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Expanding opportunities to engineer mucosal vaccination with biomaterials.

Publication ,  Journal Article
Freire Haddad, H; Roe, EF; Collier, JH
Published in: Biomaterials science
February 2023

Mucosal vaccines are receiving increasing interest both for protecting against infectious diseases and for inducing therapeutic immune responses to treat non-infectious diseases. However, the mucosal barriers of the lungs, gastrointestinal tract, genitourinary tract, nasal, and oral tissues each present unique challenges for constructing efficacious vaccines. Vaccination through each of these mucosae requires transport through the mucus and across specialized epithelia to reach tissue-specific immune cells and lymphoid structures, necessitating finely tuned and multifunctional strategies. Serving as inspiration for mucosal vaccine design, pathogens have evolved elaborate, diverse, and multipronged approaches to penetrate and infect mucosae. This review is focused on biomaterials-based strategies, many inspired by pathogens, for designing mucosal vaccine platforms. Passive and active technologies are discussed, along with the microbial processes that they seek to mimic.

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Published In

Biomaterials science

DOI

EISSN

2047-4849

ISSN

2047-4830

Publication Date

February 2023

Volume

11

Issue

5

Start / End Page

1625 / 1647

Related Subject Headings

  • Vaccines
  • Vaccination
  • Mucous Membrane
  • Immunity, Mucosal
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 1004 Medical Biotechnology
  • 0601 Biochemistry and Cell Biology
  • 0304 Medicinal and Biomolecular Chemistry
 

Citation

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Freire Haddad, H., Roe, E. F., & Collier, J. H. (2023). Expanding opportunities to engineer mucosal vaccination with biomaterials. Biomaterials Science, 11(5), 1625–1647. https://doi.org/10.1039/d2bm01694j
Freire Haddad, Helena, Emily F. Roe, and Joel H. Collier. “Expanding opportunities to engineer mucosal vaccination with biomaterials.Biomaterials Science 11, no. 5 (February 2023): 1625–47. https://doi.org/10.1039/d2bm01694j.
Freire Haddad H, Roe EF, Collier JH. Expanding opportunities to engineer mucosal vaccination with biomaterials. Biomaterials science. 2023 Feb;11(5):1625–47.
Freire Haddad, Helena, et al. “Expanding opportunities to engineer mucosal vaccination with biomaterials.Biomaterials Science, vol. 11, no. 5, Feb. 2023, pp. 1625–47. Epmc, doi:10.1039/d2bm01694j.
Freire Haddad H, Roe EF, Collier JH. Expanding opportunities to engineer mucosal vaccination with biomaterials. Biomaterials science. 2023 Feb;11(5):1625–1647.
Journal cover image

Published In

Biomaterials science

DOI

EISSN

2047-4849

ISSN

2047-4830

Publication Date

February 2023

Volume

11

Issue

5

Start / End Page

1625 / 1647

Related Subject Headings

  • Vaccines
  • Vaccination
  • Mucous Membrane
  • Immunity, Mucosal
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 1004 Medical Biotechnology
  • 0601 Biochemistry and Cell Biology
  • 0304 Medicinal and Biomolecular Chemistry