical murine model.” In Progress in Biomedical Optics and Imaging Proceedings of Spie, Vol. 8947, 2014. https://doi.org/10.1117/12.2040950.Full Text
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Barrott, Jared J., Aaron P. Smith, Takuya Osada, Nimmi Ramanujam, Michael R. Zalutsky, Kim Lyerly, and Timothy A. J. Haystead. “Abstract C86: Tethered Hsp90 inhibitors carrying optical or radioiodinated probes reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.” In Molecular Cancer Therapeutics, 12:C86–C86. American Association for Cancer Research (AACR), 2013. https://doi.org/10.1158/1535-7163.targ-13-c86.Full Text
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Farahani, K., J. Siewerdsen, N. Agar, and N. Ramanujam. “Image-Guided Oncologic Surgery.” In Medical Physics, 39:4014–4014, 2012. https://doi.org/10.1118/1.4736373.Full Text Link to Item
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Chang, V. T. C., P. Cartwright, and N. Ramanujam. “In Vivo estimation of total hemoglobin concentration and hemoglobin saturation in the detection of cervical epithelial pre-cancers.” In Optics Infobase Conference Papers, 2007. https://doi.org/10.1364/fio.2007.fwe2.Full Text
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Ramanujam, N., and J. Q. Brown. “Physiologic, metabolic, and structural alterations in breast cancer: Assessment via optical technologies.” In Optics Infobase Conference Papers, 2006. https://doi.org/10.1364/fio.2006.jwc1.Full Text
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Chiles, S., K. Roldan-Perez, K. Riching, G. Palmer, and N. Ramanujam. “Effect of optical clearing agents on the optical properties of squamous epithelial tissue.” In Lasers in Surgery and Medicine, 2–2. WILEY-LISS, 2006.Link to Item
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Palmer, G. M., and N. Ramanujam. “Use of genetic algorithms to optimize fiber optic probe design for the extraction of tissue optical properties.” In Optics Infobase Conference Papers, 2006. https://doi.org/10.1364/bio.2006.me45.Full Text
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Ramanujam, N., and J. Q. Brown. “Physiologic, Metabolic, and Structural Alterations in Breast Cancer: Assessment via Optical Technologies.” In Optics Infobase Conference Papers, 2006.
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Choe, R., T. Durduran, G. Yu, M. J. M. Nijland, B. Chance, A. G. Yodh, and N. Ramanujam. “Transabdominal Near-infrared Fetal Brain Oximetry.” In Optics Infobase Conference Papers, 2004.
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Gill, E. M., N. Ramanujam, C. A. Ivarie, J. M. Squirrell, and B. L. Allen-Hoffmann. “Imaging collagen in a dermal equivalent using multi-photon microscopy.” In Optics Infobase Conference Papers, 2004.
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Palmer, G. M., Q. Liu, N. Ramanujam, C. Zhu, T. M. Breslin, F. Xu, and K. W. Gilchrist. “Monte Carlo based inverse model of diffuse reflectance for determination of UV-VIS optical properties and its application to breast cancer diagnosis.” In Optics Infobase Conference Papers, 2004.
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Skala, M. C., K. M. Vrotsos, N. Ramanujam, J. M. Squirrell, K. W. Eliceiri, and A. Gendron-Fitzpatrick. “Multiphoton imaging of endogenous fluorescence in neoplastic and non-neoplastic epithelial tissues.” In Optics Infobase Conference Papers, 2004.
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Zhu, C., G. Palmer, and N. Ramanujam. “The use of a multi-separation probe for optical diagnosis of breast cancer.” In Optics Infobase Conference Papers, 2004.
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Breslin, T. M., G. Palmer, C. Fang, K. W. Gilchrist, F. Xu, and N. Ramanujam. “Auto fluorescence and diffuse reflectance properties of malignant and benign breast tissues.” In Annals of Surgical Oncology, 10:S16–S16. LIPPINCOTT WILLIAMS & WILKINS, 2003.Link to Item
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Ramanujam, N. “Sources of optical contrast in biological tissues.” In Optics Infobase Conference Papers, 2003.
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Ramanujam, N., and L. Quan. “Relationship between the depth of a target in a turbid medium and the fluorescence measured using a variable aperture method.” In Optics Infobase Conference Papers, 488–90, 2002.
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Choe, R., M. Holboke, A. G. Yodh, G. Vishnoi, N. Ramanujam, and B. Chance. “Comparison between homogeneous and Two-layer model for spectroscopic measurement of fetal cerebral blood oxygenation in-utero.” In Optics Infobase Conference Papers, 262–64, 2000.
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Ramanujam, N., K. Gossage, J. Chen, R. Richads-Kortum, and B. Chance. “Fast and non-invasive fluorescence imaging from biological signals, in vivo using a flying spot scanner.” In Optics Infobase Conference Papers, 511–13, 2000.
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Ramanujam, N., Y. Li, B. Chance, D. Heintzelman, R. Richards-Kortum, S. Thomsen, and A. Mahadevan-Jansen. “Relationship between tissue redox potentials and hemoglobin oxygenation based on fluorescence of NADH / FAD and absorption spectroscopy of oxy / deoxy hemoglobin.” In Optics Infobase Conference Papers, 208–10, 1998.
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Datasets
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Asiedu, Mercy, Marlee Kreiger, John W. Schmitt, Nimmi Ramanujam, Robert Miros, and Rae Jean Proeschold-Bell. “Design and preliminary analysis of a vaginal inserter for speculum-free cervical cancer screening,” May 5, 2017. https://doi.org/10.7924/G8X34VDZ.Data Access
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Fu, Henry L., Jenna L. Mueller, Melodi J. Whitley, Diana M. Cardona, Rebecca M. Willett, David G. Kirsch, J Quincy Brown, and Nimmi Ramanujam. “Structured Illumination Microscopy and a Quantitative Image Analysis for the Detection of Positive Margins in a Pre-Clinical Genetically Engineered Mouse Model of Sarcoma.,” 2016. https://doi.org/10.1371/journal.pone.0147006.Data Access Open Access Copy Link to Item
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Ramanujam, Nimmi. “Data from: Design of a novel low cost point of care tampon (POCkeT) colposcope for use in resource limited settings,” May 15, 2015.
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Nichols, B., J. Q. Brown, C. E. Schindler, L. G. Wilke, C. S. Mulvey, M. S. Krieger, J. Gallagher, et al. “Data for manuscript "A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins",” March 3, 2015.Open Access Copy
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Mueller, J., Z. Harmany, J. Mito, S. Kennedy, Y. Kim, L. Dodd, J. Geradts, et al. “Data set for "Quantitative segmentation of fluorescence microscopy images of heterogeneous tissue: Application to the detection of residual disease in tumor margins",” March 12, 2013.Open Access Copy
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- Teaching & Mentoring
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Recent Courses
- BME 230L: Global Women's Health Technologies 2023
- BME 290L: Intermediate Topics with Lab (GE) 2023
- GLHLTH 230L: Global Women's Health Technologies 2023
- BME 230L: Global Women's Health Technologies 2022
- BME 290L: Intermediate Topics with Lab (GE) 2022
- GLHLTH 230L: Global Women's Health Technologies 2022
- ISS 398: Bass Connections Information, Society & Culture Research Team 2022
- ISS 796: Bass Connections Information, Society & Culture Research Team 2022
- PHARM 494: Research Independent Study 2022
- BME 230L: Global Women's Health Technologies 2021
- BME 290L: Intermediate Topics with Lab (GE) 2021
- BME 494: Projects in Biomedical Engineering (GE) 2021
- EGR 393: Research Projects in Engineering 2021
- GLHLTH 230L: Global Women's Health Technologies 2021
- GLHLTH 391: Independent Study in Global Health 2021
- ISS 397: Bass Connections Information, Society & Culture Research Team 2021
- ISS 795: Bass Connections Information, Society & Culture Research Team 2021
- PHARM 493: Research Independent Study 2021
- PHARM 494: Research Independent Study 2021
- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- Biomedical Innovations to Address Global Cancer Inequities. Department of Surgery Grand Rounds for Memorial Sloan Kettering Cancer Center.. May 2021 2021
- “Injustice has a Cure: Paul Farmer & Duke Global Health Projects in Latin America & the Caribbean. Duke Global Health Institute. May 2021 2021
- “Addressing Structural and Social Barriers to Global Cancer Inequities Through Biomedical Innovation. Electrical and Computer Engineering (ECE) department at Iowa State University.. April 2021 2021
- Addressing Structural and Social Barriers to Global Cancer Inequities Through Biomedical Innovation. UW Madison Global Health Innovation Club. March 2021 2021
- Women's Health and STEM Education - The Common Denominator. World Molecular Imaging Society.. February 2021 2021
- Reimagining Biomedical Engineering. Pandemic Punditry. July 2020 2020
- Women Inspired Innovative Strategies for Health. 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society. IEE. July 2020 2020
- Women Inspired Strategies for Health. Prevent Cancer Virtual Dialogues. June 2020 2020
- E4USA "Meet the Engineer. Engineering For Us All (E4USA) project. May 2020 2020
- Meet Female Entrepreneurs Discovering New Ways to Solve Problems with Technology. Cisco. October 22, 2019 2019
- Ignite: Teaching Design Thinking and Global Citizenship in a Horizontally and Vertically Integrated Classroom. UNC World View Symposium. October 16, 2019 2019
- Empowering Women to Improve Women’s Health Through Tech, Education, & Engagement. Grace Hopper Conference. October 3, 2019 2019
- Women in Bio - RTP: Demystifying Entrepreneurship. September 12, 2019 2019
- Pay Less, Expect More –a 21st Century Model for Cancer Care. World Molecular Imaging Conference. September 4, 2019 2019
- Duke in Napa Valley. May 2019 2019
- Xcelerator workshop: Innovator Stories Session. USAID SEED Program. May 2019 2019
- Scaling Cervical Cancer Prevention in Peru. DGHI Board Meeting. April 2019 2019
- Panel on Global Health. DGHI DC event. April 2019 2019
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Outreach & Engaged Scholarship
- Bass Connections Team Leader. Empowering Prevention of Cervical Cancer: Women-inspired Strategies for Health (WISH). 2021 - 2022 2021 - 2022
- Bass Connections Team Leader. Empowering Prevention of Cervical Cancer: Women-inspired Strategies for Health (WISH). 2020 - 2021 2020 - 2021
- Bass Connections Team Leader. Pocket Colposcope: Analysis of Bringing Elements of Referral Services to Community Care. 2019 - 2020 2019 - 2020
- Bass Connections Faculty Team Leader. Pocket Colposcope: Analysis of Bringing Elements of Referral Services to Primary/Community Care. 2018 - 2019 2018 - 2019
- Bass Connections Faculty Team Member. Pocket Colposcope: Increased Distribution and Adoption . August 2017 - May 2018 2017 - 2018
- DukeEngage Program Leader . Empowering girls through STEM education. June 2017 - August 2017 2017
- Bass Connections Faculty Team Member. Pocket Colposcope: Increased Distribution and Adoption . August 2016 - May 2017 2016 - 2017
- Global Health Outreach. Pocket Colposcope. University of Nairobi. January 2016 2016
- Duke Global Health Outreach. A Viable Solution for a See-and-Treat Paradigm for Cervical Pre-cancer in Africa. July 2015 2015
- Bass Connections Faculty Team Member. Chlorhexidine for Umbilical Cord Care. August 2014 - May 2015 2014 - 2015
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Service to the Profession
- Ad Hoc Committee to Explore Future Directions in the Science of Physics in Medicine . American Association of Physicists in Medicine. 2021 2021
- Steering Committee for International Symposium of Resource-Appropriate Technologies for Global Oncology. International Symposium of Resource-Appropriate Technologies for Global Oncology. 2021 2021
- Guest Editor for the Futures of Biomedical Engineering section of Current Opinion in Biomedical Engineering . Current Opinion in Biomedical Engineering . 2020 2020
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Service to Duke
- Member. Conflict of Interest Committee. 2019 2019
- Member. PhD deliberation committee. Duke Global Health Institute. 2019 2019
- Member. Search committee, Vice-provost for the Arts. 2019 2019
- President’s Art Planning Committee. 2019 2019
- Member. Duke I&E Core Faculty Group. 2018 2018
- Member. Faculty Advisory Committee. Duke Global Health Innovation Center. 2018 2018
- Member. Global health Institute Director Search. Duke University. 2017 2017
- Reviewer. Bass proposals. 2017 2017
- Reviewer. IID Data + proposals. 2017 2017
- Chair. Office of Licensing Director Search Committee. Duke University. 2016 2016
- DGHI Doctoral Scholars Committee. Member. 2016 2016
- Member. I&E Faculty Steering Committee. Duke University. 2015 2015
- Member. Pratt Dean Search Committee. 2015 2015
- Chair. Judge for Ebola Challenge Innovations. 2014 2014
- Chair. Tops Faculty Search Committee. 2014 2014
- Duke Engage Faculty Board member. 2014 2014
- Member. Chancellor Search Committee. 2014 2014
- Member. Duke Engage Faculty Board. 2014 2014
- Member. Global Priorities Committee. 2014 2014
- Moderator. Women’s Weekend. 2014 2014
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