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Flexible, high-resolution cortical arrays with large coverage capture microscale high-frequency oscillations in patients with epilepsy.

Publication ,  Journal Article
Barth, KJ; Sun, J; Chiang, C-H; Qiao, S; Wang, C; Rahimpour, S; Trumpis, M; Duraivel, S; Dubey, A; Wingel, KE; Voinas, AE; Ferrentino, B ...
Published in: Epilepsia
July 2023

OBJECTIVE: Effective surgical treatment of drug-resistant epilepsy depends on accurate localization of the epileptogenic zone (EZ). High-frequency oscillations (HFOs) are potential biomarkers of the EZ. Previous research has shown that HFOs often occur within submillimeter areas of brain tissue and that the coarse spatial sampling of clinical intracranial electrode arrays may limit the accurate capture of HFO activity. In this study, we sought to characterize microscale HFO activity captured on thin, flexible microelectrocorticographic (μECoG) arrays, which provide high spatial resolution over large cortical surface areas. METHODS: We used novel liquid crystal polymer thin-film μECoG arrays (.76-1.72-mm intercontact spacing) to capture HFOs in eight intraoperative recordings from seven patients with epilepsy. We identified ripple (80-250 Hz) and fast ripple (250-600 Hz) HFOs using a common energy thresholding detection algorithm along with two stages of artifact rejection. We visualized microscale subregions of HFO activity using spatial maps of HFO rate, signal-to-noise ratio, and mean peak frequency. We quantified the spatial extent of HFO events by measuring covariance between detected HFOs and surrounding activity. We also compared HFO detection rates on microcontacts to simulated macrocontacts by spatially averaging data. RESULTS: We found visually delineable subregions of elevated HFO activity within each μECoG recording. Forty-seven percent of HFOs occurred on single 200-μm-diameter recording contacts, with minimal high-frequency activity on surrounding contacts. Other HFO events occurred across multiple contacts simultaneously, with covarying activity most often limited to a .95-mm radius. Through spatial averaging, we estimated that macrocontacts with 2-3-mm diameter would only capture 44% of the HFOs detected in our μECoG recordings. SIGNIFICANCE: These results demonstrate that thin-film microcontact surface arrays with both highresolution and large coverage accurately capture microscale HFO activity and may improve the utility of HFOs to localize the EZ for treatment of drug-resistant epilepsy.

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Published In

Epilepsia

DOI

EISSN

1528-1167

Publication Date

July 2023

Volume

64

Issue

7

Start / End Page

1910 / 1924

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Humans
  • Epilepsy
  • Electroencephalography
  • Drug Resistant Epilepsy
  • Brain Waves
  • Brain
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
 

Citation

APA
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Barth, K. J., Sun, J., Chiang, C.-H., Qiao, S., Wang, C., Rahimpour, S., … Viventi, J. (2023). Flexible, high-resolution cortical arrays with large coverage capture microscale high-frequency oscillations in patients with epilepsy. Epilepsia, 64(7), 1910–1924. https://doi.org/10.1111/epi.17642
Barth, Katrina J., James Sun, Chia-Han Chiang, Shaoyu Qiao, Charles Wang, Shervin Rahimpour, Michael Trumpis, et al. “Flexible, high-resolution cortical arrays with large coverage capture microscale high-frequency oscillations in patients with epilepsy.Epilepsia 64, no. 7 (July 2023): 1910–24. https://doi.org/10.1111/epi.17642.
Barth KJ, Sun J, Chiang C-H, Qiao S, Wang C, Rahimpour S, et al. Flexible, high-resolution cortical arrays with large coverage capture microscale high-frequency oscillations in patients with epilepsy. Epilepsia. 2023 Jul;64(7):1910–24.
Barth, Katrina J., et al. “Flexible, high-resolution cortical arrays with large coverage capture microscale high-frequency oscillations in patients with epilepsy.Epilepsia, vol. 64, no. 7, July 2023, pp. 1910–24. Pubmed, doi:10.1111/epi.17642.
Barth KJ, Sun J, Chiang C-H, Qiao S, Wang C, Rahimpour S, Trumpis M, Duraivel S, Dubey A, Wingel KE, Voinas AE, Ferrentino B, Doyle W, Southwell DG, Haglund MM, Vestal M, Harward SC, Solzbacher F, Devore S, Devinsky O, Friedman D, Pesaran B, Sinha SR, Cogan GB, Blanco J, Viventi J. Flexible, high-resolution cortical arrays with large coverage capture microscale high-frequency oscillations in patients with epilepsy. Epilepsia. 2023 Jul;64(7):1910–1924.
Journal cover image

Published In

Epilepsia

DOI

EISSN

1528-1167

Publication Date

July 2023

Volume

64

Issue

7

Start / End Page

1910 / 1924

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Humans
  • Epilepsy
  • Electroencephalography
  • Drug Resistant Epilepsy
  • Brain Waves
  • Brain
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences