Skip to main content

Derek Southwell

Assistant Professor of Neurosurgery
DUMC 3807, Durham, NC 27710
DUMC 3807, 1542 Blue Zone Duke South, Durham, NC 27710


I am a surgeon-scientist specialized in the treatment of epilepsy and movement disorders.  My laboratory conducts basic and translational neuroscience research on cortical inhibitory circuits.  We are interested in 1) understanding the cellular design of inhibitory circuits in mice and humans, and, 2) advancing interneuron transplantation as a therapeutic strategy for inhibitory circuit repair.

Current Appointments & Affiliations

Assistant Professor of Neurosurgery · 2021 - Present Neurosurgery, Neurosurgery
Faculty Network Member of the Duke Institute for Brain Sciences · 2019 - Present Duke Institute for Brain Sciences, University Institutes and Centers
Assistant Research Professor in Neurobiology · 2018 - Present Neurobiology, Basic Science Departments
Assistant Professor in Neurology · 2020 - Present Neurology, Neurocritical Care, Neurology
Assistant Professor in Pathology · 2020 - Present Pathology, Clinical Science Departments
Assistant Professor of Cell Biology · 2022 - Present Cell Biology, Basic Science Departments
Affiliate of the Duke Regeneration Center · 2021 - Present Duke Regeneration Center, Basic Science Departments

Education, Training & Certifications

University of California, San Francisco · 2011 M.D.
University of California, San Francisco · 2009 Ph.D.
Massachusetts Institute of Technology · 2001 B.S.