Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines.
Publication
, Journal Article
de Bruyn, G; Adhikarla, H; Brackett, CK; Jia, Y; Lakshmanane, P; Mudrak, SV; Sawant, S; Zhang, D; Chicz, RM; Sridhar, S; Tomaras, GD; Seaton, KE
Published in: NPJ Vaccines
July 13, 2025
We included measurement of pre-existing immunity to human endemic coronaviruses (HCoV) in a Phase I/II study of SARS-CoV-2 spike protein vaccine candidates. A Binding Antibody Multiplex Assay measured HCoV-specific IgG to the receptor binding domain or full-length spike of human coronaviruses HKU1, 229E, NL63, and OC43. We found no evidence for the impact of HCoV antibodies on neutralizing and binding antibody responses to the candidate SARS-CoV-2 vaccines.
Duke Scholars
Published In
NPJ Vaccines
DOI
EISSN
2059-0105
Publication Date
July 13, 2025
Volume
10
Issue
1
Start / End Page
153
Location
England
Related Subject Headings
- 3207 Medical microbiology
- 3204 Immunology
Citation
APA
Chicago
ICMJE
MLA
NLM
de Bruyn, G., Adhikarla, H., Brackett, C. K., Jia, Y., Lakshmanane, P., Mudrak, S. V., … Seaton, K. E. (2025). Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines. NPJ Vaccines, 10(1), 153. https://doi.org/10.1038/s41541-025-01203-z
Bruyn, Guy de, Haritha Adhikarla, Caroline K. Brackett, Yichen Jia, Premkumar Lakshmanane, Sarah V. Mudrak, Sheetal Sawant, et al. “Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines.” NPJ Vaccines 10, no. 1 (July 13, 2025): 153. https://doi.org/10.1038/s41541-025-01203-z.
de Bruyn G, Adhikarla H, Brackett CK, Jia Y, Lakshmanane P, Mudrak SV, et al. Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines. NPJ Vaccines. 2025 Jul 13;10(1):153.
de Bruyn, Guy, et al. “Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines.” NPJ Vaccines, vol. 10, no. 1, July 2025, p. 153. Pubmed, doi:10.1038/s41541-025-01203-z.
de Bruyn G, Adhikarla H, Brackett CK, Jia Y, Lakshmanane P, Mudrak SV, Sawant S, Zhang D, Chicz RM, Sridhar S, Tomaras GD, Seaton KE. Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines. NPJ Vaccines. 2025 Jul 13;10(1):153.
Published In
NPJ Vaccines
DOI
EISSN
2059-0105
Publication Date
July 13, 2025
Volume
10
Issue
1
Start / End Page
153
Location
England
Related Subject Headings
- 3207 Medical microbiology
- 3204 Immunology