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Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate.

Publication ,  Journal Article
Zalutsky, MR; Stabin, MG; Larsen, RH; Bigner, DD
Published in: Nucl Med Biol
April 1997

A paired-label study was performed in athymic mice bearing subcutaneous D-54 MG human glioma xenografts to compare the localization of human/mouse anti-tenascin chimeric antibody 81C6 labeled by reaction with N-succinimidyl 3-[211At]astatobenzoate and N-succinimidyl 3-[131I]iodobenzoate. Over the 48-h observation period, the distribution of 211At- and 131I-labeled antibody were quite similar in tumor and normal tissues except stomach. These data were used to calculate human radiation doses for both intravenously and intrathecal administered 211At-labeled chimeric 81C6 using a quality factor of 5 for alpha-emissions.

Duke Scholars

Published In

Nucl Med Biol

DOI

ISSN

0969-8051

Publication Date

April 1997

Volume

24

Issue

3

Start / End Page

255 / 261

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Tissue Distribution
  • Radiopharmaceuticals
  • Radionuclide Imaging
  • Radiation Dosage
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Transplantation
  • Mice
  • Iodine Radioisotopes
  • Injections, Spinal
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zalutsky, M. R., Stabin, M. G., Larsen, R. H., & Bigner, D. D. (1997). Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate. Nucl Med Biol, 24(3), 255–261. https://doi.org/10.1016/s0969-8051(97)00060-7
Zalutsky, M. R., M. G. Stabin, R. H. Larsen, and D. D. Bigner. “Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate.Nucl Med Biol 24, no. 3 (April 1997): 255–61. https://doi.org/10.1016/s0969-8051(97)00060-7.
Zalutsky MR, Stabin MG, Larsen RH, Bigner DD. Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate. Nucl Med Biol. 1997 Apr;24(3):255–61.
Zalutsky, M. R., et al. “Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate.Nucl Med Biol, vol. 24, no. 3, Apr. 1997, pp. 255–61. Pubmed, doi:10.1016/s0969-8051(97)00060-7.
Zalutsky MR, Stabin MG, Larsen RH, Bigner DD. Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate. Nucl Med Biol. 1997 Apr;24(3):255–261.
Journal cover image

Published In

Nucl Med Biol

DOI

ISSN

0969-8051

Publication Date

April 1997

Volume

24

Issue

3

Start / End Page

255 / 261

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Tissue Distribution
  • Radiopharmaceuticals
  • Radionuclide Imaging
  • Radiation Dosage
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Transplantation
  • Mice
  • Iodine Radioisotopes
  • Injections, Spinal