Encyclopedia of Respiratory Medicine, Second Edition
Chronic Lung Allograft Dysfunction
Publication
, Chapter
Smith, JB; Todd, JL
January 1, 2021
Lung transplantation is an effective short-term intervention for select patients with end-stage lung disease; however, long-term outcomes remain limited with a median posttransplant survival of only 5–6years. Chronic lung allograft dysfunction (CLAD) is the leading cause of late death among lung transplant recipients. CLAD is characterized by an irreversible decline in lung function and correlates histologically with allograft fibrosis. This article summarizes the key diagnostic features of CLAD and its clinical phenotypes. We also discuss the pathobiology and risk factors for CLAD, consider therapeutic strategies, and comment on future avenues to improve long-term lung recipient outcomes.
Duke Scholars
DOI
ISBN
9780081027233
Publication Date
January 1, 2021
Volume
5
Start / End Page
741 / 756
Citation
APA
Chicago
ICMJE
MLA
NLM
Smith, J. B., & Todd, J. L. (2021). Chronic Lung Allograft Dysfunction. In Encyclopedia of Respiratory Medicine, Second Edition (Vol. 5, pp. 741–756). https://doi.org/10.1016/B978-0-08-102723-3.00173-6
Smith, J. B., and J. L. Todd. “Chronic Lung Allograft Dysfunction.” In Encyclopedia of Respiratory Medicine, Second Edition, 5:741–56, 2021. https://doi.org/10.1016/B978-0-08-102723-3.00173-6.
Smith JB, Todd JL. Chronic Lung Allograft Dysfunction. In: Encyclopedia of Respiratory Medicine, Second Edition. 2021. p. 741–56.
Smith, J. B., and J. L. Todd. “Chronic Lung Allograft Dysfunction.” Encyclopedia of Respiratory Medicine, Second Edition, vol. 5, 2021, pp. 741–56. Scopus, doi:10.1016/B978-0-08-102723-3.00173-6.
Smith JB, Todd JL. Chronic Lung Allograft Dysfunction. Encyclopedia of Respiratory Medicine, Second Edition. 2021. p. 741–756.
DOI
ISBN
9780081027233
Publication Date
January 1, 2021
Volume
5
Start / End Page
741 / 756