Overview
I am a surgeon-scientist specialized in the treatment of epilepsy and movement disorders. My laboratory conducts basic and translational neuroscience research on cortical inhibitory circuits. We are interested in 1) understanding the cellular design of inhibitory circuits in mice and humans, and, 2) advancing interneuron transplantation as a therapeutic strategy for inhibitory circuit repair.
Current Appointments & Affiliations
Associate Professor of Neurosurgery
·
2025 - Present
Neurosurgery,
Neurosurgery
Faculty Network Member of the Duke Institute for Brain Sciences
·
2019 - Present
Duke Institute for Brain Sciences,
University Institutes and Centers
Assistant Research Professor in Neurobiology
·
2018 - Present
Neurobiology,
Basic Science Departments
Assistant Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Associate Professor in Pathology
·
2025 - Present
Pathology,
Clinical Science Departments
Associate Professor in Neurology
·
2025 - Present
Neurology, Neurocritical Care,
Neurology
Affiliate of the Duke Regeneration Center
·
2021 - Present
Duke Regeneration Center,
Basic Science Departments
Recent Publications
RNA-programmable cell type monitoring and manipulation in the human cortex with CellREADR.
Preprint · December 6, 2024 Full text Link to item CiteInterneuron Transplantation for Drug-Resistant Epilepsy.
Journal Article Neurosurg Clin N Am · January 2024 Current epilepsy surgical techniques, such as brain resection, laser ablation, and neurostimulation, target seizure networks macroscopically, and they may yield an unfavorable balance between seizure reduction, procedural invasiveness, and neurologic morbi ... Full text Link to item CiteThe Temporal Lobe Club: Newer Approaches to Treat Temporal Lobe Epilepsy.
Journal Article Epilepsy Curr · 2024 This brief review summarizes presentations at the Temporal Lobe Club Special Interest Group session held in December 2022 at the American Epilepsy Society meeting. The session addressed newer methods to treat temporal epilepsy, including methods currently ... Full text Link to item CiteRecent Grants
A Study of Inhibitory Interneurons (NRTX1001) for the Treatment of Drug-resistant Bilateral Temporal Lobe Focal Seizures
Clinical TrialPrincipal Investigator · Awarded by Neurona Therapeutics, Inc · 2024 - 2039A First-in-human (FIH), Multicenter, Open Label, Single Arm, Dose Escalation Study of Inhibitory Interneurons (NRTX-1001) in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE)
Clinical TrialPrincipal Investigator · Awarded by Neurona Therapeutics, Inc · 2022 - 2036Neurobiology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029View All Grants
Education, Training & Certifications
University of California, San Francisco ·
2011
M.D.
University of California, San Francisco ·
2009
Ph.D.
Massachusetts Institute of Technology ·
2001
B.S.