Joel Meyer | Scholars@Duke

Joel Meyer
Associate Professor of Environmental Genomics in the Division of Environmental Sciences and Policy

Dr. Meyer studies the effects of toxic agents and stressors on human and wildlife health. He is particularly interested in understanding the mechanisms by which environmental agents cause DNA damage, the molecular processes that organisms employ to protect prevent and repair DNA damage, and genetic differences that may lead to increased or decreased sensitivity to DNA damage. Mitochondrial DNA damage and repair, as well as mitochondrial function in general, are a particular focus. He studies these effects in the nematode Caenorhabditis elegans, in cell culture, and collaboratively in other laboratory model organisms as well as in human populations in the USA and globally.

Current Appointments & Affiliations

Associate Professor of Environmental Genomics in the Division of Environmental Sciences and Policy, Environmental Sciences and Policy, Nicholas School of the Environment 2014
Faculty Network Member of The Energy Initiative, Nicholas Institute-Energy Initiative, Initiatives 2012
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013
Affiliate, Duke Global Health Institute, Duke Global Health Institute, University Institutes and Centers 2017

Contact Information

A354 Lev Sci Res Ctr, Durham, NC 27708
Box 90328, Durham, NC 27708-0328
joel.meyer@duke.edu (919) 613-8109
Meyer Lab Website

Background
Education, Training, & Certifications
- Ph.D., Duke University 2003
- B.S., Juniata College 1992
Previous Appointments & Affiliations
- Truman and Nellie Semans/Alex Brown and Sons Associate Professor of Molecular Environmental Toxicology, Environmental Sciences and Policy, Nicholas School of the Environment 2017 - 2022
- Associate Professor in the Department of Civil and Environmental Engineering, Civil and Environmental Engineering, Pratt School of Engineering 2015 - 2021
- Director of Graduate Studies of the Environmental Science Graduate Program, Environmental Sciences and Policy, Nicholas School of the Environment 2013 - 2016
- Assistant Professor of Environmental Genomics, Environmental Sciences and Policy, Nicholas School of the Environment 2007 - 2014
- Assistant Professor in the Department of Civil and Environmental Engineering, Civil and Environmental Engineering, Pratt School of Engineering 2009 - 2012
Recognition
In the News
- NOV 3, 2017 Nicholas School of the Environment
  
  From Clean Up To Cutting Edge Research
- APR 18, 2017
  
  Five Faculty Named Bass Fellows for Excellence in Teaching and Research
- AUG 5, 2014
  
  Study Eyes Health Risks Of Drilling And Mining In Peru
Expertise
Subject Headings
Global Scholarship
- Research
Research
Selected Grants
- Duke University Program in Environmental Health awarded by National Institutes of Health 2013 - 2024
- An acoustofluidic device for high-resolution 3D imaging and sorting of C. elegans without anesthetics awarded by Ascent Bio-Nano Technologies, Inc. 2022 - 2024
- Does exposure to mitochondrial toxicants during germ cell development result in lifelong alterations in mitochondrial function mediated by epigenetic changes? awarded by National Institutes of Health 2017 - 2022
- A Randomized Phase II Clinical Trial of L-Citrulline to Improve Asthma Control in Obese Late Onset Asthma awarded by University of Colorado - Denver 2019 - 2022
- Exploring the role of mitochondrial homeostatic processes in the accumulation and transmission of environmentally-induced mtDNA mutations across generations awarded by National Institutes of Health 2021 - 2022
- IPA for Ian Ryde awarded by VA New Jersey Health Care System 2020 - 2021
- GW150184 Mitochondrial dysfunction and Gulf War Illness awarded by United States Army Medical Research Acquisition Activity 2016 - 2021
- Center for Environmental Implications of Nanotechnology awarded by National Science Foundation 2008 - 2021
- Exercise, MANF, and chemical-induced neurodegeneration awarded by National Institutes of Health 2019 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- Are mitochondria a major target of antimicrobial silver nanoparticles? awarded by National Institutes of Health 2017 - 2020
- Role of Mitochondrial CYP2E1 in Chemical Exposure-Driven Neurodegeneration awarded by National Institutes of Health 2016 - 2019
- Duke University Program in Environmental Health awarded by National Institute of Environmental Health Sciences 2013 - 2019
- Cooperative Program in Nanomaterials Hazard and Exposure Assessment Traineeships (NanoHEAT) awarded by Environmental Protection Agency 2015 - 2018
- IPA for Ian Ryde awarded by VA New Jersey Health Care System 2017 - 2018
- Mental Stress-Induced Left Ventricular Dysfunction and Mitochondrial Dysfunction in Women awarded by National Institutes of Health 2018
- REU Site: Research Experiences for Undergraduates in Environmental Implications of Nanotechnology awarded by National Science Foundation 2014 - 2018
- Fluoride and human health: Assessing novel biomarkers in detecting bone disorder awarded by National Institutes of Health 2015 - 2017
- Genetic sensitivity to mitochondrial toxicity awarded by National Institutes of Health 2016 - 2017
- The Role of Mitochondrial DNA Damage in Neurodegeneration awarded by National Institutes of Health 2011 - 2017
- REU: Research Experience for Undergraudates on Environmental Implications of Nanotechnology awarded by National Science Foundation 2010 - 2014
- COPAS BIOSORT Worm Sorter awarded by National Institutes of Health 2009 - 2010
Fellowships, Supported Research, & Other Grants
- Racial Inequality Research Grant: Environmental Health Study of the Pauli Murray Center awarded by Duke Office of Provost 2022
- Reckoning with Race, Racism, and the History of the American South Initiative: Making bonds, breaking bonds: Chemical industries, environmental justice, and the global history of race in the American South awarded by Duke Office of the Provost 2021
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Leuthner, Tess C., Laura Benzing, Brendan F. Kohrn, Christina M. Bergemann, Michael J. Hipp, Kathleen A. Hershberger, Danielle F. Mello, et al. “Resistance of mitochondrial DNA to cadmium and Aflatoxin B1 damage-induced germline mutation accumulation in C. elegans.” Nucleic Acids Res, August 10, 2022. https://doi.org/10.1093/nar/gkac666.
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  - Berky, A. J., E. Robie, S. N. Chipa, E. J. Ortiz, E. J. Palmer, N. A. Rivera, A. M. M. Avalos, J. N. Meyer, H. Hsu-Kim, and W. K. Pan. “Risk of lead exposure from wild game consumption from cross-sectional studies in Madre de Dios, Peru.” The Lancet Regional Health Americas 12 (August 1, 2022). https://doi.org/10.1016/j.lana.2022.100266.
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  - Maglioni, Silvia, Alfonso Schiavi, Marlen Melcher, Vanessa Brinkmann, Zhongrui Luo, Anna Laromaine, Nuno Raimundo, Joel N. Meyer, Felix Distelmaier, and Natascia Ventura. “Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans.” Nature Communications 13, no. 1 (May 2022): 2620. https://doi.org/10.1038/s41467-022-29972-4.
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  - King, Dillon E., Anna Clare Sparling, Dillon Lloyd, Matthew Joseph Satusky, Mackenzie Martinez, Carole Grenier, Christina Michelle Bergemann, et al. “Sex-specific DNA methylation and associations with in utero tobacco smoke exposure at nuclear-encoded mitochondrial genes.” Epigenetics, March 3, 2022, 1–17. https://doi.org/10.1080/15592294.2022.2043591.
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  - Joglekar, Rashmi, Marty Cauley, Taylor Lipsich, David L. Corcoran, Heather B. Patisaul, Edward D. Levin, Joel N. Meyer, Margaret M. McCarthy, and Susan K. Murphy. “Developmental nicotine exposure and masculinization of the rat preoptic area.” Neurotoxicology 89 (March 2022): 41–54. https://doi.org/10.1016/j.neuro.2022.01.005.
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  - Markovich, Zachary R., Jessica H. Hartman, Ian T. Ryde, Kathleen A. Hershberger, Abigail S. Joyce, Patrick L. Ferguson, and Joel N. Meyer. “Mild pentachlorophenol-mediated uncoupling of mitochondria depletes ATP but does not cause an oxidized redox state or dopaminergic neurodegeneration in Caenorhabditis elegans.” Current Research in Toxicology 3 (January 2022): 100084. https://doi.org/10.1016/j.crtox.2022.100084.
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  - Mello, Danielle F., Christina M. Bergemann, Kinsey Fisher, Rojin Chitrakar, Shefali R. Bijwadia, Yang Wang, Alexis Caldwell, Larry Ryan Baugh, and Joel N. Meyer. “Rotenone Modulates Caenorhabditis elegans Immunometabolism and Pathogen Susceptibility.” Frontiers in Immunology 13 (January 2022): 840272. https://doi.org/10.3389/fimmu.2022.840272.
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  - Mello, Danielle F., Laura L. Maurer, Ian T. Ryde, Dong Hoon Songr, Stella M. Marinakos, Chuanjia Jiang, Mark R. Wiesner, Heileen Hsu-Kim, and Joel N. Meyer. “In Vivo Effects of Silver Nanoparticles on Development, Behavior, and Mitochondrial Function are Altered by Genetic Defects in Mitochondrial Dynamics.” Environmental Science & Technology 56, no. 2 (January 2022): 1113–24. https://doi.org/10.1021/acs.est.1c05915.
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  - Leuthner, Tess C., and Joel N. Meyer. “Mitochondrial DNA Mutagenesis: Feature of and Biomarker for Environmental Exposures and Aging.” Current Environmental Health Reports 8, no. 4 (December 2021): 294–308. https://doi.org/10.1007/s40572-021-00329-1.
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  - Bijwadia, Shefali R., Katherine Morton, and Joel N. Meyer. “Quantifying Levels of Dopaminergic Neuron Morphological Alteration and Degeneration in Caenorhabditis elegans.” Journal of Visualized Experiments : Jove, no. 177 (November 2021). https://doi.org/10.3791/62894.
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  - Wang, Lu, Danielle F. Mello, Robert M. Zucker, Nelson A. Rivera, Nicholas M. K. Rogers, Nicholas K. Geitner, William K. Boyes, Mark R. Wiesner, Heileen Hsu-Kim, and Joel N. Meyer. “Lack of Detectable Direct Effects of Silver and Silver Nanoparticles on Mitochondria in Mouse Hepatocytes.” Environmental Science & Technology, August 2021. https://doi.org/10.1021/acs.est.1c02295.
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  - Hershberger, Kathleen A., John P. Rooney, Elena A. Turner, Lauren J. Donoghue, Rakesh Bodhicharla, Laura L. Maurer, Ian T. Ryde, et al. “Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans.” Redox Biol 43 (July 2021): 102000. https://doi.org/10.1016/j.redox.2021.102000.
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  - Hartman, Jessica H., Samuel J. Widmayer, Christina M. Bergemann, Dillon E. King, Katherine S. Morton, Riccardo F. Romersi, Laura E. Jameson, et al. “Xenobiotic metabolism and transport in Caenorhabditis elegans.” Journal of Toxicology and Environmental Health. Part B, Critical Reviews 24, no. 2 (February 2021): 51–94. https://doi.org/10.1080/10937404.2021.1884921.
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  - Gonzalez-Hunt, Claudia P., Anthony L. Luz, Ian T. Ryde, Elena A. Turner, Olga R. Ilkayeva, Dhaval P. Bhatt, Matthew D. Hirschey, and Joel N. Meyer. “Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone.” Toxicology 447 (January 15, 2021): 152630. https://doi.org/10.1016/j.tox.2020.152630.
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  - Huang, Wei, Yaping Liu, Anthony Luz, Mark Berrong, Joel N. Meyer, Yujing Zou, Excel Swann, et al. “Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-Induced Myeloid-Derived Suppressor Cells.” Front Immunol 12 (2021): 754083. https://doi.org/10.3389/fimmu.2021.754083.
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  - King, Dillon E., A Clare Sparling, Rashmi Joglekar, Joel N. Meyer, and Susan K. Murphy. “Direct comparisons of bisulfite pyrosequencing versus targeted bisulfite sequencing.” Micropubl Biol 2021 (2021). https://doi.org/10.17912/micropub.biology.000444.
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  - Leuthner, Tess C., Jessica H. Hartman, Ian T. Ryde, and Joel N. Meyer. “PCR-Based Determination of Mitochondrial DNA Copy Number in Multiple Species.” Methods in Molecular Biology (Clifton, N.J.) 2310 (January 2021): 91–111. https://doi.org/10.1007/978-1-0716-1433-4_8.
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  - Yang, Ping, Zixuan Shao, Nicholas A. Besley, Samantha E. Neal, Kristen L. Buehne, John Park, Hampar Karageozian, et al. “Risuteganib Protects against Hydroquinone-induced Injury in Human RPE Cells.” Invest Ophthalmol Vis Sci 61, no. 10 (August 3, 2020): 35. https://doi.org/10.1167/iovs.61.10.35.
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  - Berky, Axel J., Emily Robie, Ernesto J. Ortiz, Joel N. Meyer, Heileen Hsu-Kim, and William K. Pan. “Evaluation of Peruvian Government Interventions to Reduce Childhood Anemia.” Annals of Global Health 86, no. 1 (August 2020): 98. https://doi.org/10.5334/aogh.2896.
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  - Harris, Jamie B., Jessica H. Hartman, Anthony L. Luz, Joanna Y. Wilson, Audrey Dinyari, and Joel N. Meyer. “Zebrafish CYP1A expression in transgenic Caenorhabditis elegans protects from exposures to benzo[a]pyrene and a complex polycyclic aromatic hydrocarbon mixture.” Toxicology 440 (July 2020): 152473. https://doi.org/10.1016/j.tox.2020.152473.
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  - Zhang, Jinxin, Jessica H. Hartman, Chuyi Chen, Shujie Yang, Qi Li, Zhenhua Tian, Po-Hsun Huang, Lin Wang, Joel N. Meyer, and Tony Jun Huang. “Fluorescence-based sorting of Caenorhabditis elegans via acoustofluidics.” Lab on a Chip 20, no. 10 (May 2020): 1729–39. https://doi.org/10.1039/d0lc00051e.
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  - Nash, Amanda, Mariya Samoylova, Tess Leuthner, Minghua Zhu, Liwen Lin, Joel N. Meyer, and Todd V. Brennan. “Effects of Immunosuppressive Medications on Mitochondrial Function.” The Journal of Surgical Research 249 (May 2020): 50–57. https://doi.org/10.1016/j.jss.2019.12.010.
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  - Neal, Samantha E., Kristen L. Buehne, Nicholas A. Besley, Ping Yang, Peter Silinski, Jiyong Hong, Ian T. Ryde, Joel N. Meyer, and Glenn J. Jaffe. “Resveratrol Protects Against Hydroquinone-Induced Oxidative Threat in Retinal Pigment Epithelial Cells.” Invest Ophthalmol Vis Sci 61, no. 4 (April 9, 2020): 32. https://doi.org/10.1167/iovs.61.4.32.
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  - Mello, Danielle F., Rafael Trevisan, Nelson Rivera, Nicholas K. Geitner, Richard T. Di Giulio, Mark R. Wiesner, Heileen Hsu-Kim, and Joel N. Meyer. “Caveats to the use of MTT, neutral red, Hoechst and Resazurin to measure silver nanoparticle cytotoxicity.” Chemico Biological Interactions 315 (January 2020): 108868. https://doi.org/10.1016/j.cbi.2019.108868.
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  - Hartman, Jessica H., Christopher T. Richie, Kacy L. Gordon, Danielle F. Mello, Priscila Castillo, April Zhu, Yun Wang, et al. “MANF deletion abrogates early larval Caenorhabditis elegans stress response to tunicamycin and Pseudomonas aeruginosa.” European Journal of Cell Biology 98, no. 5–8 (December 2019): 151043. https://doi.org/10.1016/j.ejcb.2019.05.002.
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  - Laranjeiro, Ricardo, Girish Harinath, Jennifer E. Hewitt, Jessica H. Hartman, Mary Anne Royal, Joel N. Meyer, Siva A. Vanapalli, and Monica Driscoll. “Swim exercise in Caenorhabditis elegans extends neuromuscular and gut healthspan, enhances learning ability, and protects against neurodegeneration.” Proceedings of the National Academy of Sciences of the United States of America 116, no. 47 (November 2019): 23829–39. https://doi.org/10.1073/pnas.1909210116.
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  - Leung, Maxwell C. K., and Joel N. Meyer. “Mitochondria as a target of organophosphate and carbamate pesticides: Revisiting common mechanisms of action with new approach methodologies.” Reproductive Toxicology (Elmsford, N.Y.) 89 (October 2019): 83–92. https://doi.org/10.1016/j.reprotox.2019.07.007.
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  - Smith, Latasha L., Ian T. Ryde, Jessica H. Hartman, Riccardo F. Romersi, Zachary Markovich, and Joel N. Meyer. “Strengths and limitations of morphological and behavioral analyses in detecting dopaminergic deficiency in Caenorhabditis elegans.” Neurotoxicology 74 (September 2019): 209–20. https://doi.org/10.1016/j.neuro.2019.07.002.
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  - Dreier, David A., Danielle F. Mello, Joel N. Meyer, and Christopher J. Martyniuk. “Linking Mitochondrial Dysfunction to Organismal and Population Health in the Context of Environmental Pollutants: Progress and Considerations for Mitochondrial Adverse Outcome Pathways.” Environmental Toxicology and Chemistry 38, no. 8 (August 2019): 1625–34. https://doi.org/10.1002/etc.4453.
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  - Maglioni, Silvia, Danielle F. Mello, Alfonso Schiavi, Joel N. Meyer, and Natascia Ventura. “Mitochondrial bioenergetic changes during development as an indicator of C. elegans health-span.” Aging 11, no. 16 (August 2019): 6535–54. https://doi.org/10.18632/aging.102208.
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  - Bachman, Hunter, Hai Fu, Po-Hsun Huang, Zhenhua Tian, Jonah Embry-Seckler, Joseph Rufo, Zhemiao Xie, et al. “Open source acoustofluidics.” Lab on a Chip 19, no. 14 (July 2019): 2404–14. https://doi.org/10.1039/c9lc00340a.
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  - Hartman, Jessica H., Claudia Gonzalez-Hunt, Samantha M. Hall, Ian T. Ryde, Kim A. Caldwell, Guy A. Caldwell, and Joel N. Meyer. “Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration.” International Journal of Molecular Sciences 20, no. 13 (June 2019): E3202. https://doi.org/10.3390/ijms20133202.
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  - Berky, Axel J., Ian T. Ryde, Beth Feingold, Ernesto J. Ortiz, Lauren H. Wyatt, Caren Weinhouse, Heileen Hsu-Kim, Joel N. Meyer, and William K. Pan. “Predictors of mitochondrial DNA copy number and damage in a mercury-exposed rural Peruvian population near artisanal and small-scale gold mining: An exploratory study.” Environmental and Molecular Mutagenesis 60, no. 2 (March 2019): 197–210. https://doi.org/10.1002/em.22244.
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  - Zhang, Jinxin, Shujie Yang, Chuyi Chen, Jessica H. Hartman, Po-Hsun Huang, Lin Wang, Zhenhua Tian, et al. “Surface acoustic waves enable rotational manipulation of Caenorhabditis elegans.” Lab on a Chip 19, no. 6 (March 2019): 984–92. https://doi.org/10.1039/c8lc01012a.
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  - Cothren, Steven D., Joel N. Meyer, and Jessica H. Hartman. “Blinded Visual Scoring of Images Using the Freely-available Software Blinder.” Bio Protocol 8, no. 23 (December 2018): e3103. https://doi.org/10.21769/bioprotoc.3103.
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  - Hibshman, Jonathan D., Tess C. Leuthner, Chelsea Shoben, Danielle F. Mello, David R. Sherwood, Joel N. Meyer, and L Ryan Baugh. “Nonselective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans.” American Journal of Physiology. Cell Physiology 315, no. 6 (December 2018): C781–92. https://doi.org/10.1152/ajpcell.00109.2018.
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  - Weinhouse, Caren, Lisa Truong, Joel N. Meyer, and Patrick Allard. “Caenorhabditis elegans as an emerging model system in environmental epigenetics.” Environmental and Molecular Mutagenesis 59, no. 7 (August 2018): 560–75. https://doi.org/10.1002/em.22203.
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  - Hartman, Jessica H., Latasha L. Smith, Kacy L. Gordon, Ricardo Laranjeiro, Monica Driscoll, David R. Sherwood, and Joel N. Meyer. “Swimming Exercise and Transient Food Deprivation in Caenorhabditis elegans Promote Mitochondrial Maintenance and Protect Against Chemical-Induced Mitotoxicity.” Scientific Reports 8, no. 1 (May 2018): 8359. https://doi.org/10.1038/s41598-018-26552-9.
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  - Sanders, Laurie H., Jeremy P. Rouanet, Evan H. Howlett, Tess C. Leuthner, John P. Rooney, J Timothy Greenamyre, and Joel N. Meyer. “Newly Revised Quantitative PCR-Based Assay for Mitochondrial and Nuclear DNA Damage.” Curr Protoc Toxicol 76, no. 1 (May 2018): e50. https://doi.org/10.1002/cptx.50.
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  - Meyer, Joel N., Jessica H. Hartman, and Danielle F. Mello. “Mitochondrial Toxicity.” Toxicological Sciences : An Official Journal of the Society of Toxicology 162, no. 1 (March 2018): 15–23. https://doi.org/10.1093/toxsci/kfy008.
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  - Luz, Anthony L., Christopher D. Kassotis, Heather M. Stapleton, and Joel N. Meyer. “The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARγ activation, in 3T3-L1 cells.” Toxicology 393 (January 2018): 150–59. https://doi.org/10.1016/j.tox.2017.11.010.
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  - Meyer, Joel N., and Sherine S. L. Chan. “Sources, mechanisms, and consequences of chemical-induced mitochondrial toxicity.” Toxicology 391 (November 2017): 2–4. https://doi.org/10.1016/j.tox.2017.06.002.
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  - Meyer, Joel N., Tess C. Leuthner, and Anthony L. Luz. “Mitochondrial fusion, fission, and mitochondrial toxicity.” Toxicology 391 (November 2017): 42–53. https://doi.org/10.1016/j.tox.2017.07.019.
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  - Gonzalez-Moragas, Laura, Laura L. Maurer, Victoria M. Harms, Joel N. Meyer, Anna Laromaine, and Anna Roig. “Materials and toxicological approaches to study metal and metal-oxide nanoparticles in the model organism Caenorhabditis elegans.” Materials Horizons 4, no. 5 (September 2017): 719–46. https://doi.org/10.1039/c7mh00166e.
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  - Hartman, Jessica H., Jordan S. Kozal, Richard T. Di Giulio, and Joel N. Meyer. “Zebrafish have an ethanol-inducible hepatic 4-nitrophenol hydroxylase that is not CYP2E1-like.” Environmental Toxicology and Pharmacology 54 (September 2017): 142–45. https://doi.org/10.1016/j.etap.2017.07.004.
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  - Luz, Anthony L., Tewodros R. Godebo, Latasha L. Smith, Tess C. Leuthner, Laura L. Maurer, and Joel N. Meyer. “Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability.” Toxicology 387 (July 2017): 81–94. https://doi.org/10.1016/j.tox.2017.05.018.
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  - Weinstein, John R., Renée Asteria-Peñaloza, Anaité Diaz-Artiga, Gilberto Davila, S Katharine Hammond, Ian T. Ryde, Joel N. Meyer, Neal Benowitz, and Lisa M. Thompson. “Exposure to polycyclic aromatic hydrocarbons and volatile organic compounds among recently pregnant rural Guatemalan women cooking and heating with solid fuels.” International Journal of Hygiene and Environmental Health 220, no. 4 (June 2017): 726–35. https://doi.org/10.1016/j.ijheh.2017.03.002.
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  - Wyatt, Lauren H., Anthony L. Luz, Xiou Cao, Laura L. Maurer, Ashley M. Blawas, Alejandro Aballay, William K. Y. Pan, and Joel N. Meyer. “Effects of methyl and inorganic mercury exposure on genome homeostasis and mitochondrial function in Caenorhabditis elegans.” Dna Repair 52 (April 2017): 31–48. https://doi.org/10.1016/j.dnarep.2017.02.005.
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  - Lewis, Jessica J., John W. Hollingsworth, Ryan T. Chartier, Ellen M. Cooper, William Michael Foster, Genna L. Gomes, Peter S. Kussin, et al. “Biogas Stoves Reduce Firewood Use, Household Air Pollution, and Hospital Visits in Odisha, India.” Environ Sci Technol 51, no. 1 (January 3, 2017): 560–69. https://doi.org/10.1021/acs.est.6b02466.
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  - Chen, Yang, Joel N. Meyer, Helene Z. Hill, Gudrun Lange, Michael R. Condon, Jacquelyn C. Klein, Duncan Ndirangu, and Michael J. Falvo. “Role of mitochondrial DNA damage and dysfunction in veterans with Gulf War Illness.” Plos One 12, no. 9 (January 2017): e0184832. https://doi.org/10.1371/journal.pone.0184832.
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  - Chen, Yang, Joel N. Meyer, Helene Z. Hill, Gudrun Lange, Michael R. Condon, Jacquelyn C. Klein, Duncan Ndirangu, and Michael J. Falvo. “Correction: Role of mitochondrial DNA damage and dysfunction in veterans with Gulf War Illness.” Plos One 12, no. 10 (January 2017): e0186711. https://doi.org/10.1371/journal.pone.0186711.
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  - Hartman, Jessica H., Grover P. Miller, and Joel N. Meyer. “Toxicological Implications of Mitochondrial Localization of CYP2E1.” Toxicology Research 6, no. 3 (January 2017): 273–89. https://doi.org/10.1039/c7tx00020k.
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  - Luz, Anthony T., Tewodros R. Godebo, Dhaval P. Bhatt, Olga R. Ilkayeva, Laura L. Maurer, Matthew D. Hirschey, and Joel N. Meyer. “Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-Like Effect in Caenorhabditis elegans.” Toxicol Sci 154, no. 1 (November 2016): 195. https://doi.org/10.1093/toxsci/kfw185.
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  - Santa-Gonzalez, Gloria A., Andrea Gomez-Molina, Mauricio Arcos-Burgos, Joel N. Meyer, and Mauricio Camargo. “Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest.” Redox Biology 9 (October 2016): 124–33. https://doi.org/10.1016/j.redox.2016.07.004.
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  - Luz, Anthony L., and Joel N. Meyer. “Effects of reduced mitochondrial DNA content on secondary mitochondrial toxicant exposure in Caenorhabditis elegans.” Mitochondrion 30 (September 2016): 255–64. https://doi.org/10.1016/j.mito.2016.08.014.
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  - Maurer, Laura L., Xinyu Yang, Adam J. Schindler, Ross K. Taggart, Chuanjia Jiang, Heileen Hsu-Kim, David R. Sherwood, and Joel N. Meyer. “Intracellular trafficking pathways in silver nanoparticle uptake and toxicity in Caenorhabditis elegans.” Nanotoxicology 10, no. 7 (September 2016): 831–35. https://doi.org/10.3109/17435390.2015.1110759.
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  - Luz, Anthony L., Tewodros R. Godebo, Dhaval P. Bhatt, Olga R. Ilkayeva, Laura L. Maurer, Matthew D. Hirschey, and Joel N. Meyer. “From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans.” Toxicol Sci 152, no. 2 (August 2016): 349–62. https://doi.org/10.1093/toxsci/kfw093.
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  - Luz, Anthony L., Cristina Lagido, Matthew D. Hirschey, and Joel N. Meyer. “In Vivo Determination of Mitochondrial Function Using Luciferase-Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant-Induced Dysfunction.” Curr Protoc Toxicol 69 (August 1, 2016): 25.8.1-25.8.22. https://doi.org/10.1002/cptx.10.
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  - Maurer, L. L., and J. N. Meyer. “A systematic review of evidence for silver nanoparticle-induced mitochondrial toxicity.” Environmental Science: Nano 3, no. 2 (April 1, 2016): 311–22. https://doi.org/10.1039/c5en00187k.
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  - Wyatt, Lauren H., Sarah E. Diringer, Laura A. Rogers, Heileen Hsu-Kim, William K. Pan, and Joel N. Meyer. “Antagonistic Growth Effects of Mercury and Selenium in Caenorhabditis elegans Are Chemical-Species-Dependent and Do Not Depend on Internal Hg/Se Ratios.” Environmental Science & Technology 50, no. 6 (March 2016): 3256–64. https://doi.org/10.1021/acs.est.5b06044.
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  - Gonzalez-Hunt, Claudia P., John P. Rooney, Ian T. Ryde, Charumathi Anbalagan, Rashmi Joglekar, and Joel N. Meyer. “PCR-Based Analysis of Mitochondrial DNA Copy Number, Mitochondrial DNA Damage, and Nuclear DNA Damage.” Current Protocols in Toxicology 67 (February 2016): 20.11.1-20.11.25. https://doi.org/10.1002/0471140856.tx2011s67.
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  - Van Houten, Bennett, Senyene E. Hunter, and Joel N. Meyer. “Mitochondrial DNA damage induced autophagy, cell death, and disease.” Frontiers in Bioscience (Landmark Edition) 21, no. 1 (January 2016): 42–54. https://doi.org/10.2741/4375.
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  - “Erratum.” Autophagy 12, no. 2 (2016): 443. https://doi.org/10.1080/15548627.2016.1147886.
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  - Luz, Anthony L., Latasha L. Smith, John P. Rooney, and Joel N. Meyer. “Seahorse Xfe 24 Extracellular Flux Analyzer-Based Analysis of Cellular Respiration in Caenorhabditis elegans.” Current Protocols in Toxicology 66 (November 2015): 25.7.1-25.7.15. https://doi.org/10.1002/0471140856.tx2507s66.
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  - Maurer, Laura L., Ian T. Ryde, Xinyu Yang, and Joel N. Meyer. “Caenorhabditis elegans as a Model for Toxic Effects of Nanoparticles: Lethality, Growth, and Reproduction.” Current Protocols in Toxicology 66 (November 2015): 20.10.1-20.10.25. https://doi.org/10.1002/0471140856.tx2010s66.
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  - Gorka, Danielle E., Joshua S. Osterberg, Carley A. Gwin, Benjamin P. Colman, Joel N. Meyer, Emily S. Bernhardt, Claudia K. Gunsch, Richard T. DiGulio, and Jie Liu. “Reducing Environmental Toxicity of Silver Nanoparticles through Shape Control.” Environmental Science & Technology 49, no. 16 (August 2015): 10093–98. https://doi.org/10.1021/acs.est.5b01711.
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  - Robey, R Brooks, Judith Weisz, Nancy B. Kuemmerle, Anna C. Salzberg, Arthur Berg, Dustin G. Brown, Laura Kubik, et al. “Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?” Carcinogenesis 36 Suppl 1 (June 2015): S203–31. https://doi.org/10.1093/carcin/bgv037.
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  - Bone, Audrey J., Cole W. Matson, Benjamin P. Colman, Xinyu Yang, Joel N. Meyer, and Richard T. Di Giulio. “Silver nanoparticle toxicity to Atlantic killifish (Fundulus heteroclitus) and Caenorhabditis elegans: a comparison of mesocosm, microcosm, and conventional laboratory studies.” Environmental Toxicology and Chemistry 34, no. 2 (February 2015): 275–82. https://doi.org/10.1002/etc.2806.
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  - Jayasundara, Nishad, Lindsey Van Tiem Garner, Joel N. Meyer, Kyle N. Erwin, and Richard T. Di Giulio. “AHR2-Mediated transcriptomic responses underlying the synergistic cardiac developmental toxicity of PAHs.” Toxicological Sciences : An Official Journal of the Society of Toxicology 143, no. 2 (February 2015): 469–81. https://doi.org/10.1093/toxsci/kfu245.
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  - Luz, Anthony L., John P. Rooney, Laura L. Kubik, Claudia P. Gonzalez, Dong Hoon Song, and Joel N. Meyer. “Mitochondrial Morphology and Fundamental Parameters of the Mitochondrial Respiratory Chain Are Altered in Caenorhabditis elegans Strains Deficient in Mitochondrial Dynamics and Homeostasis Processes.” Plos One 10, no. 6 (January 2015): e0130940. https://doi.org/10.1371/journal.pone.0130940.
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  - Rooney, John P., Ian T. Ryde, Laurie H. Sanders, Evan H. Howlett, Meryl D. Colton, Kaylyn E. Germ, Greg D. Mayer, J Timothy Greenamyre, and Joel N. Meyer. “PCR based determination of mitochondrial DNA copy number in multiple species.” Methods Mol Biol 1241 (2015): 23–38. https://doi.org/10.1007/978-1-4939-1875-1_3.
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  - Shaughnessy, Daniel T., Kimberly McAllister, Leroy Worth, Astrid C. Haugen, Joel N. Meyer, Frederick E. Domann, Bennett Van Houten, et al. “Mitochondria, energetics, epigenetics, and cellular responses to stress.” Environ Health Perspect 122, no. 12 (December 2014): 1271–78. https://doi.org/10.1289/ehp.1408418.
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  - Ahn, Jeong-Min, Hyun-Jeong Eom, Xinyu Yang, Joel N. Meyer, and Jinhee Choi. “Comparative toxicity of silver nanoparticles on oxidative stress and DNA damage in the nematode, Caenorhabditis elegans.” Chemosphere 108 (August 2014): 343–52. https://doi.org/10.1016/j.chemosphere.2014.01.078.
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  - Colton, Meryl D., Kevin W. H. Kwok, Jennifer A. Brandon, Isaac H. Warren, Ian T. Ryde, Ellen M. Cooper, David E. Hinton, Daniel Rittschof, and Joel N. Meyer. “Developmental toxicity and DNA damage from exposure to parking lot runoff retention pond samples in the Japanese medaka (Oryzias latipes).” Marine Environmental Research 99 (August 2014): 117–24. https://doi.org/10.1016/j.marenvres.2014.04.007.
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  - Rooney, J. P., A. L. Luz, C. P. González-Hunt, R. Bodhicharla, I. T. Ryde, C. Anbalagan, and J. N. Meyer. “Effects of 5'-fluoro-2-deoxyuridine on mitochondrial biology in Caenorhabditis elegans.” Experimental Gerontology 56 (August 2014): 69–76. https://doi.org/10.1016/j.exger.2014.03.021.
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  - Sendoel, Ataman, Simona Maida, Xue Zheng, Youjin Teo, Lilli Stergiou, Carlo-Alberto Rossi, Deni Subasic, et al. “DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis.” Nature Cell Biology 16, no. 8 (August 2014): 812–20. https://doi.org/10.1038/ncb3010.
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  - Levard, C., X. Yang, J. N. Meyer, and G. V. Lowry. “Response to comment on "sulfidation of silver nanoparticles: Natural antidote to their toxicity".” Environmental Science and Technology 48, no. 10 (May 20, 2014): 6051–52. https://doi.org/10.1021/es500991r.
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  - Yang, Xinyu, Chuanjia Jiang, Heileen Hsu-Kim, Appala Raju Badireddy, Michael Dykstra, Mark Wiesner, David E. Hinton, and Joel N. Meyer. “Silver nanoparticle behavior, uptake, and toxicity in Caenorhabditis elegans: effects of natural organic matter.” Environmental Science & Technology 48, no. 6 (March 2014): 3486–95. https://doi.org/10.1021/es404444n.
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  - Bodhicharla, Rakesh, Ian T. Ryde, G. L. Prasad, and Joel N. Meyer. “The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces mitochondrial and nuclear DNA damage in Caenorhabditis elegans.” Environmental and Molecular Mutagenesis 55, no. 1 (January 2014): 43–50. https://doi.org/10.1002/em.21815.
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  - Choi, J., O. V. Tsyusko, J. M. Unrine, N. Chatterjee, J. M. Ahn, X. Yang, B. L. Thornton, I. T. Ryde, D. Starnes, and J. N. Meyer. “A micro-sized model for the in vivo study of nanoparticle toxicity: What has Caenorhabditis elegans taught us?” Environmental Chemistry 11, no. 3 (January 1, 2014): 227–46. https://doi.org/10.1071/EN13187.
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  - Furda, Amy, Janine H. Santos, Joel N. Meyer, and Bennett Van Houten. “Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells.” Methods in Molecular Biology (Clifton, N.J.) 1105 (January 2014): 419–37. https://doi.org/10.1007/978-1-62703-739-6_31.
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  - González-Hunt, Claudia P., Maxwell C. K. Leung, Rakesh K. Bodhicharla, Madeline G. McKeever, Andrew E. Arrant, Kathleen M. Margillo, Ian T. Ryde, et al. “Exposure to mitochondrial genotoxins and dopaminergic neurodegeneration in Caenorhabditis elegans.” Plos One 9, no. 12 (January 2014): e114459. https://doi.org/10.1371/journal.pone.0114459.
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  - Rand, Amy A., John P. Rooney, Craig M. Butt, Joel N. Meyer, and Scott A. Mabury. “Cellular toxicity associated with exposure to perfluorinated carboxylates (PFCAs) and their metabolic precursors.” Chemical Research in Toxicology 27, no. 1 (January 2014): 42–50. https://doi.org/10.1021/tx400317p.
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  - Rooney, John P., Rakesh Bodhicharla, Amanda S. Bess, Maxwell C. K. Leung, Ian T. Ryde, Alex Q. Ji, and Joel N. Meyer. “Developmental exposure to ultraviolet C radiation results in altered energy production later in life in Caenorhabditis elegans.” Mitochondrion 13, no. 6 (November 2013): 922–922. https://doi.org/10.1016/j.mito.2013.07.063.
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  - Arnold, M. C., A. R. Badireddy, M. R. Wiesner, R. T. Di Giulio, and J. N. Meyer. “Cerium oxide nanoparticles are more toxic than equimolar bulk cerium oxide in Caenorhabditis elegans.” Archives of Environmental Contamination and Toxicology 65, no. 2 (August 2013): 224–33. https://doi.org/10.1007/s00244-013-9905-5.
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  - Leung, Maxwell C. K., John P. Rooney, Ian T. Ryde, Autumn J. Bernal, Amanda S. Bess, Tracey L. Crocker, Alex Q. Ji, and Joel N. Meyer. “Effects of early life exposure to ultraviolet C radiation on mitochondrial DNA content, transcription, ATP production, and oxygen consumption in developing Caenorhabditis elegans.” Bmc Pharmacology & Toxicology 14 (February 2013): 9. https://doi.org/10.1186/2050-6511-14-9.
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  - Bess, Amanda S., Ian T. Ryde, David E. Hinton, and Joel N. Meyer. “UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts.” Journal of Biochemical and Molecular Toxicology 27, no. 1 (January 2013): 28–41. https://doi.org/10.1002/jbt.21440.
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  - Bess, Amanda S., Maxwell C. K. Leung, Ian T. Ryde, John P. Rooney, David E. Hinton, and Joel N. Meyer. “Effects of mutations in mitochondrial dynamics-related genes on the mitochondrial response to ultraviolet C radiation in developing Caenorhabditis elegans.” Worm 2, no. 1 (January 2013): e23763. https://doi.org/10.4161/worm.23763.
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  - Levard, Clement, Ernest M. Hotze, Benjamin P. Colman, Amy L. Dale, Lisa Truong, X. Y. Yang, Audrey J. Bone, et al. “Sulfidation of silver nanoparticles: natural antidote to their toxicity.” Environmental Science & Technology 47, no. 23 (January 2013): 13440–48. https://doi.org/10.1021/es403527n.
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  - Turner, Elena A., Gretchen L. Kroeger, Mariah C. Arnold, B Lila Thornton, Richard T. Di Giulio, and Joel N. Meyer. “Assessing different mechanisms of toxicity in mountaintop removal/valley fill coal mining-affected watershed samples using Caenorhabditis elegans.” Plos One 8, no. 9 (January 2013): e75329. https://doi.org/10.1371/journal.pone.0075329.
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  - Meyer, J. N., M. C. K. Leung, J. P. Rooney, A. Sendoel, M. O. Hengartner, G. E. Kisby, and A. S. Bess. “Mitochondria as a target of environmental toxicants.” Toxicological Sciences 134, no. 1 (2013): 1–17. https://doi.org/10.1093/toxsci/kft102.
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  - Meyer, Joel N., and Amanda S. Bess. “Involvement of autophagy and mitochondrial dynamics in determining the fate and effects of irreparable mitochondrial DNA damage.” Autophagy 8, no. 12 (December 2012): 1822–23. https://doi.org/10.4161/auto.21741.
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  - Brar, Sukhdev S., Joel N. Meyer, Carl D. Bortner, Bennett Van Houten, and William J. Martin. “Mitochondrial DNA-depleted A549 cells are resistant to bleomycin.” American Journal of Physiology. Lung Cellular and Molecular Physiology 303, no. 5 (September 2012): L413–24. https://doi.org/10.1152/ajplung.00343.2011.
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  - Bess, A. S., T. L. Crocker, I. T. Ryde, and J. N. Meyer. “Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans.” Nucleic Acids Research 40, no. 16 (2012): 7916–31. https://doi.org/10.1093/nar/gks532.
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  - Furda, Amy M., Amanda Smith Bess, Joel N. Meyer, and Bennett Van Houten. “Analysis of DNA damage and repair in nuclear and mitochondrial DNA of animal cells using quantitative PCR.” Methods in Molecular Biology (Clifton, N.J.) 920 (January 2012): 111–32. https://doi.org/10.1007/978-1-61779-998-3_9.
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  - Hunter, S. E., M. A. Gustafson, K. M. Margillo, S. A. Lee, I. T. Ryde, and J. N. Meyer. “In vivo repair of alkylating and oxidative DNA damage in the mitochondrial and nuclear genomes of wild-type and glycosylase-deficient Caenorhabditis elegans.” Dna Repair (Amst) 11, no. 11 (2012): 857–63.
  - Kasiviswanathan, R., M. A. Gustafson, W. C. Copeland, and J. N. Meyer. “Human mitochondrial DNA polymerase gamma exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers.” J Biol Chem 287, no. 12 (2012): 9222–29.
  - Meyer, J. N. “In vivo analysis of the ability of Caenorhabditis elegans to metabolize the human CYP3A and CYP1A2 diagnostic substrates testosterone and phenacetin (Accepted).” Worm Breeder’S Gazette, 2012.
  - Meyer, J. N. “A call for fuller reporting of toxicity test data (Accepted).” Integrated Environmental Assessment and Management, 2012.
  - Yang, Xinyu, Andreas Gondikas, Stella Marinakos, Melanie Auffan, Jie Liu, Heileen Hsu-Kim, and Joel Meyer. “The mechanism of silver nanoparticle toxicity is dependent on dissolved silver and surface coating in Caenorhabditis elegans (Accepted).” Environmental Science & Technology, 2011.
  - Hunter, Senyene E., Dawoon Jung, Richard T. Di Giulio, and Joel N. Meyer. “The QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number.” Methods (San Diego, Calif.) 51, no. 4 (August 2010): 444–51. https://doi.org/10.1016/j.ymeth.2010.01.033.
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  - Boamah, Ernest K., Angelika Brekman, Maria Tomasz, Natura Myeku, Maria Figueiredo-Pereira, Senyene Hunter, Joel Meyer, Rahul C. Bhosle, and Jill Bargonetti. “DNA adducts of decarbamoyl mitomycin C efficiently kill cells without wild-type p53 resulting from proteasome-mediated degradation of checkpoint protein 1.” Chemical Research in Toxicology 23, no. 7 (July 2010): 1151–62. https://doi.org/10.1021/tx900420k.
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  - Alexeyenko, Andrey, Deena M. Wassenberg, Edward K. Lobenhofer, Jerry Yen, Elwood Linney, Erik L. L. Sonnhammer, and Joel N. Meyer. “Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity.” Plos One 5, no. 5 (May 5, 2010): e10465. https://doi.org/10.1371/journal.pone.0010465.
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  - Meyer, Joel N. “QPCR: a tool for analysis of mitochondrial and nuclear DNA damage in ecotoxicology.” Ecotoxicology (London, England) 19, no. 4 (April 2010): 804–11. https://doi.org/10.1007/s10646-009-0457-4.
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  - Alexeyenko, A., D. M. Wassenberg, E. K. Lobenhofer, J. Yen, E. Linney, E. L. L. Sonnhammer, and J. N. Meyer. “Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity.” Plos One 5, no. 5 (2010): e10465. https://doi.org/10.1371/journal.pone.0010465.
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  - Boyd, W. A., T. L. Crocker, A. M. Rodriguez, M. C. Leung, D. W. Lehmann, J. H. Freedman, B. Van Houten, and J. N. Meyer. “Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure.” Mutat Res 683, no. 1–2 (2010): 57–67.
  - Leung, M. C. K., J. V. Goldstone, W. A. Boyd, J. H. Freedman, and J. N. Meyer. “Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B1 but not benzo[a]pyrene in vivo.” Toxicological Sciences 118 (2010): 444–53.
  - Meyer, J. N., C. A. Lord, X. Y. Yang, E. A. Turner, A. R. Badireddy, S. Marinakos, A. Chilkoti, M. R. Wiesner, and M. Auffan. “Intracellular uptake and associated toxicity of silver nanoparticles in Caenorhabditis elegans.” Aquatic Toxicol 100 (2010): 140–50.
  - Meyer, J. N., and B. Van Houten. “Apparently normal DNA repair and transcript expression in the RB885 strain carrying an intronic deletion in the xpc-1 gene.” Worm Breeder’S Gazette 18 (2010): 23.
  - Alexeyenko, A., D. M. Wassenberg, E. K. Lobenhofer, J. Yen, E. L. L. Sonnhammer, E. Linney, and J. N. Meyer. “Interactome-based analysis of the transcriptomic response to dioxin in developing zebrafish Danio rerio.” Plos One 5 (2010): e10465.
  - Haugen, Astrid C., Nicholas A. Di Prospero, Joel S. Parker, Rick D. Fannin, Jeff Chou, Joel N. Meyer, Christopher Halweg, et al. “Altered gene expression and DNA damage in peripheral blood cells from Friedreich's ataxia patients: cellular model of pathology.” Plos Genetics 6, no. 1 (January 2010): e1000812. https://doi.org/10.1371/journal.pgen.1000812.
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  - Jung, Dawoon, Youngeun Cho, Joel N. Meyer, and Richard T. Di Giulio. “The long amplicon quantitative PCR for DNA damage assay as a sensitive method of assessing DNA damage in the environmental model, Atlantic killifish (Fundulus heteroclitus).” Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp 149, no. 2 (March 2009): 182–86. https://doi.org/10.1016/j.cbpc.2008.07.007.
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  - Eischeid, Anne C., Joel N. Meyer, and Karl G. Linden. “UV disinfection of adenoviruses: molecular indications of DNA damage efficiency.” Applied and Environmental Microbiology 75, no. 1 (January 2009): 23–28. https://doi.org/10.1128/aem.02199-08.
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  - Eischeid, A. C., J. N. Meyer, and K. G. Linden. “DNA damage assessment in UV-treated adenovirus.” Water Quality Technology Conference and Exposition 2008, December 1, 2008, 2968–75.
  - Leung, Maxwell C. K., Phillip L. Williams, Alexandre Benedetto, Catherine Au, Kirsten J. Helmcke, Michael Aschner, and Joel N. Meyer. “Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology.” Toxicological Sciences : An Official Journal of the Society of Toxicology 106, no. 1 (November 2008): 5–28. https://doi.org/10.1093/toxsci/kfn121.
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  - Billiard, Sonya M., Joel N. Meyer, Deena M. Wassenberg, Peter V. Hodson, and Richard T. Di Giulio. “Nonadditive effects of PAHs on Early Vertebrate Development: mechanisms and implications for risk assessment.” Toxicological Sciences : An Official Journal of the Society of Toxicology 105, no. 1 (September 2008): 5–23. https://doi.org/10.1093/toxsci/kfm303.
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  - Jung, Dawoon, Joel N. Meyer, and Richard T. Di Giulio. “Effects of polycyclic aromatic hydrocarbons on mitochondrial DNA damage in the killifish (Fundulus heteroclitus).” Marine Environmental Research 66, no. 1 (July 1, 2008): 32–32.
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  - Burnett, Karen G., Lisa J. Bain, William S. Baldwin, Gloria V. Callard, Sarah Cohen, Richard T. Di Giulio, David H. Evans, et al. “Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics.” Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics 2, no. 4 (December 2007): 257–86. https://doi.org/10.1016/j.cbd.2007.09.001.
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  - Wielgus, Albert R., Colin F. Chignell, David S. Miller, Ben Van Houten, Joel Meyer, Dan-Ning Hu, and Joan E. Roberts. “Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wort.” Photochemistry and Photobiology 83, no. 3 (May 2007): 706–13. https://doi.org/10.1562/2006-08-09-ra-1001.
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  - Chan, Sherine S. L., Janine H. Santos, Joel N. Meyer, Bhaskar S. Mandavilli, Dennis L. Cook, Consuelo L. McCash, Grace E. Kissling, et al. “Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination.” Environmental and Molecular Mutagenesis 48, no. 3–4 (April 2007): 190–200. https://doi.org/10.1002/em.20191.
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  - Meyer, Joel N., Windy A. Boyd, Gregory A. Azzam, Astrid C. Haugen, Jonathan H. Freedman, and Bennett Van Houten. “Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans.” Genome Biology 8, no. 5 (January 2007): R70. https://doi.org/10.1186/gb-2007-8-5-r70.
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  - Santos, Janine Hertzog, Joel N. Meyer, and Bennett Van Houten. “Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis.” Human Molecular Genetics 15, no. 11 (June 2006): 1757–68. https://doi.org/10.1093/hmg/ddl098.
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  - Santos, Janine H., Joel N. Meyer, Bhaskar S. Mandavilli, and Bennett Van Houten. “Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells.” Methods in Molecular Biology (Clifton, N.J.) 314 (January 2006): 183–99. https://doi.org/10.1385/1-59259-973-7:183.
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  - Timme-Laragy, Alicia R., Joel N. Meyer, Robert A. Waterland, and Richard T. Di Giulio. “Analysis of CpG methylation in the killifish CYP1A promoter.” Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp 141, no. 4 (August 2005): 406–11. https://doi.org/10.1016/j.cbpc.2005.09.009.
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  - Meyer, Joel N., David C. Volz, Jonathan H. Freedman, and Richard T. Di Giulio. “Differential display of hepatic mRNA from killifish (Fundulus heteroclitus) inhabiting a Superfund estuary.” Aquatic Toxicology (Amsterdam, Netherlands) 73, no. 4 (July 2005): 327–41. https://doi.org/10.1016/j.aquatox.2005.03.022.
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  - Santos, Janine Hertzog, Joel N. Meyer, Milan Skorvaga, Lois A. Annab, and Bennett Van Houten. “Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage.” Aging Cell 3, no. 6 (December 2004): 399–411. https://doi.org/10.1111/j.1474-9728.2004.00124.x.
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  - Meyer, Joel N., Jim D. Smith, Gary W. Winston, and Richard T. Di Giulio. “Antioxidant defenses in killifish (Fundulus heteroclitus) exposed to contaminated sediments and model prooxidants: short-term and heritable responses.” Aquatic Toxicology (Amsterdam, Netherlands) 65, no. 4 (December 2003): 377–95. https://doi.org/10.1016/j.aquatox.2003.06.001.
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  - Meyer, Joel N., Deena M. Wassenberg, Sibel I. Karchner, Mark E. Hahn, and Richard T. Di Giulio. “Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories.” Environmental Toxicology and Chemistry 22, no. 10 (October 2003): 2337–43. https://doi.org/10.1897/02-495.
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  - Meyer, J. N., and R. T. Di Giulio. “Heritable adaptation and fitness costs in killifish (Fundulus heteroclitus) inhabiting a polluted estuary.” Ecological Applications 13, no. 2 (January 1, 2003): 490–503. https://doi.org/10.1890/1051-0761(2003)013[0490:HAAFCI]2.0.CO;2.
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  - Meyer, Joel, and Richard Di Giulio. “Patterns of heritability of decreased EROD activity and resistance to PCB 126-induced teratogenesis in laboratory-reared offspring of killifish (Fundulus heteroclitus) from a creosote-contaminated site in the Elizabeth River, VA, USA.” Marine Environmental Research 54, no. 3–5 (September 2002): 621–26. https://doi.org/10.1016/s0141-1136(02)00170-8.
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  - Meyer, Joel N., Diane E. Nacci, and Richard T. Di Giulio. “Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments.” Toxicological Sciences : An Official Journal of the Society of Toxicology 68, no. 1 (July 2002): 69–81. https://doi.org/10.1093/toxsci/68.1.69.
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  - Meyer, J. N., E. D. MacLean, and R. T. Di Giulio. “Increased sensitivity to oxidative stress in a creosote-adapted population of mummichog (Fundulus heteroclitus).” Marine Environmental Research 50, no. 1–5 (January 1, 2000): 78. https://doi.org/10.1016/s0141-1136(00)00158-6.
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  - Keller, J. M., J. N. Meyer, M. Mattie, T. Augspurger, M. Rau, J. Dong, and E. D. Levin. “Assessment of immunotoxicology in wild populations: Review and recommendations.” Reviews in Toxicology 3, no. 1–4 (December 1, 1999): 167–212.
- Book Sections
  - Maurer, L. L., A. L. Luz, and J. N. Meyer. “Detection of Mitochondrial Toxicity of Environmental Pollutants Using Caenorhabditis elegans.” In Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants, 2–2:655–89, 2018. https://doi.org/10.1002/9781119329725.ch43.
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  - Furda, Amy M., Amanda Smith Bess, Joel N. Meyer, and Bennett Van Houten. “Analysis of DNA Damage and Repair in Nuclear and Mitochondrial DNA of Animal Cells Using Quantitative PCR.” In Methods in Molecular Biology, 111–32. Humana Press, 2012. https://doi.org/10.1007/978-1-61779-998-3_9.
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  - Weintraub, E. R. “Introduction.” In Toward a History of Game Theory, edited by E. R. Weintraub, 3–12. Durham and London: Duke University Press, 1992.
- Other Articles
  - Klionsky, Daniel J., Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, et al. “Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).” Autophagy, 2016. https://doi.org/10.1080/15548627.2015.1100356.
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- Conference Papers
  - Maeso-Díaz, Raquel, George D. Dalton, Sehhoon Oh, Kuo Du, Linda Tang, Tianyi Chen, Rajesh K. Dutta, Jessica H. Hartman, Joel N. Meyer, and Anna Mae Diehl. “Aging reduces liver resiliency by dysregulating Hedgehog signaling.” In Aging Cell, 21:e13530, 2022. https://doi.org/10.1111/acel.13530.
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  - Maglioni, S., A. Schiavi, M. Melcher, V. Brinkmann, Z. Luo, A. Laromaine, N. Raimundo, J. N. Meyer, F. Distelmaier, and N. Ventura. “Lutein rescues a nlg-1-mediated synaptic defect in a C. elegans mitochondrial complex I deficiency model.” In Naunyn Schmiedebergs Archives of Pharmacology, 395:S59–S59, 2022.
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  - Alexander, Thomas, Michael J. Falvo, Ian Ryde, Jacquelyn Klein-Adams, Duncan S. Ndirangu, Matthew Watson, Wei Qian, Nancy A. Eager, Michael Condon, and Joel N. Meyer. “Characterizing The Bioenergetic Profile Of White Blood Cells For Utility In Assessing Mitochondrial Dysfunction In Gulf War Illness.” In Medicine and Science in Sports and Exercise, 52:302–302, 2020.
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  - King, D., M. Martinez, D. Lloyd, R. Maguire, C. Hoyo, J. N. Meyer, and S. K. Murphy. “Analysis of Illumina 450K DNA Methylation in NEST Cord Blood Reveals Sex Differences at Mitochondrial Genes in the Nuclear Genome.” In Environmental and Molecular Mutagenesis, 61:34–35, 2020.
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  - Leuthner, T. C., R. N. Keith, C. Jackson, S. P. Glaholt, J. N. Meyer, and J. R. Shaw. “Variation in Signatures of Cadmium-induced Mitochondrial DNA Mutations Reveal Evolutionary Effects of Pollution.” In Environmental and Molecular Mutagenesis, 60:81–81. WILEY, 2019.
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  - Leuthner, T. C., S. R. Kennedy, and J. N. Meyer. “Ultra-sensitive Duplex Sequencing Reveals Influence of Exogenous Stressors on Mitochondrial DNA Mutagenesis.” In Environmental and Molecular Mutagenesis, 60:53–54. WILEY, 2019.
    Link to Item
  - Hartman, Jessica Helene, Kacy L. Gordon, David R. Sherwood, and Joel N. Meyer. “Humanized, transgenic worms to study the role of mitochondrial CYP2E1 in toxicant-induced mitochondrial dysfunction and neurodegeneration.” In Drug Metabolism and Pharmacokinetics, 33:S35–S35. Elsevier BV, 2018. https://doi.org/10.1016/j.dmpk.2017.11.130.
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  - Leuthner, T., N. R. Keith, C. Jackson, J. N. Meyer, and J. R. Shaw. “Adaptation to cadmium reveals mechanism and susceptibility to mitochondrial genotoxicity.” In Environmental and Molecular Mutagenesis, 58:S46–S46. WILEY, 2017.
    Link to Item
  - Bess, A. S., T. L. Crocker, I. T. Ryde, and J. N. Meyer. “Mitochondrial Dynamics and Autophagy Aid in Removal of Persistent Mitochondrial DNA Damage.” In Environmental and Molecular Mutagenesis, 52:S47–S47. WILEY-BLACKWELL, 2011.
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  - Bess, A. S., T. L. Crocker, and J. N. Meyer. “Mitochondrial Fusion and Autophagy Aid in Removal of Helix-Distorting Mitochondrial DNA Damage.” In Environmental and Molecular Mutagenesis, 51:716–716. WILEY-BLACKWELL, 2010.
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  - Meyer, J. N., D. Jung, and R. T. Di Giulio. “Quantifying Mitochondrial and Nuclear DNA Damage in Sentinel Species.” In Environmental and Molecular Mutagenesis, 51:702–702. WILEY-BLACKWELL, 2010.
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  - Meyer, J. N., A. E. Arrant, A. J. Bernal, M. C. -. K. Leung, and T. L. Crocker. “The use of c. elegans to study mitochondrial DNA damage, Fission/Fusion events and autophagy.” In Environmental and Molecular Mutagenesis, 49:522–522. WILEY-BLACKWELL, 2008.
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  - Giulio, R. D., S. Billiard, J. Meyer, D. Wassenberg, and P. Hodson. “Synergistic developmental toxicity of polycyclic aromatic hydrocarbons: Towards a mechanistic understanding.” In Marine Environmental Research, 62:S45–46, 2006. https://doi.org/10.1016/j.marenvres.2006.04.037.
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  - Meyer, J. N., W. A. Boyd, A. C. Haugen, J. H. Freedman, and B. Van Houten. “A caenorhabditis elegans model of Friedreich's ataxia shows iron sensitivity, mitochondrial DNA damage, and altered gene expression.” In Environmental and Molecular Mutagenesis, 44:215–215. WILEY-LISS, 2004.
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Teaching & Mentoring
Recent Courses
- ENVIRON 360: Environmental Health: Pollutant Chemistry and Toxicology 2022
- ENVIRON 393: Research Independent Study 2022
- ENVIRON 394: Research Independent Study 2022
- ENVIRON 501: Environmental Toxicology 2022
- ENVIRON 593: Independent Studies and Projects 2022
- ENVIRON 819: Mechanisms in Environmental Toxicology 2022
- ENVIRON 847S: Seminar in Toxicology 2022
- ENVIRON 848S: Seminar in Toxicology 2022
- ENVIRON 899: Master's Project 2022
- PHARM 394: Research Independent Study 2022
- PHARM 494: Research Independent Study 2022
- PHARM 847S: Seminar in Toxicology 2022
- PHARM 848S: Seminar in Toxicology 2022
- ENVIRON 360D: Environmental Health: Pollutant Chemistry and Toxicology 2021
- ENVIRON 393: Research Independent Study 2021
- ENVIRON 394: Research Independent Study 2021
- ENVIRON 501: Environmental Toxicology 2021
- ENVIRON 593: Independent Studies and Projects 2021
- ENVIRON 847S: Seminar in Toxicology 2021
- ENVIRON 848S: Seminar in Toxicology 2021
- ENVIRON 899: Master's Project 2021
- PHARM 394: Research Independent Study 2021
- PHARM 847S: Seminar in Toxicology 2021
- PHARM 848S: Seminar in Toxicology 2021
- ENVIRON 393: Research Independent Study 2020
- ENVIRON 394: Research Independent Study 2020
- ENVIRON 501D: Environmental Toxicology 2020
- ENVIRON 593: Independent Studies and Projects 2020
- ENVIRON 819: Mechanisms in Environmental Toxicology 2020
- ENVIRON 847S: Seminar in Toxicology 2020
- ENVIRON 848S: Seminar in Toxicology 2020
- ENVIRON 899: Master's Project 2020
- PHARM 394: Research Independent Study 2020
- PHARM 494: Research Independent Study 2020
- PHARM 847S: Seminar in Toxicology 2020
- PHARM 848S: Seminar in Toxicology 2020
Scholarly, Clinical, & Service Activities
Outreach & Engaged Scholarship

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