Skip to main content

rol-6 and dpy-10C. elegans mutants have normal mitochondrial function after normalizing to delayed development.

Publication ,  Journal Article
Sparling, AC; King, DE; Meyer, JN
Published in: microPublication biology
January 2023

Collagen mutations are commonly used in the creation of Caenorhabditis elegans transgenic strains, but their secondary effects are not fully characterized . We compared the mitochondrial function of N2, dpy-10, rol-6, and PE255 C. elegans . N2 worms exhibited ~2-fold greater volume, mitochondrial DNA copy number, and nuclear DNA copy number than collagen mutants (p<0.05). Whole-worm respirometry and ATP levels were higher in N2 worms, but differences in respirometry largely disappeared after normalization to mitochondrial DNA copy number. This data suggests that rol-6 and dpy-10 mutants are developmentally delayed but have comparable mitochondrial function to N2 worms once the data is normalized to developmental stage.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

microPublication biology

DOI

EISSN

2578-9430

ISSN

2578-9430

Publication Date

January 2023

Volume

2023
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sparling, A. C., King, D. E., & Meyer, J. N. (2023). rol-6 and dpy-10C. elegans mutants have normal mitochondrial function after normalizing to delayed development. MicroPublication Biology, 2023. https://doi.org/10.17912/micropub.biology.000798
Sparling, A Clare, Dillon E. King, and Joel N. Meyer. “rol-6 and dpy-10C. elegans mutants have normal mitochondrial function after normalizing to delayed development.MicroPublication Biology 2023 (January 2023). https://doi.org/10.17912/micropub.biology.000798.
Sparling, A. Clare, et al. “rol-6 and dpy-10C. elegans mutants have normal mitochondrial function after normalizing to delayed development.MicroPublication Biology, vol. 2023, Jan. 2023. Epmc, doi:10.17912/micropub.biology.000798.

Published In

microPublication biology

DOI

EISSN

2578-9430

ISSN

2578-9430

Publication Date

January 2023

Volume

2023