Epigenome editing technologies for discovery and medicine.
Publication
, Journal Article
McCutcheon, SR; Rohm, D; Iglesias, N; Gersbach, CA
Published in: Nature biotechnology
August 2024
Epigenome editing has rapidly evolved in recent years, with diverse applications that include elucidating gene regulation mechanisms, annotating coding and noncoding genome functions and programming cell state and lineage specification. Importantly, given the ubiquitous role of epigenetics in complex phenotypes, epigenome editing has unique potential to impact a broad spectrum of diseases. By leveraging powerful DNA-targeting technologies, such as CRISPR, epigenome editing exploits the heritable and reversible mechanisms of epigenetics to alter gene expression without introducing DNA breaks, inducing DNA damage or relying on DNA repair pathways.
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Published In
Nature biotechnology
DOI
EISSN
1546-1696
ISSN
1087-0156
Publication Date
August 2024
Volume
42
Issue
8
Start / End Page
1199 / 1217
Related Subject Headings
- Humans
- Gene Editing
- Epigenomics
- Epigenome
- Epigenesis, Genetic
- CRISPR-Cas Systems
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
McCutcheon, S. R., Rohm, D., Iglesias, N., & Gersbach, C. A. (2024). Epigenome editing technologies for discovery and medicine. Nature Biotechnology, 42(8), 1199–1217. https://doi.org/10.1038/s41587-024-02320-1
McCutcheon, Sean R., Dahlia Rohm, Nahid Iglesias, and Charles A. Gersbach. “Epigenome editing technologies for discovery and medicine.” Nature Biotechnology 42, no. 8 (August 2024): 1199–1217. https://doi.org/10.1038/s41587-024-02320-1.
McCutcheon SR, Rohm D, Iglesias N, Gersbach CA. Epigenome editing technologies for discovery and medicine. Nature biotechnology. 2024 Aug;42(8):1199–217.
McCutcheon, Sean R., et al. “Epigenome editing technologies for discovery and medicine.” Nature Biotechnology, vol. 42, no. 8, Aug. 2024, pp. 1199–217. Epmc, doi:10.1038/s41587-024-02320-1.
McCutcheon SR, Rohm D, Iglesias N, Gersbach CA. Epigenome editing technologies for discovery and medicine. Nature biotechnology. 2024 Aug;42(8):1199–1217.
Published In
Nature biotechnology
DOI
EISSN
1546-1696
ISSN
1087-0156
Publication Date
August 2024
Volume
42
Issue
8
Start / End Page
1199 / 1217
Related Subject Headings
- Humans
- Gene Editing
- Epigenomics
- Epigenome
- Epigenesis, Genetic
- CRISPR-Cas Systems
- Animals