Direct monitoring of organic reactions on polymeric supports
Publication
, Journal Article
Carrasco, MR; Fitzgerald, MC; Oda, Y; Kent, SBH
Published in: Tetrahedron Letters
September 8, 1997
A method to use matrix-assisted laser desorption/ionization mass spectrometry MALDI-MS) for real time monitoring of organic reactions on polymeric supports used in solid-phase synthesis is described. The strategy utilizes a synthetic construct that allows for the rapid and convenient direct MALDI analysis of the attached substrates as well as their subsequent chemical cleavage as desired. We have used this strategy to monitor nucleophilic substitutions, palladium-catalyzed coupling reactions, and solid phase peptide synthesis reactions using both Boc- and Fmoc-based chemistries.
Duke Scholars
Published In
Tetrahedron Letters
DOI
ISSN
0040-4039
Publication Date
September 8, 1997
Volume
38
Issue
36
Start / End Page
6331 / 6334
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry
Citation
APA
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ICMJE
MLA
NLM
Carrasco, M. R., Fitzgerald, M. C., Oda, Y., & Kent, S. B. H. (1997). Direct monitoring of organic reactions on polymeric supports. Tetrahedron Letters, 38(36), 6331–6334. https://doi.org/10.1016/S0040-4039(97)01456-1
Carrasco, M. R., M. C. Fitzgerald, Y. Oda, and S. B. H. Kent. “Direct monitoring of organic reactions on polymeric supports.” Tetrahedron Letters 38, no. 36 (September 8, 1997): 6331–34. https://doi.org/10.1016/S0040-4039(97)01456-1.
Carrasco MR, Fitzgerald MC, Oda Y, Kent SBH. Direct monitoring of organic reactions on polymeric supports. Tetrahedron Letters. 1997 Sep 8;38(36):6331–4.
Carrasco, M. R., et al. “Direct monitoring of organic reactions on polymeric supports.” Tetrahedron Letters, vol. 38, no. 36, Sept. 1997, pp. 6331–34. Scopus, doi:10.1016/S0040-4039(97)01456-1.
Carrasco MR, Fitzgerald MC, Oda Y, Kent SBH. Direct monitoring of organic reactions on polymeric supports. Tetrahedron Letters. 1997 Sep 8;38(36):6331–6334.
Published In
Tetrahedron Letters
DOI
ISSN
0040-4039
Publication Date
September 8, 1997
Volume
38
Issue
36
Start / End Page
6331 / 6334
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry