Research Interests
Gene therapy, genomics and epigenomics, biomolecular and cellular engineering, regenerative medicine, and synthetic biology.
Selected Grants
Chromatin dysregulation in neurodevelopmental disorders
ResearchCollaborator · Awarded by National Institutes of Health · 2024 - 2029Epigenetic Programming of T Cells for Enhanced Cellular Immunotherapy
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029Optimizing Gene Therapy for Respiratory Insufficiency in Duchenne Muscular Dystrophy
ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2028To support research on the development of CRISPR-based epigenome editing tools to refine genome wide association studies
ResearchPrincipal Investigator · Awarded by Open Philanthropy Project · 2018 - 2027Understanding gene regulation in schizophrenia-associated loci using high-throughput epigenetic CRISPR screens
FellowshipSponsor · Awarded by National Institutes of Health · 2024 - 2027University Training Program in Biomolecular and Tissue Engineering
Inst. Training Prgm or CMECo-Principal Investigator · Awarded by National Institutes of Health · 1994 - 2027Training Program in Developmental and Stem Cell Biology
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2001 - 2027Genome Editing for the Treatment of Neurofibromatosis Type I
ResearchPrincipal Investigator · Awarded by Gilbert Family Foundation · 2022 - 2026Highly parallelized characterization of histone reader dysfunction
FellowshipCo-Mentor · Awarded by National Institutes of Health · 2024 - 2026Oxidative stress mechanisms regulating gamma-globin gene transcription in sickle cell disease
ResearchCollaborator · Awarded by National Institutes of Health · 2022 - 2026Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026High-Throughput Functional Annotation of Gene Regulatory Elements and Variants Critical to Complex Cellular Phenotypes
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2026Engineering Human Heart Tissues with Polyploid Cardiomyocytes
ResearchCo Investigator · Awarded by National Institutes of Health · 2022 - 2026Summer Scholars in Genome Sciences & Medicine
Inst. Training Prgm or CMESignificant Contributor · Awarded by National Institutes of Health · 2017 - 2026Epigenome Editing for Stable Reactivation of Maternal PWS Genes
ResearchPrincipal Investigator · Awarded by Foundation for Prader-Willi Research · 2024 - 2026Beyond GWAS: High Throughput Functional Genomics & Epigenome Editing to Elucidate the Effects of Genetic Associations for Schizophrenia
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2021 - 2026Epigenetic Engineering of Tumor-Infiltrating Lymphocytes
ResearchPrincipal Investigator · Awarded by Yosemite · 2025 - 2025The function and regulation of the novel pregnancy-specific hexokinase HKDC1
ResearchCo Investigator · Awarded by University of Illinois at Chicago · 2017 - 2025The Duke FUNCTION Center: Pioneering the comprehensive identification of combinatorial noncoding causes of disease
ResearchCo-Principal Investigator · Awarded by National Human Genome Research Institute · 2020 - 2025Multi-omics functional analysis of non-coding regulatory genome for genomic medicine
ResearchCollaborator · Awarded by National Human Genome Research Institute · 2020 - 2025Genetic and Genomics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025Lewy body neuropathologies and SNCA gene: variants expression and splicing
ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2025Mechanotransduction in Meniscus Health and Repair
ResearchCollaborator · Awarded by National Institutes of Health · 2019 - 2024Microphysiological Human Tissue Systems for Monitoring of Genome Editing Outcomes
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2024Epigenomic Reprogramming in Patient Derived Models of Colorectal Cancer
ResearchCo Investigator · Awarded by National Institutes of Health · 2018 - 2024Exploring the Use of Gene Therapies to Treat Neurofibromatosis Type I
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2024Evolving High Potency AAV Vectors for Neuromuscular Genome Editing
ResearchCo Investigator · Awarded by National Institutes of Health · 2018 - 2024Inductive repair of human kidney tissues by cell type-specific sensing and reprogramming
ResearchCollaborator · Awarded by University of Michigan · 2021 - 2024Quantifying the genetic diversity of human regulatory element activity
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2019 - 2024Engineering epigenome editing tools for sustained reactivation of maternal PWS genes
ResearchCo Investigator · Awarded by Foundation for Prader-Willi Research · 2020 - 2024Epigenome editing of the Prader-Willi syndrome imprinted domain with CRISPR/Cas9
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2024Epigenome Editing Technologies for Treating Diverse Disease
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2023Postdoctoral Training in Genomic Medicine Research
Inst. Training Prgm or CMECo-Mentor · Awarded by National Institutes of Health · 2017 - 2023IRES Track 1 IRTG Engaged in Dissecting and Reengineering the Regulatory Genome
ResearchMentor · Awarded by National Science Foundation · 2019 - 2023The Branched Chain Ketoacid Dehydrogenase Kinase-Phosphatase System as a New Regulatory Node in Myocardial Fuel Section
ResearchCollaborator · Awarded by National Institutes of Health · 2018 - 2023Thwarting Influenza with RNA-powered Modulators (ThIRM)
ResearchPrincipal Investigator · Awarded by Georgia Institute of Technology · 2019 - 2023Epigenome Editing Therapy to Treat Mouse Models of Prader-Willi Syndrome
ResearchPrincipal Investigator · Awarded by Levo Therapeutics, Inc · 2020 - 2022Regulatory Mechanisms of CD4+ T Cell Differentiation
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2017 - 2022Editing the Kidney Epigenome
ResearchPrincipal Investigator · Awarded by University of Washington · 2021 - 2022Uncovering novel gene regulatory mechanisms underlying glucocorticoid response phenotypes through targeted mutagenesis of an essential transcription factor
ResearchCo-Mentor · Awarded by National Institutes of Health · 2022 - 2022Dissecting Mechanisms by which p53 Suppresses Transformation and Radiation Carcinogenesis
ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2022EFRI CEE : Engineering Technologies to Determine Causal Relationships Between Chromatin Structure and Gene Regulation
ResearchPrincipal Investigator · Awarded by National Science Foundation · 2018 - 2022An organotypic model recapitulating colon cancer microenvironment and metastasis
ResearchCo Investigator · Awarded by University of Texas Southwestern Medical Center · 2017 - 2022Systemic Inflammation in Microphysiological Models of Muscle and Vascular Disease
ResearchCo Investigator · Awarded by National Institutes of Health · 2017 - 2022REU Site for Meeting the Grand Challenges in Engineering
Inst. Training Prgm or CMEMentor · Awarded by National Science Foundation · 2017 - 2022In Vivo Epigenome Editing with CRISPR-Based Histone Acetyltransferase Transgenic Mice
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2016 - 2022Investigating Autophagy in GSD-Ia
ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2021Bioinformatics and Computational Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2005 - 2021Epigenome Editing Technologies to Control Diverse Biological Functions
ResearchPrincipal Investigator · Awarded by Allen Institute for Brain Science · 2017 - 2021Enhancing Neuronal Reprogramming with Epigenome Editing
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2021CRISPR/Cas9-Based Gene Editing for the Correction of Duchenne Muscular Dystrophy
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2021Genome Editing For Duchenne Muscular Dystrophy
ResearchPrincipal Investigator · Awarded by Sarepta Therapeutics, Inc. · 2017 - 2021Genetics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1979 - 2020Treating Duchenne Cardiomyopathy in the Mouse Model by Gene Repair
ResearchPrincipal Investigator · Awarded by University of Missouri · 2016 - 2020Identification and application of cis-regulatory enhancer elements for muscle stem cell function and muscle regeneration in aging
ResearchCo Investigator · Awarded by American Federation for Aging Research · 2019 - 2020Combinatorial Biomimetic Systems for High-Throughput Manipulation of Genome-Edited Dystrophic Muscle Stem Cells
ResearchPrincipal Investigator · Awarded by Cornell University · 2018 - 2020Functional characterization of regulatory variants associated with maternal hyperglycemia
FellowshipCo-Mentor · Awarded by National Institutes of Health · 2017 - 2020Collaborative Research: Adapting Cas9 Protein from CRISPR as a Structural Unit for Molecular Assembly
ResearchPrincipal Investigator · Awarded by National Science Foundation · 2017 - 2020Designing a next generation vector for CRISPR/Cas9-mediated gene editing to treat Duchenne muscular dystrophy
FellowshipPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2018 - 2020Developing Brain-penetrant G9a/GLP Inhibitors for Treating Prader-Willi Syndrome
ResearchCo-Principal Investigator · Awarded by Levo Therapeutics, Inc · 2018 - 2020NONHUMAN PRIMATE TESTING CENTER FOR EVALUATION OF SOMATIC CELL GENOME EDITING TOOLS
ResearchCo Investigator · Awarded by University of California - Davis · 2019 - 2020Development of AAV-Based Curative Therapies for Correcting Duchenne Muscular Dystrophy by Targeted Genomic Integration
FellowshipPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2017 - 2019Enhancing Neuronal Reprogramming with Epigenome Editing
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2019Non-viral delivery of CRISPR/Cas9 for targeted gene replacement
ResearchMentor · Awarded by National Institutes of Health · 2018 - 2019Novel Approaches for Correcting Respiratory Insufficiency in Pompe Disease
ResearchCo-Mentor · Awarded by National Institutes of Health · 2014 - 2019Reprogrammed autologous T cells to promote transplant tolerance
ResearchPrincipal Investigator · Awarded by Element Genomics, Inc. · 2018 - 2019Systemically administrered EGRFvIII-targeted bispecific antibody as an immunotherapeutic for glioblastoma.
FellowshipCollaborator · Awarded by National Institutes of Health · 2015 - 2019Defining the Mechanisms of Gene Regulation and Drug Resistance in Cancer
ResearchPrincipal Investigator · Awarded by Thorek Memorial Foundation · 2017 - 2019Decoding and Reprogramming the Corticosteroid Transcriptional Regulatory Network
ResearchInvestigator · Awarded by National Institutes of Health · 2015 - 2018Trans-regulatory mechanisms of glucocorticoid-mediated transcriptional repression
FellowshipCo-Mentor · Awarded by National Institutes of Health · 2016 - 2018Genome engineering for Duchenne muscular dystrophy
FellowshipPrincipal Investigator · Awarded by American Heart Association · 2017 - 2018Engineering Novel Genome Engineering Systems
ResearchPrincipal Investigator · Awarded by Locus Biosciences, Inc. · 2016 - 2018Circulatory system and integrated muscle tissue for drug and tissue toxicity
ResearchCo Investigator · Awarded by National Institutes of Health · 2012 - 2018Engineering Targeted Epigenetic Modifiers for Precise Control of Gene Regulation
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2018A Platform Technology for High-Throughput Screening of Gene Regulatory Elements
ResearchPrincipal Investigator · Awarded by Element Genomics, Inc. · 2016 - 2017MD140071 Multiplex CRISPR/Cas9-Based Genome Engineering for the Genetic Correction of Duchenne Muscular Dystrophy
ResearchPrincipal Investigator · Awarded by United States Army Medical Research and Materiel Command · 2015 - 2017Functional Tissue Engineering of Cartilage Using Induced Pluripotent Stem Cells
FellowshipCollaborator · Awarded by National Institutes of Health · 2015 - 2017CRISPR/Cas9-based genome editing in mouse models of Duchenne muscular dystrophy
FellowshipPrincipal Investigator · Awarded by Hartwell Foundation · 2015 - 2017Scaffold-Mediated Gene Delivery for Engineering of Osteochondral Tissues
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2017Gertude B. Elion Mentored Medical Research Award
ResearchPrincipal Investigator · Awarded by Triangle Community Foundation · 2016 - 2017Genome Editing of Stem Cells for Analysis of Osteoarthritis Causal Variants
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2014 - 2017CAREER: Photoregulated Gene Expression for Spatiotemporal Control of Morphogenesis
ResearchPrincipal Investigator · Awarded by National Science Foundation · 2012 - 2017Engineering Morphogenetic Factors for Enhanced Genetic Reprogramming
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2016Engineering New Biological Therapies for Arthritis
ResearchCollaborator · Awarded by Arthritis Foundation · 2014 - 2015Live-Animal Micro-CT System
EquipmentMajor User · Awarded by National Institutes of Health · 2012 - 2014Spatially Controlled Gene Delivery of Morphogenetic Factors from Woven Scaffolds
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2014External Relationships
- Editas Medicine
- Element Genomics (UCB Pharma)
- Facet Bio
- Locus Biosciences
- Sarepta Therapeutics
- Sollus Therapeutics, Inc.
- TreeCo
- Tune Therapeutics
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.