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Charles Gersbach

John W. Strohbehn Distinguished Professor of Biomedical Engineering
Biomedical Engineering
Box 90281, 136 Hudson Hall, Durham, NC 27708
2123 CIEMAS, Durham, NC 27708

Current Appointments & Affiliations


John W. Strohbehn Distinguished Professor of Biomedical Engineering · 2021 - Present Biomedical Engineering, Pratt School of Engineering
Professor of Biomedical Engineering · 2021 - Present Biomedical Engineering, Pratt School of Engineering
Associate Professor of Surgery · 2019 - Present Surgery, Surgical Sciences, Surgery
Associate Professor in Orthopaedic Surgery · 2015 - Present Orthopaedic Surgery, Clinical Science Departments
Associate Professor in Cell Biology · 2020 - Present Cell Biology, Basic Science Departments
Professor in Molecular Genetics and Microbiology · 2025 - Present Molecular Genetics and Microbiology, Basic Science Departments
Member of the Duke Cancer Institute · 2013 - Present Duke Cancer Institute, Institutes and Centers
Associate of the Duke Initiative for Science & Society · 2017 - Present Duke Science & Society, University Initiatives & Academic Support Units
Affiliate of the Duke Regeneration Center · 2021 - Present Duke Regeneration Center, Basic Science Departments

In the News


Published February 13, 2025
Activating Complex Regions of the Genome to Treat Rare Diseases
Published November 8, 2024
Genomic Medicine, Beyond CRISPR
Published October 2, 2024
Duke 100 Trailblazer: Charles Gersbach

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Recent Publications


Molecular and cellular engineering: Epigenetic engineering

Journal Article Current Opinion in Biomedical Engineering · September 1, 2026 Full text Cite

Transcription factor collaboration enables precise T cell state engineering.

Journal Article bioRxiv · April 22, 2026 Transcription factors (TFs) collaborate to regulate gene expression programs that define cell fate. In CD8 + T cells, this coordinated regulation underlies exhaustion, a dysfunctional state that constrains immunity in chronic infection and cancer. Here, we ... Full text Link to item Cite
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Recent Grants


Pharmacological Sciences Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2025 - 2030

Chromatin dysregulation in neurodevelopmental disorders

ResearchCollaborator · Awarded by National Institute of Neurological Disorders and Stroke · 2024 - 2029

Epigenetic Programming of T Cells for Enhanced Cellular Immunotherapy

ResearchPrincipal Investigator · Awarded by National Cancer Institute · 2024 - 2029

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Education


Georgia Institute of Technology · 2006 Ph.D.
Georgia Institute of Technology · 2001 B.S.