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Spatial Confinement Modulates Macrophage Response in Microporous Annealed Particle (MAP) Scaffolds.

Publication ,  Journal Article
Liu, Y; Suarez-Arnedo, A; Riley, L; Miley, T; Xia, J; Segura, T
Published in: Advanced healthcare materials
October 2023

Macrophages are essential in the initiation, maintenance, and transition of inflammatory processes such as foreign body response and wound healing. Mounting evidence suggests that physical factors also modulate macrophage activation. 2D in vitro systems demonstrate that constraining macrophages to small areas or channels modulates their phenotypes and changes their responses to known inflammatory agents such as lipopolysaccharide. However, how dimensionality and pore size affect macrophage phenotype is less explored. In this work, the change in macrophage M1/M2 polarization when confined in microporous annealed particle (MAP) scaffolds is studied. Particles sizes (40, 70, and 130 µm) are selected using outputs from software LOVAMAP that analyzes the characteristics of 3D pores in MAP gels. As the size of building block particle correlates with pore size inside the scaffolds, the three  types of scaffold allow us to study how the degree of spatial confinement modulates the behavior of embedded macrophages. Spatially confining macrophages in scaffolds with pore size on the scale of cells leads to a reduced level of the inflammatory response, which is correlated with a change in cell morphology and motility.

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Published In

Advanced healthcare materials

DOI

EISSN

2192-2659

ISSN

2192-2640

Publication Date

October 2023

Volume

12

Issue

26

Start / End Page

e2300823

Related Subject Headings

  • Wound Healing
  • Tissue Scaffolds
  • Macrophages
  • Biocompatible Materials
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 1004 Medical Biotechnology
  • 0903 Biomedical Engineering
  • 0304 Medicinal and Biomolecular Chemistry
 

Citation

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Liu, Y., Suarez-Arnedo, A., Riley, L., Miley, T., Xia, J., & Segura, T. (2023). Spatial Confinement Modulates Macrophage Response in Microporous Annealed Particle (MAP) Scaffolds. Advanced Healthcare Materials, 12(26), e2300823. https://doi.org/10.1002/adhm.202300823
Liu, Yining, Alejandra Suarez-Arnedo, Lindsay Riley, Tasman Miley, Jingyi Xia, and Tatiana Segura. “Spatial Confinement Modulates Macrophage Response in Microporous Annealed Particle (MAP) Scaffolds.Advanced Healthcare Materials 12, no. 26 (October 2023): e2300823. https://doi.org/10.1002/adhm.202300823.
Liu Y, Suarez-Arnedo A, Riley L, Miley T, Xia J, Segura T. Spatial Confinement Modulates Macrophage Response in Microporous Annealed Particle (MAP) Scaffolds. Advanced healthcare materials. 2023 Oct;12(26):e2300823.
Liu, Yining, et al. “Spatial Confinement Modulates Macrophage Response in Microporous Annealed Particle (MAP) Scaffolds.Advanced Healthcare Materials, vol. 12, no. 26, Oct. 2023, p. e2300823. Epmc, doi:10.1002/adhm.202300823.
Liu Y, Suarez-Arnedo A, Riley L, Miley T, Xia J, Segura T. Spatial Confinement Modulates Macrophage Response in Microporous Annealed Particle (MAP) Scaffolds. Advanced healthcare materials. 2023 Oct;12(26):e2300823.
Journal cover image

Published In

Advanced healthcare materials

DOI

EISSN

2192-2659

ISSN

2192-2640

Publication Date

October 2023

Volume

12

Issue

26

Start / End Page

e2300823

Related Subject Headings

  • Wound Healing
  • Tissue Scaffolds
  • Macrophages
  • Biocompatible Materials
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 1004 Medical Biotechnology
  • 0903 Biomedical Engineering
  • 0304 Medicinal and Biomolecular Chemistry