Charles Gersbach
Rooney Family Associate Professor of Biomedical Engineering
Current Research Interests
Gene therapy, genomics and epigenomics, biomolecular and cellular engineering, regenerative medicine, and synthetic biology.
Current Appointments & Affiliations
- Rooney Family Associate Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2016
- Associate Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2015
- Associate Professor of Surgery, Surgery, Surgical Sciences, Surgery 2019
- Associate Professor of Orthopaedic Surgery, Orthopaedics, Orthopaedics 2015
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013
- Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016
- Associate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2017
- Core Faculty in Innovation & Entrepreneurship, Duke Innovation & Entrepreneurship, Initiatives 2019
Contact Information
- 2353C CIEMAS, Durham, NC 27708
- Box 90281, 136 Hudson Hall, Durham, NC 27708
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charles.gersbach@duke.edu
(919) 613-2147
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Google Scholar
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http://gersbach.bme.duke.edu/
- Background
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Education, Training, & Certifications
- Ph.D., Georgia Institute of Technology 2006
- B.S., Georgia Institute of Technology 2001
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Duke Appointment History
- Assistant Professor of Orthopaedic Surgery, Orthopaedics, Orthopaedics 2013 - 2015
- Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2009 - 2015
- Investigator in the Institute for Genome Sciences & Policy, Institutes and Centers, School of Medicine 2012 - 2014
- Assistant Research Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2009
- Recognition
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In the News
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APR 15, 2019 Pratt School of Engineering -
FEB 18, 2019 Pratt School of Engineering -
DEC 17, 2018 Duke Research Blog -
OCT 3, 2018 Duke Med Alumni News -
APR 27, 2018 -
APR 26, 2018 Pratt School of Engineering -
APR 9, 2018 -
NOV 29, 2017 -
APR 4, 2017 Pratt School of Engineering -
APR 3, 2017 The Scientist -
MAR 15, 2017 CNBC -
MAY 5, 2016 -
JAN 4, 2016 The New York Times -
JAN 4, 2016 BBC News -
DEC 31, 2015 -
OCT 27, 2015 -
MAY 26, 2015 -
APR 6, 2015 -
FEB 19, 2015 -
FEB 18, 2015 -
FEB 10, 2015
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Awards & Honors
- Allen Distinguished Investigator. Paul G. Allen Frontiers Group. 2017
- Fellow. American Institute for Medical and Biological Engineering. 2017
- Thomas Langford Lectureship Award. Duke University. 2016
- Outstanding New Investigator. American Society of Gene and Cell Therapy. 2014
- Capers and Marion McDonald Teaching and Research Award. Duke University. 2013
- Faculty Early Career Development (CAREER) Program. National Science Foundation. 2012
- Rising Star Award. Society for Physical Regulation in Biology and Medicine. 2012
- Basil O’Connor Starter Scholar Research Award. March of Dimes Foundation. 2011
- NIH Director’s New Innovator Award. National Institutes of Health. 2011
- Ralph E. Powe Junior Faculty Enhancement Award. Oak Ridge Associated Universities. 2011
- Hartwell Individual Biomedical Research Award. The Hartwell Foundation. 2010
- Research
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Selected Grants
- Mechanotransduction in Meniscus Health and Repair awarded by National Institutes of Health 2019 - 2023
- Epigenomic Reprogramming in Patient Derived Models of Colorectal Cancer awarded by National Institutes of Health 2018 - 2023
- The Branched Chain Ketoacid Dehydrogenase Kinase-Phosphatase System as a New Regulatory Node in Myocardial Fuel Section awarded by National Institutes of Health 2018 - 2023
- Engineering Technologies to Determine Causal Relationships Between Chromatin Structure and Gene Regulation awarded by National Science Foundation 2018 - 2022
- Summer Scholars Program in Genome Sciences and Medicine awarded by National Institutes of Health 2017 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- University Training Program in Biomolecular and Tissue Engineering awarded by National Institutes of Health 1994 - 2022
- Deciphering the regulation of gene expression in the etiology of LOAD awarded by National Institutes of Health 2017 - 2022
- Postdoctoral Training in Genomic Medicine Research awarded by National Institutes of Health 2017 - 2022
- IRES Track 1 IRTG Engaged in Dissecting and Reengineering the Regulatory Genome awarded by National Science Foundation 2019 - 2022
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
- To support research on the development of CRISPR-based epigenome editing tools to refine genome wide association studies awarded by Open Philanthropy Project 2018 - 2021
- Evolving High Potency AAV Vectors for Neuromuscular Genome Editing awarded by National Institutes of Health 2018 - 2021
- Regulatory Mechanisms of CD4+ T Cell Differentiation awarded by National Institutes of Health 2017 - 2021
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- CRISPR/Cas9-Based Gene Editing for the Correction of Duchenne Muscular Dystrophy awarded by National Institutes of Health 2016 - 2021
- In Vivo Epigenome Editing with CRISPR-Based Histone Acetyltransferase Transgenic Mice awarded by National Institutes of Health 2016 - 2021
- Designing a next generation vector for CRISPR/Cas9-mediated gene editing to treat Duchenne muscular dystrophy awarded by North Carolina Biotechnology Center 2018 - 2020
- Genome Editing For Duchenne Muscular Dystrophy awarded by Sarepta Therapeutics, Inc. 2017 - 2020
- Epigenome Editing Technologies to Control Diverse Biological Functions awarded by Allen Institute for Brain Science 2017 - 2020
- Collaborative Research: Adapting Cas9 Protein from CRISPR as a Structural Unit for Molecular Assembly awarded by National Science Foundation 2017 - 2020
- Functional characterization of regulatory variants associated with maternal hyperglycemia awarded by National Institutes of Health 2017 - 2020
- Non-viral delivery of CRISPR/Cas9 for targeted gene replacement awarded by National Institutes of Health 2018 - 2020
- REU Site for Meeting the Grand Challenges in Engineering awarded by National Science Foundation 2017 - 2020
- Developing Brain-penetrant G9a/GLP Inhibitors for Treating Prader-Willi Syndrome awarded by Levo Therapeutics, Inc 2018 - 2020
- Enhancing Neuronal Reprogramming with Epigenome Editing awarded by National Institutes of Health 2018 - 2020
- Enhancing Neuronal Reprogramming with Epigenome Editing awarded by National Institutes of Health 2017 - 2019
- Investigating Autophagy in GSD-Ia awarded by National Institutes of Health 2015 - 2019
- Development of AAV-Based Curative Therapies for Correcting Duchenne Muscular Dystrophy by Targeted Genomic Integration awarded by North Carolina Biotechnology Center 2017 - 2019
- An organotypic model recapitulating colon cancer microenvironment and metastasis awarded by Cleveland Clinic Foundation 2017 - 2019
- Treating Duchenne Cardiomyopathy in the Mouse Model by Gene Repair awarded by University of Missouri 2016 - 2019
- Combinatorial Biomimetic Systems for High-Throughput Manipulation of Genome-Edited Dystrophic Muscle Stem Cells awarded by Cornell University 2018 - 2019
- Systemic Inflammation in Microphysiological Models of Muscle and Vascular Disease awarded by National Institutes of Health 2017 - 2019
- Novel Approaches for Correcting Respiratory Insufficiency in Pompe Disease awarded by National Institutes of Health 2014 - 2019
- Reprogrammed autologous T cells to promote transplant tolerance awarded by Element Genomics, Inc. 2018 - 2019
- Systemic EGFRvIII-targeted bispecific antibody as immunotherapy for glioblastoma awarded by National Institutes of Health 2015 - 2019
- Defining the Mechanisms of Gene Regulation and Drug Resistance in Cancer awarded by Thorek Memorial Foundation 2017 - 2019
- Decoding and Reprogramming the Corticosteroid Transcriptional Regulatory Network awarded by National Institutes of Health 2015 - 2018
- Trans-regulatory mechanisms of glucocorticoid-mediated transcriptional repression awarded by National Institutes of Health 2016 - 2018
- Genome engineering for Duchenne muscular dystrophy awarded by American Heart Association 2017 - 2018
- Engineering Novel Genome Engineering Systems awarded by Locus Biosciences, Inc. 2016 - 2018
- Circulatory system and integrated muscle tissue for drug and tissue toxicity awarded by National Institutes of Health 2012 - 2018
- Engineering Targeted Epigenetic Modifiers for Precise Control of Gene Regulation awarded by National Institutes of Health 2013 - 2018
- A Platform Technology for High-Throughput Screening of Gene Regulatory Elements awarded by Element Genomics, Inc. 2016 - 2017
- Functional Tissue Engineering of Cartilage Using Induced Pluripotent Stem Cells awarded by National Institutes of Health 2015 - 2017
- MD140071 Multiplex CRISPR/Cas9-Based Genome Engineering for the Genetic Correction of Duchenne Muscular Dystrophy awarded by United States Army Medical Research and Materiel Command 2015 - 2017
- CRISPR/Cas9-based genome editing in mouse models of Duchenne muscular dystrophy awarded by Hartwell Foundation 2015 - 2017
- Scaffold-Mediated Gene Delivery for Engineering of Osteochondral Tissues awarded by National Institutes of Health 2015 - 2017
- Gertude B. Elion Mentored Medical Research Award awarded by Triangle Community Foundation 2016 - 2017
- Genome Editing of Stem Cells for Analysis of Osteoarthritis Causal Variants awarded by National Institutes of Health 2014 - 2017
- CAREER: Photoregulated Gene Expression for Spatiotemporal Control of Morphogenesis awarded by National Science Foundation 2012 - 2017
- Engineering Morphogenetic Factors for Enhanced Genetic Reprogramming awarded by National Institutes of Health 2011 - 2016
- Engineering New Biological Therapies for Arthritis awarded by Arthritis Foundation 2014 - 2015
- Live-Animal Micro-CT System awarded by National Institutes of Health 2012 - 2014
- Spatially Controlled Gene Delivery of Morphogenetic Factors from Woven Scaffolds awarded by National Institutes of Health 2011 - 2014
- Publications & Artistic Works
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Selected Publications
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Books
- Holtzman, L, and Gersbach, CA. Editing the Epigenome: Reshaping the Genomic Landscape. August 2018. Full Text
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Academic Articles
- Kocak, DD, Josephs, EA, Bhandarkar, V, Adkar, SS, Kwon, JB, and Gersbach, CA. "Increasing the specificity of CRISPR systems with engineered RNA secondary structures." Nature Biotechnology (April 15, 2019). Full Text
- Nelson, CE, Wu, Y, Gemberling, MP, Oliver, ML, Waller, MA, Bohning, JD, Robinson-Hamm, JN, Bulaklak, K, Castellanos Rivera, RM, Collier, JH, Asokan, A, and Gersbach, CA. "Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy." Nature Medicine 25, no. 3 (March 2019): 427-432. Full Text
- Adkar, SS, Wu, C-L, Willard, VP, Dicks, A, Ettyreddy, A, Steward, N, Bhutani, N, Gersbach, CA, and Guilak, F. "Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing." Stem Cells (Dayton, Ohio) 37, no. 1 (January 2019): 65-76. Full Text
- Chen, L-F, Lin, YT, Gallegos, DA, Hazlett, MF, Gómez-Schiavon, M, Yang, MG, Kalmeta, B, Zhou, AS, Holtzman, L, Gersbach, CA, Grandl, J, Buchler, NE, and West, AE. "Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes." Cell Reports 26, no. 5 (January 2019): 1174-1188.e5. Full Text
- Hakim, CH, Wasala, NB, Nelson, CE, Wasala, LP, Yue, Y, Louderman, JA, Lessa, TB, Dai, A, Zhang, K, Jenkins, GJ, Nance, ME, Pan, X, Kodippili, K, Yang, NN, Chen, S-J, Gersbach, CA, and Duan, D. "AAV CRISPR editing rescues cardiac and muscle function for 18 months in dystrophic mice." Jci Insight 3, no. 23 (December 6, 2018). Full Text
- Black, JB, and Gersbach, CA. "Synthetic transcription factors for cell fate reprogramming." Current Opinion in Genetics & Development 52 (October 2018): 13-21. (Review) Full Text
- Huynh, NPT, Brunger, JM, Gloss, CC, Moutos, FT, Gersbach, CA, and Guilak, F. "Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffolds." Tissue Engineering. Part A 24, no. 19-20 (October 2018): 1531-1544. Full Text
- McDowell, IC, Barrera, A, D'Ippolito, AM, Vockley, CM, Hong, LK, Leichter, SM, Bartelt, LC, Majoros, WH, Song, L, Safi, A, Koçak, DD, Gersbach, CA, Hartemink, AJ, Crawford, GE, Engelhardt, BE, and Reddy, TE. "Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding." Genome Res 28, no. 9 (September 2018): 1272-1284. Full Text Link to Item
- D'Ippolito, AM, McDowell, IC, Barrera, A, Hong, LK, Leichter, SM, Bartelt, LC, Vockley, CM, Majoros, WH, Safi, A, Song, L, Gersbach, CA, Crawford, GE, and Reddy, TE. "Pre-established Chromatin Interactions Mediate the Genomic Response to Glucocorticoids." Cell Systems 7, no. 2 (August 2018): 146-160.e7. Full Text
- Klann, TS, Black, JB, and Gersbach, CA. "CRISPR-based methods for high-throughput annotation of regulatory DNA." Current Opinion in Biotechnology 52 (August 2018): 32-41. (Review) Full Text
- Kocak, DD, and Gersbach, CA. "From CRISPR scissors to virus sensors." Nature 557, no. 7704 (May 2018): 168-169. (Letter) Full Text
- Thakore, PI, Kwon, JB, Nelson, CE, Rouse, DC, Gemberling, MP, Oliver, ML, and Gersbach, CA. "RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors." Nature Communications 9, no. 1 (April 26, 2018): 1674-null. Full Text
- Gersbach, CA, and Barrangou, R. "Pulling the genome in opposite directions to dissect gene networks." Genome Biology 19, no. 1 (March 26, 2018). Full Text
- Pickar, AK, and Gersbach, CA. "Gene therapies for hemophilia hit the mark in clinical trials." Nature Medicine 24, no. 2 (February 7, 2018): 121-122. Full Text
- Gemberling, M, and Gersbach, CA. "Boosting, Not Breaking: CRISPR Activators Treat Disease Models." Molecular Therapy : the Journal of the American Society of Gene Therapy 26, no. 2 (February 2018): 334-336. Full Text
- Klann, TS, Crawford, GE, Reddy, TE, and Gersbach, CA. "Screening Regulatory Element Function with CRISPR/Cas9-based Epigenome Editing." Methods in Molecular Biology (Clifton, N.J.) 1767 (January 2018): 447-480. Full Text
- Manandhar, D, Song, L, Kabadi, A, Kwon, JB, Edsall, LE, Ehrlich, M, Tsumagari, K, Gersbach, CA, Crawford, GE, and Gordân, R. "Incomplete MyoD-induced transdifferentiation is associated with chromatin remodeling deficiencies." Nucleic Acids Research 45, no. 20 (November 2017): 11684-11699. Full Text
- Nelson, CE, Robinson-Hamm, JN, and Gersbach, CA. "Genome engineering: A new approach to gene therapy for neuromuscular disorders." Nature Reviews Neurology 13, no. 11 (November 1, 2017): 647-661. (Review) Full Text
- Pathak, GP, Spiltoir, JI, Höglund, C, Polstein, LR, Heine-Koskinen, S, Gersbach, CA, Rossi, J, and Tucker, CL. "Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2." Nucleic Acids Research 45, no. 20 (November 2017): e167-null. Full Text
- Polstein, LR, Juhas, M, Hanna, G, Bursac, N, and Gersbach, CA. "An Engineered Optogenetic Switch for Spatiotemporal Control of Gene Expression, Cell Differentiation, and Tissue Morphogenesis." Acs Synthetic Biology 6, no. 11 (November 2017): 2003-2013. Full Text
- Adkar, SS, Brunger, JM, Willard, VP, Wu, C-L, Gersbach, CA, and Guilak, F. "Genome Engineering for Personalized Arthritis Therapeutics." Trends in molecular medicine 23, no. 10 (October 2017): 917-931. (Review) Full Text
- Farhang, N, Brunger, JM, Stover, JD, Thakore, PI, Lawrence, B, Guilak, F, Gersbach, CA, Setton, LA, and Bowles, RD. "* CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory Environments." Tissue Engineering. Part A 23, no. 15-16 (August 2017): 738-749. Full Text
- Huang, J, Chen, M, Whitley, MJ, Kuo, H-C, Xu, ES, Walens, A, Mowery, YM, Van Mater, D, Eward, WC, Cardona, DM, Luo, L, Ma, Y, Lopez, OM, Nelson, CE, Robinson-Hamm, JN, Reddy, A, Dave, SS, Gersbach, CA, Dodd, RD, and Kirsch, DG. "Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma." Nature Communications 8 (July 10, 2017): 15999-null. Full Text
- Black, JB, Perez-Pinera, P, and Gersbach, CA. "Mammalian Synthetic Biology: Engineering Biological Systems." Annual Review of Biomedical Engineering 19 (June 2017): 249-277. (Review) Full Text
- Klann, TS, Black, JB, Chellappan, M, Safi, A, Song, L, Hilton, IB, Crawford, GE, Reddy, TE, and Gersbach, CA. "CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome." Nature Biotechnology 35, no. 6 (June 2017): 561-568. Full Text
- Brunger, JM, Zutshi, A, Willard, VP, Gersbach, CA, and Guilak, F. "CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation-Resistant Tissues." Arthritis & rheumatology (Hoboken, N.J.) 69, no. 5 (May 2017): 1111-1121. Full Text
- Brunger, JM, Zutshi, A, Willard, VP, Gersbach, CA, and Guilak, F. "Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs." Stem Cell Reports 8, no. 5 (May 2017): 1202-1213. Full Text
- Barrangou, R, and Gersbach, CA. "Expanding the CRISPR Toolbox: Targeting RNA with Cas13b." Molecular cell 65, no. 4 (February 2017): 582-584. Full Text
- Hilton, IB, and Gersbach, CA. "Genetic engineering: Chemical control for CRISPR editing." Nature Chemical Biology 13, no. 1 (January 2017): 2-3. Full Text
- Housden, BE, Muhar, M, Gemberling, M, Gersbach, CA, Stainier, DYR, Seydoux, G, Mohr, SE, Zuber, J, and Perrimon, N. "Loss-of-function genetic tools for animal models: cross-species and cross-platform differences." Nature Reviews. Genetics 18, no. 1 (January 2017): 24-40. (Review) Full Text
- Black, JB, Adler, AF, Wang, H-G, D'Ippolito, AM, Hutchinson, HA, Reddy, TE, Pitt, GS, Leong, KW, and Gersbach, CA. "Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells." Cell Stem Cell 19, no. 3 (September 2016): 406-414. Full Text
- Lee, J, Xu, L, Gibson, TM, Gersbach, CA, and Sullenger, BA. "Differential effects of toll-like receptor stimulation on mRNA-driven myogenic conversion of human and mouse fibroblasts." Biochemical and Biophysical Research Communications 478, no. 3 (September 2016): 1484-1490. Full Text
- Robinson-Hamm, JN, and Gersbach, CA. "Gene therapies that restore dystrophin expression for the treatment of Duchenne muscular dystrophy." Human Genetics 135, no. 9 (September 2016): 1029-1040. (Review) Full Text
- Moutos, FT, Glass, KA, Compton, SA, Ross, AK, Gersbach, CA, Guilak, F, and Estes, BT. "Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing." Proceedings of the National Academy of Sciences of the United States of America 113, no. 31 (August 2016): E4513-E4522. Full Text
- Hwang, PY, Jing, L, Chen, J, Lim, F-L, Tang, R, Choi, H, Cheung, KM, Risbud, MV, Gersbach, CA, Guilak, F, Leung, VY, and Setton, LA. "N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions." Scientific reports 6 (June 13, 2016): 28038-. Full Text
- Nelson, CE, and Gersbach, CA. "Engineering Delivery Vehicles for Genome Editing." Annual review of chemical and biomolecular engineering 7 (June 2016): 637-662. (Review) Full Text
- Landau, DJ, Brooks, ED, Perez-Pinera, P, Amarasekara, H, Mefferd, A, Li, S, Bird, A, Gersbach, CA, and Koeberl, DD. "In Vivo Zinc Finger Nuclease-mediated Targeted Integration of a Glucose-6-phosphatase Transgene Promotes Survival in Mice With Glycogen Storage Disease Type IA." Molecular Therapy : the Journal of the American Society of Gene Therapy 24, no. 4 (April 2016): 697-706. Full Text
- Josephs, EA, Kocak, DD, Fitzgibbon, CJ, McMenemy, J, Gersbach, CA, and Marszalek, PE. "Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage." Nucleic Acids Research 44, no. 5 (March 2016): 2474-null. Full Text
- Maeder, ML, and Gersbach, CA. "Genome-editing Technologies for Gene and Cell Therapy." Molecular Therapy : the Journal of the American Society of Gene Therapy 24, no. 3 (March 2016): 430-446. (Review) Full Text
- Nelson, CE, and Gersbach, CA. "Cas9 loosens its grip on off-target sites." Nature Biotechnology 34, no. 3 (March 2016): 298-299. Full Text
- Thakore, PI, Black, JB, Hilton, IB, and Gersbach, CA. "Editing the epigenome: technologies for programmable transcription and epigenetic modulation." Nature Methods 13, no. 2 (February 2016): 127-137. (Review) Full Text
- Nelson, CE, Hakim, CH, Ousterout, DG, Thakore, PI, Moreb, EA, Castellanos Rivera, RM, Madhavan, S, Pan, X, Ran, FA, Yan, WX, Asokan, A, Zhang, F, Duan, D, and Gersbach, CA. "In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy." Science (New York, N.Y.) 351, no. 6271 (January 2016): 403-407. Full Text
- Ousterout, DG, and Gersbach, CA. "The Development of TALE Nucleases for Biotechnology." Methods in molecular biology (Clifton, N.J.) 1338 (January 2016): 27-42. Full Text
- Thakore, PI, and Gersbach, CA. "Design, Assembly, and Characterization of TALE-Based Transcriptional Activators and Repressors." Methods in molecular biology (Clifton, N.J.) 1338 (January 2016): 71-88. Full Text
- Doudna, JA, and Gersbach, CA. "Genome editing: the end of the beginning." Genome biology 16 (December 23, 2015): 292-. Full Text
- Thakore, PI, D'Ippolito, AM, Song, L, Safi, A, Shivakumar, NK, Kabadi, AM, Reddy, TE, Crawford, GE, and Gersbach, CA. "Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements." Nature Methods 12, no. 12 (December 2015): 1143-1149. Full Text
- Hilton, IB, and Gersbach, CA. "Enabling functional genomics with genome engineering." Genome Research 25, no. 10 (October 2015): 1442-1455. (Review) Full Text
- Josephs, EA, Kocak, DD, Fitzgibbon, CJ, McMenemy, J, Gersbach, CA, and Marszalek, PE. "Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage." Nucleic acids research 43, no. 18 (October 2015): 8924-8941. Full Text
- Polstein, LR, Perez-Pinera, P, Kocak, DD, Vockley, CM, Bledsoe, P, Song, L, Safi, A, Crawford, GE, Reddy, TE, and Gersbach, CA. "Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators." Genome Research 25, no. 8 (August 2015): 1158-1169. Full Text
- Polstein, LR, Perez-Pinera, P, Kocak, DD, Vockley, CM, Bledsoe, P, Song, L, Safi, A, Crawford, GE, Reddy, TE, and Gersbach, CA. "Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators." GENOME RESEARCH 25, no. 8 (August 2015): 1158-1169. Full Text Link to Item
- Gibson, TM, and Gersbach, CA. "Single-molecule analysis of myocyte differentiation reveals bimodal lineage commitment." Integrative biology : quantitative biosciences from nano to macro 7, no. 6 (June 2015): 663-671. Full Text
- Kabadi, AM, Thakore, PI, Vockley, CM, Ousterout, DG, Gibson, TM, Guilak, F, Reddy, TE, and Gersbach, CA. "Enhanced MyoD-induced transdifferentiation to a myogenic lineage by fusion to a potent transactivation domain." Acs Synthetic Biology 4, no. 6 (June 2015): 689-699. Full Text
- Frank, CL, Liu, F, Wijayatunge, R, Song, L, Biegler, MT, Yang, MG, Vockley, CM, Safi, A, Gersbach, CA, Crawford, GE, and West, AE. "Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum." Nature Neuroscience 18, no. 5 (May 2015): 647-656. Full Text
- Hilton, IB, D'Ippolito, AM, Vockley, CM, Thakore, PI, Crawford, GE, Reddy, TE, and Gersbach, CA. "Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers." Nature Biotechnology 33, no. 5 (May 2015): 510-517. Full Text
- Diekman, BO, Thakore, PI, O'Connor, SK, Willard, VP, Brunger, JM, Christoforou, N, Leong, KW, Gersbach, CA, and Guilak, F. "Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells." Tissue engineering. Part A 21, no. 7-8 (April 2015): 1261-1274. Full Text
- Ousterout, DG, Kabadi, AM, Thakore, PI, Perez-Pinera, P, Brown, MT, Majoros, WH, Reddy, TE, and Gersbach, CA. "Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases." Molecular Therapy 23, no. 3 (March 5, 2015): 523-532. Full Text
- Ousterout, DG, Kabadi, AM, Thakore, PI, Perez-Pinera, P, Brown, MT, Majoros, WH, Reddy, TE, and Gersbach, CA. "Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases." Molecular therapy : the journal of the American Society of Gene Therapy 23, no. 3 (March 2015): 523-532. Full Text
- Ousterout, DG, Kabadi, AM, Thakore, PI, Perez-Pinera, P, Brown, MT, Majoros, WH, Reddy, TE, and Gersbach, CA. "Correction of Dystrophin Expression in Cells From Duchenne Muscular Dystrophy Patients Through Genomic Excision of Exon 51 by Zinc Finger Nucleases." MOLECULAR THERAPY 23, no. 3 (March 2015): 523-532. Full Text Link to Item
- Polstein, LR, and Gersbach, CA. "A light-inducible CRISPR-Cas9 system for control of endogenous gene activation." Nature Chemical Biology 11, no. 3 (March 2015): 198-200. Full Text
- Ousterout, DG, Kabadi, AM, Thakore, PI, Majoros, WH, Reddy, TE, and Gersbach, CA. "Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy." Nature Communications 6 (February 18, 2015): 6244-null. Full Text
- Polstein, LR, and Gersbach, CA. "A light-inducible CRISPR-Cas9 system for control of endogenous gene activation." Nature Chemical Biology 11, no. 3 (January 1, 2015): 198-200. Full Text
- Chakraborty, S, Ji, H, Chen, J, Gersbach, CA, and Leong, KW. "Vector modifications to eliminate transposase expression following piggyBac-mediated transgenesis." Scientific reports 4 (December 10, 2014): 7403-. Full Text
- Chakraborty, S, Ji, H, Kabadi, AM, Gersbach, CA, Christoforou, N, and Leong, KW. "A CRISPR/Cas9-based system for reprogramming cell lineage specification." Stem Cell Reports 3, no. 6 (December 2014): 940-947. Full Text
- Gersbach, CA. "Genome engineering: the next genomic revolution." Nature Methods 11, no. 10 (October 2014): 1009-1011. Full Text
- Kabadi, AM, Ousterout, DG, Hilton, IB, and Gersbach, CA. "Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector." Nucleic Acids Research 42, no. 19 (October 2014): e147-null. Full Text
- Kabadi, AM, and Gersbach, CA. "Special issue on engineered DNA-binding proteins." Acs Synthetic Biology 3, no. 10 (October 2014): 702-703. Full Text
- Kabadi, AM, and Gersbach, CA. "Engineering synthetic TALE and CRISPR/Cas9 transcription factors for regulating gene expression." Methods (San Diego, Calif.) 69, no. 2 (September 2014): 188-197. Full Text
- Gersbach, CA, Gaj, T, and Barbas, CF. "Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies." Accounts of Chemical Research 47, no. 8 (August 2014): 2309-2318. Full Text
- Gersbach, CA, and Perez-Pinera, P. "Activating human genes with zinc finger proteins, transcription activator-like effectors and CRISPR/Cas9 for gene therapy and regenerative medicine." Expert opinion on therapeutic targets 18, no. 8 (August 2014): 835-839. Full Text
- Glass, KA, Link, JM, Brunger, JM, Moutos, FT, Gersbach, CA, and Guilak, F. "Tissue-engineered cartilage with inducible and tunable immunomodulatory properties." Biomaterials 35, no. 22 (July 2014): 5921-5931. Full Text
- High, K, Gregory, PD, and Gersbach, C. "CRISPR technology for gene therapy." Nature Medicine 20, no. 5 (May 2014): 476-477. Full Text
- Brunger, JM, Huynh, NPT, Guenther, CM, Perez-Pinera, P, Moutos, FT, Sanchez-Adams, J, Gersbach, CA, and Guilak, F. "Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage." Proceedings of the National Academy of Sciences of the United States of America 111, no. 9 (March 2014): E798-E806. Full Text
- Gersbach, CA, Gaj, T, and Barbas, CF. "Comparing genome editing technologies." Genetic Engineering and Biotechnology News 34, no. 5 (March 1, 2014). Full Text
- Glass, KA, Link, JM, Brunger, JM, Moutos, FT, Gersbach, CA, and Guilak, F. "Tissue-engineered cartilage with inducible and tunable immunomodulatory properties." Biomaterials 35, no. 22 (January 1, 2014): 5921-5931. Full Text
- Kabadi, AM, and Gersbach, CA. "Engineering synthetic TALE and CRISPR/Cas9 transcription factors for regulating gene expression." Methods 69, no. 2 (January 1, 2014): 188-197. Full Text
- Polstein, LR, and Gersbach, CA. "Light-inducible gene regulation with engineered zinc finger proteins." Methods in Molecular Biology (Clifton, N.J.) 1148 (January 2014): 89-107. Full Text
- "Corrigendum: Reading Frame Correction by Targeted Genome Editing Restores Dystrophin Expression in Cells From Duchenne Muscular Dystrophy Patients." Molecular Therapy 21, no. 11 (November 2013): 2130-2130. Full Text
- Duvall, CL, Prokop, A, Gersbach, CA, and Davidson, JM. "Gene Delivery into Cells and Tissues." (November 1, 2013): 687-723. (Chapter) Full Text
- Perez-Pinera, P, Kocak, DD, Vockley, CM, Adler, AF, Kabadi, AM, Polstein, LR, Thakore, PI, Glass, KA, Ousterout, DG, Leong, KW, Guilak, F, Crawford, GE, Reddy, TE, and Gersbach, CA. "RNA-guided gene activation by CRISPR-Cas9-based transcription factors." Nat Methods 10, no. 10 (October 2013): 973-976. Full Text Link to Item
- Ousterout, DG, Perez-Pinera, P, Thakore, PI, Kabadi, AM, Brown, MT, Qin, X, Fedrigo, O, Mouly, V, Tremblay, JP, and Gersbach, CA. "Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients." Molecular Therapy : the Journal of the American Society of Gene Therapy 21, no. 9 (September 2013): 1718-1726. Full Text
- Gaj, T, Gersbach, CA, and Barbas, CF. "ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering." Trends in Biotechnology 31, no. 7 (July 2013): 397-405. (Review) Full Text
- Dumbauld, DW, Lee, TT, Singh, A, Scrimgeour, J, Gersbach, CA, Zamir, EA, Fu, J, Chen, CS, Curtis, JE, Craig, SW, and García, AJ. "How vinculin regulates force transmission." Proceedings of the National Academy of Sciences of the United States of America 110, no. 24 (June 2013): 9788-9793. Full Text
- Gibson, TM, and Gersbach, CA. "The role of single-cell analyses in understanding cell lineage commitment." Biotechnol J 8, no. 4 (April 2013): 397-407. (Review) Full Text Link to Item
- Bhakta, MS, Henry, IM, Ousterout, DG, Das, KT, Lockwood, SH, Meckler, JF, Wallen, MC, Zykovich, A, Yu, Y, Leo, H, Xu, L, Gersbach, CA, and Segal, DJ. "Highly active zinc-finger nucleases by extended modular assembly." Genome Research 23, no. 3 (March 2013): 530-538. Full Text
- Perez-Pinera, P, Ousterout, DG, Brunger, JM, Farin, AM, Glass, KA, Guilak, F, Crawford, GE, Hartemink, AJ, and Gersbach, CA. "Synergistic and tunable human gene activation by combinations of synthetic transcription factors." Nature Methods 10, no. 3 (March 2013): 239-242. Full Text
- Tremblay, JP, Xiao, X, Aartsma-Rus, A, Barbas, C, Blau, HM, Bogdanove, AJ, Boycott, K, Braun, S, Breakefield, XO, Bueren, JA, Buschmann, M, Byrne, BJ, Calos, M, Cathomen, T, Chamberlain, J, Chuah, M, Cornetta, K, Davies, KE, Dickson, JG, Duchateau, P, Flotte, TR, Gaudet, D, Gersbach, CA, Gilbert, R, Glorioso, J, Herzog, RW, High, KA, Huang, W, Huard, J, Joung, JK, Liu, D, Liu, D, Lochmüller, H, Lustig, L, Martens, J, Massie, B, Mavilio, F, Mendell, JR, Nathwani, A, Ponder, K, Porteus, M, Puymirat, J, Samulski, J, Takeda, S, Thrasher, A, VandenDriessche, T, Wei, Y, Wilson, JM, Wilton, SD, Wolfe, JH, and Gao, G. "Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases." Molecular Therapy : the Journal of the American Society of Gene Therapy 21, no. 2 (February 2013): 266-268. (Letter) Full Text
- Gaj, T, Gersbach, CA, and Barbas, CF. "ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering." Trends in Biotechnology 31, no. 7 (2013): 397-405. Full Text
- Gersbach, CA, and Barbas, CF. "Targeted plasmid integration into the Human Genome by engineered recombinases." Topics in Current Genetics 23 (January 1, 2013): 267-284. Full Text
- Gersbach, CA. "Engineered Proteins for Controlling Gene Expression." (2013): 125-138. Full Text
- Gibson, TM, and Gersbach, CA. "The role of single-cell analyses in understanding cell lineage commitment." Biotechnology Journal 8, no. 4 (2013): 397-407. Full Text
- Ousterout, DG, Perez-Pinera, P, Thakore, PI, Kabadi, AM, Brown, MT, Qin, X, Fedrigo, O, Mouly, V, Tremblay, JP, and Gersbach, CA. "Reading frame correction by targeted genome editing restores dystrophin expression in cells from duchenne muscular dystrophy patients." Molecular Therapy 21, no. 9 (2013): 1718-1726. Full Text
- Perez-Pinera, P, Kocak, DD, Vockley, CM, Adler, AF, Kabadi, AM, Polstein, LR, Thakore, PI, Glass, KA, Ousterout, DG, Leong, KW, Guilak, F, Crawford, GE, Reddy, TE, and Gersbach, CA. "RNA-guided gene activation by CRISPR-Cas9-based transcription factors." Nature Methods 10, no. 10 (2013): 973-976. Full Text
- Polstein, LR, and Gersbach, CA. "Light-inducible spatiotemporal control of gene activation by customizable zinc finger transcription factors." Journal of the American Chemical Society 134, no. 40 (October 2012): 16480-16483. Full Text
- Perez-Pinera, P, Ousterout, DG, and Gersbach, CA. "Advances in targeted genome editing." Current Opinion in Chemical Biology 16, no. 3-4 (August 2012): 268-277. (Review) Full Text
- Polstein, LR, and Gersbach, CA. "Photoregulated Gene Expression in Human Cells With Light-Inducible Engineered Transcription Factors." Asme 2012 Summer Bioengineering Conference, Parts a and B (June 20, 2012). Full Text
- Perez-Pinera, P, Ousterout, DG, Brown, MT, and Gersbach, CA. "Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases." Nucleic Acids Res 40, no. 8 (April 2012): 3741-3752. Full Text Link to Item
- "Engineered bioactive molecules." 5 (October 1, 2011): 131-145. (Chapter)
- Gersbach, CA, Gaj, T, Gordley, RM, Mercer, AC, and Barbas, CF. "Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase." Nucleic Acids Research 39, no. 17 (September 2011): 7868-7878. Full Text
- Gaj, T, Mercer, AC, Gersbach, CA, Gordley, RM, and Barbas, CF. "Structure-guided reprogramming of serine recombinase DNA sequence specificity." Proceedings of the National Academy of Sciences of the United States of America 108, no. 2 (January 11, 2011): 510-515. Full Text
- Gaj, T, Mercer, AC, Gersbach, CA, Gordley, RM, and Barbas, CF. "Structure-guided reprogramming of serine recombinase DNA sequence specificity." Proceedings of the National Academy of Sciences of the United States of America 108, no. 2 (January 2011): 498-503. Full Text
- Gersbach, CA. "Engineered Proteins for Controlling Gene Expression." (2011): 159-176. Full Text
- Gersbach, CA, Gaj, T, Gordley, RM, and Barbas, CF. "Directed evolution of recombinase specificity by split gene reassembly." Nucleic Acids Res 38, no. 12 (July 2010): 4198-4206. Full Text Link to Item
- Gordley, RM, Gersbach, CA, and Barbas, CF. "Synthesis of programmable integrases." Proc Natl Acad Sci U S A 106, no. 13 (March 31, 2009): 5053-5058. Full Text Link to Item
- Pregizer, S, Barski, A, Gersbach, CA, García, AJ, and Frenkel, B. "Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2." J Cell Biochem 102, no. 6 (December 15, 2007): 1458-1471. Full Text Link to Item
- Gersbach, CA, Coyer, SR, Le Doux, JM, and García, AJ. "Biomaterial-mediated retroviral gene transfer using self-assembled monolayers." Biomaterials 28, no. 34 (December 2007): 5121-5127. Full Text Link to Item
- Gersbach, CA, Guldberg, RE, and García, AJ. "In vitro and in vivo osteoblastic differentiation of BMP-2- and Runx2-engineered skeletal myoblasts." J Cell Biochem 100, no. 5 (April 1, 2007): 1324-1336. Full Text Link to Item
- Gersbach, CA, Phillips, JE, and García, AJ. "Genetic engineering for skeletal regenerative medicine." Annu Rev Biomed Eng 9 (2007): 87-119. (Review) Full Text Link to Item
- Phillips, JE, Gersbach, CA, and García, AJ. "Virus-based gene therapy strategies for bone regeneration." Biomaterials 28, no. 2 (January 2007): 211-229. (Review) Full Text
- Gersbach, CA, Le Doux, JM, Guldberg, RE, and García, AJ. "Inducible regulation of Runx2-stimulated osteogenesis." Gene Ther 13, no. 11 (June 2006): 873-882. Full Text Link to Item
- Phillips, JE, Gersbach, CA, Wojtowicz, AM, and García, AJ. "Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation." J Cell Sci 119, no. Pt 3 (February 1, 2006): 581-591. Full Text Link to Item
- Gersbach, CA, Phillips, JE, Guldberg, RE, and García, AJ. "Runx2-genetically engineered cells for bone tissue engineering." Proceedings of the 2005 Summer Bioengineering Conference 2005 (December 1, 2005): 603-604.
- Lan, MA, Gersbach, CA, Michael, KE, Keselowsky, BG, and García, AJ. "Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries." Biomaterials 26, no. 22 (August 2005): 4523-4531. Full Text Link to Item
- Drevs, J, Zirrgiebel, U, Schmidt-Gersbach, CIM, Mross, K, Medinger, M, Lee, L, Pinheiro, J, Wood, J, Thomas, AL, Unger, C, Henry, A, Steward, WP, Laurent, D, Lebwohl, D, Dugan, M, and Marmé, D. "Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials." Annals of Oncology 16, no. 4 (April 1, 2005): 558-565. Full Text
- Gersbach, CA, Byers, BA, Guldberg, RE, Pavlath, GK, and Garcia, AJ. "Runx2-stimulated transdifferentiation of primary skeletal myoblasts into an osteoblastic mineralizing phenotype for bone tissue engineering." Transactions 7th World Biomaterials Congress (December 1, 2004): 328-null.
- Gersbach, CA, Byers, BA, Pavlath, GK, Guldberg, RE, and García, AJ. "Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro." Biotechnol Bioeng 88, no. 3 (November 5, 2004): 369-378. Full Text Link to Item
- Gersbach, CA, Byers, BA, Pavlath, GK, and García, AJ. "Runx2/Cbfa1 stimulates transdifferentiation of primary skeletal myoblasts into a mineralizing osteoblastic phenotype." Exp Cell Res 300, no. 2 (November 1, 2004): 406-417. Full Text Link to Item
- GERSBACH, CA. "Runx2/Cbfa1 stimulates transdifferentiation of primary skeletal myoblasts into a mineralizing osteoblastic phenotype." Exp. Cell Res. 300 (2004): 406-417.
- García, AJ, Guldberg, RE, Byers, BA, Gersbach, CA, and Phillips, JE. "Addressing cell-sourcing limitations with gene therapy." IEEE Eng Med Biol Mag 22, no. 5 (September 2003): 65-70. Link to Item
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Book Sections
- Thakore, PI, and Gersbach, CA. "Genome Engineering for Therapeutic Applications." In Translating Gene Therapy to the Clinic: Techniques and Approaches, 27-43. November 17, 2014. Full Text
- Polstein, LR, and Gersbach, CA. "Spatiotemporal genetic control of cellular systems." In Tissue and Organ Regeneration: Advances in Micro- and Nanotechnology, 156-197. April 30, 2014. Full Text
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Conference Papers
- Farhang, N, Brunger, JM, Stover, JD, Thakore, PI, Lawrence, BD, Guilak, F, Gersbach, CA, Setton, LA, and Bowles, RD. "CRISPRi Immunomodulation for Tissue Engineering/Stem Cell Therapies Targeting Intervertebral Disc Degeneration." September 1, 2015. Link to Item
- Glass, KA, Ross, AK, Compton, SA, Gersbach, CA, Moutos, FT, Estes, BT, and Guilak, F. "Anatomically-Shaped Tissue-Engineered Cartilage with Tunable and Inducible Anti-Inflammatory Capabilities." September 1, 2015. Link to Item
- Black, J, Adler, A, Hutchinson, H, Wang, H, Pitt, G, Leong, K, and Gersbach, C. "59. Multiplex Gene Activation by CRISPR/Cas9-Based Transcription Factors for the Direct Conversion of Fibroblasts to a Neuronal Phenotype." May 2015. Full Text
- Schulz, E, Bergmann, T, Gebbing, M, Schildgen, V, Schildgen, O, Gersbach, C, and Ehrhardt, A. "Mutation Detection Following Non-Homologous End Joining (NHEJ): A Comparison of Different Semi Quantitative and Quantitative Methods." May 2014. Link to Item
- Perez-Pinera, P, Ousterout, DG, Brunger, JM, Farin, AM, Glass, KA, Guilak, F, Crawford, GE, Hartemink, AJ, and Gersbach, CA. "Synergistic and Tunable Gene Activation by Combinations of Synthetic Transcription Factors." June 2013. Link to Item
- Glass, KA, Brunger, JM, Gersbach, CA, and Guilak, F. "Tunable expression of IL-1Ra in genetically modified mesenchymal stem cells for cartilage tissue engineering." : Elsevier BV, April 2013. Full Text
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- Teaching & Mentoring
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Recent Courses
- BME 494: Projects in Biomedical Engineering (GE) 2019
- BME 562: Biology by Design (GE, MC) 2019
- BME 590L: Special Topics with Lab 2019
- BME 899: Special Readings in Biomedical Engineering 2019
- EGR 393: Research Projects in Engineering 2019
- BME 493: Projects in Biomedical Engineering (GE) 2018
- BME 792: Continuation of Graduate Independent Study 2018
- EGR 491: Projects in Engineering 2018
- BME 394: Projects in Biomedical Engineering (GE) 2017
- BME 791: Graduate Independent Study 2017
- Scholarly, Clinical, & Service Activities
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Outreach & Engaged Scholarship
- Bass Connections Faculty Team Leader. Duke Undergraduate International Genetically Engineered Machine. 2018 - 2019 2018 - 2019
- Bass Connections Faculty Team Member. Duke Undergraduate International Genetically Engineered Machine (iGEM) Team. August 2017 - May 2018 2017 - 2018
- Bass Connections Faculty Team Member. Duke Undergraduate International Genetically Engineered Machine (iGEM) Team. August 2016 - May 2017 2016 - 2017
- Bass Connections Faculty Team Member. International Genetically Engineered Machine (iGEM). May 2015 - May 2016 2015 - 2016
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