Skip to main content
Journal cover image

Racial difference in the association between non-alcoholic fatty liver disease and incident type 2 diabetes: findings from the CARDIA study.

Publication ,  Journal Article
Hatano, Y; VanWagner, LB; Carnethon, MR; Bancks, MP; Carson, AP; Lloyd-Jones, DM; Østbye, T; Viera, AJ; Yano, Y
Published in: Diabetologia
July 2023

AIMS/HYPOTHESIS: Type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) are prevalent diseases of metabolic origin. We examined the association between NAFLD and the development of type 2 diabetes among non-Asian adults, and whether the association differs by race. METHODS: We analysed data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, a population-based prospective cohort study. Participants underwent non-contrast abdominal computed tomography (CT) at baseline (2010-2011) and assessment of glucose measures at the follow-up exam (2015-2016). NAFLD was defined as liver attenuation ≤51 Hounsfield units on CT images after exclusion for other liver fat causes. Race was self-reported. We used targeted maximum likelihood estimation (TMLE) with machine-learning algorithms to estimate difference in type 2 diabetes risk between the NAFLD and non-NAFLD groups. RESULTS: Of the 1995 participants without type 2 diabetes at baseline (mean age±SD, 50.0±3.6 years; 59% women; 55.0% White and 45.0% Black), 21.7% of White and 16.8% of Black participants had NAFLD at baseline, and 3.7% of White and 8.0% of Black participants developed type 2 diabetes at follow up. After multivariable adjustment, risk difference for type 2 diabetes associated with NAFLD vs no NAFLD was 4.1% (95% CI 0.3%, 7.9%) among White participants and -1.9% (95% CI -5.7%, 2.0%) in Black participants. CONCLUSIONS/INTERPRETATION: NAFLD was associated with a higher risk of type 2 diabetes among White participants but not among Black participants. This finding suggests that the effect of liver fat on impaired glucose metabolism may be smaller in Black than in White individuals.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Diabetologia

DOI

EISSN

1432-0428

Publication Date

July 2023

Volume

66

Issue

7

Start / End Page

1235 / 1246

Location

Germany

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Race Factors
  • Prospective Studies
  • Non-alcoholic Fatty Liver Disease
  • Middle Aged
  • Male
  • Humans
  • Female
  • Endocrinology & Metabolism
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hatano, Y., VanWagner, L. B., Carnethon, M. R., Bancks, M. P., Carson, A. P., Lloyd-Jones, D. M., … Yano, Y. (2023). Racial difference in the association between non-alcoholic fatty liver disease and incident type 2 diabetes: findings from the CARDIA study. Diabetologia, 66(7), 1235–1246. https://doi.org/10.1007/s00125-023-05903-w
Hatano, Yu, Lisa B. VanWagner, Mercedes R. Carnethon, Michael P. Bancks, April P. Carson, Donald M. Lloyd-Jones, Truls Østbye, Anthony J. Viera, and Yuichiro Yano. “Racial difference in the association between non-alcoholic fatty liver disease and incident type 2 diabetes: findings from the CARDIA study.Diabetologia 66, no. 7 (July 2023): 1235–46. https://doi.org/10.1007/s00125-023-05903-w.
Hatano Y, VanWagner LB, Carnethon MR, Bancks MP, Carson AP, Lloyd-Jones DM, et al. Racial difference in the association between non-alcoholic fatty liver disease and incident type 2 diabetes: findings from the CARDIA study. Diabetologia. 2023 Jul;66(7):1235–46.
Hatano, Yu, et al. “Racial difference in the association between non-alcoholic fatty liver disease and incident type 2 diabetes: findings from the CARDIA study.Diabetologia, vol. 66, no. 7, July 2023, pp. 1235–46. Pubmed, doi:10.1007/s00125-023-05903-w.
Hatano Y, VanWagner LB, Carnethon MR, Bancks MP, Carson AP, Lloyd-Jones DM, Østbye T, Viera AJ, Yano Y. Racial difference in the association between non-alcoholic fatty liver disease and incident type 2 diabetes: findings from the CARDIA study. Diabetologia. 2023 Jul;66(7):1235–1246.
Journal cover image

Published In

Diabetologia

DOI

EISSN

1432-0428

Publication Date

July 2023

Volume

66

Issue

7

Start / End Page

1235 / 1246

Location

Germany

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Race Factors
  • Prospective Studies
  • Non-alcoholic Fatty Liver Disease
  • Middle Aged
  • Male
  • Humans
  • Female
  • Endocrinology & Metabolism