The association of race and ethnicity with risk-reducing mastectomies in patients with non-BRCA mutations.

INTRODUCTION: We compared rates of risk reducing mastectomies (RRM) in patients with breast cancer (BC)-related pathogenic variants. METHODS: Female patients ages ≥18 with a BC-related pathogenic variant, without a concurrent or prior BC diagnosis, were identified from a single academic center's database. Patients were stratified by BRCA mutations, high penetrance mutations (HPM), and moderate penetrance mutations (MPM). Race and ethnicity were classified as non-Hispanic White (NHW), non-Hispanic Black (NHB), non-Hispanic other (NHO), and Hispanic. RESULTS: Our study included 528 patients, which included 79.2 ​% (n ​= ​418) NHW, 7.0 ​% (n ​= ​37) NHB, 3.6 ​% (n = ​19) NHO, and 3.4 ​% (n ​= ​18) Hispanic patients. Overall, 16.5 ​% of patients underwent RRM: 18.4 ​% of NHW, 10.8 ​% of NHB, 5.6 ​% of Hispanic (p ​= ​0.45). For NHB and Hispanic patients, no individuals with HPMs (NHB 0/6, Hispanic 0/5) or MPMs (NHB 0/11, Hispanic 0/4) underwent RRM. CONCLUSIONS: Our findings suggest that race and ethnicity may be associated with the decision to undergo RRM.

Duke Scholars

Author Ton Wang Surgical Oncology

Author Jennifer K Plichta Surgical Oncology

Author Samantha Thomas  

Author Akiko Chiba Surgical Oncology

Author Juliet Dalton