Current Appointments & Affiliations
John W. Strohbehn Distinguished Professor of Biomedical Engineering
·
2021 - Present
Biomedical Engineering,
Pratt School of Engineering
Professor of Biomedical Engineering
·
2021 - Present
Biomedical Engineering,
Pratt School of Engineering
Associate Professor of Surgery
·
2019 - Present
Surgery, Surgical Sciences,
Surgery
Associate Professor in Orthopaedic Surgery
·
2015 - Present
Orthopaedic Surgery,
Clinical Science Departments
Associate Professor in Cell Biology
·
2020 - Present
Cell Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2013 - Present
Duke Cancer Institute,
Institutes and Centers
Associate of the Duke Initiative for Science & Society
·
2017 - Present
Duke Science & Society,
University Initiatives & Academic Support Units
Core Faculty in Innovation & Entrepreneurship
·
2019 - Present
Duke Innovation & Entrepreneurship,
University Initiatives & Academic Support Units
Affiliate of the Duke Regeneration Center
·
2021 - Present
Duke Regeneration Center,
Basic Science Departments
Recent Publications
Synthetic biomolecular condensates enhance translation from a target mRNA in living cells.
Journal Article Nat Chem · March 2025 Biomolecular condensates composed of proteins and RNA are one approach by which cells regulate post-transcriptional gene expression. Their formation typically involves the phase separation of intrinsically disordered proteins with a target mRNA, sequesteri ... Full text Link to item CiteCharacterization and bioinformatic filtering of ambient gRNAs in single-cell CRISPR screens using CLEANSER.
Journal Article Cell Genom · February 12, 2025 Single-cell RNA sequencing CRISPR (perturb-seq) screens enable high-throughput investigation of the genome, allowing for characterization of thousands of genomic perturbations on gene expression. Ambient gRNAs, which are contaminating gRNAs, are a major so ... Full text Link to item CiteActivation of the imprinted Prader-Willi syndrome locus by CRISPR-based epigenome editing
Journal Article Cell Genomics · February 12, 2025 Epigenome editing with DNA-targeting technologies such as CRISPR-dCas9 can be used to dissect gene regulatory mechanisms and potentially treat associated disorders. For example, Prader-Willi syndrome (PWS) results from loss of paternally expressed imprinte ... Full text CiteRecent Grants
Chromatin dysregulation in neurodevelopmental disorders
ResearchCollaborator · Awarded by National Institutes of Health · 2024 - 2029Epigenetic Programming of T Cells for Enhanced Cellular Immunotherapy
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029Optimizing Gene Therapy for Respiratory Insufficiency in Duchenne Muscular Dystrophy
ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2028View All Grants
Education, Training & Certifications
Georgia Institute of Technology ·
2006
Ph.D.
Georgia Institute of Technology ·
2001
B.S.