Overview
Dr. Meyer studies the effects of toxic agents and stressors on human and wildlife health. He is particularly interested in understanding the mechanisms by which environmental agents cause DNA damage, the molecular processes that organisms employ to protect prevent and repair DNA damage, and genetic differences that may lead to increased or decreased sensitivity to DNA damage. Mitochondrial DNA damage and repair, as well as mitochondrial function in general, are a particular focus. He studies these effects in the nematode Caenorhabditis elegans, in cell culture, and collaboratively in other laboratory model organisms as well as in human populations in the USA and globally.
Current Appointments & Affiliations
Sally Kleberg Distinguished Professorship
·
2024 - Present
Environmental Natural Science,
Nicholas School of the Environment
Professor of Environmental Genomics
·
2024 - Present
Environmental Natural Science,
Nicholas School of the Environment
Professor in the Department of Civil and Environmental Engineering
·
2024 - Present
Civil and Environmental Engineering,
Pratt School of Engineering
Member of the Duke Cancer Institute
·
2013 - Present
Duke Cancer Institute,
Institutes and Centers
Affiliate, Duke Global Health Institute
·
2017 - Present
Duke Global Health Institute,
University Institutes and Centers
Recent Publications
Programmed mitophagy at the oocyte-to-zygote transition promotes lineage endurance.
Journal Article Nature cell biology · February 2026 The quality of mitochondria inherited from the oocyte determines embryonic viability, lifelong metabolic health of the progeny and lineage endurance. High levels of endogenous reactive oxygen species and exogenous toxicants pose threats to mitochondrial DN ... Full text CiteProgeny effects of rotenone exposure depend on parental toxicity.
Journal Article Toxicological sciences : an official journal of the Society of Toxicology · February 2026 Parental exposure to toxicants can affect progeny health. However, laboratory studies often employ exposures that result in loading of pollutants to gametes, or toxic effects to parents which could indirectly affect germ cell or gamete health. Here, we too ... Full text CitePersistent effects of early-life arsenic exposure in <i>Caenorhabditis elegans</i>.
Journal Article Environmental science. Processes & impacts · January 2026 Arsenic exposure is a major global health challenge. In addition to well-documented toxic effects in exposed people and animals, there is evidence that exposure to arsenic may lead to transgenerational effects. Transgenerational effects of low levels of ex ... Full text CiteRecent Grants
Understanding environmental mitochondrial health
ResearchPrincipal Investigator · Awarded by National Institute of Environmental Health Sciences · 2026 - 2034Duke University Program in Environmental Health
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institute of Environmental Health Sciences · 2019 - 2029Which mechanisms of pollutant-induced mitochondrial dysfunction cause dopaminergic neurodegeneration?
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2027View All Grants
Education, Training & Certifications
Duke University ·
2003
Ph.D.
Juniata College ·
1992
B.S.