Derek Southwell
Assistant Professor of Neurosurgery
Current Appointments & Affiliations
- Assistant Professor of Neurosurgery, Neurosurgery, Neurosurgery 2021
- Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2019
- Assistant Research Professor in Neurobiology, Neurobiology, Basic Science Departments 2018
- Assistant Professor in Neurology, Neurology, Neurocritical Care, Neurology 2020
- Assistant Professor in Pathology, Pathology, Clinical Science Departments 2020
- Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021
Contact Information
- DUMC 3807, Durham, NC 27710
- DUMC 3807, 1542 Blue Zone Duke South, Durham, NC 27710
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derek.southwell@duke.edu
(919) 660-3928
- Background
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Education, Training, & Certifications
- Residency, Neurosurgery, University of California - San Francisco 2013 - 2018
- Residency, Neurosurgery, Stanford University, School of Medicine 2011 - 2013
- M.D., University of California - San Francisco 2011
- Ph.D., University of California - San Francisco 2009
- B.S., Massachusetts Institute of Technology 2001
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Previous Appointments & Affiliations
- Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2020 - 2021
- Assistant Professor of Neurosurgery, Neurosurgery, Neurosurgery 2018 - 2020
- Assistant Professor in Neurology, Neurology, Neurocritical Care, Neurology 2019 - 2020
- Assistant Professor in Pathology, Pathology, Clinical Science Departments 2019 - 2020
- Recognition
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Awards & Honors
- Translating Duke Health Scholar. Duke University. 2018
- Whitehead Scholar. Duke University. 2018
- Eli and Edyth Broad Regeneration Medicine and Stem Cell Fellowship . University of California, San Francisco. 2016
- Rosegay Award. San Francisco Neurological Society. 2016
- Integra Foundation Award. Congress of Neurological Surgeons. 2014
- Academy Award. American Academy of Neurological Surgeons. 2012
- Stem Cell Scholar. California Institute for Regenerative Medicine. 2006
- Phi Beta Kappa. Massachusetts Institute of Technology. 2001
- Undergraduate Research Fellowship. Howard Hughes Medical Institute. 1999
- Research
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Selected Grants
- A First-in-human (FIH), Multicenter, Open Label, Single Arm, Dose Escalation Study of Inhibitory Interneurons (NRTX-1001) in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE) awarded by Neurona Therapeutics, Inc 2022 - 2036
- A Wireless µECoG Prosthesis for Speech awarded by National Institutes of Health 2021 - 2026
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- NINDS Research Education Programs for Residents and Fellows in Neurosurgery awarded by National Institutes of Health 2009 - 2025
- Advancing the therapeutic potential of inhibitory interneuron transplantation awarded by Esther A. & Joseph Klingenstein Fund 2020 - 2024
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- Next-Generation Wireless Intracranial Electrode Arrays for Post-traumatic Epilepsy awarded by United States Army Medical Research Acquisition Activity 2021 - 2024
- Realistic Measurements of tDCS-Modulated Activity and Electric Fields in the Human Brain In Vivo awarded by National Institutes of Health 2019 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Examining the therapeutic potential of interneuron transplantation in a human organotypic epilepsy model awarded by Albert Einstein College of Medicine 2020 - 2021
- Development of a Novel Epilepsy Therapy: Interneuron Transplantation into Human Epileptic Tissue Specimens awarded by American Academy of Neurology 2020 - 2021
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Park, Christine, Saurabh R. Sinha, and Derek G. Southwell. “Laser ablative treatment of musicogenic epilepsy arising from dominant mesial temporal lobe: illustrative case.” J Neurosurg Case Lessons 3, no. 23 (June 6, 2022): CASE2295. https://doi.org/10.3171/CASE2295.Full Text Link to Item
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Sun, James, Katrina Barth, Shaoyu Qiao, Chia-Han Chiang, Charles Wang, Shervin Rahimpour, Michael Trumpis, et al. “Intraoperative microseizure detection using a high-density micro-electrocorticography electrode array.” Brain Commun 4, no. 3 (2022): fcac122. https://doi.org/10.1093/braincomms/fcac122.Full Text Open Access Copy Link to Item
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Chiang, Chia-Han, Charles Wang, Katrina Barth, Shervin Rahimpour, Michael Trumpis, Suseendrakumar Duraivel, Iakov Rachinskiy, et al. “Flexible, high-resolution thin-film electrodes for human and animal neural research.” J Neural Eng 18, no. 4 (June 17, 2021). https://doi.org/10.1088/1741-2552/ac02dc.Full Text Link to Item
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Ali, Muhaddisa Barat, Irene Yu-Hua Gu, Mitchel S. Berger, Johan Pallud, Derek Southwell, Georg Widhalm, Alexandre Roux, Tomás Gomez Vecchio, and Asgeir Store Jakola. “Domain Mapping and Deep Learning from Multiple MRI Clinical Datasets for Prediction of Molecular Subtypes in Low Grade Gliomas.” Brain Sci 10, no. 7 (July 18, 2020). https://doi.org/10.3390/brainsci10070463.Full Text Link to Item
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Rutkowski, M. J., D. G. Southwell, T. M. Cardinal, and L. S. Blevins. “Acromegaly due to McCune-Albright syndrome.” Us Endocrinology 16, no. 1 (June 1, 2020): 47–50. https://doi.org/10.17925/use.2020.16.1.47.Full Text
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Harward, Stephen C., and Derek G. Southwell. “Interneuron transplantation: a prospective surgical therapy for medically refractory epilepsy.” Neurosurg Focus 48, no. 4 (April 1, 2020): E18. https://doi.org/10.3171/2020.2.FOCUS19955.Full Text Link to Item
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Southwell, Derek G., Helia Seifikar, Ruchi Malik, Karen Lavi, Daniel Vogt, John L. Rubenstein, and Vikaas S. Sohal. “Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition.” J Neurosci 40, no. 11 (March 11, 2020): 2215–27. https://doi.org/10.1523/JNEUROSCI.1063-19.2019.Full Text Link to Item
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Breshears, Jonathan D., Derek G. Southwell, and Edward F. Chang. “Inhibition of Manual Movements at Speech Arrest Sites in the Posterior Inferior Frontal Lobe.” Neurosurgery 85, no. 3 (September 1, 2019): E496–501. https://doi.org/10.1093/neuros/nyy592.Full Text Link to Item
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Southwell, Derek G., Jonathan D. Breshears, William R. Lyon, and Michael W. McDermott. “A Method for Cranial Nerve XI Silencing During Surgery of the Foramen Magnum Region: Technical Case Report.” Oper Neurosurg (Hagerstown) 16, no. 4 (April 1, 2019): E130–33. https://doi.org/10.1093/ons/opy134.Full Text Link to Item
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Southwell, Derek G., Jonathan D. Breshears, William R. Lyon, and Michael W. McDermott. “In Reply: A Method for Cranial Nerve XI Silencing During Surgery of the Foramen Magnum Region: Technical Case Report.” Oper Neurosurg (Hagerstown) 16, no. 1 (January 1, 2019): E36. https://doi.org/10.1093/ons/opy316.Full Text Link to Item
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Southwell, Derek G., Harjus S. Birk, Seunggu J. Han, Jing Li, Jeffrey W. Sall, and Mitchel S. Berger. “Resection of gliomas deemed inoperable by neurosurgeons based on preoperative imaging studies.” J Neurosurg 129, no. 3 (September 2018): 567–75. https://doi.org/10.3171/2017.5.JNS17166.Full Text Link to Item
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Southwell, Derek G., Harjus S. Birk, Paul S. Larson, Philip A. Starr, Leo P. Sugrue, and Kurtis I. Auguste. “Laser ablative therapy of sessile hypothalamic hamartomas in children using interventional MRI: report of 5 cases.” J Neurosurg Pediatr 21, no. 5 (May 2018): 460–65. https://doi.org/10.3171/2017.10.PEDS17292.Full Text Link to Item
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Rutkowski, Martin J., Ryan M. Alward, Rebecca Chen, Jeffrey Wagner, Arman Jahangiri, Derek G. Southwell, Sandeep Kunwar, Lewis Blevins, Han Lee, and Manish K. Aghi. “Atypical pituitary adenoma: a clinicopathologic case series.” J Neurosurg 128, no. 4 (April 2018): 1058–65. https://doi.org/10.3171/2016.12.JNS162126.Full Text Link to Item
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Southwell, Derek G., Martin J. Rutkowski, Marta San Luciano, Caroline Racine, Jill Ostrem, Philip A. Starr, and Paul S. Larson. “Before and after the veterans affairs cooperative program 468 study: Deep brain stimulator target selection for treatment of Parkinson's disease.” Parkinsonism Relat Disord 48 (March 2018): 40–44. https://doi.org/10.1016/j.parkreldis.2017.12.013.Full Text Link to Item
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Southwell, Derek G., Marco Riva, Kesshi Jordan, Eduardo Caverzasi, Jing Li, David W. Perry, Roland G. Henry, and Mitchel S. Berger. “Language outcomes after resection of dominant inferior parietal lobule gliomas.” J Neurosurg 127, no. 4 (October 2017): 781–89. https://doi.org/10.3171/2016.8.JNS16443.Full Text Link to Item
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Southwell, Derek G., Joseph A. Osorio, Christopher S. Liverman, Lauren M. Friedman, Ramana K. Naidu, Lawrence R. Poree, Melanie M. Henry, and Line Jacques. “Intrathecal catheter-associated inflammatory mass in a neurofibromatosis type-1 patient receiving fentanyl and bupivacaine.” Surg Neurol Int 8 (2017): 159. https://doi.org/10.4103/sni.sni_80_17.Full Text Link to Item
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Southwell, Derek G., Shawn L. Hervey-Jumper, David W. Perry, and Mitchel S. Berger. “Intraoperative mapping during repeat awake craniotomy reveals the functional plasticity of adult cortex.” J Neurosurg 124, no. 5 (May 2016): 1460–69. https://doi.org/10.3171/2015.5.JNS142833.Full Text Link to Item
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Southwell, Derek G., Jared A. Narvid, Alastair J. Martin, Salman E. Qasim, Philip A. Starr, and Paul S. Larson. “Comparison of Deep Brain Stimulation Lead Targeting Accuracy and Procedure Duration between 1.5- and 3-Tesla Interventional Magnetic Resonance Imaging Systems: An Initial 12-Month Experience.” Stereotact Funct Neurosurg 94, no. 2 (2016): 102–7. https://doi.org/10.1159/000443407.Full Text Link to Item
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Southwell, Derek G., Cory R. Nicholas, Allan I. Basbaum, Michael P. Stryker, Arnold R. Kriegstein, John L. Rubenstein, and Arturo Alvarez-Buylla. “Interneurons from embryonic development to cell-based therapy.” Science 344, no. 6180 (April 11, 2014): 1240622. https://doi.org/10.1126/science.1240622.Full Text Link to Item
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Nicholas, Cory R., Jiadong Chen, Yunshuo Tang, Derek G. Southwell, Nadine Chalmers, Daniel Vogt, Christine M. Arnold, et al. “Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development.” Cell Stem Cell 12, no. 5 (May 2, 2013): 573–86. https://doi.org/10.1016/j.stem.2013.04.005.Full Text Link to Item
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Southwell, Derek G., Mercedes F. Paredes, Rui P. Galvao, Daniel L. Jones, Robert C. Froemke, Joy Y. Sebe, Clara Alfaro-Cervello, et al. “Intrinsically determined cell death of developing cortical interneurons.” Nature 491, no. 7422 (November 1, 2012): 109–13. https://doi.org/10.1038/nature11523.Full Text Link to Item
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Southwell, Derek G., Paul A. Garcia, Mitchel S. Berger, Nicholas M. Barbaro, and Edward F. Chang. “Long-term seizure control outcomes after resection of gangliogliomas.” Neurosurgery 70, no. 6 (June 2012): 1406–13. https://doi.org/10.1227/NEU.0b013e3182500a4c.Full Text Link to Item
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Southwell, Derek G., Robert C. Froemke, Arturo Alvarez-Buylla, Michael P. Stryker, and Sunil P. Gandhi. “Cortical plasticity induced by inhibitory neuron transplantation.” Science 327, no. 5969 (February 26, 2010): 1145–48. https://doi.org/10.1126/science.1183962.Full Text Link to Item
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Baraban, Scott C., Derek G. Southwell, Rosanne C. Estrada, Daniel L. Jones, Joy Y. Sebe, Clara Alfaro-Cervello, Jose M. García-Verdugo, John L. R. Rubenstein, and Arturo Alvarez-Buylla. “Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice.” Proc Natl Acad Sci U S A 106, no. 36 (September 8, 2009): 15472–77. https://doi.org/10.1073/pnas.0900141106.Full Text Link to Item
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Alvarez-Dolado, Manuel, Maria Elisa Calcagnotto, Kameel M. Karkar, Derek G. Southwell, Dorothy M. Jones-Davis, Rosanne C. Estrada, John L. R. Rubenstein, Arturo Alvarez-Buylla, and Scott C. Baraban. “Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain.” J Neurosci 26, no. 28 (July 12, 2006): 7380–89. https://doi.org/10.1523/JNEUROSCI.1540-06.2006.Full Text Link to Item
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Southwell, D. G., J. E. Bechtold, W. D. Lew, and A. H. Schmidt. “Improving the detection of acetabular osteolysis using oblique radiographs.” J Bone Joint Surg Br 81, no. 2 (March 1999): 289–95. https://doi.org/10.1302/0301-620x.81b2.9334.Full Text Link to Item
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Book Sections
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Osorio, J. A., J. K. Scheer, D. G. Southwell, and C. P. Ames. “Osteotomy for cervical kyphosis.” In Degenerative Cervical Myelopathy and Radiculopathy: Treatment Approaches and Options, 409–20, 2018. https://doi.org/10.1007/978-3-319-97952-6_34.Full Text
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- Teaching & Mentoring
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Recent Courses
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