Derek Southwell | Scholars@Duke

Derek Southwell
Assistant Professor of Neurosurgery

Current Appointments & Affiliations

Assistant Professor of Neurosurgery, Neurosurgery, Neurosurgery 2021
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2019
Assistant Research Professor in Neurobiology, Neurobiology, Basic Science Departments 2018
Assistant Professor in Neurology, Neurology, Neurocritical Care, Neurology 2020
Assistant Professor in Pathology, Pathology, Clinical Science Departments 2020
Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2020
Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2019

Contact Information

DUMC 3807, Durham, NC 27710
DUMC 3807, 1542 Blue Zone Duke South, Durham, NC 27710
derek.southwell@duke.edu (919) 660-3928

Background
Education, Training, & Certifications
- Residency, Neurosurgery, University of California - San Francisco 2013 - 2018
- Residency, Neurosurgery, Stanford University, School of Medicine 2011 - 2013
- M.D., University of California - San Francisco 2011
- Ph.D., University of California - San Francisco 2009
- B.S., Massachusetts Institute of Technology 2001
Duke Appointment History
- Assistant Professor of Neurosurgery, Neurosurgery, Neurosurgery 2018 - 2020
- Assistant Professor in Neurology, Neurology, Neurocritical Care, Neurology 2019 - 2020
- Assistant Professor in Pathology, Pathology, Clinical Science Departments 2019 - 2020
Recognition
Awards & Honors
Research
Selected Grants
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- NINDS Research Education Programs for Residents and Fellows in Neurosurgery awarded by National Institutes of Health 2009 - 2025
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- Advancing the therapeutic potential of inhibitory interneuron transplantation awarded by Esther A. & Joseph Klingenstein Fund 2020 - 2023
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Development of a Novel Epilepsy Therapy: Interneuron Transplantation into Human Epileptic Tissue Specimens awarded by American Academy of Neurology 2020 - 2021
- Realistic Measurements of tDCS-Modulated Activity and Electric Fields in the Human Brain In Vivo awarded by National Institutes of Health 2019 - 2021
- Examining the therapeutic potential of interneuron transplantation in a human organotypic epilepsy model awarded by Albert Einstein College of Medicine 2020 - 2021
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Chiang, Chia-Han, Charles Wang, Katrina Barth, Shervin Rahimpour, Michael Trumpis, Suseendrakumar Duraivel, Iakov Rachinskiy, et al. “Flexible, high-resolution thin-film electrodes for human and animal neural research.” J Neural Eng, May 19, 2021. https://doi.org/10.1088/1741-2552/ac02dc.
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  - Ali, Muhaddisa Barat, Irene Yu-Hua Gu, Mitchel S. Berger, Johan Pallud, Derek Southwell, Georg Widhalm, Alexandre Roux, Tomás Gomez Vecchio, and Asgeir Store Jakola. “Domain Mapping and Deep Learning from Multiple MRI Clinical Datasets for Prediction of Molecular Subtypes in Low Grade Gliomas.” Brain Sci 10, no. 7 (July 18, 2020). https://doi.org/10.3390/brainsci10070463.
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  - Rutkowski, M. J., D. G. Southwell, T. M. Cardinal, and L. S. Blevins. “Acromegaly due to McCune-Albright syndrome.” Us Endocrinology 16, no. 1 (June 1, 2020): 47–50. https://doi.org/10.17925/use.2020.16.1.47.
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  - Harward, Stephen C., and Derek G. Southwell. “Interneuron transplantation: a prospective surgical therapy for medically refractory epilepsy.” Neurosurg Focus 48, no. 4 (April 1, 2020): E18. https://doi.org/10.3171/2020.2.FOCUS19955.
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  - Southwell, Derek G., Helia Seifikar, Ruchi Malik, Karen Lavi, Daniel Vogt, John L. Rubenstein, and Vikaas S. Sohal. “Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition.” J Neurosci 40, no. 11 (March 11, 2020): 2215–27. https://doi.org/10.1523/JNEUROSCI.1063-19.2019.
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  - Breshears, Jonathan D., Derek G. Southwell, and Edward F. Chang. “Inhibition of Manual Movements at Speech Arrest Sites in the Posterior Inferior Frontal Lobe.” Neurosurgery 85, no. 3 (September 1, 2019): E496–501. https://doi.org/10.1093/neuros/nyy592.
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  - Southwell, Derek G., Jonathan D. Breshears, William R. Lyon, and Michael W. McDermott. “A Method for Cranial Nerve XI Silencing During Surgery of the Foramen Magnum Region: Technical Case Report.” Oper Neurosurg (Hagerstown) 16, no. 4 (April 1, 2019): E130–33. https://doi.org/10.1093/ons/opy134.
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  - Southwell, Derek G., Jonathan D. Breshears, William R. Lyon, and Michael W. McDermott. “In Reply: A Method for Cranial Nerve XI Silencing During Surgery of the Foramen Magnum Region: Technical Case Report.” Oper Neurosurg (Hagerstown) 16, no. 1 (January 1, 2019): E36. https://doi.org/10.1093/ons/opy316.
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  - Southwell, Derek G., Harjus S. Birk, Seunggu J. Han, Jing Li, Jeffrey W. Sall, and Mitchel S. Berger. “Resection of gliomas deemed inoperable by neurosurgeons based on preoperative imaging studies.” J Neurosurg 129, no. 3 (September 2018): 567–75. https://doi.org/10.3171/2017.5.JNS17166.
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  - Southwell, Derek G., Harjus S. Birk, Paul S. Larson, Philip A. Starr, Leo P. Sugrue, and Kurtis I. Auguste. “Laser ablative therapy of sessile hypothalamic hamartomas in children using interventional MRI: report of 5 cases.” J Neurosurg Pediatr 21, no. 5 (May 2018): 460–65. https://doi.org/10.3171/2017.10.PEDS17292.
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  - Rutkowski, Martin J., Ryan M. Alward, Rebecca Chen, Jeffrey Wagner, Arman Jahangiri, Derek G. Southwell, Sandeep Kunwar, Lewis Blevins, Han Lee, and Manish K. Aghi. “Atypical pituitary adenoma: a clinicopathologic case series.” J Neurosurg 128, no. 4 (April 2018): 1058–65. https://doi.org/10.3171/2016.12.JNS162126.
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  - Southwell, Derek G., Martin J. Rutkowski, Marta San Luciano, Caroline Racine, Jill Ostrem, Philip A. Starr, and Paul S. Larson. “Before and after the veterans affairs cooperative program 468 study: Deep brain stimulator target selection for treatment of Parkinson's disease.” Parkinsonism Relat Disord 48 (March 2018): 40–44. https://doi.org/10.1016/j.parkreldis.2017.12.013.
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  - Southwell, Derek G., Marco Riva, Kesshi Jordan, Eduardo Caverzasi, Jing Li, David W. Perry, Roland G. Henry, and Mitchel S. Berger. “Language outcomes after resection of dominant inferior parietal lobule gliomas.” J Neurosurg 127, no. 4 (October 2017): 781–89. https://doi.org/10.3171/2016.8.JNS16443.
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  - Southwell, Derek G., Joseph A. Osorio, Christopher S. Liverman, Lauren M. Friedman, Ramana K. Naidu, Lawrence R. Poree, Melanie M. Henry, and Line Jacques. “Intrathecal catheter-associated inflammatory mass in a neurofibromatosis type-1 patient receiving fentanyl and bupivacaine.” Surg Neurol Int 8 (2017): 159. https://doi.org/10.4103/sni.sni_80_17.
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  - Southwell, Derek G., Shawn L. Hervey-Jumper, David W. Perry, and Mitchel S. Berger. “Intraoperative mapping during repeat awake craniotomy reveals the functional plasticity of adult cortex.” J Neurosurg 124, no. 5 (May 2016): 1460–69. https://doi.org/10.3171/2015.5.JNS142833.
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  - Southwell, Derek G., Jared A. Narvid, Alastair J. Martin, Salman E. Qasim, Philip A. Starr, and Paul S. Larson. “Comparison of Deep Brain Stimulation Lead Targeting Accuracy and Procedure Duration between 1.5- and 3-Tesla Interventional Magnetic Resonance Imaging Systems: An Initial 12-Month Experience.” Stereotact Funct Neurosurg 94, no. 2 (2016): 102–7. https://doi.org/10.1159/000443407.
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  - Southwell, Derek G., Cory R. Nicholas, Allan I. Basbaum, Michael P. Stryker, Arnold R. Kriegstein, John L. Rubenstein, and Arturo Alvarez-Buylla. “Interneurons from embryonic development to cell-based therapy.” Science 344, no. 6180 (April 11, 2014): 1240622. https://doi.org/10.1126/science.1240622.
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  - Nicholas, Cory R., Jiadong Chen, Yunshuo Tang, Derek G. Southwell, Nadine Chalmers, Daniel Vogt, Christine M. Arnold, et al. “Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development.” Cell Stem Cell 12, no. 5 (May 2, 2013): 573–86. https://doi.org/10.1016/j.stem.2013.04.005.
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  - Southwell, Derek G., Mercedes F. Paredes, Rui P. Galvao, Daniel L. Jones, Robert C. Froemke, Joy Y. Sebe, Clara Alfaro-Cervello, et al. “Intrinsically determined cell death of developing cortical interneurons.” Nature 491, no. 7422 (November 1, 2012): 109–13. https://doi.org/10.1038/nature11523.
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  - Southwell, Derek G., Paul A. Garcia, Mitchel S. Berger, Nicholas M. Barbaro, and Edward F. Chang. “Long-term seizure control outcomes after resection of gangliogliomas.” Neurosurgery 70, no. 6 (June 2012): 1406–13. https://doi.org/10.1227/NEU.0b013e3182500a4c.
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  - Southwell, Derek G., Robert C. Froemke, Arturo Alvarez-Buylla, Michael P. Stryker, and Sunil P. Gandhi. “Cortical plasticity induced by inhibitory neuron transplantation.” Science 327, no. 5969 (February 26, 2010): 1145–48. https://doi.org/10.1126/science.1183962.
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  - Baraban, Scott C., Derek G. Southwell, Rosanne C. Estrada, Daniel L. Jones, Joy Y. Sebe, Clara Alfaro-Cervello, Jose M. García-Verdugo, John L. R. Rubenstein, and Arturo Alvarez-Buylla. “Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice.” Proc Natl Acad Sci U S A 106, no. 36 (September 8, 2009): 15472–77. https://doi.org/10.1073/pnas.0900141106.
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  - Alvarez-Dolado, Manuel, Maria Elisa Calcagnotto, Kameel M. Karkar, Derek G. Southwell, Dorothy M. Jones-Davis, Rosanne C. Estrada, John L. R. Rubenstein, Arturo Alvarez-Buylla, and Scott C. Baraban. “Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain.” J Neurosci 26, no. 28 (July 12, 2006): 7380–89. https://doi.org/10.1523/JNEUROSCI.1540-06.2006.
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  - Southwell, D. G., J. E. Bechtold, W. D. Lew, and A. H. Schmidt. “Improving the detection of acetabular osteolysis using oblique radiographs.” J Bone Joint Surg Br 81, no. 2 (March 1999): 289–95. https://doi.org/10.1302/0301-620x.81b2.9334.
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- Book Sections
  - Osorio, J. A., J. K. Scheer, D. G. Southwell, and C. P. Ames. “Osteotomy for cervical kyphosis.” In Degenerative Cervical Myelopathy and Radiculopathy: Treatment Approaches and Options, 409–20, 2018. https://doi.org/10.1007/978-3-319-97952-6_34.
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Teaching & Mentoring
Recent Courses
- NEUROBIO 393: Research Independent Study 2021
- NEUROBIO 793: Research in Neurobiology 2021

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Education, Training, & Certifications

Duke Appointment History

Awards & Honors

Selected Grants

Selected Publications

Academic Articles

Book Sections

Recent Courses