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Chromatix: a differentiable, GPU-accelerated wave-optics library.

Publication ,  Journal Article
Deb, D; Both, G-J; Bezzam, E; Kohli, A; Yang, S; Chaware, A; Allier, C; Cai, C; Anderberg, G; Eybposh, MH; Schneider, MC; Heintzmann, R ...
Published in: bioRxiv
March 25, 2026

Modem microscopy methods incorporate computational modeling as an integral part of the imaging process, either to solve inverse problems or optimize the optical system design itself. These methods often depend on differentiable optics simulations, yet no standardized framework exists-forcing computational optics researchers to repeatedly and independently implement simulations with limited reusability and performance. These common problems limit the potential impact of computational optics as a field. Here we present Chromatix: an open-source, GPU-accelerated, differentiable wave optics simulation library. Chromatix builds on JAX to democratize fast, parallelized simulation of diverse optical systems and expand the design space in computational optics. Chromatix standardizes a growing collection of optical elements and propagation methods allowing a broad range of applications, which we demonstrate here for snapshot microscopy, holography, and phase retrieval. We demonstrate speed improvements of 2-6× on a single GPU and up to 22× on 8 GPUs.

Duke Scholars

Published In

bioRxiv

DOI

EISSN

2692-8205

Publication Date

March 25, 2026

Location

United States
 

Citation

APA
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Deb, D., Both, G.-J., Bezzam, E., Kohli, A., Yang, S., Chaware, A., … Turaga, S. C. (2026). Chromatix: a differentiable, GPU-accelerated wave-optics library. BioRxiv. https://doi.org/10.1101/2025.04.29.651152
Deb, Diptodip, Gert-Jan Both, Eric Bezzam, Amit Kohli, Siqi Yang, Arney Chaware, Cédric Allier, et al. “Chromatix: a differentiable, GPU-accelerated wave-optics library.BioRxiv, March 25, 2026. https://doi.org/10.1101/2025.04.29.651152.
Deb D, Both G-J, Bezzam E, Kohli A, Yang S, Chaware A, et al. Chromatix: a differentiable, GPU-accelerated wave-optics library. bioRxiv. 2026 Mar 25;
Deb, Diptodip, et al. “Chromatix: a differentiable, GPU-accelerated wave-optics library.BioRxiv, Mar. 2026. Pubmed, doi:10.1101/2025.04.29.651152.
Deb D, Both G-J, Bezzam E, Kohli A, Yang S, Chaware A, Allier C, Cai C, Anderberg G, Eybposh MH, Schneider MC, Heintzmann R, Rivera-Sanchez FA, Simmerer C, Meng G, Tormes-Vaquerano J, Han S, Shanmugavel SC, Maruvada T, Yang X, Kim Y, Diederich B, Joo C, Waller L, Durr NJ, Pégard NC, La Rivière PJ, Horstmeyer R, Chowdhury S, Turaga SC. Chromatix: a differentiable, GPU-accelerated wave-optics library. bioRxiv. 2026 Mar 25;

Published In

bioRxiv

DOI

EISSN

2692-8205

Publication Date

March 25, 2026

Location

United States