Mitigating the cytotoxicity of graphene quantum dots and enhancing their applications in bioimaging and drug delivery
Publication
, Journal Article
Chandra, A; Deshpande, S; Shinde, DB; Pillai, VK; Singh, N
Published in: ACS Macro Letters
October 21, 2014
Despite the promising photophysical properties of fluorescent graphene quantum dots (GQDs), their cellular toxicity needs to be addressed before their full potential could be completely realized in biomedicine. A simple method for mitigating the toxicity of GQDs by embedding them in PEG matrix is reported here. The enhanced biocompatibility of polymer modified, P-GQDs, is attributed to reduced reactive oxygen species generation, as measured by an intracellular ROS assay. We also demonstrate the enhanced loading and efficient intracellular delivery of therapeutics by P-GQDs. (Graph Presented).
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Published In
ACS Macro Letters
DOI
EISSN
2161-1653
Publication Date
October 21, 2014
Volume
3
Issue
10
Start / End Page
1064 / 1068
Related Subject Headings
- 3406 Physical chemistry
- 3403 Macromolecular and materials chemistry
- 0306 Physical Chemistry (incl. Structural)
- 0303 Macromolecular and Materials Chemistry
Citation
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Chandra, A., Deshpande, S., Shinde, D. B., Pillai, V. K., & Singh, N. (2014). Mitigating the cytotoxicity of graphene quantum dots and enhancing their applications in bioimaging and drug delivery. ACS Macro Letters, 3(10), 1064–1068. https://doi.org/10.1021/mz500479k
Chandra, A., S. Deshpande, D. B. Shinde, V. K. Pillai, and N. Singh. “Mitigating the cytotoxicity of graphene quantum dots and enhancing their applications in bioimaging and drug delivery.” ACS Macro Letters 3, no. 10 (October 21, 2014): 1064–68. https://doi.org/10.1021/mz500479k.
Chandra A, Deshpande S, Shinde DB, Pillai VK, Singh N. Mitigating the cytotoxicity of graphene quantum dots and enhancing their applications in bioimaging and drug delivery. ACS Macro Letters. 2014 Oct 21;3(10):1064–8.
Chandra, A., et al. “Mitigating the cytotoxicity of graphene quantum dots and enhancing their applications in bioimaging and drug delivery.” ACS Macro Letters, vol. 3, no. 10, Oct. 2014, pp. 1064–68. Scopus, doi:10.1021/mz500479k.
Chandra A, Deshpande S, Shinde DB, Pillai VK, Singh N. Mitigating the cytotoxicity of graphene quantum dots and enhancing their applications in bioimaging and drug delivery. ACS Macro Letters. 2014 Oct 21;3(10):1064–1068.
Published In
ACS Macro Letters
DOI
EISSN
2161-1653
Publication Date
October 21, 2014
Volume
3
Issue
10
Start / End Page
1064 / 1068
Related Subject Headings
- 3406 Physical chemistry
- 3403 Macromolecular and materials chemistry
- 0306 Physical Chemistry (incl. Structural)
- 0303 Macromolecular and Materials Chemistry