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The state of the septin cytoskeleton from assembly to function.

Publication ,  Journal Article
Woods, BL; Gladfelter, AS
Published in: Curr Opin Cell Biol
February 2021

Septins are conserved guanine nucleotide-binding proteins that polymerize into filaments at the cell cortex or in association with other cytoskeletal proteins, such as actin or microtubules. As integral players in many morphogenic and signaling events, septins form scaffolds important for the recruitment of the cytokinetic machinery, organization of the plasma membrane, and orientation of cell polarity. Mutations in septins or their misregulation are associated with numerous diseases. Despite growing appreciation for the importance of septins in different aspects of cell biology and disease, septins remain relatively poorly understood compared with other cytoskeletal proteins. Here in this review, we highlight some of the recent developments of the last two years in the field of septin cell biology.

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Published In

Curr Opin Cell Biol

DOI

EISSN

1879-0410

Publication Date

February 2021

Volume

68

Start / End Page

105 / 112

Location

England

Related Subject Headings

  • Septins
  • Polymerization
  • Multiprotein Complexes
  • Microtubules
  • Humans
  • Fungi
  • Eukaryotic Cells
  • Developmental Biology
  • Cytoskeleton
  • Cytoplasm
 

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Woods, B. L., & Gladfelter, A. S. (2021). The state of the septin cytoskeleton from assembly to function. Curr Opin Cell Biol, 68, 105–112. https://doi.org/10.1016/j.ceb.2020.10.007
Woods, Benjamin L., and Amy S. Gladfelter. “The state of the septin cytoskeleton from assembly to function.Curr Opin Cell Biol 68 (February 2021): 105–12. https://doi.org/10.1016/j.ceb.2020.10.007.
Woods BL, Gladfelter AS. The state of the septin cytoskeleton from assembly to function. Curr Opin Cell Biol. 2021 Feb;68:105–12.
Woods, Benjamin L., and Amy S. Gladfelter. “The state of the septin cytoskeleton from assembly to function.Curr Opin Cell Biol, vol. 68, Feb. 2021, pp. 105–12. Pubmed, doi:10.1016/j.ceb.2020.10.007.
Woods BL, Gladfelter AS. The state of the septin cytoskeleton from assembly to function. Curr Opin Cell Biol. 2021 Feb;68:105–112.
Journal cover image

Published In

Curr Opin Cell Biol

DOI

EISSN

1879-0410

Publication Date

February 2021

Volume

68

Start / End Page

105 / 112

Location

England

Related Subject Headings

  • Septins
  • Polymerization
  • Multiprotein Complexes
  • Microtubules
  • Humans
  • Fungi
  • Eukaryotic Cells
  • Developmental Biology
  • Cytoskeleton
  • Cytoplasm