Skip to main content

A sublingual nanofiber vaccine to prevent urinary tract infections.

Publication ,  Journal Article
Kelly, SH; Votaw, NL; Cossette, BJ; Wu, Y; Shetty, S; Shores, LS; Issah, LA; Collier, JH
Published in: Science advances
November 2022

Urinary tract infections (UTIs) are a major public health problem affecting millions of individuals each year. Recurrent UTIs are managed by long-term antibiotic use, making the alarming rise of antibiotic resistance a substantial threat to future UTI treatment. Extended antibiotic regimens may also have adverse effects on the microbiome. Here, we report the use of a supramolecular vaccine to provide long-term protection against uropathogenic Escherichia coli, which cause 80% of uncomplicated UTIs. We designed mucus-penetrating peptide-polymer nanofibers to enable sublingual (under the tongue) vaccine delivery and elicit antibody responses systemically and in the urogenital tract. In a mouse model of UTI, we demonstrate equivalent efficacy to high-dose oral antibiotics but with significantly less perturbation of the gut microbiome. We also formulate our vaccine as a rapid-dissolving sublingual tablet that raises response in mice and rabbits. Our approach represents a promising alternative to antibiotics for the treatment and prevention of UTIs.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Science advances

DOI

EISSN

2375-2548

ISSN

2375-2548

Publication Date

November 2022

Volume

8

Issue

47

Start / End Page

eabq4120

Related Subject Headings

  • Vaccines
  • Urinary Tract Infections
  • Rabbits
  • Nanofibers
  • Mice
  • Escherichia coli Infections
  • Anti-Bacterial Agents
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kelly, S. H., Votaw, N. L., Cossette, B. J., Wu, Y., Shetty, S., Shores, L. S., … Collier, J. H. (2022). A sublingual nanofiber vaccine to prevent urinary tract infections. Science Advances, 8(47), eabq4120. https://doi.org/10.1126/sciadv.abq4120
Kelly, Sean H., Nicole L. Votaw, Benjamin J. Cossette, Yaoying Wu, Shamitha Shetty, Lucas S. Shores, Luqman A. Issah, and Joel H. Collier. “A sublingual nanofiber vaccine to prevent urinary tract infections.Science Advances 8, no. 47 (November 2022): eabq4120. https://doi.org/10.1126/sciadv.abq4120.
Kelly SH, Votaw NL, Cossette BJ, Wu Y, Shetty S, Shores LS, et al. A sublingual nanofiber vaccine to prevent urinary tract infections. Science advances. 2022 Nov;8(47):eabq4120.
Kelly, Sean H., et al. “A sublingual nanofiber vaccine to prevent urinary tract infections.Science Advances, vol. 8, no. 47, Nov. 2022, p. eabq4120. Epmc, doi:10.1126/sciadv.abq4120.
Kelly SH, Votaw NL, Cossette BJ, Wu Y, Shetty S, Shores LS, Issah LA, Collier JH. A sublingual nanofiber vaccine to prevent urinary tract infections. Science advances. 2022 Nov;8(47):eabq4120.

Published In

Science advances

DOI

EISSN

2375-2548

ISSN

2375-2548

Publication Date

November 2022

Volume

8

Issue

47

Start / End Page

eabq4120

Related Subject Headings

  • Vaccines
  • Urinary Tract Infections
  • Rabbits
  • Nanofibers
  • Mice
  • Escherichia coli Infections
  • Anti-Bacterial Agents
  • Animals