Skip to main content
Journal cover image

To find the road traveled to tumor immunity: the trafficking itineraries of molecular chaperones in antigen-presenting cells.

Publication ,  Journal Article
Berwin, B; Nicchitta, CV
Published in: Traffic
October 2001

Molecular chaperones, both endoplasmic reticulum and cytosol derived, have been identified as tumor rejection antigens; in animal models, they can elicit prophylactic and therapeutic immune responses against their tumor of origin. Chaperone immunogenic activity derives from three principal characteristics: they bind an array of immunogenic (poly)peptides, they can be efficiently internalized by professional antigen-presenting cells, and once internalized, they traffic to a subcellular compartment(s) where peptide release can occur. Within the antigen-presenting cell, chaperone-derived peptides can be assembled onto major histocompatibility class I molecules for presentation at the antigen-presenting cell surface, thereby yielding the requisite and specific CD8+ T-cell responses that contribute to the process of tumor rejection. Though it is clear that chaperones, in particular GRP94 (gp96), calreticulin and Hsp70, can elicit cellular immune responses, the subcellular basis of chaperone processing by antigen-presenting cells remains mysterious. In this review, we discuss recent reports describing the identification of a chaperone internalization receptor and the physiological release of chaperones from necrotic cells, and we present views on the trafficking pathways within antigen-presenting cells that may function to deliver the chaperone-associated peptides to subcellular organelles for their subsequent exchange onto major histocompatibility complex molecules.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Traffic

DOI

ISSN

1398-9219

Publication Date

October 2001

Volume

2

Issue

10

Start / End Page

690 / 697

Location

England

Related Subject Headings

  • Receptors, Cell Surface
  • Peptides
  • Neoplasms
  • Molecular Chaperones
  • Membrane Proteins
  • Humans
  • HSP70 Heat-Shock Proteins
  • Endoplasmic Reticulum
  • Developmental Biology
  • Biological Transport, Active
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Berwin, B., & Nicchitta, C. V. (2001). To find the road traveled to tumor immunity: the trafficking itineraries of molecular chaperones in antigen-presenting cells. Traffic, 2(10), 690–697. https://doi.org/10.1034/j.1600-0854.2001.21003.x
Berwin, B., and C. V. Nicchitta. “To find the road traveled to tumor immunity: the trafficking itineraries of molecular chaperones in antigen-presenting cells.Traffic 2, no. 10 (October 2001): 690–97. https://doi.org/10.1034/j.1600-0854.2001.21003.x.
Berwin, B., and C. V. Nicchitta. “To find the road traveled to tumor immunity: the trafficking itineraries of molecular chaperones in antigen-presenting cells.Traffic, vol. 2, no. 10, Oct. 2001, pp. 690–97. Pubmed, doi:10.1034/j.1600-0854.2001.21003.x.
Journal cover image

Published In

Traffic

DOI

ISSN

1398-9219

Publication Date

October 2001

Volume

2

Issue

10

Start / End Page

690 / 697

Location

England

Related Subject Headings

  • Receptors, Cell Surface
  • Peptides
  • Neoplasms
  • Molecular Chaperones
  • Membrane Proteins
  • Humans
  • HSP70 Heat-Shock Proteins
  • Endoplasmic Reticulum
  • Developmental Biology
  • Biological Transport, Active